{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T15:59:27Z","timestamp":1781798367466,"version":"3.54.5"},"reference-count":55,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,7,28]],"date-time":"2020-07-28T00:00:00Z","timestamp":1595894400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004085","name":"Ministry of Education, Science and Technology","doi-asserted-by":"publisher","award":["NRF-2017R1A2B4012775"],"award-info":[{"award-number":["NRF-2017R1A2B4012775"]}],"id":[{"id":"10.13039\/501100004085","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research Bulletin"],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1016\/j.brainresbull.2020.07.020","type":"journal-article","created":{"date-parts":[[2020,7,22]],"date-time":"2020-07-22T11:39:15Z","timestamp":1595417955000},"page":"160-169","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Neurovascular integrative effects of long-term environmental enrichment on chronic cerebral hypoperfusion rat model"],"prefix":"10.1016","volume":"163","author":[{"given":"Min Kyung","family":"Song","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoon Ju","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae-min","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youn-Jung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainresbull.2020.07.020_bib0005","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/nrn1824","article-title":"Astrocyte-endothelial interactions at the blood-brain barrier","volume":"7","author":"Abbott","year":"2006","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.brainresbull.2020.07.020_bib0010","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.nbd.2009.07.030","article-title":"Structure and function of the blood-brain barrier","volume":"37","author":"Abbott","year":"2010","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.brainresbull.2020.07.020_bib0015","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.mvr.2012.05.008","article-title":"Involvement of oxidative stress in hypoxia-induced blood-brain barrier breakdown","volume":"84","author":"Al Ahmad","year":"2012","journal-title":"Microvasc. Res."},{"key":"10.1016\/j.brainresbull.2020.07.020_bib0020","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1002\/glia.22575","article-title":"Glial influence on the blood brain barrier","volume":"61","author":"Alvarez","year":"2013","journal-title":"Glia"},{"key":"10.1016\/j.brainresbull.2020.07.020_bib0025","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1179\/016164104225016272","article-title":"The nature and effects of cortical microvascular pathology in aging and Alzheimer\u2019s disease","volume":"26","author":"Bailey","year":"2004","journal-title":"Neurol. Res."},{"key":"10.1016\/j.brainresbull.2020.07.020_bib0030","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.brainresbull.2015.10.001","article-title":"Enriched environment improves synaptic plasticity and cognitive deficiency in chronic cerebral hypoperfused rats","volume":"119","author":"Bayat","year":"2015","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.brainresbull.2020.07.020_bib0035","doi-asserted-by":"crossref","first-page":"29","DOI":"10.3389\/fncel.2011.00029","article-title":"Environmental enrichment decreases GABAergic inhibition and improves cognitive abilities, synaptic plasticity, and visual functions in a mouse model of down syndrome","volume":"5","author":"Begenisic","year":"2011","journal-title":"Front Cell Neurosci."},{"key":"10.1016\/j.brainresbull.2020.07.020_bib0040","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0006-8993(02)04089-1","article-title":"Enriched environment delays the onset of hippocampal damage after global cerebral ischemia in rats","volume":"964","author":"Belayev","year":"2003","journal-title":"Brain Res."},{"key":"10.1016\/j.brainresbull.2020.07.020_bib0045","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1177\/109980040000100406","article-title":"Effects of environment on enhancing functional plasticity following cerebral ischemia","volume":"1","author":"Briones","year":"2000","journal-title":"Biol. Res. Nurs."},{"key":"10.1016\/j.brainresbull.2020.07.020_bib0050","doi-asserted-by":"crossref","first-page":"211","DOI":"10.3389\/fncel.2014.00211","article-title":"Astrocytic modulation of blood brain barrier: perspectives on Parkinson\u2019s disease","volume":"8","author":"Cabezas","year":"2014","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.brainresbull.2020.07.020_bib0055","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1007\/s12264-010-0818-2","article-title":"Minocycline reduces astrocytic reactivation and neuroinflammation in the hippocampus of a vascular cognitive impairment rat model","volume":"26","author":"Cai","year":"2010","journal-title":"Neurosci. Bull."