{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T18:16:19Z","timestamp":1791137779662,"version":"4.1.0"},"reference-count":385,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2004,11,1]],"date-time":"2004-11-01T00:00:00Z","timestamp":1099267200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Research Reviews"],"published-print":{"date-parts":[[2004,11]]},"DOI":"10.1016\/j.brainresrev.2004.07.014","type":"journal-article","created":{"date-parts":[[2004,9,10]],"date-time":"2004-09-10T13:21:56Z","timestamp":1094822516000},"page":"328-355","source":"Crossref","is-referenced-by-count":108,"title":["Sphingolipid metabolites in neural signalling and function"],"prefix":"10.1016","volume":"46","author":[{"given":"Laura","family":"Colombaioni","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mercedes","family":"Garcia-Gil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainresrev.2004.07.014_bib1","doi-asserted-by":"crossref","first-page":"8387","DOI":"10.1523\/JNEUROSCI.21-21-08387.2001","article-title":"Plasma membrane ganglioside sialidase regulates axonal growth and regeneration in hippocampal neurons in culture","volume":"21","author":"Abad Rodriguez","year":"2001","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib2","doi-asserted-by":"crossref","first-page":"8467","DOI":"10.1074\/jbc.273.14.8467","article-title":"Purification and characterization of 1-O-acylceramide synthase, a novel phospholipase A2 with transacylase activity","volume":"19273","author":"Abe","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib3","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1093\/oxfordjournals.jbchem.a123736","article-title":"Improved inhibitors of glucosylceramide synthase","volume":"111","author":"Abe","year":"1992","journal-title":"J. Biochem. (Tokyo)"},{"key":"10.1016\/j.brainresrev.2004.07.014_bib4","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/S1016-8478(23)13530-8","article-title":"Suppression of ceramide-mediated apoptosis by HSP70","volume":"9","author":"Ahn","year":"1999","journal-title":"Mol. Cells"},{"key":"10.1016\/j.brainresrev.2004.07.014_bib5","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/0304-3940(83)90018-6","article-title":"Effect of tricyclic antidepressants on sphingomyelinase and other sphingolipid hydrolases in C6 cultured glioma cells","volume":"36","author":"Albouz","year":"1983","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib6","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S0014-5793(01)03168-4","article-title":"Depolarisation induces rapid and transient formation of intracellular sphingosine-1-phosphate","volume":"509","author":"Alemany","year":"2001","journal-title":"FEBS Lett."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib7","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1002\/(SICI)1098-1136(199904)26:2<176::AID-GLIA8>3.0.CO;2-K","article-title":"Edg-2 in myelin-forming cells: isoforms, genomic mapping, and exclusion in Charcot\u2013Marie\u2013Tooth disease","volume":"26","author":"Allard","year":"1999","journal-title":"Glia"},{"key":"10.1016\/j.brainresrev.2004.07.014_bib8","first-page":"57","article-title":"Neutral sphingomyelinase-inhibiting guanidines prevent herpes simplex virus-1 replication","volume":"26","author":"Amtmann","year":"2000","journal-title":"Drugs Exp. Clin. Res."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib9","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1080\/10298420290015836","article-title":"Gangliosides prevent excitotoxicity through activation of TrkB receptor","volume":"4","author":"Bachis","year":"2002","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib10","doi-asserted-by":"crossref","first-page":"14354","DOI":"10.1016\/S0021-9258(18)71685-2","article-title":"Synaptic vesicle ceramide kinase. A calcium-stimulated lipid kinase that co-purifies with brain synaptic vesicles","volume":"264","author":"Bajjalieh","year":"1989","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib11","doi-asserted-by":"crossref","first-page":"35622","DOI":"10.1074\/jbc.M105673200","article-title":"Involvement of phospholipase D in sphingosine 1-phosphate-induced activation of phosphatidylinositol 3-kinase and Akt in Chinese hamster ovary cells overexpressing EDG3","volume":"276","author":"Banno","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib12","doi-asserted-by":"crossref","first-page":"30419","DOI":"10.1074\/jbc.273.46.30419","article-title":"BAD enables ceramide to signal apoptosis via Ras and Raf-1","volume":"273","author":"Basu","year":"1998","journal-title":"J. Biol. Chem."},{"issue":"9","key":"10.1016\/j.brainresrev.2004.07.014_bib13","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1172\/JCI0216450","article-title":"Hereditary sensory neuropathy type 1 mutations confer dominant negative effects on serine palmitoyltransferase, critical for sphingolipid synthesis","volume":"110","author":"Bejaoui","year":"2002","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib14","doi-asserted-by":"crossref","first-page":"10539","DOI":"10.1074\/jbc.M109064200","article-title":"Sphingosine 1-phosphate, present in serum-derived lipoproteins, activates matriptase","volume":"277","author":"Benaud","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib15","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S0005-2760(97)00180-X","article-title":"The potent lipid mitogen sphingosylphosphocholine activates the DNA binding activity of upstream stimulating factor (USF), a basic helix\u2013loop\u2013helix\u2013zipper protein","volume":"1390","author":"Berger","year":"1998","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.brainresrev.2004.07.014_bib16","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1042\/bj3220327","article-title":"Sphingosylphosphocholine modulates the ryanodine receptor\/calcium-release channel of cardiac sarcoplasmic reticulum membranes","volume":"322","author":"Betto","year":"1997","journal-title":"Biochem. J."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib17","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1046\/j.1471-4159.1999.0721040.x","article-title":"Differential effects of glycolipid biosynthesis inhibitors on ceramide-induced cell death in neuroblastoma cells","volume":"72","author":"Bieberich","year":"1999","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib18","doi-asserted-by":"crossref","first-page":"44396","DOI":"10.1074\/jbc.M107239200","article-title":"Regulation of apoptosis during neuronal differentiation by ceramide and b-series complex gangliosides","volume":"276","author":"Bieberich","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib19","doi-asserted-by":"crossref","first-page":"12646","DOI":"10.1074\/jbc.271.21.12646","article-title":"(1S,2R)-d-erythro-2-(N-myristoylamino)-1-phenyl-1-propanol as an inhibitor of ceramidase","volume":"271","author":"Bielawska","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib20","doi-asserted-by":"crossref","first-page":"10922","DOI":"10.1074\/jbc.272.16.10922","article-title":"Association of p75(NTR) with caveolin and localization of neurotrophin-induced sphingomyelin hydrolysis to caveolae","volume":"272","author":"Bilderback","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib21","doi-asserted-by":"crossref","first-page":"2669","DOI":"10.1096\/fj.01-0539com","article-title":"Selective hydrolysis of a mitochondrial pool of sphingomyelin induces apoptosis","volume":"15","author":"Birbes","year":"2001","journal-title":"FASEB J."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib22","doi-asserted-by":"crossref","first-page":"16211","DOI":"10.1074\/jbc.272.26.16211","article-title":"Sphingosine 1-phosphate stimulates tyrosine phosphorylation of Crk","volume":"272","author":"Blakesley","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib23","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.1046\/j.1471-4159.1999.721759.x","article-title":"The stimulation of ketogenesis by cannabinoids in cultured astrocytes defines carnitine palmitoyltransferase I as a new ceramide-activated enzyme","volume":"72","author":"Blazquez","year":"1999","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib24","doi-asserted-by":"crossref","first-page":"2315","DOI":"10.1096\/fj.00-0122com","article-title":"De novo-synthesized ceramide signals apoptosis in astrocytes via extracellular signal-regulated kinase","volume":"14","author":"Blazquez","year":"2000","journal-title":"FASEB J."