{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T20:39:29Z","timestamp":1790627969681,"version":"4.1.0"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["30371089"],"award-info":[{"award-number":["30371089"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81171210"],"award-info":[{"award-number":["81171210"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research Bulletin"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1016\/j.brainresbull.2019.06.011","type":"journal-article","created":{"date-parts":[[2019,6,17]],"date-time":"2019-06-17T13:41:56Z","timestamp":1560778916000},"page":"285-296","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["FGF9 alters the Wallerian degeneration process by inhibiting Schwann cell transformation and accelerating macrophage infiltration"],"prefix":"10.1016","volume":"152","author":[{"given":"Wenjing","family":"Lv","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binbin","family":"Deng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weisong","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xueqin","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingxiao","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongyao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yakun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxiao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainresbull.2019.06.011_bib0005","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1016\/j.neuron.2012.06.021","article-title":"c-Jun reprograms Schwann cells of injured nerves to generate a repair cell essential for regeneration","volume":"75","author":"Arthur-Farraj","year":"2012","journal-title":"Neuron"},{"key":"10.1016\/j.brainresbull.2019.06.011_bib0010","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1016\/j.bbi.2010.07.249","article-title":"Transcriptional profiling of the injured sciatic nerve of mice carrying the Wld(S) mutant gene: identification of genes involved in neuroprotection, neuroinflammation, and nerve regeneration","volume":"24","author":"Barrette","year":"2010","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.brainresbull.2019.06.011_bib0015","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.devcel.2013.12.002","article-title":"Contrasting the glial response to axon injury in the central and peripheral nervous systems","volume":"28","author":"Brosius Lutz","year":"2014","journal-title":"Dev. Cell"},{"key":"10.1016\/j.brainresbull.2019.06.011_bib0020","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1038\/nn.4200","article-title":"Remodeling myelination: implications for mechanisms of neural plasticity","volume":"19","author":"Chang","year":"2016","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.brainresbull.2019.06.011_bib0025","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1007\/s00401-015-1482-4","article-title":"Role of macrophages in Wallerian degeneration and axonal regeneration after peripheral nerve injury","volume":"130","author":"Chen","year":"2015","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.brainresbull.2019.06.011_bib0030","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1146\/annurev.neuro.30.051606.094337","article-title":"Peripheral regeneration","volume":"30","author":"Chen","year":"2007","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.brainresbull.2019.06.011_bib0035","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1002\/1097-4547(20000801)61:3<273::AID-JNR5>3.0.CO;2-I","article-title":"Fibroblast growth factor-9 modulates the expression of myelin related proteins and multiple fibroblast growth factor receptors in developing oligodendrocytes","volume":"61","author":"Cohen","year":"2000","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.brainresbull.2019.06.011_bib0040","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1177\/145749690809700407","article-title":"Techniques of peripheral nerve repair","volume":"97","author":"Dahlin","year":"2008","journal-title":"Scand. J. Surg."},{"key":"10.1016\/j.brainresbull.2019.06.011_bib0045","doi-asserted-by":"crossref","DOI":"10.1002\/jcb.27105","article-title":"FGF9 modulates Schwann cell myelination in developing nerves and induces a pro-inflammatory environment during injury","author":"Deng","year":"2018","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.brainresbull.2019.06.011_bib0050","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1186\/1742-2094-8-110","article-title":"Wallerian degeneration: gaining perspective on inflammatory events after peripheral nerve injury","volume":"8","author":"Gaudet","year":"2011","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.brainresbull.2019.06.011_bib0055","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/j.conb.2013.06.010","article-title":"Signals regulating myelination in peripheral nerves and the Schwann cell response to injury","volume":"23","author":"Glenn","year":"2013","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.brainresbull.2019.06.011_bib0060","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1038\/nrm3528","article-title":"Exploring