},{"key":"10.1016\/j.brainresbull.2020.07.020_bib0060","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.brainresbull.2011.10.006","article-title":"Chronic brain hypoperfusion causes early glial activation and neuronal death, and subsequent long-term memory impairment","volume":"87","author":"Cechetti","year":"2012","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.brainresbull.2020.07.020_bib0065","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.lfs.2012.05.013","article-title":"Environmental enrichment prevents behavioral deficits and oxidative stress caused by chronic cerebral hypoperfusion in the rat","volume":"91","author":"Cechetti","year":"2012","journal-title":"Life Sci."},{"key":"10.1016\/j.brainresbull.2020.07.020_bib0070","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.brainres.2011.07.026","article-title":"The alterations of oligodendrocyte, myelin in corpus callosum, and cognitive dysfunction following chronic cerebral ischemia in rats","volume":"1414","author":"Chida","year":"2011","journal-title":"Brain Res."},{"key":"10.1016\/j.brainresbull.2020.07.020_bib0075","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1161\/STROKEAHA.115.011679","article-title":"Characterization of white matter injury in a rat model of chronic cerebral hyperfusion","volume":"47","author":"Choi","year":"2016","journal-title":"Stroke"},{"key":"10.1016\/j.brainresbull.2020.07.020_bib0080","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1111\/j.1750-3639.2008.00138.x","article-title":"Amoeboid microglia in the periventricular white matter induce oligodendrocyte damage through expression of proinflammatory cytokines via MAP kinase signaling pathway in hypoxic neonatal rats","volume":"18","author":"Deng","year":"2008","journal-title":"Brain Pathol."},{"key":"10.1016\/j.brainresbull.2020.07.020_bib0085","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.ijdevneu.2016.06.006","article-title":"Environmental enrichment attenuates the blood brain barrier dysfunction induced by the neonatal hypoxia-ischemia","volume":"53","author":"Diaz","year":"2016","journal-title":"Int. J. Dev. Neurosci."},{"key":"10.1016\/j.brainresbull.2020.07.020_bib0090","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1002\/glia.1107","article-title":"Immune function of astrocytes","volume":"36","author":"Dong","year":"2001","journal-title":"Glia"},{"key":"10.1016\/j.brainresbull.2020.07.020_bib0095","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.neuroscience.2012.11.062","article-title":"Mitochondrial bioenergetic deficits in the hippocampi of rats with chronic ischemia-induced vascular dementia","volume":"231","author":"Du","year":"2013","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainresbull.2020.07.020_bib0100","doi-asserted-by":"crossref","first-page":"6453","DOI":"10.3390\/ijms15046453","article-title":"The role of pericytes in neurovascular unit remodeling in brain disorders","volume":"15","author":"ElAli","year":"2014","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.brainresbull.2020.07.020_bib0105","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.brainresrev.2007.01.003","article-title":"Permanent, bilateral common carotid artery occlusion in the rat: a model for chronic cerebral hypoperfusion-related neurodegenerative diseases","volume":"54","author":"Farkas","year":"2007","journal-title":"Brain Res. Rev."},{"key":"10.1016\/j.brainresbull.2020.07.020_bib0110","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1046\/j.1365-2362.2002.00994.x","article-title":"Cyclooxygenase-2-positive macrophages infiltrate the Alzheimer\u2019s disease brain and damage the blood-brain barrier","volume":"32","author":"Fiala","year":"2002","journal-title":"Eur. J. Clin. Invest."},{"key":"10.1016\/j.brainresbull.2020.07.020_bib0115","doi-asserted-by":"crossref","first-page":"2672","DOI":"10.1161\/STR.0b013e3182299496","article-title":"Vascular contributions to cognitive impairment and dementia: a statement for healthcare professionals from the american heart association\/american stroke association","volume":"42","author":"Gorelick","year":"2011","journal-title":"Stroke"},{"key":"10.1016\/j.brainresbull.2020.07.020_bib0120","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.ejphar.2012.01.025","article-title":"Chrysin improves cognitive deficits and brain damage induced by chronic cerebral hypoperfusion in rats","volume":"680","author":"He","year":"2012","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.brainresbull.2020.07.020_bib0125","doi-asserted-by":"crossref","first-page":"103","DOI":"10.3389\/fnins.2014.00103","article-title":"The contribution of astrocytes to the regulation of cerebral blood flow","volume":"8","author":"Howarth","year":"2014","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.brainresbull.2020.07.020_bib0130","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1016\/j.neuron.2013.10.008","article-title":"The pathobiology of vascular dementia","volume":"80","author":"Iadecola","year":"2013","journal-title":"Neuron"},{"key":"10.1016\/j.brainresbull.2020.07.020_bib0135","doi-asserted-by":"crossref","first-page":"S40","DOI":"10.1161\/STROKEAHA.108.533638","article-title":"Threats to the mind: aging, amyloid, and