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib25","first-page":"213","article-title":"Protein kinase C isoenzymes: regulation and function","volume":"27","author":"Blobe","year":"1996","journal-title":"Cancer Surv."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib26","doi-asserted-by":"crossref","first-page":"35617","DOI":"10.1074\/jbc.M007346200","article-title":"Ceramide directly activates protein kinase C zeta to regulate a stress-activated protein kinase signaling complex","volume":"275","author":"Bourbon","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib27","doi-asserted-by":"crossref","first-page":"890","DOI":"10.1016\/S0006-291X(03)00763-0","article-title":"Ceramide inhibits the potassium channel Kv1.3 by the formation of membrane platforms","volume":"305","author":"Bock","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib28","doi-asserted-by":"crossref","first-page":"1814","DOI":"10.1096\/fj.02-0149fje","article-title":"Phosphatidylcholine synthesis is elevated in neuronal models of Gaucher disease due to direct activation of CTP: phosphocholine cytidylyltransferase by glucosylceramide","volume":"16","author":"Bodennec","year":"2002","journal-title":"FASEB J."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib29","doi-asserted-by":"crossref","first-page":"35258","DOI":"10.1074\/jbc.M105442200","article-title":"Cystic fibrosis transmembrane regulator regulates uptake of sphingoid base phosphates and lysophosphatidic acid: modulation of cellular activity of sphingosine 1-phosphate","volume":"276","author":"Boujaoude","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib30","doi-asserted-by":"crossref","first-page":"8199","DOI":"10.1523\/JNEUROSCI.19-19-08199.1999","article-title":"Ceramide signaling downstream of the p75 neurotrophin receptor mediates the effects of nerve growth factor on outgrowth of cultured hippocampal neurons","volume":"19","author":"Brann","year":"1999","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib31","doi-asserted-by":"crossref","first-page":"9812","DOI":"10.1074\/jbc.M109862200","article-title":"Nerve growth factor-induced p75-mediated death of cultured hippocampal neurons is age-dependent and transduced through ceramide generated by neutral sphingomyelinase","volume":"277","author":"Brann","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib32","doi-asserted-by":"crossref","first-page":"22173","DOI":"10.1074\/jbc.272.35.22173","article-title":"Fas- or ceramide-induced apoptosis is mediated by a Rac1-regulated activation of Jun N-terminal kinase\/p38 kinases and GADD153","volume":"272","author":"Brenner","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib33","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1046\/j.1471-4159.1998.70020871.x","article-title":"Inhibition of glycosphingolipid biosynthesis does not impair growth or morphogenesis of the postimplantation mouse embryo","volume":"70","author":"Brigande","year":"1998","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib34","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1086\/301773","article-title":"CAS, the human homologue of the yeast chromosome-segregation gene CSE1, in proliferation, apoptosis, and cancer","volume":"62","author":"Brinkmann","year":"1998","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib35","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1146\/annurev.cellbio.14.1.111","article-title":"Functions of lipid rafts in biological membranes","volume":"14","author":"Brown","year":"1998","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib36","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1046\/j.1471-4159.1996.66020733.x","article-title":"Ceramide induces apoptosis in cultured mesencephalic neurons","volume":"66","author":"Brugg","year":"1996","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib37","doi-asserted-by":"crossref","first-page":"5252","DOI":"10.1093\/emboj\/18.19.5252","article-title":"Cathepsin D targeted by acid sphingomyelinase-derived ceramide","volume":"18","author":"Brunner","year":"1999","journal-title":"EMBO J."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib38","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/S1043-6618(03)00049-5","article-title":"The roles of ceramide and complex sphingolipids in neuronal cell function","volume":"47","author":"Buccoliero","year":"2003","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib39","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1023\/A:1020207613196","article-title":"The role of sphingolipids in neuronal development: lessons from models of sphingolipid storage diseases","volume":"27","author":"Buccoliero","year":"2002","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib40","doi-asserted-by":"crossref","first-page":"3154","DOI":"10.1016\/S0021-9258(19)50708-6","article-title":"Inhibition of sphingosine kinase in vitro and in platelets. Implications for signal transduction pathways","volume":"267","author":"Buehrer","year":"1992","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib41","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1097\/00001756-200210070-00003","article-title":"Regulation of nociceptin\/orphanin FQ gene expression in astrocytes by ceramide","volume":"13","author":"Buzas","year":"2002","journal-title":"NeuroReport"},{"key":"10.1016\/j.brainresrev.2004.07.014_bib42","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1002\/(SICI)1098-1136(199609)18:1<49::AID-GLIA5>3.0.CO;2-Z","article-title":"Activation of acidic sphingomyelinase and protein kinase C zeta is required for IL-1 induction of LIF mRNA in a Schwann cell line","volume":"18","author":"Carlson","year":"1996","journal-title":"Glia"},{"key":"10.1016\/j.brainresrev.2004.07.014_bib43","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1038\/383716a0","article-title":"Death of oligodendrocytes mediated by the interaction of nerve growth factor with its receptor p75","volume":"383","author":"Casaccia-Bonnefil","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.brainresrev.2004.07.014_bib44","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1002\/(SICI)1097-4547(19960201)43:3<382::AID-JNR13>3.0.CO;2-7","article-title":"Central glial and neuronal populations display differential sensitivity to ceramide-dependent cell death","volume":"43","author":"Casaccia-Bonnefil","year":"1996","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib45","doi-asserted-by":"crossref","first-page":"C780","DOI":"10.1152\/ajpcell.00382.2002","article-title":"Expression and functional characterization of SCaMPER: a sphingolipid-modulated calcium channel of cardiomyocytes","volume":"284","author":"Cavalli","year":"2003","journal-title":"Am. J. Physiol., Cell Physiol."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib46","doi-asserted-by":"crossref","first-page":"12587","DOI":"10.1074\/jbc.M112010200","article-title":"De novo ceramide regulates the alternative splicing of caspase 9 and Bcl-x in A549 lung adenocarcinoma cells. Dependence on protein phosphatase-1","volume":"277","author":"Chalfant","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib47","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0306-4522(03)00259-8","article-title":"Ganglioside\/calmodulin kinase II signal inducing cdc42-mediated neuronal actin reorganization","volume":"120","author":"Chen","year":"2003","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainresrev.2004.07.014_bib48","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1006\/exnr.2000.7504","article-title":"A functional role for complex gangliosides: motor deficits in GM2\/GD2 synthase knockout mice","volume":"166","author":"Chiavegatto","year":"2000","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib49","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/0-306-46814-X_7","article-title":"Ceramide inhibits L-type calcium channel currents in rat pinealocytes","volume":"460","author":"Chik","year":"1999","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib50","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1046\/j.1471-4159.2001.00566.x","article-title":"Ceramide inhibits the outward potassium current in rat pinealocytes","volume":"79","author":"Chik","year":"2001","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib51","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1124\/mol.61.3.486","article-title":"Distinct effects of different calcium-mobilizing agents on cell death in NG108-15 neuroblastoma\u00d7glioma cells","volume":"61","author":"Chin","year":"2002","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib52","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.brainresrev.2003.08.007","article-title":"Fas ligand\/Fas system in the brain: regulator of immune and apoptotic responses","volume":"44","author":"Choi","year":"2004","journal-title":"Brains Res. Rev."