{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T17:14:32Z","timestamp":1778692472364,"version":"3.51.4"},"reference-count":87,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["SFRH\/BD\/87886\/2012"],"award-info":[{"award-number":["SFRH\/BD\/87886\/2012"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001871","name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","doi-asserted-by":"publisher","award":["PTDC\/SAU-SNC\/115506\/2009-FCOMP 01-0124-FEDER-015919"],"award-info":[{"award-number":["PTDC\/SAU-SNC\/115506\/2009-FCOMP 01-0124-FEDER-015919"]}],"id":[{"id":"10.13039\/501100001871","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research Bulletin"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1016\/j.brainresbull.2019.07.009","type":"journal-article","created":{"date-parts":[[2019,7,10]],"date-time":"2019-07-10T19:18:56Z","timestamp":1562786336000},"page":"95-106","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["Altered serotonin innervation in the rat epileptic brain"],"prefix":"10.1016","volume":"152","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3199-340X","authenticated-orcid":false,"given":"Gisela H.","family":"Maia","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joana I.","family":"Soares","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00e9rgio G.","family":"Almeida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliana M.","family":"Leite","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helena X.","family":"Baptista","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alisa N.","family":"Lukoyanova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e1tia S.","family":"Brazete","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5206-7819","authenticated-orcid":false,"given":"Nikolai V.","family":"Lukoyanov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainresbull.2019.07.009_bib0005","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1196\/annals.1296.005","article-title":"Anatomic and functional topography of the dorsal raphe nucleus","volume":"1018","author":"Abrams","year":"2004","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.brainresbull.2019.07.009_bib0010","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.euroneuro.2006.08.009","article-title":"Effect of chronic citalopram on serotonin-related and stress-regulated genes in the dorsal raphe nucleus of the rat","volume":"17","author":"Abumaria","year":"2007","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.brainresbull.2019.07.009_bib0015","first-page":"9","article-title":"Topographic distribution of dorsal and median raphe neurons with hippocampal","volume":"47","author":"Acsady","year":"1996","journal-title":"septal and dual projection J Acta Biologica Hungarica."},{"key":"10.1016\/j.brainresbull.2019.07.009_bib0020","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.yebeh.2003.10.010","article-title":"Differences in memory performance and other clinical characteristics in patients with mesial temporal lobe epilepsy with and without hippocampal atrophy","volume":"5","author":"Alessio","year":"2004","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.brainresbull.2019.07.009_bib0025","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1038\/274374a0","article-title":"Structural and functional restoration by collateral sprouting of hippocampal 5-HT axons","volume":"274","author":"Azmitia","year":"1978","journal-title":"Nature"},{"key":"10.1016\/j.brainresbull.2019.07.009_bib0030","doi-asserted-by":"crossref","first-page":"5041","DOI":"10.1523\/JNEUROSCI.13-12-05041.1993","article-title":"Increase of tryptophan hydroxylase enzyme protein by dexamethasone in adrenalectomized rat midbrain","volume":"13","author":"Azmitia","year":"1993","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainresbull.2019.07.009_bib0035","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0893-133X(96)80057-1","article-title":"Cellular localization of the 5-HT1A receptor in primate brain neurons and glial cells","volume":"14","author":"Azmitia","year":"1996","journal-title":"Neuropsychopharmacology."},{"key":"10.1016\/j.brainresbull.2019.07.009_bib0040","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.brainres.2008.03.060","article-title":"Dystrophic serotonergic axons in neurodegenerative diseases","volume":"1217","author":"Azmitia","year":"2008","journal-title":"Brain Res."