{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T12:34:05Z","timestamp":1783341245099,"version":"3.54.6"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,7,15]],"date-time":"2020-07-15T00:00:00Z","timestamp":1594771200000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"National Research, Development and Innovation Fund of Hungary"},{"DOI":"10.13039\/501100000780","name":"European Union","doi-asserted-by":"publisher","award":["EFOP-3.6.3-VEKOP-16-2017-00002"],"award-info":[{"award-number":["EFOP-3.6.3-VEKOP-16-2017-00002"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research Bulletin"],"published-print":{"date-parts":[[2020,7]]},"DOI":"10.1016\/j.brainresbull.2020.04.012","type":"journal-article","created":{"date-parts":[[2020,4,27]],"date-time":"2020-04-27T07:31:59Z","timestamp":1587972719000},"page":"65-73","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":37,"special_numbering":"C","title":["Modulation of nose-to-brain delivery of a P-glycoprotein (MDR1) substrate model drug (quinidine) in rats"],"prefix":"10.1016","volume":"160","author":[{"given":"Luca Anna","family":"Bors","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1gnes","family":"Bajza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00edra","family":"M\u00e1ndoki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benedek J\u00f3zsef","family":"Tasi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gy\u00f6rgy","family":"Cserey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T\u00edmea","family":"Imre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e1l","family":"Szab\u00f3","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franciska","family":"Erd\u0151","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainresbull.2020.04.012_bib0005","doi-asserted-by":"crossref","first-page":"2742","DOI":"10.1021\/acs.molpharmaceut.5b00103","article-title":"Microarray determination of the expression of drug transporters in humans and animal species used for the investigation of nasal absorption","volume":"12","author":"Al-Ghabeish","year":"2015","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.brainresbull.2020.04.012_bib0010","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1038\/nrd.2015.21","article-title":"From blood-brain barrier to blood-brain interface: new opportunities for CNS drug delivery","volume":"15","author":"Banks","year":"2016","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.brainresbull.2020.04.012_bib0015","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/scipharm87010006","article-title":"Overcoming the blood-brain barrier. Challenges and tricks for CNS drug delivery","volume":"87","author":"Bors","year":"2019","journal-title":"Sci. Pharm."},{"key":"10.1016\/j.brainresbull.2020.04.012_bib0020","doi-asserted-by":"crossref","first-page":"2475","DOI":"10.1007\/s11095-012-0915-1","article-title":"Intranasal treatment of central nervous system dysfunction in humans","volume":"30","author":"Chapman","year":"2013","journal-title":"Pharm. Res."},{"key":"10.1016\/j.brainresbull.2020.04.012_bib0025","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.ejps.2006.11.018","article-title":"Distribution and clearance of bioadhesive formulations from the olfactory region in man: effect of polymer type and nasal delivery device","volume":"30","author":"Charlton","year":"2007","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.brainresbull.2020.04.012_bib0030","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1177\/0269881119862527","article-title":"Intranasal dopamine attenuates fear responses induced by electric shock to the foot and by electrical stimulation of the dorsal periaqueductal gray matter","volume":"33","author":"de Carvalho","year":"2019","journal-title":"J. Psychopharmacol."},{"key":"10.1016\/j.brainresbull.2020.04.012_bib0035","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.ijpharm.2016.05.010","article-title":"Expression of P-glycoprotein in excised human nasal mucosa and optimized models of RPMI 2650 cells","volume":"508","author":"Dolberg","year":"2016","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.brainresbull.2020.04.012_bib0040","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1080\/08958370701864250","article-title":"Derivation of an inhalation reference concentration based upon olfactory neuronal loss in male rats following subchronic acetaldehyde inhalation","volume":"20","author":"Dorman","year":"2008","journal-title":"Inhal. Toxicol."},{"key":"10.1016\/j.brainresbull.2020.04.012_bib0045","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fnagi.2019.00196","article-title":"Age-related functional and expressional changes in efflux pathways at the blood-brain barrier","volume":"11","author":"Erd\u0151","year":"2019","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.brainresbull.2020.04.012_bib0050","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.brainresbull.2018.10.009","article-title":"Evaluation of intranasal delivery route of drug administration for brain targeting","volume":"143","author":"Erd\u0151","year":"2018","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.brainresbull.2020.04.012_bib0055","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1248\/bpb.b14-00398","article-title":"The effect of cilia and the mucociliary clearance on successful drug delivery","volume":"38","author":"Gizurarson","year":"2015","journal-title":"Biol. Pharm. Bull."},{"key":"10.1016\/j.brainresbull.2020.04.012_bib0060","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1007\/s11095-004-9013-3","article-title":"Functional evidence for P-glycoprotein at the nose-brain barrier","volume":"22","author":"Graff","year":"2005","journal-title":"Pharm. Res."