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib53","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1038\/380634a0","article-title":"Calcium mobilization via sphingosine kinase in signalling by the FceRI antigen receptor","volume":"380","author":"Choi","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.brainresrev.2004.07.014_bib54","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1097\/00001756-200103050-00036","article-title":"GT1b ganglioside induces death of dopaminergic neurons in rat mesencephalic cultures","volume":"12","author":"Chung","year":"2001","journal-title":"NeuroReport"},{"key":"10.1016\/j.brainresrev.2004.07.014_bib55","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0092-8674(00)80093-8","article-title":"Myelination in the absence of galactocerebroside and sulfatide: normal structure with abnormal function and regional instability","volume":"86","author":"Coetzee","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.brainresrev.2004.07.014_bib56","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1007\/BF00292433","article-title":"Disruption of murine Hexa gene leads to enzymatic deficiency and to neuronal lysosomal storage, similar to that observed in Tay-Sachs disease","volume":"6","author":"Cohen-Tannoudji","year":"1995","journal-title":"Mamm. Genome"},{"key":"10.1016\/j.brainresrev.2004.07.014_bib57","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0165-3806(01)00326-1","article-title":"Role of mitochondria in serum withdrawal-induced apoptosis of immortalized neuronal precursors","volume":"134","author":"Colombaioni","year":"2002","journal-title":"Dev. Brain Res."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib58","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/S0197-0186(01)00090-0","article-title":"Serum deprivation increases ceramide levels and induces apoptosis in undifferentiated HN9.10e cells","volume":"40","author":"Colombaioni","year":"2002","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib59","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1046\/j.1471-4159.2000.0751172.x","article-title":"Relative contribution of different receptor subtypes in the response of neuroblastoma cells to tumor necrosis factor-alpha","volume":"75","author":"Condorelli","year":"2000","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib60","doi-asserted-by":"crossref","first-page":"3963","DOI":"10.1523\/JNEUROSCI.22-10-03963.2002","article-title":"Beta-amyloid-induced synthesis of the ganglioside GD3 is a requisite for cell cycle reactivation and apoptosis in neurons","volume":"22","author":"Copani","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib61","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0014-5793(02)03489-0","article-title":"Role of sphingomyelinase and ceramide in modulating rafts: do biophysical properties determine biologic outcome?","volume":"531","author":"Cremesti","year":"2002","journal-title":"FEBS Lett."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib62","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1002\/ana.10312","article-title":"Evidence that accumulation of ceramides and cholesterol esters mediates oxidative stress-induced death of motor neurons in amyotrophic lateral sclerosis","volume":"52","author":"Cutler","year":"2002","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib63","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S1388-1981(02)00336-0","article-title":"Sphingosine in apoptosis signaling","volume":"1585","author":"Cuvillier","year":"2002","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.brainresrev.2004.07.014_bib64","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1038\/381800a0","article-title":"Suppression of ceramide-mediated programmed cell death by sphingosine-1-phosphate","volume":"381","author":"Cuvillier","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.brainresrev.2004.07.014_bib65","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1046\/j.1471-4159.2003.01590.x","article-title":"Ceramide increases mitochondrial free calcium levels via caspase 8 and Bid: role in initiation of cell death","volume":"84","author":"Darios","year":"2003","journal-title":"J. Neurochem."},{"issue":"3","key":"10.1016\/j.brainresrev.2004.07.014_bib66","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/85879","article-title":"Mutations in SPTLC1, encoding serine palmitoyltransferase, long chain base subunit-1, cause hereditary sensory neuropathy type I","volume":"27","author":"Dawkins","year":"2001","journal-title":"Nat. Genet."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib67","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1073\/pnas.92.5.1347","article-title":"Retinoblastoma gene product as a downstream target for a ceramide-dependent pathway of growth arrest","volume":"92","author":"Dbaibo","year":"1995","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib68","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/S0006-291X(05)81427-5","article-title":"Sphingosylphosphorylcholine is a remarkably potent mitogen for a variety of cell lines","volume":"181","author":"Desai","year":"1991","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib69","doi-asserted-by":"crossref","first-page":"0042.1","DOI":"10.1186\/gb-2002-3-8-research0042","article-title":"Identification of genes involved in ceramide-dependent neuronal apoptosis using cDNA arrays","volume":"3","author":"Decraene","year":"2002","journal-title":"Genome Biol."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib70","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1126\/science.277.5332.1652","article-title":"Requirement for GD3 ganglioside in CD95- and ceramide-induced apoptosis","volume":"277","author":"De Maria","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.brainresrev.2004.07.014_bib71","doi-asserted-by":"crossref","first-page":"15523","DOI":"10.1016\/S0021-9258(18)82288-8","article-title":"Ceramide activates a heterotrimeric protein phosphatase 2A","volume":"268","author":"Dobrowsky","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib72","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1126\/science.8079174","article-title":"Activation of the sphingomyelin cycle through the low-affinity neurotrophin receptor","volume":"265","author":"Dobrowsky","year":"1994","journal-title":"Science"},{"key":"10.1016\/j.brainresrev.2004.07.014_bib73","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/S0006-8993(02)03986-0","article-title":"Lipid rafts of purified mouse brain synaptosomes prepared with or without detergent reveal different lipid and protein domains","volume":"962","author":"Eckert","year":"2003","journal-title":"Brain Res."