},{"key":"10.1016\/j.brainresbull.2019.07.009_bib0045","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1111\/j.1471-4159.2006.04277.x","article-title":"Serotonin and epilepsy","volume":"100","author":"Bagdy","year":"2007","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainresbull.2019.07.009_bib0050","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1016\/S0028-3908(99)00010-6","article-title":"A review of central 5-HT receptors and their function","volume":"38","author":"Barnes","year":"1999","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.brainresbull.2019.07.009_bib0055","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1111\/j.1749-6632.1978.tb31540.x","article-title":"Changes in seizure susceptibility after intracerebral treatment with 5, 7\u2010dihydroxytryptamine: role of serotonergic neurons","volume":"305","author":"Browning","year":"1978","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.brainresbull.2019.07.009_bib0060","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1002\/(SICI)1096-9861(19970901)385:3<385::AID-CNE4>3.0.CO;2-#","article-title":"Neuron loss, granule cell axon reorganization, and functional changes in the dentate gyrus of epileptic kainate\u2010treated rats","volume":"385","author":"Buckmaster","year":"1997","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.brainresbull.2019.07.009_bib0065","doi-asserted-by":"crossref","first-page":"6650","DOI":"10.1523\/JNEUROSCI.22-15-06650.2002","article-title":"Axon sprouting in a model of temporal lobe epilepsy creates a predominantly excitatory feedback circuit","volume":"22","author":"Buckmaster","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainresbull.2019.07.009_bib0070","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1528-1157.1994.tb02905.x","article-title":"Spontaneous recurrent seizures in rats: amino acid and monoamine determination in the hippocampus","volume":"35","author":"Cavalheiro","year":"1994","journal-title":"Epilepsia"},{"key":"10.1016\/j.brainresbull.2019.07.009_bib0075","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1136\/bmj.2.5006.1403","article-title":"Aetiological aspects of Ammon\u2019s horn sclerosis associated with temporal lobe epilepsy","volume":"2","author":"Cavanagh","year":"1956","journal-title":"Br. Med. J."},{"key":"10.1016\/j.brainresbull.2019.07.009_bib0080","doi-asserted-by":"crossref","first-page":"25","DOI":"10.3389\/fnint.2013.00025","article-title":"Serotonin modulation of cortical neurons and networks","volume":"7","author":"Celada","year":"2013","journal-title":"Front. Integr. Neurosci."},{"key":"10.1016\/j.brainresbull.2019.07.009_bib0085","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/j.biopsych.2005.01.013","article-title":"Differential hormonal regulation of tryptophan hydroxylase-2 mRNA in the murine dorsal raphe nucleus","volume":"57","author":"Clark","year":"2005","journal-title":"Biol Psych."},{"key":"10.1016\/j.brainresbull.2019.07.009_bib0090","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.eplepsyres.2014.12.013","article-title":"Hippocampal serotonin depletion is related to the presence of generalized tonic\u2013clonic seizures, but not to psychiatric disorders in patients with temporal lobe epilepsy","volume":"111","author":"da Fonseca","year":"2015","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.brainresbull.2019.07.009_bib0095","doi-asserted-by":"crossref","first-page":"8394","DOI":"10.1523\/JNEUROSCI.4460-14.2015","article-title":"Synergy of direct and indirect cholinergic septo-hippocampal pathways coordinates firing in hippocampal networks","volume":"35","author":"Dannenberg","year":"2015","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainresbull.2019.07.009_bib0100","first-page":"65","article-title":"Ultrastructure of the serotonin innervation in the mammalian central nervous system","volume":"Vol. 21","author":"Descarries","year":"2010"},{"key":"10.1016\/j.brainresbull.2019.07.009_bib0105","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s00429-008-0189-x","article-title":"Brain structural and functional abnormalities in mood disorders: implications for neurocircuitry models of depression","volume":"213","author":"Drevets","year":"2008","journal-title":"Brain Struct. Funct."