{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T22:59:34Z","timestamp":1784069974975,"version":"3.55.0"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Ningbo Natural Science Foundation, China","award":["2018A610310"],"award-info":[{"award-number":["2018A610310"]}]},{"name":"Yuyao City Science and Technology Council Foundation, China","award":["2018YZD01"],"award-info":[{"award-number":["2018YZD01"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81771262"],"award-info":[{"award-number":["81771262"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81820108011"],"award-info":[{"award-number":["81820108011"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research Bulletin"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1016\/j.brainresbull.2020.08.026","type":"journal-article","created":{"date-parts":[[2020,8,29]],"date-time":"2020-08-29T20:16:43Z","timestamp":1598732203000},"page":"221-234","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":50,"special_numbering":"C","title":["IGF-1R stimulation alters microglial polarization via TLR4\/NF-\u03baB pathway after cerebral hemorrhage in mice"],"prefix":"10.1016","volume":"164","author":[{"given":"Zhezhe","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijie","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qichuan","family":"Zhuge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenzhong","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainresbull.2020.08.026_bib0005","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.bbi.2013.02.005","article-title":"Characterization of phenotype markers and neuronotoxic potential of polarised primary microglia in vitro","volume":"32","author":"Chhor","year":"2013","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.brainresbull.2020.08.026_bib0010","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/s13041-015-0101-6","article-title":"Alpha-lipoic acid treatment is neurorestorative and promotes functional recovery after stroke in rats","volume":"8","author":"Choi","year":"2015","journal-title":"Mol Brain"},{"key":"10.1016\/j.brainresbull.2020.08.026_bib0015","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0054462","article-title":"The insulin-like growth factor 1 receptor is essential for axonal regeneration in adult central nervous system neurons","volume":"8","author":"Dupraz","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.brainresbull.2020.08.026_bib0020","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.brainres.2014.09.037","article-title":"Therapeutically targeting astrocytes with stem and progenitor cell transplantation following traumatic spinal cord injury","volume":"1619","author":"Falnikar","year":"2015","journal-title":"Brain Res"},{"key":"10.1016\/j.brainresbull.2020.08.026_bib0025","doi-asserted-by":"crossref","first-page":"5984","DOI":"10.4049\/jimmunol.1400054","article-title":"CD36-mediated hematoma absorption following intracerebral hemorrhage: negative regulation by TLR4 signaling","volume":"192","author":"Fang","year":"2014","journal-title":"J Immunol"},{"key":"10.1016\/j.brainresbull.2020.08.026_bib0030","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1186\/s12974-019-1634-x","article-title":"The role of Toll-like receptor 4 in apoptosis of brain tissue after induction of intracerebral hemorrhage","volume":"16","author":"Fei","year":"2019","journal-title":"J Neuroinflammation"},{"key":"10.1016\/j.brainresbull.2020.08.026_bib0035","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.3727\/096368914X679345","article-title":"Combined Bone Mesenchymal Stem Cell and Olfactory Ensheathing Cell Transplantation Promotes Neural Repair Associated With CNTF Expression in Traumatic Brain-Injured Rats","volume":"24","author":"Fu","year":"2015","journal-title":"Cell Transplant"},{"key":"10.1016\/j.brainresbull.2020.08.026_bib0040","doi-asserted-by":"crossref","first-page":"4431","DOI":"10.3390\/ijms15034431","article-title":"Transplanted neural stem cells modulate regulatory T, gammadelta T cells and corresponding cytokines after intracerebral hemorrhage in rats","volume":"15","author":"Gao","year":"2014","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.brainresbull.2020.08.026_bib0045","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.3389\/fnins.2019.01223","article-title":"Curcumin Mitigates Neuro-Inflammation by Modulating Microglia Polarization Through Inhibiting TLR4 Axis Signaling Pathway Following Experimental Subarachnoid Hemorrhage","volume":"13","author":"Gao","year":"2019","journal-title":"Frontiers in neuroscience"},{"key":"10.1016\/j.brainresbull.2020.08.026_bib0050","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1126\/science.1194637","article-title":"Fate mapping analysis reveals that adult microglia derive from primitive