mechanisms of FGF signalling through the lens of structural biology","volume":"14","author":"Goetz","year":"2013","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.brainresbull.2019.06.011_bib0065","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1002\/glia.22796","article-title":"CSF-1-activated macrophages are target-directed and essential mediators of Schwann cell dedifferentiation and dysfunction in Cx32-deficient mice","volume":"63","author":"Groh","year":"2015","journal-title":"Glia"},{"key":"10.1016\/j.brainresbull.2019.06.011_bib0070","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1093\/brain\/awr283","article-title":"Colony-stimulating factor-1 mediates macrophage-related neural damage in a model for Charcot-Marie-Tooth disease type 1X","volume":"135","author":"Groh","year":"2012","journal-title":"Brain"},{"key":"10.1016\/j.brainresbull.2019.06.011_bib0075","doi-asserted-by":"crossref","first-page":"16382","DOI":"10.1074\/jbc.272.26.16382","article-title":"Heparin-induced self-association of fibroblast growth factor-2. Evidence for two oligomerization processes","volume":"272","author":"Herr","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresbull.2019.06.011_bib0080","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1038\/gt.2011.7","article-title":"Schwann cell targeting via intrasciatic injection of AAV8 as gene therapy strategy for peripheral nerve regeneration","volume":"18","author":"Homs","year":"2011","journal-title":"Gene Ther."},{"key":"10.1016\/j.brainresbull.2019.06.011_bib0085","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1002\/glia.20761","article-title":"Negative regulation of myelination: relevance for development, injury, and demyelinating disease","volume":"56","author":"Jessen","year":"2008","journal-title":"Glia"},{"key":"10.1016\/j.brainresbull.2019.06.011_bib0090","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/j.mcn.2003.11.007","article-title":"Targeted disruption of the FGF-2 gene affects the response to peripheral nerve injury","volume":"25","author":"Jungnickel","year":"2004","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.brainresbull.2019.06.011_bib0095","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/S0736-5748(99)00026-X","article-title":"FGF-9 is an autocrine\/paracrine neurotrophic substance for spinal motoneurons","volume":"17","author":"Kanda","year":"1999","journal-title":"Int. J. Dev. Neurosci."},{"key":"10.1016\/j.brainresbull.2019.06.011_bib0100","doi-asserted-by":"crossref","first-page":"553","DOI":"10.5966\/sctm.2013-0011","article-title":"Plastic fantastic: schwann cells and repair of the peripheral nervous system","volume":"2","author":"Kim","year":"2013","journal-title":"Stem Cells Transl. Med."},{"key":"10.1016\/j.brainresbull.2019.06.011_bib0105","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.brainres.2015.11.033","article-title":"Myelin and macrophages in the PNS: an intimate relationship in trauma and disease","volume":"1641","author":"Klein","year":"2016","journal-title":"Brain Res."},{"key":"10.1016\/j.brainresbull.2019.06.011_bib0110","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1002\/humu.21067","article-title":"Molecular pathology of the fibroblast growth factor family","volume":"30","author":"Krejci","year":"2009","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.brainresbull.2019.06.011_bib0115","doi-asserted-by":"crossref","first-page":"15169","DOI":"10.1523\/JNEUROSCI.2466-12.2012","article-title":"Erbin is required for myelination in regenerated axons after injury","volume":"32","author":"Liang","year":"2012","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainresbull.2019.06.011_bib0120","article-title":"Intramuscular delivery of scAAV9-hIGF1 prolongs survival in the hSOD1G93A ALS mouse model via upregulation of D-Amino acid oxidase","author":"Lin","year":"2016","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.brainresbull.2019.06.011_bib0125","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.ydbio.2009.02.011","article-title":"Neuron-derived FGF9 is essential for scaffold formation of Bergmann radial fibers and migration of granule neurons in the cerebellum","volume":"329","author":"Lin","year":"2009","journal-title":"Dev. Biol."},{"key":"10.1016\/j.brainresbull.2019.06.011_bib0130","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1093\/brain\/awv102","article-title":"Fibroblast growth factor signalling in multiple sclerosis: inhibition of myelination and induction of pro-inflammatory environment by FGF9","volume":"138","author":"Lindner","year":"2015","journal-title":"Brain"},{"key":"10.1016\/j.brainresbull.2019.06.011_bib0135","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.ajpath.2013.06.002","article-title":"Similarities between inherited demyelinating neuropathies and Wallerian degeneration: an old repair program may cause myelin and axon perturbation under nonlesion conditions","volume":"183","author":"Martini","year":"2013","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.brainresbull.2019.06.011_bib0140","doi-asserted-by":"crossref","first-page":"31024","DOI":"10.1074\/jbc.M110.116970","article-title":"Schwann