},{"key":"10.1016\/j.brainresbull.2019.07.009_bib0110","series-title":"Seizures and Epilepsy","author":"Engel","year":"1989"},{"key":"10.1016\/j.brainresbull.2019.07.009_bib0115","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1136\/jnnp-2017-315732","article-title":"Functional connectivity disturbances of the ascending reticular activating system in temporal lobe epilepsy","volume":"88","author":"Englot","year":"2017","journal-title":"J Neurol Neurosurg Psychiatry."},{"key":"10.1016\/j.brainresbull.2019.07.009_bib0120","doi-asserted-by":"crossref","first-page":"1926","DOI":"10.1212\/WNL.45.10.1926","article-title":"Anticonvulsant effect of fluoxetine in humans","volume":"45","author":"Favale","year":"1995","journal-title":"Neurology."},{"key":"10.1016\/j.brainresbull.2019.07.009_bib0125","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/S1059-1311(02)00315-1","article-title":"The anticonvulsant effect of citalopram as an indirect evidence of serotonergic impairment in human epileptogenesis","volume":"12","author":"Favale","year":"2003","journal-title":"Seizure."},{"key":"10.1016\/j.brainresbull.2019.07.009_bib0130","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1139\/y97-033","article-title":"Inhibitory control of GABAergic interneurons in the hippocampus","volume":"75","author":"Freund","year":"1997","journal-title":"Can. J. Physiol. Pharmacol."},{"key":"10.1016\/j.brainresbull.2019.07.009_bib0135","doi-asserted-by":"crossref","first-page":"38","DOI":"10.3389\/fnana.2018.00038","article-title":"Evidence for sprouting of dopamine and serotonin axons in the pallidum of parkinsonian monkeys","volume":"12","author":"Gagnon","year":"2018","journal-title":"Front. Neuroanat."},{"key":"10.1016\/j.brainresbull.2019.07.009_bib0140","doi-asserted-by":"crossref","first-page":"2382","DOI":"10.1098\/rstb.2011.0378","article-title":"Probing the diversity of serotonin neurons","volume":"367","author":"Gaspar","year":"2012","journal-title":"Philos. Trans. R. Soc. Lond., B, Biol. Sci."},{"key":"10.1016\/j.brainresbull.2019.07.009_bib0145","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1002\/jnr.20635","article-title":"In situ expression of brain\u2010derived neurotrophic factor or neurotrophin\u20103 promotes sprouting of cortical serotonergic axons following a neurotoxic lesion","volume":"82","author":"Grider","year":"2005","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.brainresbull.2019.07.009_bib0150","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1046\/j.1365-2818.1999.00457.x","article-title":"The efficiency of systematic sampling in stereology\u2014reconsidered","volume":"193","author":"Gundersen","year":"1999","journal-title":"J. Microsc."},{"key":"10.1016\/j.brainresbull.2019.07.009_bib0155","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1007\/s00213-010-2089-z","article-title":"Functional topography of midbrain and pontine serotonergic systems: implications for synaptic regulation of serotonergic circuits","volume":"213","author":"Hale","year":"2011","journal-title":"Psychopharmacology (Berl.)"},{"key":"10.1016\/j.brainresbull.2019.07.009_bib0160","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0306-4522(00)00296-7","article-title":"Increased amyloid precursor protein expression and serotonergic sprouting following excitotoxic lesion of the rat magnocellular nucleus basalis: neuroprotection by Ca2+ antagonist nimodipine","volume":"101","author":"Harkany","year":"2000","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainresbull.2019.07.009_bib0165","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1006\/nbdi.2001.0398","article-title":"\u03b2-Amyloid (1-42)-induced cholinergic lesions in rat nucleus basalis bidirectionally modulate serotonergic innervation of the basal forebrain and cerebral cortex","volume":"8","author":"Harkany","year":"2001","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.brainresbull.2019.07.009_bib0170","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1016\/j.biopsych.2007.02.015","article-title":"5-HT1A receptor binding in temporal lobe epilepsy patients with and without major depression","volume":"62","author":"Hasler","year":"2007","journal-title":"Biol Psych."},{"key":"10.1016\/j.brainresbull.2019.07.009_bib0175","series-title":"Epilepsy Surgery","first-page":"55","article-title":"Epidemiology of intractable epilepsy","author":"Hauser","year":"2001"},{"key":"10.1016\/j.brainresbull.2019.07.009_bib0180","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1111\/epi.12246","article-title":"High\u2010dose rapamycin blocks mossy fiber sprouting but not seizures in a mouse model of temporal lobe epilepsy","volume":"54","author":"Heng","year":"2013","journal-title":"Epilepsia."