macrophages","volume":"330","author":"Ginhoux","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.brainresbull.2020.08.026_bib0055","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1007\/s10571-012-9832-4","article-title":"Neurotrophin expression in neural stem cells grafted acutely to transected spinal cord of adult rats linked to functional improvement","volume":"32","author":"Gu","year":"2012","journal-title":"Cell Mol Neurobiol"},{"key":"10.1016\/j.brainresbull.2020.08.026_bib0060","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.npep.2012.06.001","article-title":"BDNF expression with functional improvement in transected spinal cord treated with neural stem cells in adult rats","volume":"47","author":"He","year":"2013","journal-title":"Neuropeptides"},{"key":"10.1016\/j.brainresbull.2020.08.026_bib0065","doi-asserted-by":"crossref","first-page":"398","DOI":"10.3389\/fnmol.2017.00398","article-title":"Peli1 Contributions in Microglial Activation, Neuroinflammatory Responses and Neurological Deficits Following Experimental Subarachnoid Hemorrhage","volume":"10","author":"Huang","year":"2017","journal-title":"Front Mol Neurosci"},{"key":"10.1016\/j.brainresbull.2020.08.026_bib0070","doi-asserted-by":"crossref","first-page":"489","DOI":"10.5607\/en.2018.27.6.489","article-title":"Insulin-like Growth Factor-1 Receptor Dictates Beneficial Effects of Treadmill Training by Regulating Survival and Migration of Neural Stem Cell Grafts in the Injured Spinal Cord","volume":"27","author":"Hwang","year":"2018","journal-title":"Exp Neurobiol"},{"key":"10.1016\/j.brainresbull.2020.08.026_bib0075","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1007\/s12035-014-8766-x","article-title":"Thioredoxin-interacting protein: a novel target for neuroprotection in experimental thromboembolic stroke in mice","volume":"51","author":"Ishrat","year":"2015","journal-title":"Molecular neurobiology"},{"key":"10.1016\/j.brainresbull.2020.08.026_bib0080","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.pharmthera.2016.04.001","article-title":"Antidepressant therapies inhibit inflammation and microglial M1-polarization","volume":"163","author":"Kalkman","year":"2016","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.brainresbull.2020.08.026_bib0085","first-page":"e4289","article-title":"Modeling intracerebral hemorrhage in mice: injection of autologous blood or bacterial collagenase","author":"Krafft","year":"2012","journal-title":"J Vis Exp"},{"key":"10.1016\/j.brainresbull.2020.08.026_bib0090","doi-asserted-by":"crossref","first-page":"365","DOI":"10.3389\/fnagi.2017.00365","article-title":"Insulin-Like Growth Factor-1 and Neuroinflammation","volume":"9","author":"Labandeira-Garcia","year":"2017","journal-title":"Front Aging Neurosci"},{"key":"10.1016\/j.brainresbull.2020.08.026_bib0095","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1093\/brain\/awm306","article-title":"Anti-inflammatory mechanism of intravascular neural stem cell transplantation in haemorrhagic stroke","volume":"131","author":"Lee","year":"2008","journal-title":"Brain"},{"key":"10.1016\/j.brainresbull.2020.08.026_bib0100","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1124\/jpet.114.215673","volume":"350","author":"Lee","year":"2014","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.brainresbull.2020.08.026_bib0105","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/1742-2094-9-46","article-title":"Heme activates TLR4-mediated inflammatory injury via MyD88\/TRIF signaling pathway in intracerebral hemorrhage","volume":"9","author":"Lin","year":"2012","journal-title":"J Neuroinflammation"},{"key":"10.1016\/j.brainresbull.2020.08.026_bib0110","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/3706047","article-title":"AC-YVAD-CMK Inhibits Pyroptosis and Improves Functional Outcome after Intracerebral Hemorrhage","volume":"2018","author":"Lin","year":"2018","journal-title":"Biomed Res Int"},{"key":"10.1016\/j.brainresbull.2020.08.026_bib0115","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.intimp.2016.10.025","article-title":"Peroxiredoxin 1-mediated activation of TLR4\/NF-kappaB pathway contributes to neuroinflammatory injury in intracerebral hemorrhage","volume":"41","author":"Liu","year":"2016","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.brainresbull.2020.08.026_bib0120","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s12974-018-1081-0","article-title":"Salidroside provides neuroprotection by modulating microglial polarization after cerebral ischemia","volume":"15","author":"Liu","year":"2018","journal-title":"J Neuroinflammation"},{"key":"10.1016\/j.brainresbull.2020.08.026_bib0125","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1006\/mcne.1994.1052","article-title":"Astrocytes express insulin-like growth factor-I (IGF-I) and its binding protein, IGFBP-2, during demyelination induced by experimental autoimmune encephalomyelitis","volume":"5","author":"Liu","year":"1994","journal-title":"Mol Cell