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib74","doi-asserted-by":"crossref","first-page":"6952","DOI":"10.1523\/JNEUROSCI.17-18-06952.1997","article-title":"Involvement of sphingosine 1-phosphate in nerve growth factor-mediated neuronal survival and differentiation","volume":"17","author":"Edsall","year":"1997","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib75","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1046\/j.1471-4159.2001.00164.x","article-title":"Sphingosine kinase expression regulates apoptosis and caspase activation in PC12 cells","volume":"76","author":"Edsall","year":"2001","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib76","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1023\/A:1020288403626","article-title":"Identification of ceramide binding proteins in neuronal cells: a critical point of view","volume":"27","author":"Elsen","year":"2002","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib77","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/0014-4827(92)90392-L","article-title":"A ceramide analogue (PDMP) inhibits glycolipid synthesis in fish embryos","volume":"198","author":"Fenderson","year":"1992","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib78","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/0165-3806(83)90006-8","article-title":"Gangliosides enhance neurite outgrowth in PC12 cells","volume":"8","author":"Ferrari","year":"1983","journal-title":"Dev. Brain Res."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib79","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/0165-5728(95)00145-X","article-title":"Stimulation of the sphingomyelin pathway induces interleukin-6 gene expression in human astrocytoma cells","volume":"63","author":"Fiebich","year":"1995","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib80","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1242\/jcs.111.5.549","article-title":"Nerve growth factor and ceramides modulate cell death in the early developing inner ear","volume":"111","author":"Frago","year":"1998","journal-title":"J. Cell. Sci."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib81","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1242\/jcs.00223","article-title":"Programmed cell death in the developing inner ear is balanced by nerve growth factor and insulin-like growth factor I","volume":"116","author":"Frago","year":"2003","journal-title":"J. Cell. Sci."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib82","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1046\/j.1471-4159.1997.69041612.x","article-title":"Mitochondrial free radical signal in ceramide-dependent apoptosis: a putative mechanism for neuronal death in Parkinson's disease","volume":"69","author":"France-Lanord","year":"1997","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib83","first-page":"5962","article-title":"Discovery and evaluation of inhibitors of human sphingosine kinase","volume":"63","author":"French","year":"2003","journal-title":"Cancer Res."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib84","doi-asserted-by":"crossref","first-page":"5832","DOI":"10.1074\/jbc.275.8.5832","article-title":"GD3 synthase gene expression in PC12 cells results in the continuous activation of TrkA and ERK1\/2 and enhanced proliferation","volume":"275","author":"Fukumoto","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib85","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.1046\/j.1471-4159.1998.70051876.x","article-title":"The transcription factor NF-kappaB mediates increases in calcium currents and decreases in NMDA- and AMPA\/kainate-induced currents induced by tumor necrosis factor-alpha in hippocampal neurons","volume":"70","author":"Furukawa","year":"1998","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib86","doi-asserted-by":"crossref","first-page":"2418","DOI":"10.1016\/S0021-9258(18)31651-X","article-title":"Ganglioside GD1 alpha in cerebellar Purkinje cells. Its specific absence in mouse mutants with Purkinje cell abnormality and altered immunoreactivity in response to conjunctive stimuli causing long-term desensitization","volume":"269","author":"Furuya","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib87","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1002\/(SICI)1097-4547(19960401)44:1<73::AID-JNR10>3.0.CO;2-9","article-title":"Restricted occurrence of an unusual ganglioside GD1 alpha in rat brain and its possible involvement in dendritic growth of cerebellar Purkinje neurons","volume":"44","author":"Furuya","year":"1996","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib88","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1046\/j.1471-4159.1998.71010366.x","article-title":"Ceramide and its interconvertible metabolite sphingosine function as indispensable lipid factors involved in survival and dendritic differentiation of cerebellar Purkinje cells","volume":"71","author":"Furuya","year":"1998","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib89","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1097\/00004647-200103000-00006","article-title":"Cell permeable exogenous ceramide reduces infarct size in spontaneously hypertensive rats supporting in vitro studies that have implicated ceramide in induction of tolerance to ischemia","volume":"21","author":"Furuya","year":"2001","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib90","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/S0169-328X(97)00230-1","article-title":"Induction of nerve growth factor synthesis by sphingomyelinase and ceramide in primary astrocyte cultures","volume":"52","author":"Galve-Roperh","year":"1997","journal-title":"Mol. Brain Res."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib91","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S0014-5793(97)00985-X","article-title":"Ceramide-induced translocation of protein kinase C zeta in primary cultures of astrocytes","volume":"415","author":"Galve-Roperh","year":"1997","journal-title":"FEBS Lett."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib92","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1124\/mol.62.6.1385","article-title":"Mechanism of extracellular signal-regulated kinase activation by the CB(1) cannabinoid receptor","volume":"62","author":"Galve-Roperh","year":"2002","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib93","doi-asserted-by":"crossref","first-page":"11369","DOI":"10.1074\/jbc.272.17.11369","article-title":"Direct effect of ceramide on the mitochondrial electron transport chain leads to generation of reactive oxygen species, role of mitochondrial glutathione","volume":"272","author":"Garcia-Ruiz","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib94","doi-asserted-by":"crossref","first-page":"6080","DOI":"10.1074\/jbc.274.10.6080","article-title":"Ceramide induces cytochrome c release from isolated mitochondria. Importance of mitochondrial redox state","volume":"274","author":"Ghafourifar","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib95","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1126\/science.2163543","article-title":"Intracellular calcium release mediated by sphingosine derivatives generated in cells","volume":"248","author":"Ghosh","year":"1990","journal-title":"Science"},{"key":"10.1016\/j.brainresrev.2004.07.014_bib96","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1006\/nbdi.2000.0312","article-title":"Ceramide initiates NFkappaB-mediated caspase activation in neuronal apoptosis","volume":"7","author":"Gill","year":"2000","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib97","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1006\/mcne.1999.0776","article-title":"Molecular cloning, tissue-specific expression, and chromosomal localization of a novel nerve growth factor-regulated G-protein-coupled receptor, nrg-1","volume":"14","author":"Glickman","year":"1999","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib98","doi-asserted-by":"crossref","first-page":"1589","DOI":"10.1096\/fasebj.12.15.1589","article-title":"Diversity of cellular receptors and functions for the lysophospholipid growth factors lysophosphatidic acid and sphingosine 1-phosphate","volume":"12","author":"Goetzl","year":"1998","journal-title":"FASEB J."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib99","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1042\/bj3250435","article-title":"Stimulation of DNA synthesis by natural ceramide 1-phosphate","volume":"325","author":"Gomez-Munoz","year":"1997","journal-title":"Biochem. J."