{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T12:54:57Z","timestamp":1791550497358,"version":"4.3.4"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T00:00:00Z","timestamp":1786060800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Research Bulletin"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.brainresbull.2026.112075","type":"journal-article","created":{"date-parts":[[2026,8,8]],"date-time":"2026-08-08T15:08:36Z","timestamp":1786201716000},"page":"112075","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Rutin ameliorates perioperative neurocognitive disorders by inhibiting microglial HIF-1\u03b1\/PKM2\u2011driven glycolysis"],"prefix":"10.1016","volume":"245","author":[{"given":"Min","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rong","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanyue","family":"Zong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainresbull.2026.112075_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2023.148425","article-title":"Effects of oral \u03b2-caryophyllene (BCP) treatment on perioperative neurocognitive disorders: attenuation of neuroinflammation associated with microglial activation and reinforcement of autophagy activity in aged mice","volume":"1815","author":"Chen","year":"2023","journal-title":"Brain Res."},{"key":"10.1016\/j.brainresbull.2026.112075_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2024.111791","article-title":"Dexamethasone protects against asthma via regulating Hif-1\u03b1-glycolysis-lactate axis and protein lactylation","volume":"131","author":"Chen","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.brainresbull.2026.112075_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.prp.2025.156092","article-title":"Exploring alkaloids and flavonoids from natural sources: emerging natural agents for inhibiting cervical cancer progression through apoptosis induction, anti-inflammatory effects, and oxidative stress reduction","volume":"272","author":"Chen","year":"2025","journal-title":"Pathol. Res. Pract."},{"issue":"1","key":"10.1016\/j.brainresbull.2026.112075_bib4","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1186\/s12974-022-02656-y","article-title":"Targeting neuroinflammation as a preventive and therapeutic approach for perioperative neurocognitive disorders","volume":"19","author":"Cheng","year":"2022","journal-title":"J. Neuroinflamm."},{"issue":"1","key":"10.1016\/j.brainresbull.2026.112075_bib5","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1186\/s12974-021-02187-y","article-title":"Early glycolytic reprogramming controls microglial inflammatory activation","volume":"18","author":"Cheng","year":"2021","journal-title":"J. Neuroinflamm."},{"issue":"22","key":"10.1016\/j.brainresbull.2026.112075_bib6","doi-asserted-by":"crossref","DOI":"10.3390\/nu17223571","article-title":"Rutin as a circadian modulator preserves skeletal muscle mitochondrial function and reduces oxidative stress to protect against d-galactose-induced aging in vitro and in vivo","volume":"17","author":"Choi","year":"2025","journal-title":"Nutrients"},{"key":"10.1016\/j.brainresbull.2026.112075_bib7","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2025.1599167","article-title":"Molecular mechanisms of neuroprotective effect of rutin","volume":"16","author":"Chunmei","year":"2025","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.brainresbull.2026.112075_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.jclinane.2023.111320","article-title":"Postoperative neurocognitive disorders: a clinical guide","volume":"92","author":"Dilmen","year":"2024","journal-title":"J. Clin. Anesth."},{"key":"10.1016\/j.brainresbull.2026.112075_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2024.107503","article-title":"Exploring the therapeutic potential of rutin through investigating its inhibitory mechanism on lactate dehydrogenase: multi-spectral methods and computer simulation","volume":"149","author":"Ding","year":"2024","journal-title":"Bioorg. Chem."