},{"key":"10.1016\/j.brainresbull.2019.07.009_bib0185","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1046\/j.1528-1157.2002.48701.x","article-title":"Effects of fluoxetine and TFMPP on spontaneous seizures in rats with pilocarpine\u2010induced epilepsy","volume":"43","author":"Hernandez","year":"2002","journal-title":"Epilepsia."},{"key":"10.1016\/j.brainresbull.2019.07.009_bib0190","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1002\/cne.22237","article-title":"Vesicular glutamate transporter 3-expressing nonserotonergic projection neurons constitute a subregion in the rat midbrain raphe nuclei","volume":"518","author":"Hioki","year":"2010","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.brainresbull.2019.07.009_bib0195","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1002\/syn.20581","article-title":"Nonserotonergic projection neurons in the midbrain raphe nuclei contain the vesicular glutamate transporter VGLUT3","volume":"63","author":"Jackson","year":"2009","journal-title":"Synapse."},{"key":"10.1016\/j.brainresbull.2019.07.009_bib0200","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1152\/physrev.1992.72.1.165","article-title":"Structure and function of the brain serotonin system","volume":"72","author":"Jacobs","year":"1992","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.brainresbull.2019.07.009_bib0205","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1016\/S1474-4422(12)70201-6","article-title":"Can neurobiological pathogenic mechanisms of depression facilitate the development of seizure disorders?","volume":"11","author":"Kanner","year":"2012","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.brainresbull.2019.07.009_bib0210","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1002\/syn.890010204","article-title":"The serotoninergic innervation of cerebral cortex: different classes of axon terminals arise from dorsal and median raphe nuclei","volume":"1","author":"Kosofsky","year":"1987","journal-title":"Synapse."},{"key":"10.1016\/j.brainresbull.2019.07.009_bib0215","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0165-3806(02)00386-3","article-title":"Abnormal postnatal ontogeny of the locus coeruleus in the epileptic mutant mouse quaking","volume":"136","author":"Le Saux","year":"2002","journal-title":"Brain Res. Dev. Brain Res."},{"key":"10.1016\/j.brainresbull.2019.07.009_bib0220","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.pnpbp.2005.11.025","article-title":"Dorsal raphe vs. Median raphe serotonergic antagonism. Anatomical, physiological, behavioral, neuroendocrinological, neuropharmacological and clinical evidences: relevance for neuropharmacological therapy","volume":"30","author":"Lechin","year":"2006","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.brainresbull.2019.07.009_bib0225","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/0006-8993(87)90057-6","article-title":"Monoaminergic correlates of kindling","volume":"403","author":"Lewis","year":"1987","journal-title":"Brain Res."},{"key":"10.1016\/j.brainresbull.2019.07.009_bib0230","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1017\/S0317167100029449","article-title":"A study of monoamine metabolism in human epilepsy","volume":"16","author":"Louw","year":"1989","journal-title":"Can. J. Neurol. Sci."},{"key":"10.1016\/j.brainresbull.2019.07.009_bib0235","series-title":"Serotonin and Sleep: Molecular, Functional and Clinical Aspects","first-page":"25","article-title":"Topographic organization and chemoarchitecture of the dorsal raphe nucleus and the median raphe nucleus","author":"Lowry","year":"2008"},{"key":"10.1016\/j.brainresbull.2019.07.009_bib0240","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1152\/jn.2000.83.2.693","article-title":"Recurrent excitatory connectivity in the dentate gyrus of kindled and kainic acid\u2013treated rats","volume":"83","author":"Lynch","year":"2000","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.brainresbull.2019.07.009_bib0245","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0084722","article-title":"Loss of hippocampal neurons after kainate treatment correlates with behavioral