Neurosci"},{"key":"10.1016\/j.brainresbull.2020.08.026_bib0130","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1179\/1743132814Y.0000000333","article-title":"Protective effects and anti-apoptotic role of nerve growth factor on spinal cord neurons in sciatic nerve-injured rats","volume":"36","author":"Lu","year":"2014","journal-title":"Neurol Res"},{"key":"10.1016\/j.brainresbull.2020.08.026_bib0135","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s12943-015-0482-2","article-title":"Insulin-like growth factors are essential to prevent anoikis in oestrogen-responsive breast cancer cells: importance of the type I IGF receptor and PI3-kinase\/Akt pathway","volume":"15","author":"Luey","year":"2016","journal-title":"Mol Cancer"},{"key":"10.1016\/j.brainresbull.2020.08.026_bib0140","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1038\/jcbfm.2010.167","article-title":"Vascular adhesion protein-1 inhibition provides antiinflammatory protection after an intracerebral hemorrhagic stroke in mice","volume":"31","author":"Ma","year":"2011","journal-title":"J Cereb Blood Flow Metab"},{"key":"10.1016\/j.brainresbull.2020.08.026_bib0145","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/6742427","article-title":"Anti-Inflammatory Strategy for M2 Microglial Polarization Using Retinoic Acid-Loaded Nanoparticles","volume":"2017","author":"Machado-Pereira","year":"2017","journal-title":"Mediators Inflamm"},{"key":"10.1016\/j.brainresbull.2020.08.026_bib0150","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1038\/nature17187","article-title":"Sensory experience regulates cortical inhibition by inducing IGF1 in VIP neurons","volume":"531","author":"Mardinly","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.brainresbull.2020.08.026_bib0155","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.ghir.2019.02.003","article-title":"Cell-specific expression of insulin\/insulin-like growth factor-I receptor hybrids in the mouse brain","volume":"45","author":"Martinez-Rachadell","year":"2019","journal-title":"Growth Horm IGF Res"},{"key":"10.1016\/j.brainresbull.2020.08.026_bib0160","doi-asserted-by":"crossref","first-page":"379","DOI":"10.5966\/sctm.2015-0103","article-title":"Human Cortical Neural Stem Cells Expressing Insulin-Like Growth Factor-I: A Novel Cellular Therapy for Alzheimer\u2019s Disease","volume":"5","author":"McGinley","year":"2016","journal-title":"Stem Cells Transl Med"},{"key":"10.1016\/j.brainresbull.2020.08.026_bib0165","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/s10571-009-9457-4","article-title":"Neuroprotective effects of IGF-I following kainic acid-induced hippocampal degeneration in the rat","volume":"30","author":"Miltiadous","year":"2010","journal-title":"Cell Mol Neurobiol"},{"key":"10.1016\/j.brainresbull.2020.08.026_bib0170","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1177\/1479164118802550","article-title":"Effects of obesity on insulin: insulin-like growth factor 1 hybrid receptor expression and Akt phosphorylation in conduit and resistance arteries","volume":"16","author":"Mughal","year":"2019","journal-title":"Diab Vasc Dis Res"},{"key":"10.1016\/j.brainresbull.2020.08.026_bib0175","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1002\/neu.480241203","article-title":"Insulin-like growth factors: putative muscle-derived trophic agents that promote motoneuron survival","volume":"24","author":"Neff","year":"1993","journal-title":"J Neurobiol"},{"key":"10.1016\/j.brainresbull.2020.08.026_bib0180","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.expneurol.2018.11.009","article-title":"rhIGF-1 reduces the permeability of the blood-brain barrier following intracerebral hemorrhage in mice","volume":"312","author":"Nowrangi","year":"2019","journal-title":"Exp Neurol"},{"key":"10.1016\/j.brainresbull.2020.08.026_bib0185","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1080\/21691401.2019.1575843","article-title":"Graphene oxide-PLGA hybrid nanofibres for the local delivery of IGF-1 and BDNF in spinal cord repair","volume":"47","author":"Pan","year":"2019","journal-title":"Artif Cells Nanomed Biotechnol"},{"key":"10.1016\/j.brainresbull.2020.08.026_bib0190","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1210\/endo.138.4.5092","article-title":"Specific inhibition of insulin-like growth factor-1 and insulin receptor tyrosine kinase activity and biological function by tyrphostins","volume":"138","author":"Parrizas","year":"1997","journal-title":"Endocrinology"},{"issue":"Suppl 1","key":"10.1016\/j.brainresbull.2020.08.026_bib0195","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1111\/j.1471-4159.2009.05984.x","article-title":"Differential gene expression in LPS\/IFNgamma activated microglia and macrophages: in vitro versus in vivo","volume":"109","author":"Schmid","year":"2009","journal-title":"J