{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T22:14:07Z","timestamp":1778537647198,"version":"3.51.4"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100005047","name":"Natural Science Foundation of Liaoning Province","doi-asserted-by":"publisher","award":["2019-ZD0939"],"award-info":[{"award-number":["2019-ZD0939"]}],"id":[{"id":"10.13039\/501100005047","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31171122"],"award-info":[{"award-number":["31171122"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81703513"],"award-info":[{"award-number":["81703513"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970326"],"award-info":[{"award-number":["81970326"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81773731"],"award-info":[{"award-number":["81773731"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81573431"],"award-info":[{"award-number":["81573431"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research Bulletin"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1016\/j.brainresbull.2019.10.003","type":"journal-article","created":{"date-parts":[[2019,10,15]],"date-time":"2019-10-15T13:26:29Z","timestamp":1571145989000},"page":"9-20","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["FGF-21 ameliorates essential hypertension of SHR via baroreflex afferent function"],"prefix":"10.1016","volume":"154","author":[{"given":"Pei","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bing","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ke-Xin","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhuo","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xun","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Long","family":"Lu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu-Qi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Wen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiong-Xiong","family":"Fan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin-Ling","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ning","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guo-Fen","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bai-Yan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainresbull.2019.10.003_bib0005","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1089\/gtmb.2016.0320","article-title":"Gender-specific association between FGFR4 Gly388Arg gene variants and hypertension","volume":"21","author":"Al-Daghri","year":"2017","journal-title":"Genet. Test. Mol. Biomarkers"},{"key":"10.1016\/j.brainresbull.2019.10.003_bib0010","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1161\/HYPERTENSIONAHA.109.138065","article-title":"Leptin impairs cardiovagal baroreflex function at the level of the solitary tract nucleus","volume":"54","author":"Arnold","year":"2009","journal-title":"Hypertension"},{"key":"10.1016\/j.brainresbull.2019.10.003_bib0015","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1687-9856-2014-7","article-title":"Significant gender difference in serum levels of fibroblast growth factor 21 in Danish children and adolescents","volume":"2014","author":"Bisgaard","year":"2014","journal-title":"Int. J. Pediatr. Endocrinol."},{"key":"10.1016\/j.brainresbull.2019.10.003_bib0020","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.2337\/dc09-0684","article-title":"Circulating fibroblast growth factor-21 is elevated in impaired glucose tolerance and type 2 diabetes and correlates with muscle and hepatic insulin resistance","volume":"32","author":"Chavez","year":"2009","journal-title":"Diabetes Care"},{"key":"10.1016\/j.brainresbull.2019.10.003_bib0025","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1161\/CIRCRESAHA.109.208439","article-title":"Angiotensin II inhibits neuronal nitric oxide synthase activation through the ERK1\/2-RSK signaling pathway to modulate central control of blood pressure","volume":"106","author":"Cheng","year":"2010","journal-title":"Circ. Res."},{"key":"10.1016\/j.brainresbull.2019.10.003_bib0030","doi-asserted-by":"crossref","first-page":"2454","DOI":"10.1161\/ATVBAHA.113.301599","article-title":"Serum fibroblast growth factor-21 levels are associated with carotid atherosclerosis independent of established cardiovascular risk factors","volume":"33","author":"Chow","year":"2013","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.brainresbull.2019.10.003_bib0035","doi-asserted-by":"crossref","first-page":"E203","DOI":"10.1152\/ajpendo.00076.2017","article-title":"Hepatic FGF21 mediates sex differences in high-fat high-fructose diet-induced fatty liver","volume":"313","author":"Chukijrungroat","year":"2017","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.brainresbull.2019.10.003_bib0040","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.cmet.2012.08.002","article-title":"betaKlotho is required for fibroblast growth factor 21 effects on growth and metabolism","volume":"16","author":"Ding","year":"2012","journal-title":"Cell Metab."