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib100","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1194\/jlr.M300158-JLR200","article-title":"Ceramide-1-phosphate blocks apoptosis through inhibition of acid sphingomyelinase in macrophages","volume":"45","author":"Gomez-Munoz","year":"2004","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib101","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1046\/j.1471-4159.1996.66020869.x","article-title":"Ceramide protects hippocampal neurons against excitotoxic oxidative insults, and amyloid beta-peptide toxicity","volume":"66","author":"Goodman","year":"1996","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib102","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1002\/(SICI)1097-4547(19990915)57:6<884::AID-JNR14>3.0.CO;2-A","article-title":"Overexpression of Akt (protein kinase B) confers protection against apoptosis and prevents formation of ceramide in response to pro-apoptotic stimuli","volume":"57","author":"Goswami","year":"1999","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib103","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1023\/A:1020292504535","article-title":"CrmA protects against apoptosis and ceramide formation in PC12 cells","volume":"27","author":"Goswami","year":"2002","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib104","doi-asserted-by":"crossref","first-page":"24154","DOI":"10.1074\/jbc.272.39.24154","article-title":"Direct inhibition of mitochondrial respiratory chain complex III by cell-permeable ceramide","volume":"272","author":"Gudz","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib105","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1006\/excr.2001.5323","article-title":"TNFalpha enhances the DNA single-strand breakage induced by the short-chain lipid hydroperoxide analogue tert-butylhydroperoxide via ceramide-dependent inhibition of complex III followed by enforced superoxide and hydrogen peroxide formation","volume":"270","author":"Guidarelli","year":"2002","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib106","doi-asserted-by":"crossref","first-page":"4749","DOI":"10.1128\/MCB.14.7.4749","article-title":"Direct stimulation of Vav guanine nucleotide exchange activity for Ras by phorbol esters and diglycerides","volume":"14","author":"Gulbins","year":"1994","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib107","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/1074-7613(95)90142-6","article-title":"FAS-induced apoptosis is mediated via a ceramide-initiated RAS signaling pathway","volume":"2","author":"Gulbins","year":"1995","journal-title":"Immunity"},{"key":"10.1016\/j.brainresrev.2004.07.014_bib108","doi-asserted-by":"crossref","first-page":"7661","DOI":"10.1073\/pnas.94.14.7661","article-title":"Ceramide-induced inhibition of T lymphocyte voltage-gated potassium channel is mediated by tyrosine kinases","volume":"94","author":"Gulbins","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib109","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/S0014-5793(02)03479-8","article-title":"Glycosphingolipid-dependent cross-talk between glycosynapses interfacing tumor cells with their host cells: essential basis to define tumor malignancy","volume":"531","author":"Hakomori","year":"2002","journal-title":"FEBS Lett."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib110","doi-asserted-by":"crossref","first-page":"41557","DOI":"10.1074\/jbc.M305294200","article-title":"Sphingosine-dependent protein kinase-1, directed to 14-3-3, is identified as the kinase domain of protein kinase C delta","volume":"278","author":"Hamaguchi","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib111","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1046\/j.1471-4159.2002.00997.x","article-title":"Substantial sulfatide deficiency and ceramide elevation in very early Alzheimer's disease: potential role in disease pathogenesis","volume":"82","author":"Han","year":"2002","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib112","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/0009-8981(89)90224-6","article-title":"Regulation of protein kinase C by sphingosine and lysosphingolipids","volume":"185","author":"Hannun","year":"1989","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.brainresrev.2004.07.014_bib113","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0962-8924(99)01694-3","article-title":"Ceramide in the eukaryotic stress response","volume":"10","author":"Hannun","year":"2000","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib114","doi-asserted-by":"crossref","first-page":"25847","DOI":"10.1074\/jbc.R200008200","article-title":"The Ceramide-centric universe of lipid-mediated cell regulation: stress encounters of the lipid kind","volume":"277","author":"Hannun","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib115","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1046\/j.1471-4159.2003.02219.x","article-title":"Sphingosine-1-phosphate induces proliferation and morphological changes of neural progenitor cells","volume":"88","author":"Harada","year":"2004","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib116","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/S0955-0674(97)80030-0","article-title":"Caveolae, DIGs, and the dynamics of sphingolipid-cholesterol microdomains","volume":"9","author":"Harder","year":"1997","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib117","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/S0014-5793(96)01460-3","article-title":"Ceramide induces apoptosis in PC12 cells","volume":"401","author":"Hartfield","year":"1997","journal-title":"FEBS Lett."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib118","doi-asserted-by":"crossref","first-page":"8007","DOI":"10.1074\/jbc.275.11.8007","article-title":"Molecular cloning of mouse ganglioside sialidase and its increased expression in Neuro2a cell differentiation","volume":"275","author":"Hasegawa","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib119","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1038\/sj.cdd.4401382","article-title":"Cathepsin D links TNF-induced acid sphingomyelinase to Bid-mediated caspase-9 and -3 activation","volume":"11","author":"Heinrich","year":"2004","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib120","doi-asserted-by":"crossref","first-page":"3262","DOI":"10.1523\/JNEUROSCI.23-08-03262.2003","article-title":"Lipid rafts in the maintenance of synapses, dendritic spines, and surface AMPA receptor stability","volume":"23","author":"Hering","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib121","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1046\/j.1471-4159.1998.70010047.x","article-title":"Retinoic acid induces apoptosis-associated neural differentiation of a murine teratocarcinoma cell line","volume":"70","author":"Herget","year":"1998","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib122","doi-asserted-by":"crossref","first-page":"30344","DOI":"10.1074\/jbc.M000714200","article-title":"Production of ceramides causes apoptosis during early neural differentiation in vitro","volume":"275","author":"Herget","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib123","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/S0006-8993(99)01288-3","article-title":"FK506 prevents stroke-induced generation of ceramide and apoptosis signaling","volume":"826","author":"Herr","year":"1999","journal-title":"Brain Res."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib124","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0306-3623(97)00356-X","article-title":"Growth factors and gangliosides as neuroprotective agents in excitotoxicity and ischemia","volume":"30","author":"Hicks","year":"1998","journal-title":"Gen. Pharmacol."