},{"issue":"1","key":"10.1016\/j.brainresbull.2026.112075_bib10","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1007\/s12031-022-02084-w","article-title":"Normalization of HPA axis, cholinergic neurotransmission, and inhibiting brain oxidative and inflammatory dynamics are associated with the adaptogenic-like effect of rutin against psychosocial defeat stress","volume":"73","author":"Emudainohwo","year":"2023","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.brainresbull.2026.112075_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2026.150202","article-title":"Neuroprotective and memory-enhancing effects of Aloysia gratissima extract and rutin in an MPTP-induced model of Parkinson's disease","volume":"1877-1878","author":"Erminda Schreiner","year":"2026","journal-title":"Brain Res."},{"issue":"2","key":"10.1016\/j.brainresbull.2026.112075_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexcr.2025.114537","article-title":"Flavonoids in the regulation of microglial-mediated neuroinflammation; focus on fisetin, rutin, and quercetin","volume":"447","author":"Jasim","year":"2025","journal-title":"Exp. Cell. Res."},{"issue":"9","key":"10.1016\/j.brainresbull.2026.112075_bib13","doi-asserted-by":"crossref","first-page":"1895","DOI":"10.1007\/s00011-023-01792-2","article-title":"Systemic inflammation, neuroinflammation and perioperative neurocognitive disorders","volume":"72","author":"Jia","year":"2023","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.brainresbull.2026.112075_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2025.114281","article-title":"Ginsenoside 1 mitigates postoperative cognitive dysfunction by enhancing microglial A\u03b2 clearance through the endo-lysosomal pathway","volume":"150","author":"Jing","year":"2025","journal-title":"Int. Immunopharmacol."},{"issue":"1","key":"10.1016\/j.brainresbull.2026.112075_bib15","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1113\/JP280572","article-title":"Regulation of glycolysis by the hypoxia-inducible factor (HIF): implications for cellular physiology","volume":"599","author":"Kierans","year":"2021","journal-title":"J. Physiol."},{"issue":"5","key":"10.1016\/j.brainresbull.2026.112075_bib16","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1001\/jamainternmed.2023.0144","article-title":"Six-year cognitive trajectory in older adults following major surgery and delirium","volume":"183","author":"Kunicki","year":"2023","journal-title":"JAMA Intern. Med."},{"issue":"1","key":"10.1016\/j.brainresbull.2026.112075_bib17","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1186\/s12974-024-03216-2","article-title":"Microglia mediate memory dysfunction via excitatory synaptic elimination in a fracture surgery mouse model","volume":"21","author":"Li","year":"2024","journal-title":"J. Neuroinflamm."},{"issue":"8","key":"10.1016\/j.brainresbull.2026.112075_bib18","doi-asserted-by":"crossref","DOI":"10.1111\/cns.14913","article-title":"Hyperglycemia-induced Sirt3 downregulation increases microglial aerobic glycolysis and inflammation in diabetic neuropathic pain pathogenesis","volume":"30","author":"Li","year":"2024","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.brainresbull.2026.112075_bib19","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.jare.2024.08.016","article-title":"Impaired microglial glycolysis promotes inflammatory responses after intracerebral haemorrhage via HK2-dependent mitochondrial dysfunction","volume":"73","author":"Li","year":"2025","journal-title":"J. Adv. Res."},{"issue":"1","key":"10.1016\/j.brainresbull.2026.112075_bib20","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1007\/s12013-024-01520-5","article-title":"TREM2 impairs glycolysis to interrupt microglial M1 polarization and inflammation via JAK2\/STAT3 axis","volume":"83","author":"Liu","year":"2025","journal-title":"Cell. Biochem. Biophys."},{"issue":"10","key":"10.1016\/j.brainresbull.2026.112075_bib21","doi-asserted-by":"crossref","DOI":"10.1111\/cns.70049","article-title":"Inhibiting endoplasmic reticulum stress alleviates perioperative neurocognitive disorders by reducing neuroinflammation mediated by NLRP3 inflammasome activation","volume":"30","author":"Meng","year":"2024","journal-title":"CNS Neurosci. Ther."