hypertension","volume":"40","author":"Iadecola","year":"2009","journal-title":"Stroke"},{"key":"10.1016\/j.brainresbull.2020.07.020_bib0140","doi-asserted-by":"crossref","first-page":"5217","DOI":"10.1523\/JNEUROSCI.5080-04.2005","article-title":"Environmental enrichment mitigates cognitive deficits in a mouse model of Alzheimer\u2019s disease","volume":"25","author":"Jankowsky","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainresbull.2020.07.020_bib0145","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1038\/jcbfm.2015.55","article-title":"Chronic cerebral hypoperfusion induces vascular plasticity and hemodynamics but also neuronal degeneration and cognitive impairment","volume":"35","author":"Jing","year":"2015","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.brainresbull.2020.07.020_bib0150","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1007\/s00401-016-1571-z","article-title":"Neuropathological diagnosis of vascular cognitive impairment and vascular dementia with implications for Alzheimer\u2019s disease","volume":"131","author":"Kalaria","year":"2016","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.brainresbull.2020.07.020_bib0155","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.jstrokecerebrovasdis.2015.09.004","article-title":"Resveratrol reverses the synaptic plasticity deficits in a chronic cerebral hypoperfusion rat model","volume":"25","author":"Li","year":"2016","journal-title":"J. Stroke Cerebrovasc. Dis."},{"key":"10.1016\/j.brainresbull.2020.07.020_bib0160","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.molbrainres.2005.05.014","article-title":"Altered expression of MAP-2, GAP-43, and synaptophysin in the hippocampus of rats with chronic cerebral hypoperfusion correlates with cognitive impairment","volume":"139","author":"Liu","year":"2005","journal-title":"Brain Res. Mol. Brain Res."},{"key":"10.1016\/j.brainresbull.2020.07.020_bib0165","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1093\/toxsci\/kfj150","article-title":"Manganese-induced neurotoxicity: the role of astroglial-derived nitric oxide in striatal interneuron degeneration","volume":"91","author":"Liu","year":"2006","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.brainresbull.2020.07.020_bib0170","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1111\/j.1755-5949.2012.00340.x","article-title":"Tight junction in blood-brain barrier: an overview of structure, regulation, and regulator substances","volume":"18","author":"Liu","year":"2012","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.brainresbull.2020.07.020_bib0175","article-title":"Experimental chronic cerebral hypoperfusion results in decreased pericyte coverage and increased blood-brain barrier permeability in the corpus callosum","author":"Liu","year":"2017","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.brainresbull.2020.07.020_bib0180","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.2741\/1915","article-title":"Matrix metalloproteinases (MMPs) in health and disease: an overview","volume":"11","author":"Malemud","year":"2006","journal-title":"Front Biosci."},{"key":"10.1016\/j.brainresbull.2020.07.020_bib0185","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.pneurobio.2011.01.005","article-title":"GFAP in health and disease","volume":"93","author":"Middeldorp","year":"2011","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.brainresbull.2020.07.020_bib0190","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.brainresrev.2007.03.011","article-title":"Aging, plasticity and environmental enrichment: structural changes and neurotransmitter dynamics in several areas of the brain","volume":"55","author":"Mora","year":"2007","journal-title":"Brain Res. Rev."},{"key":"10.1016\/j.brainresbull.2020.07.020_bib0195","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1016\/j.ceb.2004.07.010","article-title":"Regulation of matrix biology by matrix metalloproteinases","volume":"16","author":"Mott","year":"2004","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.brainresbull.2020.07.020_bib0200","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1517\/14740338.4.3.433","article-title":"Glial fibrillary acidic protein and related glial proteins as biomarkers of neurotoxicity","volume":"4","author":"O\u2019Callaghan","year":"2005","journal-title":"Expert Opin. Drug Saf."