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib125","doi-asserted-by":"crossref","first-page":"8712","DOI":"10.1523\/JNEUROSCI.18-21-08712.1998","article-title":"Ceramide inhibits inwardly rectifying K+ currents via a Ras- and Raf-1-dependent pathway in cultured oligodendrocytes","volume":"18","author":"Hida","year":"1998","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib126","doi-asserted-by":"crossref","first-page":"7458","DOI":"10.1523\/JNEUROSCI.19-17-07458.1999","article-title":"Regulation of mitogen-activated protein kinases by sphingolipid products in oligodendrocytes","volume":"19","author":"Hida","year":"1999","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib127","doi-asserted-by":"crossref","first-page":"14876","DOI":"10.1074\/jbc.271.25.14876","article-title":"Ganglioside synthesis during the development of neuronal polarity. Major changes occur during axonogenesis and axon elongation, but not during dendrite growth or synaptogenesis","volume":"271","author":"Hirschberg","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib128","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1126\/science.1065323","article-title":"Lysophospholipids receptor revelations","volume":"294","author":"Hla","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.brainresrev.2004.07.014_bib129","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.1126\/science.1057559","article-title":"Role of the sphingosine-1-phosphate receptor EDG-1 in PDGF-induced cell motility","volume":"291","author":"Hobson","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.brainresrev.2004.07.014_bib130","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/S0968-0004(98)01289-4","article-title":"Ceramide in apoptosis\u2014does it really matter?","volume":"23","author":"Hofmann","year":"1998","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib131","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1016\/S0022-2275(20)42349-1","article-title":"Serine-palmitoyl transferase activity in cultured human keratinocytes","author":"Holleran","year":"1990","journal-title":"J. Lipid Res."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib132","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1042\/0264-6021:3380161","article-title":"Activation of caspase-3-like proteases in apoptosis induced by sphingosine and other long-chain bases in Hep3B hepatoma cells","volume":"338","author":"Hung","year":"1999","journal-title":"Biochem. J."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib133","doi-asserted-by":"crossref","first-page":"7531","DOI":"10.1073\/pnas.94.14.7531","article-title":"Nuclear translocation of NF-kappa B is increased in dopaminergic neurons of patients with parkinson disease","volume":"94","author":"Hunot","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib134","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1515\/bchm3.1994.375.7.447","article-title":"The tricyclic antidepressant desipramine causes proteolytic degradation of lysosomal sphingomyelinase in human fibroblasts","volume":"37","author":"Hurwitz","year":"1994","journal-title":"Biol. Chem. Hoppe-Seyler"},{"key":"10.1016\/j.brainresrev.2004.07.014_bib135","doi-asserted-by":"crossref","first-page":"6959","DOI":"10.1073\/pnas.93.14.6959","article-title":"Ceramide-binding and activation defines protein kinase c-Raf as a ceramide-activated protein kinase","volume":"93","author":"Huwiler","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib136","doi-asserted-by":"crossref","first-page":"14556","DOI":"10.1021\/bi981401i","article-title":"Selective ceramide binding to protein kinase C-alpha and -delta isoenzymes in renal mesangial cells","volume":"37","author":"Huwiler","year":"1998","journal-title":"Biochemistry"},{"key":"10.1016\/j.brainresrev.2004.07.014_bib137","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1096\/fj.00-0370fje","article-title":"Ceramide binds to the CaLB domain of cytosolic phospholipase A2 and facilitates its membrane docking and arachidonic acid release","volume":"15","author":"Huwiler","year":"2001","journal-title":"FASEB J."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib138","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1002\/(SICI)1097-4547(19970315)47:6<617::AID-JNR7>3.0.CO;2-G","article-title":"Gangliosides inhibit growth factor-stimulated neurite outgrowth in SH-SY5Y human neuroblastoma cells","volume":"47","author":"Hynds","year":"1997","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib139","doi-asserted-by":"crossref","first-page":"32363","DOI":"10.1074\/jbc.M003075200","article-title":"Agonist-modulated targeting of the EDG-1 receptor to plasmalemmal caveolae. eNOS activation by sphingosine 1-phosphate and the role of caveolin-1 in sphingolipid signal transduction","volume":"275","author":"Igarashi","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib140","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1006\/bbrc.2000.3933","article-title":"Characterization of a zebrafish (Danio rerio) sphingosine 1-phosphate receptor expressed in the embryonic brain","volume":"279","author":"Im","year":"2000","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib141","doi-asserted-by":"crossref","first-page":"28888","DOI":"10.1074\/jbc.M201631200","article-title":"Refractory skin injury in complex knock-out mice expressing only the GM3 ganglioside","volume":"277","author":"Inoue","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib142","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1002\/(SICI)1097-4547(19981115)54:4<475::AID-JNR5>3.0.CO;2-P","article-title":"Application of exogenous ceramide to cultured rat spinal motoneurons promotes survival or death by regulation of apoptosis depending on its concentrations","volume":"54","author":"Irie","year":"1998","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib143","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/0006-8993(94)91169-X","article-title":"Distribution of cholinergic neuron-specific gangliosides (GT1a alpha and GQ1b alpha) in the rat central nervous system","volume":"665","author":"Irie","year":"1994","journal-title":"Brain Res."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib144","doi-asserted-by":"crossref","first-page":"6507","DOI":"10.1523\/JNEUROSCI.22-15-06507.2002","article-title":"A myelin galactolipid, sulfatide, is essential for maintenance of ion channels on myelinated axon but not essential for initial cluster formation","volume":"22","author":"Ishibashi","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib145","doi-asserted-by":"crossref","first-page":"33697","DOI":"10.1074\/jbc.M104441200","article-title":"Selective loss of sphingosine 1-phosphate signaling with no obvious phenotypic abnormality in mice lacking its G protein-coupled receptor, LP(B3)\/EDG-3","volume":"276","author":"Ishii","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib146","first-page":"1352","article-title":"In vitro and in vivo enhancement of ricin-A chain immunotoxin activity by novel indolizine calcium channel blockers: delayed intracellular degradation linked to lipidosis induction","volume":"52","author":"Jaffrezou","year":"1992","journal-title":"Cancer Res."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib147","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1124\/mol.52.6.935","article-title":"Coordinate regulation of stress- and mitogen-activated protein kinases in the apoptotic actions of ceramide and sphingosine","volume":"52","author":"Jarvis","year":"1997","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib148","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1042\/0264-6021:3590335","article-title":"Sphingosine-induced apoptosis is dependent on lysosomal proteases","volume":"359","author":"Kagedal","year":"2001","journal-title":"Biochem. J."