},{"issue":"7","key":"10.1016\/j.brainresbull.2026.112075_bib22","doi-asserted-by":"crossref","first-page":"3191","DOI":"10.1007\/s10571-023-01376-y","article-title":"Microglial metabolic reprogramming: emerging insights and therapeutic strategies in neurodegenerative diseases","volume":"43","author":"Miao","year":"2023","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.brainresbull.2026.112075_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2022.106163","article-title":"Rutin ameliorates inflammation and improves metabolic function: a comprehensive analysis of scientific literature","volume":"178","author":"Muvhulawa","year":"2022","journal-title":"Pharmacol. Res."},{"issue":"4","key":"10.1016\/j.brainresbull.2026.112075_bib24","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1111\/bph.13139","article-title":"Microglial M1\/M2 polarization and metabolic states","volume":"173","author":"Orihuela","year":"2016","journal-title":"Br. J. Pharmacol."},{"issue":"2","key":"10.1016\/j.brainresbull.2026.112075_bib25","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aau6328","article-title":"Sodium rutin ameliorates Alzheimer's disease-like pathology by enhancing microglial amyloid-\u03b2 clearance","volume":"5","author":"Pan","year":"2019","journal-title":"Sci. Adv."},{"issue":"1","key":"10.1016\/j.brainresbull.2026.112075_bib26","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/s41531-024-00858-0","article-title":"Enhanced glycolysis-derived lactate promotes microglial activation in Parkinson's disease via histone lactylation","volume":"11","author":"Qin","year":"2025","journal-title":"NPJ Parkinsons Dis."},{"key":"10.1016\/j.brainresbull.2026.112075_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.102846","article-title":"Metabolic reprogramming in inflammatory microglia indicates a potential way of targeting inflammation in Alzheimer's disease","volume":"66","author":"Sangineto","year":"2023","journal-title":"Redox Biol."},{"issue":"1","key":"10.1016\/j.brainresbull.2026.112075_bib28","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1186\/s12871-025-03557-2","article-title":"Managing perioperative neurocognitive disorders in geriatric patients: past, present, and future","volume":"25","author":"Saxena","year":"2025","journal-title":"BMC Anesthesiol."},{"key":"10.1016\/j.brainresbull.2026.112075_bib29","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2024.1434568","article-title":"Huanshaodan regulates microglial glucose metabolism reprogramming to alleviate neuroinflammation in AD mice through mTOR\/HIF-1\u03b1 signaling pathway","volume":"15","author":"Shang","year":"2024","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.brainresbull.2026.112075_bib30","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.ibneur.2024.12.008","article-title":"Postoperative analgesia with morphine promoting microglial activation and neuroinflammation induced by surgery aggravates perioperative neurocognitive dysfunction in aged mice","volume":"18","author":"Shao","year":"2025","journal-title":"IBRO Neurosci. Rep."},{"issue":"5","key":"10.1016\/j.brainresbull.2026.112075_bib31","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.3390\/neurolint16050082","article-title":"Neuroprotective properties of rutin hydrate against scopolamine-induced deficits in BDNF\/TrkB\/ERK\/CREB\/Bcl2 pathways","volume":"16","author":"Sreelatha","year":"2024","journal-title":"Neurol. Int."},{"issue":"1","key":"10.1016\/j.brainresbull.2026.112075_bib32","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-025-21874-x","article-title":"Rutin ameliorates sevoflurane-induced neurotoxicity by inhibiting microglial synaptic phagocytosis through the complement pathway","volume":"15","author":"Tian","year":"2025","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.brainresbull.2026.112075_bib33","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1097\/HEP.0000000000000569","article-title":"Canonical Wnt signaling promotes HSC glycolysis and liver fibrosis through an LDH-A\/HIF-1\u03b1 transcriptional complex","volume":"79","author":"Wang","year":"2024","journal-title":"Hepatology"},{"issue":"1","key":"10.1016\/j.brainresbull.2026.112075_bib34","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s13578-024-01223-7","article-title":"Complement C1q-mediated microglial synaptic elimination by enhancing desialylation underlies sevoflurane-induced developmental neurotoxicity","volume":"14","author":"Wang","year":"2024","journal-title":"Cell. Biosci."