},{"key":"10.1016\/j.brainresbull.2020.07.020_bib0205","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1002\/glia.20181","article-title":"Astrocytes in cerebral ischemic injury: morphological and general considerations","volume":"50","author":"Panickar","year":"2005","journal-title":"Glia"},{"key":"10.1016\/j.brainresbull.2020.07.020_bib0210","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.expneurol.2012.11.026","article-title":"Effects of daily environmental enrichment on behavior and dendritic spine density in hippocampus following neonatal hypoxia-ischemia in the rat","volume":"241","author":"Rojas","year":"2013","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.brainresbull.2020.07.020_bib0215","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1038\/jcbfm.2011.197","article-title":"Neurological diseases in relation to the blood-brain barrier","volume":"32","author":"Rosenberg","year":"2012","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.brainresbull.2020.07.020_bib0220","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/s40478-016-0350-3","article-title":"Astroglial NF-kB contributes to white matter damage and cognitive impairment in a mouse model of vascular dementia","volume":"4","author":"Saggu","year":"2016","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.brainresbull.2020.07.020_bib0225","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.nbd.2008.08.005","article-title":"Blood-brain barrier tight junction permeability and ischemic stroke","volume":"32","author":"Sandoval","year":"2008","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.brainresbull.2020.07.020_bib0230","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0022-510X(02)00302-7","article-title":"Cognitive impairment and chronic cerebral hypoperfusion: what can be learned from experimental models","volume":"203-204","author":"Sarti","year":"2002","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.brainresbull.2020.07.020_bib0235","doi-asserted-by":"crossref","first-page":"662","DOI":"10.3389\/fphys.2018.00662","article-title":"Histidine alleviates impairments induced by chronic cerebral hypoperfusion in mice","volume":"9","author":"Song","year":"2018","journal-title":"Front. Physiol."},{"key":"10.1016\/j.brainresbull.2020.07.020_bib0240","doi-asserted-by":"crossref","first-page":"268","DOI":"10.2174\/156720210793180819","article-title":"Environmental enrichment influences BDNF and NR1 levels in the hippocampus and restores cognitive impairment in chronic cerebral hypoperfused rats","volume":"7","author":"Sun","year":"2010","journal-title":"Curr. Neurovasc. Res."},{"key":"10.1016\/j.brainresbull.2020.07.020_bib0245","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/35044558","article-title":"Neural consequences of environmental enrichment","volume":"1","author":"van Praag","year":"2000","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.brainresbull.2020.07.020_bib0250","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0006-8993(01)03223-1","article-title":"Axonal damage and demyelination in the white matter after chronic cerebral hypoperfusion in the rat","volume":"924","author":"Wakita","year":"2002","journal-title":"Brain Res."},{"key":"10.1016\/j.brainresbull.2020.07.020_bib0255","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1016\/j.bbamem.2008.10.022","article-title":"The blood-brain barrier in brain homeostasis and neurological diseases","volume":"1788","author":"Weiss","year":"2009","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.brainresbull.2020.07.020_bib0260","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1097\/FBP.0b013e32834afef9","article-title":"Gypenosides improve cognitive impairment induced by chronic cerebral hypoperfusion in rats by suppressing oxidative stress and astrocytic activation","volume":"22","author":"Zhang","year":"2011","journal-title":"Behav. Pharmacol."},{"key":"10.1016\/j.brainresbull.2020.07.020_bib0265","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1038\/nm1387","article-title":"Role of matrix metalloproteinases in delayed cortical responses after stroke","volume":"12","author":"Zhao","year":"2006","journal-title":"Nat. Med."},{"key":"10.1016\/j.brainresbull.2020.07.020_bib0270","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.neulet.2011.04.015","article-title":"An enriched environment reverses the synaptic plasticity deficit induced by chronic cerebral hypoperfusion","volume":"502","author":"Zhu","year":"2011","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.brainresbull.2020.07.020_bib0275","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1038\/nm1210-1370","article-title":"Neurodegeneration and the neurovascular unit","volume":"16","author":"Zlokovic","year":"2010","journal-title":"Nat. Med."}],"container-title":["Brain Research Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0361923020305773?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0361923020305773?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T20:41:49Z","timestamp":1759783309000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0361923020305773"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":55,"alternative-id":["S0361923020305773"],"URL":"https:\/\/doi.org\/10.1016\/j.brainresbull.2020.07.020","relation":{},"ISSN":["0361-9230"],"issn-type":[{"value":"0361-9230","type":"print"}],"subject":[],"published":{"date-parts":[[2020,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neurovascular integrative effects of long-term environmental enrichment on chronic cerebral hypoperfusion rat model","name":"articletitle","label":"Article Title"},{"value":"Brain Research Bulletin","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainresbull.2020.07.020","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}