},{"key":"10.1016\/j.brainresbull.2019.10.003_bib0045","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.cmet.2008.06.014","article-title":"The circulating metabolic regulator FGF21 is induced by prolonged fasting and PPARalpha activation in man","volume":"8","author":"Galman","year":"2008","journal-title":"Cell Metab."},{"key":"10.1016\/j.brainresbull.2019.10.003_bib0050","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.tem.2014.03.001","article-title":"FGF21-based pharmacotherapy - potential utility for metabolic disorders","volume":"25","author":"Gimeno","year":"2014","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.brainresbull.2019.10.003_bib0055","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s12264-018-0271-1","article-title":"Anti-hypertensive action of fenofibrate via UCP2 upregulation mediated by PPAR activation in baroreflex afferent pathway","volume":"35","author":"Guan","year":"2019","journal-title":"Neurosci. Bull."},{"key":"10.1016\/j.brainresbull.2019.10.003_bib0060","doi-asserted-by":"crossref","first-page":"17271","DOI":"10.1074\/jbc.R110.113175","article-title":"Obesity-induced hypertension: role of sympathetic nervous system, leptin, and melanocortins","volume":"285","author":"Hall","year":"2010","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresbull.2019.10.003_bib0065","doi-asserted-by":"crossref","first-page":"e106","DOI":"10.1016\/j.ijcard.2013.12.127","article-title":"Hyperpolarization-activated current-mediated slow afterhyperpolarization in myelinated Ah-type of baroreceptor neurons isolated from adult female rats","volume":"172","author":"Han","year":"2014","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.brainresbull.2019.10.003_bib0070","doi-asserted-by":"crossref","first-page":"29582","DOI":"10.1038\/srep29582","article-title":"FGF21 ameliorates the neurocontrol of blood pressure in the high fructose-drinking rats","volume":"6","author":"He","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.brainresbull.2019.10.003_bib0075","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1007\/s11906-017-0730-5","article-title":"The potential role of fibroblast growth factor 21 in lipid metabolism and hypertension","volume":"19","author":"Huang","year":"2017","journal-title":"Curr. Hypertens. Rep."},{"key":"10.1016\/j.brainresbull.2019.10.003_bib0080","article-title":"Protective role of Fgf21 in adverse cardiac remodeling after myocardial infarction","volume":"130","author":"Joki","year":"2014","journal-title":"Circulation"},{"key":"10.1016\/j.brainresbull.2019.10.003_bib0085","first-page":"215","article-title":"FGF-21, a novel metabolic regulator, has a robust neuroprotective role and is markedly elevated in neurons by mood stabilizers","volume":"10","author":"Leng","year":"2013","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.brainresbull.2019.10.003_bib0090","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0165-0270(02)00010-9","article-title":"Patch clamp electrophysiology in nodose ganglia of adult rat","volume":"115","author":"Li","year":"2002","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.brainresbull.2019.10.003_bib0095","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.jneumeth.2007.04.003","article-title":"Electrophysiological and pharmacological validation of vagal afferent fiber type of neurons enzymatically isolated from rat nodose ganglia","volume":"164","author":"Li","year":"2007","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.brainresbull.2019.10.003_bib0100","doi-asserted-by":"crossref","first-page":"R1301","DOI":"10.1152\/ajpregu.90401.2008","article-title":"Electrophysiological and neuroanatomical evidence of sexual dimorphism in aortic baroreceptor and vagal afferents in rat","volume":"295","author":"Li","year":"2008","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.brainresbull.2019.10.003_bib0105","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.neuroscience.2015.06.049","article-title":"Sex- and afferent-specific differences in histamine receptor expression in vagal afferents of rats: a potential mechanism for sexual dimorphism in prevalence and severity of asthma","volume":"303","author":"Li","year":"2015","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainresbull.2019.10.003_bib0110","doi-asserted-by":"crossref","first-page":"e15534","DOI":"10.1371\/journal.pone.0015534","article-title":"Serum