},{"key":"10.1016\/j.brainresbull.2020.04.012_bib0065","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1023\/A:1025053115583","article-title":"P-glycoprotein attenuates brain uptake of substrates after nasal instillation","volume":"20","author":"Graff","year":"2003","journal-title":"Pharm. Res."},{"key":"10.1016\/j.brainresbull.2020.04.012_bib0070","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.neuropharm.2018.06.006","article-title":"Intranasal administration of progesterone: a potential efficient route of delivery for cerebroprotection after acute brain injuries","volume":"145","author":"Guennoun","year":"2019","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.brainresbull.2020.04.012_bib0075","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.ejps.2017.02.032","article-title":"Nose-to-brain transport of imatinib mesylate: a pharmacokinetic evaluation","volume":"102","author":"Hada","year":"2017","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.brainresbull.2020.04.012_bib0080","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1038\/sj.bjp.0701979","article-title":"Complete in vivo reversal of P-glycoprotein pump function in the blood-brain barrier visualized with positron emission tomography","volume":"124","author":"Hendrikse","year":"1998","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.brainresbull.2020.04.012_bib0085","article-title":"Insulin action in the hypothalamus increases second phase insulin secretion in humans","author":"Heni","year":"2019","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.brainresbull.2020.04.012_bib0090","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.ejpb.2008.10.009","article-title":"Sodium hyaluronate as a mucoadhesive component in nasal formulation enhances delivery of molecules to brain tissue","volume":"72","author":"Horv\u00e1t","year":"2009","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.brainresbull.2020.04.012_bib0095","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1002\/jps.20284","article-title":"Carrier mediated transport of chlorpheniramine and chlorcyclizine across bovine olfactory mucosa: Implications on nose-to-brain transport","volume":"94","author":"Kandimalla","year":"2005","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.brainresbull.2020.04.012_bib0100","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1002\/alr.21361","article-title":"P-glycoprotein inhibition promotes prednisone retention in human sinonasal polyp explants","volume":"4","author":"Kocharyan","year":"2014","journal-title":"Int. Forum Allergy Rhinol."},{"key":"10.1016\/j.brainresbull.2020.04.012_bib0105","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fphar.2018.00027","article-title":"Transporter-guided delivery of nanoparticles to improve drug permeation across cellular barriers and drug exposure to selective cell types","volume":"9","author":"Kou","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.brainresbull.2020.04.012_bib0110","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1517\/17425255.2012.668184","article-title":"Efflux transporters in the bloodbrain interfaces in vitro and in vivo methods and correlations","volume":"8","author":"Krajcsi","year":"2012","journal-title":"Expert Opin. Drug Metab. Toxicol."},{"key":"10.1016\/j.brainresbull.2020.04.012_bib0115","doi-asserted-by":"crossref","first-page":"4519","DOI":"10.1021\/acs.biochem.9b00696","article-title":"Insulin inhibits A\u03b242 aggregation and prevents A\u03b242-Induced membrane disruption","volume":"58","author":"Long","year":"2019","journal-title":"Biochemistry"},{"key":"10.1016\/j.brainresbull.2020.04.012_bib0120","doi-asserted-by":"crossref","first-page":"2430","DOI":"10.1172\/JCI119784","article-title":"Full blockade of intestinal P-glycoprotein and extensive inhibition of blood-brain barrier P-glycoprotein by oral treatment of mice with PSC833","volume":"100","author":"Mayer","year":"1997","journal-title":"J. Clin. Invest."},{"issue":"15","key":"10.1016\/j.brainresbull.2020.04.012_bib0125","doi-asserted-by":"crossref","first-page":"2246","DOI":"10.1021\/acs.molpharmaceut.8b00087","article-title":"Pharmacological characterization of the RPMI 2650 model as a relevant tool for assessing the permeability of intranasal drugs","author":"Mercier","year":"2018","journal-title":"Mol. Pharm."},{"key":"10.1016\/j.brainresbull.2020.04.012_bib0130","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.ejpb.2019.04.002","article-title":"Pharmacological characterization of the 3D MucilAir\u2122 nasal model","volume":"139","author":"Mercier","year":"2019","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.brainresbull.2020.04.012_bib0135","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.wjorl.2018.07.002","article-title":"P-glycoprotein and chronic rhinosinusitis","volume":"4","author":"Miyake","year":"2018","journal-title":"World J. Otorhinolaryngol. Head Neck Surg."},{"key":"10.1016\/j.brainresbull.2020.04.012_bib0140","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1038\/jcbfm.2012.126","article-title":"Drug transport across the blood-brain barrier","volume":"32","author":"Pardridge","year":"2012","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.brainresbull.2020.04.012_bib0145","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1517\/14728222.2015.1042364","article-title":"Blood-brain barrier endogenous transporters as therapeutic targets: a new model for small molecule CNS drug discovery","volume":"19","author":"Pardridge","year":"2015","journal-title":"Expert Opin. Ther. Targets"},{"key":"10.1016\/j.brainresbull.2020.04.012_bib0150","series-title":"The Rat Brain in Stereotaxic Coordinates","author":"Paxinos","year":"1998"},{"key":"10.1016\/j.brainresbull.2020.04.012_bib0155","doi-asserted-by":"crossref","first-page":"7114","DOI":"10.1073\/pnas.91.15.7114","article-title":"Glycopeptide enkephalin analogues produce analgesia in mice: evidence for penetration of the blood-brain barrier","volume":"91","author":"Polt","year":"1994","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.brainresbull.2020.04.012_bib0160","doi-asserted-by":"crossref","first-page":"826","DOI":"10.1037\/0735-7044.121.5.826","article-title":"Cognitive Impairments in the STOP Null Mouse Model of Schizophrenia","volume":"121","author":"Powell","year":"2007","journal-title":"Behav. Neurosci."