deficits","volume":"9","author":"Maia","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.brainresbull.2019.07.009_bib0250","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.bbr.2015.10.010","article-title":"Altered taste preference and loss of limbic-projecting serotonergic neurons in the dorsal raphe nucleus of chronically epileptic rats","volume":"297","author":"Maia","year":"2016","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.brainresbull.2019.07.009_bib0255","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1002\/cne.903140312","article-title":"Dual serotoninergic projections to forebrain in the rat: morphologically distinct 5\u2010HT axon terminals exhibit differential vulnerability to neurotoxic amphetamine derivatives","volume":"314","author":"Mamounas","year":"1991","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.brainresbull.2019.07.009_bib0260","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1177\/026988110201600310","article-title":"Corticosterone modulation of somatodendritic 5-HT1A receptor function in mice","volume":"16","author":"Man","year":"2002","journal-title":"J. Psychopharmacol."},{"key":"10.1016\/j.brainresbull.2019.07.009_bib0265","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1093\/brain\/89.3.499","article-title":"Epilepsy and the temporal lobes","volume":"89","author":"Margerison","year":"1966","journal-title":"Brain"},{"key":"10.1016\/j.brainresbull.2019.07.009_bib0270","doi-asserted-by":"crossref","first-page":"2071","DOI":"10.1093\/brain\/awn117","article-title":"Depression after status epilepticus: behavioural and biochemical deficits and effects of fluoxetine","volume":"131","author":"Mazarati","year":"2008","journal-title":"Brain."},{"key":"10.1016\/j.brainresbull.2019.07.009_bib0275","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.nbd.2009.02.018","article-title":"Elevated plasma corticosterone level and depressive behavior in experimental temporal lobe epilepsy","volume":"34","author":"Mazarati","year":"2009","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.brainresbull.2019.07.009_bib0280","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/S0079-6123(08)00912-6","article-title":"The dorsal raphe nucleus and serotonin: implications for neuroplasticity linked to major depression and Alzheimer\u2019s disease","volume":"172","author":"Michelsen","year":"2008","journal-title":"Prog. Brain Res."},{"key":"10.1016\/j.brainresbull.2019.07.009_bib0285","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0920-1211(99)00088-1","article-title":"A new model of chronic temporal lobe epilepsy induced by electrical stimulation of the amygdala in rat","volume":"38","author":"Nissinen","year":"2000","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.brainresbull.2019.07.009_bib0290","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/0306-4522(91)90044-O","article-title":"Ultrastructural features of the serotonin innervation in adult rat hippocampus: an immunocytochemical description in single and serial thin sections","volume":"42","author":"Oleskevich","year":"1991","journal-title":"Neuroscience."},{"key":"10.1016\/j.brainresbull.2019.07.009_bib0295","series-title":"The Rat Brain in Stereotaxic Coordinates","author":"Paxinos","year":"1998"},{"key":"10.1016\/j.brainresbull.2019.07.009_bib0300","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1006\/ebeh.2001.0247","article-title":"Depression and anxiety in patients with epilepsy","volume":"2","author":"Piazzini","year":"2001","journal-title":"Epilepsy Behav."},{"key":"10.1016\/j.brainresbull.2019.07.009_bib0305","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1111\/j.1528-1167.2010.02623.x","article-title":"Comorbidity between epilepsy and depression: experimental evidence for the involvement of serotonergic, glucocorticoid, and neuroinflammatory mechanisms","volume":"51","author":"Pineda","year":"2010","journal-title":"Epilepsia"},{"key":"10.1016\/j.brainresbull.2019.07.009_bib0310","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1038\/npp.2011.18","article-title":"Plasticity of presynaptic and postsynaptic serotonin 1A receptors in an animal model of epilepsy-associated depression","volume":"36","author":"Pineda","year":"2011","journal-title":"Neuropsychopharmacology."},{"key":"10.1016\/j.brainresbull.2019.07.009_bib0315","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1042\/BJ20121662","article-title":"Regulation of cholinergic activity by the vesicular acetylcholine transporter","volume":"450","author":"Prado","year":"2013","journal-title":"Biochem. J."