levels of FGF-21 are increased in coronary heart disease patients and are independently associated with adverse lipid profile","volume":"5","author":"Lin","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.brainresbull.2019.10.003_bib0115","doi-asserted-by":"crossref","first-page":"66135","DOI":"10.18632\/oncotarget.11880","article-title":"Neuropeptide Y-mediated sex- and afferent-specific neurotransmissions contribute to sexual dimorphism of baroreflex afferent function","volume":"7","author":"Liu","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.brainresbull.2019.10.003_bib0120","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1161\/HYPERTENSIONAHA.115.06815","article-title":"Unique expression of angiotensin Type-2 receptor in sex-specific distribution of myelinated ah-type baroreceptor neuron contributing to sex-dimorphic neurocontrol of circulation","volume":"67","author":"Liu","year":"2016","journal-title":"Hypertension"},{"key":"10.1016\/j.brainresbull.2019.10.003_bib0125","doi-asserted-by":"crossref","first-page":"716","DOI":"10.7150\/ijbs.7006","article-title":"Subtype identification in acutely dissociated rat nodose ganglion neurons based on morphologic parameters","volume":"9","author":"Lu","year":"2013","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.brainresbull.2019.10.003_bib0130","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1111\/j.1440-1681.2005.04156.x","article-title":"Gender differences in blood pressure and heart rate in spontaneously hypertensive and Wistar-Kyoto rats","volume":"32","author":"Maris","year":"2005","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.brainresbull.2019.10.003_bib0135","doi-asserted-by":"crossref","first-page":"F901","DOI":"10.1152\/ajprenal.00288.2014","article-title":"Sex- and age-related differences in the chronic pressure-natriuresis relationship: role of the angiotensin type 2 receptor","volume":"307","author":"Mirabito","year":"2014","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1016\/j.brainresbull.2019.10.003_bib0140","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1016\/j.cmet.2018.04.002","article-title":"FGF21 prevents angiotensin II-induced hypertension and vascular dysfunction by activation of ACE2\/Angiotensin-(1-7) Axis in mice","volume":"27","author":"Pan","year":"2018","journal-title":"Cell Metab."},{"key":"10.1016\/j.brainresbull.2019.10.003_bib0145","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1038\/ncomms3019","article-title":"Fibroblast growth factor 21 protects against cardiac hypertrophy in mice","volume":"4","author":"Planavila","year":"2013","journal-title":"Nat. Commun."},{"key":"10.1016\/j.brainresbull.2019.10.003_bib0150","doi-asserted-by":"crossref","first-page":"10853","DOI":"10.1073\/pnas.0904187106","article-title":"FGF21 induces PGC-1alpha and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response","volume":"106","author":"Potthoff","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.brainresbull.2019.10.003_bib0155","doi-asserted-by":"crossref","first-page":"C654","DOI":"10.1152\/ajpcell.00059.2009","article-title":"17Beta-estradiol restores excitability of a sexually dimorphic subset of myelinated vagal afferents in ovariectomized rats","volume":"297","author":"Qiao","year":"2009","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.brainresbull.2019.10.003_bib0160","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1056\/NEJM199602083340607","article-title":"Hypertension and associated metabolic abnormalities \u2014 the role of insulin resistance and the sympathoadrenal system","volume":"334","author":"Reaven","year":"1996","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.brainresbull.2019.10.003_bib0165","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1161\/01.HYP.37.5.1199","article-title":"Gender differences in the regulation of blood pressure","volume":"37","author":"Reckelhoff","year":"2001","journal-title":"Hypertension"},{"key":"10.1016\/j.brainresbull.2019.10.003_bib0170","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/2042-6410-3-7","article-title":"Sex differences in primary hypertension","volume":"3","author":"Sandberg","year":"2012","journal-title":"Biol. Sex Differ."