Neurochem"},{"key":"10.1016\/j.brainresbull.2020.08.026_bib0200","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.1523\/JNEUROSCI.22-05-01784.2002","article-title":"Adult rodent neurogenic regions: the ventricular subependyma contains neural stem cells, but the dentate gyrus contains restricted progenitors","volume":"22","author":"Seaberg","year":"2002","journal-title":"J Neurosci"},{"key":"10.1016\/j.brainresbull.2020.08.026_bib0205","doi-asserted-by":"crossref","first-page":"349","DOI":"10.3389\/fnagi.2019.00349","article-title":"Insulin-Like Growth Factor-1 Is Neuroprotective in Aged Rats With Ischemic Stroke","volume":"11","author":"Serhan","year":"2019","journal-title":"Front Aging Neurosci"},{"key":"10.1016\/j.brainresbull.2020.08.026_bib0210","doi-asserted-by":"crossref","first-page":"28","DOI":"10.3389\/fphar.2018.00028","article-title":"Asiaticoside Attenuates Cell Growth Inhibition and Apoptosis Induced by Abeta1-42 via Inhibiting the TLR4\/NF-kappaB Signaling Pathway in Human Brain Microvascular Endothelial Cells","volume":"9","author":"Song","year":"2018","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.brainresbull.2020.08.026_bib0215","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.biomaterials.2017.08.019","article-title":"The role of insulin growth factor-1 on the vascular regenerative effect of MAA coated disks and macrophage-endothelial cell crosstalk","volume":"144","author":"Talior-Volodarsky","year":"2017","journal-title":"Biomaterials"},{"key":"10.1016\/j.brainresbull.2020.08.026_bib0220","first-page":"237","article-title":"Nontraumatic intracerebral haemorrhage in young adults. Nature reviews","volume":"14","author":"Tatlisumak","year":"2018","journal-title":"Neurology"},{"key":"10.1016\/j.brainresbull.2020.08.026_bib0225","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1038\/sj.mp.4002076","article-title":"Central actions of liver-derived insulin-like growth factor I underlying its pro-cognitive effects","volume":"12","author":"Trejo","year":"2007","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.brainresbull.2020.08.026_bib0230","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/S1474-4422(09)70340-0","article-title":"Incidence, case fatality, and functional outcome of intracerebral haemorrhage over time, according to age, sex, and ethnic origin: a systematic review and meta-analysis","volume":"9","author":"van Asch","year":"2010","journal-title":"The Lancet. Neurology"},{"key":"10.1016\/j.brainresbull.2020.08.026_bib0235","doi-asserted-by":"crossref","first-page":"553","DOI":"10.3389\/fncel.2019.00553","article-title":"Meisoindigo Protects Against Focal Cerebral Ischemia-Reperfusion Injury by Inhibiting NLRP3 Inflammasome Activation and Regulating Microglia\/Macrophage Polarization via TLR4\/NF-kappaB Signaling Pathway","volume":"13","author":"Ye","year":"2019","journal-title":"Front Cell Neurosci"},{"key":"10.1016\/j.brainresbull.2020.08.026_bib0240","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1111\/jnc.14238","article-title":"Adropin preserves the blood-brain barrier through a Notch1\/Hes1 pathway after intracerebral hemorrhage in mice","volume":"143","author":"Yu","year":"2017","journal-title":"J Neurochem"},{"key":"10.1016\/j.brainresbull.2020.08.026_bib0245","doi-asserted-by":"crossref","first-page":"322","DOI":"10.2174\/18715273113126660141","article-title":"The role of neuronal insulin\/insulin-like growth factor-1 signaling for the pathogenesis of Alzheimer\u2019s disease: possible therapeutic implications","volume":"13","author":"Zemva","year":"2014","journal-title":"CNS Neurol Disord Drug Targets"},{"key":"10.1016\/j.brainresbull.2020.08.026_bib0250","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1177\/0963689719860128","article-title":"Neural Stem Cell Transplantation Improves Locomotor Function in Spinal Cord Transection Rats Associated with Nerve Regeneration and IGF-1 R Expression","volume":"28","author":"Zhao","year":"2019","journal-title":"Cell Transplant"}],"container-title":["Brain Research Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0361923020306158?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0361923020306158?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T20:42:20Z","timestamp":1759783340000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0361923020306158"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":50,"alternative-id":["S0361923020306158"],"URL":"https:\/\/doi.org\/10.1016\/j.brainresbull.2020.08.026","relation":{},"ISSN":["0361-9230"],"issn-type":[{"value":"0361-9230","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"IGF-1R stimulation alters microglial polarization via TLR4\/NF-\u03baB pathway after cerebral hemorrhage in mice","name":"articletitle","label":"Article Title"},{"value":"Brain Research Bulletin","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainresbull.2020.08.026","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}