},{"key":"10.1016\/j.brainresbull.2019.07.009_bib0320","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/0013-4694(72)90177-0","article-title":"Modification of seizure activity by electrical stimulation: II. Motor seizure","volume":"32","author":"Racine","year":"1972","journal-title":"Electroencephalogr. Clin. Neurophysiol."},{"key":"10.1016\/j.brainresbull.2019.07.009_bib0325","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0361-9230(79)90050-9","article-title":"Effects of midbrain raphe lesions or systemic p-chlorophenylalanine on the development of kindled seizures in rats","volume":"4","author":"Racine","year":"1979","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.brainresbull.2019.07.009_bib0330","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1113\/jphysiol.1991.sp018742","article-title":"Serotonin facilitates GABAergic transmission in the CA1 region of rat hippocampus in vitro","volume":"441","author":"Ropert","year":"1991","journal-title":"J. Physiol."},{"key":"10.1016\/j.brainresbull.2019.07.009_bib0335","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0006-8993(00)03265-0","article-title":"Long-lasting effects of feline amygdala kindling on monoamines, seizures and sleep","volume":"892","author":"Shouse","year":"2001","journal-title":"Brain Res."},{"key":"10.1016\/j.brainresbull.2019.07.009_bib0340","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.neulet.2018.02.044","article-title":"The pedunculopontine and laterodorsal tegmental nuclei in the kainate model of epilepsy","volume":"672","author":"Soares","year":"2018","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.brainresbull.2019.07.009_bib0345","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1097\/00002826-200405000-00009","article-title":"Citalopram as treatment of depression in patients with epilepsy","volume":"27","author":"Specchio","year":"2004","journal-title":"Clin. Neuropharmacol."},{"key":"10.1016\/j.brainresbull.2019.07.009_bib0350","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1126\/science.2449733","article-title":"Synaptic reorganization in the hippocampus induced by abnormal functional activity","volume":"239","author":"Sutula","year":"1988","journal-title":"Science."},{"key":"10.1016\/j.brainresbull.2019.07.009_bib0355","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1002\/ana.410260303","article-title":"Mossy fiber synaptic reorganization in the epileptic human temporal lobe","volume":"26","author":"Sutula","year":"1989","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.brainresbull.2019.07.009_bib0360","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.pbb.2005.01.020","article-title":"Behavioral, biochemical and histological studies in a model of pilocarpine-induced spontaneous recurrent seizures","volume":"81","author":"Szyndler","year":"2005","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.brainresbull.2019.07.009_bib0365","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1007\/s00702-010-0414-7","article-title":"Time course of changes in the concentrations of monoamines in the brain structures of pentylenetetrazole-kindled rats","volume":"117","author":"Szyndler","year":"2010","journal-title":"J. Neural Transm."},{"key":"10.1016\/j.brainresbull.2019.07.009_bib0370","doi-asserted-by":"crossref","first-page":"2336","DOI":"10.1111\/j.1528-1167.2007.01222.x","article-title":"Psychiatric comorbidity in epilepsy: a population\u2010based analysis","volume":"48","author":"Tellez\u2010Zenteno","year":"2007","journal-title":"Epilepsia."},{"key":"10.1016\/j.brainresbull.2019.07.009_bib0375","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1111\/j.1528-1167.2011.03309.x","article-title":"Serotonin 1A receptors, depression, and memory in temporal lobe epilepsy","volume":"53","author":"Theodore","year":"2012","journal-title":"Epilepsia."},{"key":"10.1016\/j.brainresbull.2019.07.009_bib0380","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/0006-8993(91)90325-P","article-title":"Collateral sprouting of serotonergic fibers in the cingulate cortex and the septum following cortical-hippocampal lesions","volume":"556","author":"Ueda","year":"1991","journal-title":"Brain Res."