},{"key":"10.1016\/j.brainresbull.2019.10.003_bib0175","doi-asserted-by":"crossref","first-page":"H910","DOI":"10.1152\/ajpheart.00332.2014","article-title":"An afferent explanation for sexual dimorphism in the aortic baroreflex of rat","volume":"307","author":"Santa Cruz Chavez","year":"2014","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.brainresbull.2019.10.003_bib0180","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1038\/nprot.2008.73","article-title":"Analyzing real-time PCR data by the comparative C(T) method","volume":"3","author":"Schmittgen","year":"2008","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.brainresbull.2019.10.003_bib0185","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1097\/00000542-198312000-00005","article-title":"Effects of isoflurane on the baroreceptor reflex","volume":"59","author":"Seagard","year":"1983","journal-title":"Anesthesiology"},{"key":"10.1016\/j.brainresbull.2019.10.003_bib0190","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/jhh.2012.52","article-title":"Elevated serum fibroblast growth factor 21 is associated with hypertension in community-dwelling adults","volume":"27","author":"Semba","year":"2013","journal-title":"J. Hum. Hypertens."},{"key":"10.1016\/j.brainresbull.2019.10.003_bib0195","doi-asserted-by":"crossref","first-page":"e0202182","DOI":"10.1371\/journal.pone.0202182","article-title":"FGF21 increases water intake, urine output and blood pressure in rats","volume":"13","author":"Turner","year":"2018","journal-title":"PLoS One"},{"key":"10.1016\/j.brainresbull.2019.10.003_bib0200","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.ijcard.2014.10.128","article-title":"KCa1.1 beta4-subunits are not responsible for iberiotoxin-resistance in baroreceptor neurons in adult male rats","volume":"178","author":"Xu","year":"2015","journal-title":"Int. J. Cardiol."},{"key":"10.1016\/j.brainresbull.2019.10.003_bib0205","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1111\/cns.13039","article-title":"Spontaneous activities in baroreflex afferent pathway contribute dominant role in parasympathetic neurocontrol of blood pressure regulation","volume":"24","author":"Xu","year":"2018","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.brainresbull.2019.10.003_bib0210","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1111\/cns.12993","article-title":"Direct activation of tachykinin receptors within baroreflex afferent pathway and neurocontrol of blood pressure regulation","volume":"25","author":"Yuan","year":"2019","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.brainresbull.2019.10.003_bib0215","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1161\/HYPERTENSIONAHA.113.02057","article-title":"In vivo transfection of manganese superoxide dismutase gene or nuclear factor kappaB shRNA in nodose ganglia improves aortic baroreceptor function in heart failure rats","volume":"63","author":"Zhang","year":"2014","journal-title":"Hypertension"},{"key":"10.1016\/j.brainresbull.2019.10.003_bib0220","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.2337\/db07-1476","article-title":"Serum FGF21 levels are increased in obesity and are independently associated with the metabolic syndrome in humans","volume":"57","author":"Zhang","year":"2008","journal-title":"Diabetes"},{"key":"10.1016\/j.brainresbull.2019.10.003_bib0225","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s12933-015-0190-7","article-title":"Serum fibroblast growth factor 21 levels is associated with lower extremity atherosclerotic disease in Chinese female diabetic patients","volume":"14","author":"Zhang","year":"2015","journal-title":"Cardiovasc. Diabetol."},{"key":"10.1016\/j.brainresbull.2019.10.003_bib0230","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neulet.2015.07.023","article-title":"KCa1.1 is potential marker for distinguishing Ah-type baroreceptor neurons in NTS and contributes to sex-specific presynaptic neurotransmission in baroreflex afferent pathway","volume":"604","author":"Zhang","year":"2015","journal-title":"Neurosci. Lett."}],"container-title":["Brain Research Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0361923019304241?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0361923019304241?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T21:51:48Z","timestamp":1778536308000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0361923019304241"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":46,"alternative-id":["S0361923019304241"],"URL":"https:\/\/doi.org\/10.1016\/j.brainresbull.2019.10.003","relation":{},"ISSN":["0361-9230"],"issn-type":[{"value":"0361-9230","type":"print"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"FGF-21 ameliorates essential hypertension of SHR via baroreflex afferent function","name":"articletitle","label":"Article Title"},{"value":"Brain Research Bulletin","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainresbull.2019.10.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}