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib149","doi-asserted-by":"crossref","first-page":"19634","DOI":"10.1074\/jbc.273.31.19634","article-title":"Embryonic stem cells with a disrupted GD3 synthase gene undergo neuronal differentiation in the absence of b-series gangliosides","volume":"273","author":"Kawai","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib150","doi-asserted-by":"crossref","first-page":"6885","DOI":"10.1074\/jbc.C000847200","article-title":"Mice expressing only monosialoganglioside GM3 exhibit lethal audiogenic seizures","volume":"276","author":"Kawai","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib151","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1002\/(SICI)1097-4547(19970415)48:2<168::AID-JNR9>3.0.CO;2-A","article-title":"Activation of CPP32 during apoptosis of neurons and astrocytes","volume":"48","author":"Keane","year":"1997","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib152","doi-asserted-by":"crossref","first-page":"13088","DOI":"10.1016\/S0021-9258(17)36802-3","article-title":"Characterization of a novel intracellular sphingolipid-gated Ca(2+)-permeable channel from rat basophilic leukemia cells","volume":"269","author":"Kindman","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib153","doi-asserted-by":"crossref","first-page":"18108","DOI":"10.1074\/jbc.M909663199","article-title":"Sphingosine is a novel activator of 3-phosphoinositide-dependent kinase 1","volume":"275","author":"King","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib154","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/S0014-5793(01)02697-7","article-title":"Stimulation of nuclear sphingosine kinase activity by platelet-derived growth factor","volume":"503","author":"Kleuser","year":"2001","journal-title":"FEBS Lett."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib155","doi-asserted-by":"crossref","first-page":"30451","DOI":"10.1016\/S0021-9258(18)43834-3","article-title":"Induction of cholinergic differentiation with neurite sprouting by de novo biosynthesis and expression of GD3 and b-series gangliosides in Neuro2a cells","volume":"269","author":"Kojima","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib156","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1146\/annurev.physiol.60.1.643","article-title":"Regulation of ceramide production and apoptosis","volume":"60","author":"Kolesnick","year":"1998","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib157","doi-asserted-by":"crossref","first-page":"25859","DOI":"10.1074\/jbc.R200001200","article-title":"Combinatorial ganglioside biosynthesis","volume":"277","author":"Kolter","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib158","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1515\/BC.2003.144","article-title":"Phosphatidylinositol-3,5-Bisphosphate is a potent and selective inhibitor of acid sphingomyelinase","volume":"384","author":"Kolzer","year":"2003","journal-title":"Biol. Chem."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib159","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/S0014-5793(04)00033-X","article-title":"Interactions of acid sphingomyelinase and lipid bilayers in the presence of the tricyclic antidepressant desipramine","volume":"559","author":"Kolzer","year":"2004","journal-title":"FEBS Lett."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib160","doi-asserted-by":"crossref","first-page":"99","DOI":"10.7164\/antibiotics.55.99","article-title":"Inhibition of recombinant sphingosine kinases by novel inhibitors of microbial origin, F-12509A and B-5354c","volume":"55","author":"Kono","year":"2002","journal-title":"J. Antibiot. (Tokyo)"},{"key":"10.1016\/j.brainresrev.2004.07.014_bib161","doi-asserted-by":"crossref","first-page":"21673","DOI":"10.1074\/jbc.274.31.21673","article-title":"Elevation of intracellular glucosylceramide levels results in an increase in endoplasmic reticulum density and in functional calcium stores in cultured neurons","volume":"274","author":"Korkotian","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib162","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1002\/1099-0844(200012)18:4<269::AID-CBF883>3.0.CO;2-H","article-title":"Effect of glucosphingolipid synthesis inhibitor (PPMP and PDMP) treatment on Tetrahymena pyriformis: data on the evolution of the signaling system","volume":"18","author":"Kovacs","year":"2000","journal-title":"Cell Biochem. Funct."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib163","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1002\/(SICI)1097-4547(19990815)57:4<541::AID-JNR14>3.0.CO;2-X","article-title":"Axonogenesis in neuro-2a cells correlates with GM1 upregulation in the nuclear and plasma membranes","volume":"57","author":"Kozireski-Chuback","year":"1999","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib164","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1002\/(SICI)1097-4547(19990101)55:1<107::AID-JNR12>3.0.CO;2-E","article-title":"Upregulation of nuclear GM1 accompanies axon-like, but not dendrite-like, outgrowth in NG108-15 cells","volume":"55","author":"Kozireski-Chuback","year":"1999","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib165","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1038\/35018092","article-title":"A sphingosine-1-phosphate receptor regulates cell migration during vertebrate heart development","volume":"406","author":"Kupperman","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.brainresrev.2004.07.014_bib166","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/0378-1119(94)90171-6","article-title":"Cloning of the rat edg-1 immediate-early gene: expression pattern suggests diverse functions","volume":"149","author":"Lado","year":"1994","journal-title":"Gene"},{"key":"10.1016\/j.brainresrev.2004.07.014_bib167","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1023\/A:1020224016830","article-title":"Ganglioside function in calcium homeostasis and signaling","volume":"27","author":"Ledeen","year":"2002","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib168","doi-asserted-by":"crossref","first-page":"13169","DOI":"10.1074\/jbc.271.22.13169","article-title":"Ceramide inactivates cellular protein kinase C-alpha","volume":"271","author":"Lee","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib169","doi-asserted-by":"crossref","first-page":"14662","DOI":"10.1074\/jbc.274.21.14662","article-title":"Improved inhibitors of glucosylceramide synthase","volume":"274","author":"Lee","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib170","doi-asserted-by":"crossref","first-page":"13795","DOI":"10.1073\/pnas.96.24.13795","article-title":"Stimulation of CD95 (Fas) blocks T lymphocyte calcium channels through sphingomyelinase and sphingolipids","volume":"96","author":"Lepple-Wienhues","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib171","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1023\/A:1020215815013","article-title":"Ceramide in apoptosis: a revisited role","volume":"27","author":"Levade","year":"2002","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib172","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1074\/jbc.272.2.1349","article-title":"Inhibition of endogenous ganglioside synthesis does not block neurite formation by retinoic acid-treated neuroblastoma cells","volume":"272","author":"Li","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib173","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1093\/glycob\/8.6.597","article-title":"Nerve growth factor-induced neurite formation in PC12 cells is independent of endogenous cellular gangliosides","volume":"8","author":"Li","year":"1998","journal-title":"Glycobiology"},{"key":"10.1016\/j.brainresrev.2004.07.014_bib174","doi-asserted-by":"crossref","first-page":"1507","DOI":"10.1023\/A:1021652506370","article-title":"Differential effects of three inhibitors of glycosphingolipid biosynthesis on neuronal differentiation of embryonal carcinoma stem cells","volume":"27","author":"Liour","year":"2002","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib175","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1002\/1097-4547(20001101)62:3<363::AID-JNR6>3.0.CO;2-E","article-title":"Expression of gangliosides in neuronal development of P19 embryonal carcinoma stem cells","volume":"62]","author":"Liour","year":"2000","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib176","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1093\/glycob\/7.8.1067","article-title":"Regulated expression system for GD3 synthase cDNA and induction of differentiation in Neuro2a cells","volume":"7","author":"Liu","year":"1997","journal-title":"Glycobiology"},{"key":"10.1016\/j.brainresrev.2004.07.014_bib177","doi-asserted-by":"crossref","first-page":"8138","DOI":"10.1073\/pnas.94.15.8138","article-title":"Mouse model of GM2 activator deficiency manifests cerebellar pathology and motor impairment","volume":"94","author":"Liu","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib178","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1172\/JCI10905","article-title":"Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation","volume":"106","author":"Liu","year":"2000","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib179","doi-asserted-by":"crossref","first-page":"40330","DOI":"10.1074\/jbc.M304455200","article-title":"Sphingosine kinase type 2 is a putative BH3-only protein that induces apoptosis","volume":"278","author":"Liu","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib180","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1042\/bj20030613","article-title":"Lyso-glycosphingolipids mobilize calcium from brain microsomes via multiple mechanisms","volume":"375","author":"Lloyd-Evans","year":"2003","journal-title":"Biochem. J."