},{"issue":"4","key":"10.1016\/j.brainresbull.2026.112075_bib35","doi-asserted-by":"crossref","first-page":"2459","DOI":"10.1007\/s12035-023-03729-6","article-title":"LncRNA-AC020978 promotes metabolic reprogramming in M1 microglial cells in postoperative cognitive disorder via PKM2","volume":"61","author":"Wang","year":"2024","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.brainresbull.2026.112075_bib36","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2025.115553","article-title":"Pharmacological suppression of lactate mitigates postoperative cognitive dysfunction","volume":"396","author":"Wang","year":"2026","journal-title":"Exp. Neurol."},{"issue":"Pt 2","key":"10.1016\/j.brainresbull.2026.112075_bib37","article-title":"Fibrinogen drives neuroinflammation and neuropathology in perioperative neurocognitive disorders","volume":"168","author":"Wang","year":"2026","journal-title":"Int. Immunopharmacol."},{"issue":"1","key":"10.1016\/j.brainresbull.2026.112075_bib38","doi-asserted-by":"crossref","first-page":"8624","DOI":"10.1038\/s41467-024-53006-w","article-title":"MDM2 induces pro-inflammatory and glycolytic responses in M1 macrophages by integrating iNOS-nitric oxide and HIF-1\u03b1 pathways in mice","volume":"15","author":"Wu","year":"2024","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.brainresbull.2026.112075_bib39","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/s11658-024-00595-5","article-title":"Impaired synaptic plasticity and decreased glutamatergic neuron excitability induced by SIRT1\/BDNF downregulation in the hippocampal CA1 region are involved in postoperative cognitive dysfunction","volume":"29","author":"Wu","year":"2024","journal-title":"Cell. Mol. Biol. Lett."},{"issue":"1","key":"10.1016\/j.brainresbull.2026.112075_bib40","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s12916-022-02705-6","article-title":"Prolonged anesthesia induces neuroinflammation and complement-mediated microglial synaptic elimination involved in neurocognitive dysfunction and anxiety-like behaviors","volume":"21","author":"Xu","year":"2023","journal-title":"BMC Med."},{"issue":"4","key":"10.1016\/j.brainresbull.2026.112075_bib41","doi-asserted-by":"crossref","first-page":"4452","DOI":"10.1007\/s12035-024-04572-z","article-title":"Immune checkpoint VISTA negatively regulates microglia glycolysis and activation via TRIM28-mediated ubiquitination of HK2 in sepsis-associated encephalopathy","volume":"62","author":"Xu","year":"2025","journal-title":"Mol. Neurobiol."},{"issue":"1","key":"10.1016\/j.brainresbull.2026.112075_bib42","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1186\/s40001-024-02129-3","article-title":"Acute hyperglycemia exacerbates neuroinflammation and cognitive impairment in sepsis-associated encephalopathy by mediating the ChREBP\/HIF-1\u03b1 pathway","volume":"29","author":"Yao","year":"2024","journal-title":"Eur. J. Med. Res."},{"issue":"10","key":"10.1016\/j.brainresbull.2026.112075_bib43","doi-asserted-by":"crossref","first-page":"2099","DOI":"10.1038\/s42255-025-01379-7","article-title":"Cholesterol metabolic reprogramming mediates microglia-induced chronic neuroinflammation and hinders neurorestoration following stroke","volume":"7","author":"Zhao","year":"2025","journal-title":"Nat. Metab."}],"container-title":["Brain Research Bulletin"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S036192302600362X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S036192302600362X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T12:32:06Z","timestamp":1791549126000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S036192302600362X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":43,"alternative-id":["S036192302600362X"],"URL":"https:\/\/doi.org\/10.1016\/j.brainresbull.2026.112075","relation":{},"ISSN":["0361-9230"],"issn-type":[{"value":"0361-9230","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Rutin ameliorates perioperative neurocognitive disorders by inhibiting microglial HIF-1\u03b1\/PKM2\u2011driven glycolysis","name":"articletitle","label":"Article Title"},{"value":"Brain Research Bulletin","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brainresbull.2026.112075","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"112075"}}