},{"key":"10.1016\/j.brainresbull.2019.07.009_bib0385","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.conb.2014.04.010","article-title":"Dual-transmitter neurons: functional implications of co-release and co-transmission","volume":"29","author":"Vaaga","year":"2014","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.brainresbull.2019.07.009_bib0390","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1126\/science.1178307","article-title":"Fast synaptic subcortical control of hippocampal circuits","volume":"326","author":"Varga","year":"2009","journal-title":"Science."},{"key":"10.1016\/j.brainresbull.2019.07.009_bib0395","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1111\/j.1528-1167.2012.03436.x","article-title":"The antidepressants citalopram and reboxetine reduce seizure frequency in rats with chronic epilepsy","volume":"53","author":"Vermoesen","year":"2012","journal-title":"Epilepsia."},{"key":"10.1016\/j.brainresbull.2019.07.009_bib0400","series-title":"Serotonin and Sleep: Molecular, Functional and Clinical Aspects","first-page":"69","article-title":"Efferent and afferent connections of the dorsal and median raphe nuclei in the rat","author":"Vertes","year":"2008"},{"key":"10.1016\/j.brainresbull.2019.07.009_bib0405","doi-asserted-by":"crossref","first-page":"27","DOI":"10.3389\/fncir.2015.00027","article-title":"The piriform, perirhinal, and entorhinal cortex in seizure generation","volume":"9","author":"Vismer","year":"2015","journal-title":"Front. Neural Circuits"},{"key":"10.1016\/j.brainresbull.2019.07.009_bib0410","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1016\/j.celrep.2019.01.014","article-title":"Dorsal raphe dual serotonin-glutamate neurons drive reward by establishing excitatory synapses on VTA mesoaccumbens dopamine neurons","volume":"26","author":"Wang","year":"2019","journal-title":"Cell Rep."},{"key":"10.1016\/j.brainresbull.2019.07.009_bib0415","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1002\/ar.1092310411","article-title":"Unbiased stereological estimation of the total number of neurons in the subdivisions of the rat hippocampus using the optical fractionator","volume":"231","author":"West","year":"1991","journal-title":"Anat. Rec."},{"key":"10.1016\/j.brainresbull.2019.07.009_bib0420","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1002\/cne.23681","article-title":"Blockade of excitatory synaptogenesis with proximal dendrites of dentate granule cells following rapamycin treatment in a mouse model of temporal lobe epilepsy","volume":"523","author":"Yamawaki","year":"2015","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.brainresbull.2019.07.009_bib0425","doi-asserted-by":"crossref","first-page":"6964","DOI":"10.1523\/JNEUROSCI.0066-09.2009","article-title":"The mammalian target of rapamycin signaling pathway mediates epileptogenesis in a model of temporal lobe epilepsy","volume":"29","author":"Zeng","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainresbull.2019.07.009_bib0430","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/0006-8993(86)90348-3","article-title":"Induced homotypic sprouting of serotonergic fibers in hippocampus. II. An immunocytochemistry study","volume":"373","author":"Zhou","year":"1986","journal-title":"Brain Res."},{"key":"10.1016\/j.brainresbull.2019.07.009_bib0435","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/0165-3806(94)00158-V","article-title":"Rapid serotonergic fiber sprouting in response to ibotenic acid lesion in the striatum and hippocampus","volume":"84","author":"Zhou","year":"1995","journal-title":"Brain Res. Dev. Brain Res."}],"container-title":["Brain Research Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0361923018308049?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0361923018308049?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T16:26:35Z","timestamp":1778689595000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0361923018308049"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":87,"alternative-id":["S0361923018308049"],"URL":"https:\/\/doi.org\/10.1016\/j.brainresbull.2019.07.009","relation":{},"ISSN":["0361-9230"],"issn-type":[{"value":"0361-9230","type":"print"}],"subject":[],"published":{"date-parts":[[2019,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Altered serotonin innervation in the rat epileptic brain","name":"articletitle","label":"Article Title"},{"value":"Brain Research Bulletin","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainresbull.2019.07.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}