cell dedifferentiation is independent of mitogenic signaling and uncoupled to proliferation: role of cAMP and JNK in the maintenance of the differentiated state","volume":"285","author":"Monje","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresbull.2019.06.011_bib0145","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1002\/glia.22852","article-title":"New insights on Schwann cell development","volume":"63","author":"Monk","year":"2015","journal-title":"Glia"},{"key":"10.1016\/j.brainresbull.2019.06.011_bib0150","doi-asserted-by":"crossref","first-page":"4782","DOI":"10.1021\/bi9625455","article-title":"Properly oriented heparin-decasaccharide-induced dimers are the biologically active form of basic fibroblast growth factor","volume":"36","author":"Moy","year":"1997","journal-title":"Biochemistry"},{"key":"10.1016\/j.brainresbull.2019.06.011_bib0155","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1016\/j.neuron.2011.11.031","article-title":"A central role for the ERK-signaling pathway in controlling Schwann cell plasticity and peripheral nerve regeneration in vivo","volume":"73","author":"Napoli","year":"2012","journal-title":"Neuron"},{"key":"10.1016\/j.brainresbull.2019.06.011_bib0160","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1111\/j.1460-9568.1995.tb01063.x","article-title":"Radiation-induced reductions in macrophage recruitment have only slight effects on myelin degeneration in sectioned peripheral nerves of mice","volume":"7","author":"Perry","year":"1995","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.brainresbull.2019.06.011_bib0165","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1083\/jcb.133.1.159","article-title":"Granulocyte macrophage colony stimulating factor produced in lesioned peripheral nerves induces the up-regulation of cell surface expression of MAC-2 by macrophages and Schwann cells","volume":"133","author":"Saada","year":"1996","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.brainresbull.2019.06.011_bib0170","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a020529","article-title":"Schwann cell myelination","volume":"7","author":"Salzer","year":"2015","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.brainresbull.2019.06.011_bib0175","doi-asserted-by":"crossref","first-page":"53","DOI":"10.4103\/1673-5374.175042","volume":"11","author":"Stratton","year":"2016","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.brainresbull.2019.06.011_bib0180","article-title":"Intrathecal delivery of ssAAV9-DAO extends survival in SOD1G93A ALS mice","author":"Wang","year":"2016","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.brainresbull.2019.06.011_bib0185","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainres.2016.06.043","article-title":"scAAV9-VEGF prolongs the survival of transgenic ALS mice by promoting activation of M2 microglia and the PI3K\/Akt pathway","volume":"1648","author":"Wang","year":"2016","journal-title":"Brain Res."},{"key":"10.1016\/j.brainresbull.2019.06.011_bib0190","doi-asserted-by":"crossref","first-page":"10356","DOI":"10.1093\/nar\/gks750","article-title":"miR-182 inhibits Schwann cell proliferation and migration by targeting FGF9 and NTM, respectively at an early stage following sciatic nerve injury","volume":"40","author":"Yu","year":"2012","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.brainresbull.2019.06.011_bib0195","doi-asserted-by":"crossref","DOI":"10.1002\/0471142735.im1401s83","article-title":"The isolation and characterization of murine macrophages","author":"Zhang","year":"2008","journal-title":"Curr. Protoc. Immunol."},{"key":"10.1016\/j.brainresbull.2019.06.011_bib0200","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.1016\/j.joca.2016.07.005","article-title":"Exogenous fibroblast growth factor 9 attenuates cartilage degradation and aggravates osteophyte formation in post-traumatic osteoarthritis","volume":"24","author":"Zhou","year":"2016","journal-title":"Osteoarthr. Cartil."}],"container-title":["Brain Research Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0361923018307937?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0361923018307937?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T20:40:06Z","timestamp":1759783206000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0361923018307937"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":40,"alternative-id":["S0361923018307937"],"URL":"https:\/\/doi.org\/10.1016\/j.brainresbull.2019.06.011","relation":{},"ISSN":["0361-9230"],"issn-type":[{"value":"0361-9230","type":"print"}],"subject":[],"published":{"date-parts":[[2019,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"FGF9 alters the Wallerian degeneration process by inhibiting Schwann cell transformation and accelerating macrophage infiltration","name":"articletitle","label":"Article Title"},{"value":"Brain Research Bulletin","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainresbull.2019.06.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}