},{"key":"10.1016\/j.brainresbull.2020.04.012_bib0165","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1136\/jcp.55.5.332","article-title":"Multidrug resistance related molecules in human and murine lung","volume":"55","author":"Scheffer","year":"2002","journal-title":"J. Clin. Pathol."},{"key":"10.1016\/j.brainresbull.2020.04.012_bib0170","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/0092-8674(94)90212-7","article-title":"Disruption of the mouse mdr1a P-glycoprotein gene leads to a deficiency in the blood-brain barrier and to increased sensitivity to drugs","volume":"77","author":"Schinkel","year":"1994","journal-title":"Cell"},{"key":"10.1016\/j.brainresbull.2020.04.012_bib0175","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.psyneuen.2018.04.001","article-title":"Sleep after intranasal progesterone vs. zolpidem and placebo in postmenopausal women \u2013 a randomized, double-blind cross over study","volume":"92","author":"Sch\u00fcssler","year":"2018","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.brainresbull.2020.04.012_bib0180","doi-asserted-by":"crossref","first-page":"248","DOI":"10.2133\/dmpk.DMPK-10-RG-108","article-title":"Nasal delivery of P-gp substrates to the brain through the nosebrain pathway","volume":"26","author":"Shingaki","year":"2011","journal-title":"Drug Metab. Pharmacokinet."},{"key":"10.1016\/j.brainresbull.2020.04.012_bib0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.peptides.2019.170175","article-title":"Intranasal insulin treatment modulates the neurotropic, inflammatory, and oxidant mechanisms in the cortex and hippocampus in a low-grade inflammation model","volume":"123","author":"Simon","year":"2020","journal-title":"Peptides"},{"key":"10.1016\/j.brainresbull.2020.04.012_bib0190","series-title":"Theory and Practice of Histological Techniques","first-page":"107","article-title":"The hematoxylins","author":"Stevens","year":"2007"},{"issue":"8","key":"10.1016\/j.brainresbull.2020.04.012_bib0195","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1177\/1087057111414896","article-title":"Quinidine as an ABC probe for testing drug interactions at the blood-brain barrier: an in vitro in vivo correlation study","volume":"16","author":"Szir\u00e1ki","year":"2011","journal-title":"J. Biomol. Screen."},{"key":"10.1016\/j.brainresbull.2020.04.012_bib0200","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1177\/1087057112468156","article-title":"The use of microdialysis techniques in mice to study P-gp function at the blood-brain barrier","volume":"18","author":"Szir\u00e1ki","year":"2013","journal-title":"J. Biomol. Screen."},{"key":"10.1016\/j.brainresbull.2020.04.012_bib0205","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.neuroscience.2004.05.029","article-title":"Delivery of insulin-like growth factor-I to the rat brain and spinal cord along olfactory and trigeminal pathways following intranasal administration","volume":"127","author":"Thorne","year":"2004","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainresbull.2020.04.012_bib0210","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/S0165-0270(02)00033-X","article-title":"Serial cerebrospinal fluid sampling in a rat model to study drug uptake from the nasal cavity","volume":"116","author":"Van Den Berg","year":"2002","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.brainresbull.2020.04.012_bib0215","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.nlm.2017.10.015","article-title":"Intra-nasal dopamine alleviates cognitive deficits in tgDISC1 rats which overexpress the human DISC1 gene","volume":"146","author":"Wang","year":"2017","journal-title":"Neurobiol. Learn. Mem."},{"key":"10.1016\/j.brainresbull.2020.04.012_bib0220","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.ejps.2005.01.009","article-title":"Transfer of morphine along the olfactory pathway to the central nervous system after nasal administration to rodents","volume":"24","author":"Westin","year":"2005","journal-title":"Eur. J. Pharm. Sci."},{"key":"10.1016\/j.brainresbull.2020.04.012_bib0225","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s00418-008-0410-2","article-title":"Epithelial and endothelial barriers in the olfactory region of the nasal cavity of the rat","volume":"130","author":"Wolburg","year":"2008","journal-title":"Histochem. Cell Biol."}],"container-title":["Brain Research Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0361923020300459?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0361923020300459?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T20:39:46Z","timestamp":1759783186000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0361923020300459"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7]]},"references-count":45,"alternative-id":["S0361923020300459"],"URL":"https:\/\/doi.org\/10.1016\/j.brainresbull.2020.04.012","relation":{},"ISSN":["0361-9230"],"issn-type":[{"value":"0361-9230","type":"print"}],"subject":[],"published":{"date-parts":[[2020,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Modulation of nose-to-brain delivery of a P-glycoprotein (MDR1) substrate model drug (quinidine) in rats","name":"articletitle","label":"Article Title"},{"value":"Brain Research Bulletin","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainresbull.2020.04.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}