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib181","doi-asserted-by":"crossref","first-page":"23594","DOI":"10.1074\/jbc.M300212200","article-title":"Glucosylceramide and glucosylsphingosine modulate calcium mobilization from brain microsomes via different mechanisms","volume":"278","author":"Lloyd-Evans","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib182","doi-asserted-by":"crossref","first-page":"19200","DOI":"10.1016\/S0021-9258(17)32152-X","article-title":"Protein kinase C zeta isoform is critical for kappa B-dependent promoter activation by sphingomyelinase","volume":"269","author":"Lozano","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib183","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1080\/09553000310001642876","article-title":"Radiation-induced apoptosis of oligodendrocytes and its association with increased ceramide and down-regulated protein kinase B\/Akt activity","volume":"80","author":"Lu","year":"2004","journal-title":"Int. J. Radiat. Biol."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib184","doi-asserted-by":"crossref","first-page":"14550","DOI":"10.1074\/jbc.273.23.14550","article-title":"Sphingomyelin synthase, a potential regulator of intracellular levels of ceramide and diacylglycerol during SV40 transformation. Does sphingomyelin synthase account for the putative phosphatidylcholine-specific phospholipase C?","volume":"273","author":"Luberto","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib185","doi-asserted-by":"crossref","first-page":"41128","DOI":"10.1074\/jbc.M206747200","article-title":"Inhibition of tumor necrosis factor-induced cell death in MCF7 by a novel inhibitor of neutral sphingomyelinase","volume":"277","author":"Luberto","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib186","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1023\/A:1020267831851","article-title":"Ceramide regulation of apoptosis versus differentiation: a walk on a fine line. Lessons from neurobiology","volume":"27","author":"Luberto","year":"2002","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib187","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1006\/mcne.1994.1024","article-title":"Cloning and characterization of a putative G-protein coupled receptor potentially involved in development","volume":"5","author":"MacLennan","year":"1994","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib188","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1159\/000017452","article-title":"Antisense studies in PC12 cells suggest a role for H218, a sphingosine 1-phosphate receptor, in growth-factor-induced cell\u2013cell interaction and neurite outgrowth","volume":"22","author":"MacLennan","year":"2000","journal-title":"Dev. Neurosci."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib189","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1046\/j.0953-816x.2001.01634.x","article-title":"An essential role for the H218\/AGR16\/EDG-5\/LP(B2) sphingosine 1-phosphate receptor in neuronal excitability","volume":"14","author":"MacLennan","year":"2001","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib190","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/S0005-2736(03)00023-3","article-title":"Molecular characterization of the detergent-insoluble cholesterol-rich membrane microdomain (raft) of the central nervous system","volume":"1610","author":"Maekawa","year":"2003","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.brainresrev.2004.07.014_bib191","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1042\/bj20020867","article-title":"Assessment of the role of sphingosine 1-phosphate and its receptors in high-density lipoprotein-induced stimulation of astroglial cell function","volume":"370","author":"Malchinkhuu","year":"2003","journal-title":"Biochem. J."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib192","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S1388-1981(02)00339-6","article-title":"GD3 ganglioside and apoptosis","volume":"1585","author":"Malisan","year":"2002","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.brainresrev.2004.07.014_bib193","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1046\/j.1471-4159.1998.70010130.x","article-title":"Programmed cell death in cortical chick embryo astrocytes is associated with activation of protein kinase PK60 and ceramide formation","volume":"70","author":"Mangoura","year":"1998","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib194","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1073\/pnas.93.5.1993","article-title":"Molecular cloning and characterization of SCaMPER, a sphingolipid Ca2+ release-mediating protein from endoplasmic reticulum","volume":"93","author":"Mao","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib195","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1385\/JMN:20:3:233","article-title":"Beta-secretase processing of the Alzheimer's amyloid protein precursor (APP)","volume":"20","author":"Marlow","year":"2003","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib196","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1046\/j.1471-4159.1999.0730001.x","article-title":"Glycolipid-enriched caveolae and caveolae-like domains in the nervous system","volume":"73","author":"Masserini","year":"1999","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib197","doi-asserted-by":"crossref","first-page":"25020","DOI":"10.1074\/jbc.273.39.25020","article-title":"Calcium release-activated calcium current (ICRAC) is a direct target for sphingosine","volume":"273","author":"Mathes","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib198","doi-asserted-by":"crossref","first-page":"3181","DOI":"10.1016\/S0021-9258(17)41846-1","article-title":"Sphingosine-1-phosphate, a putative second messenger, mobilizes calcium from internal stores via an inositol trisphosphate-independent pathway","volume":"269","author":"Mattie","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib199","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1002\/(SICI)1097-4547(19970915)49:6<681::AID-JNR3>3.0.CO;2-3","article-title":"Activation of NF-kappaB protects hippocampal neurons against oxidative stress-induced apoptosis: evidence for induction of manganese superoxide dismutase and suppression of peroxynitrite production and protein tyrosine nitration","volume":"49","author":"Mattson","year":"1997","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib200","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0014-5793(02)03404-X","article-title":"Embryonic brain expression analysis of lysophospholipid receptor genes suggests roles for s1p1 in neurogenesis and s1p1-3 in angiogenesis","volume":"531","author":"McGiffert","year":"2002","journal-title":"FEBS Lett."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib201","doi-asserted-by":"crossref","first-page":"21834","DOI":"10.1074\/jbc.273.34.21834","article-title":"A novel sphingosine-dependent protein kinase (SDK1) specifically phosphorylates certain isoforms of 14-3-3 protein","volume":"273","author":"Megidish","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib202","doi-asserted-by":"crossref","first-page":"3369","DOI":"10.1021\/bi982548c","article-title":"Endogenous substrates of sphingosine-dependent kinases (SDKs) are chaperone proteins: heat shock proteins, glucose-regulated proteins, protein disulfide isomerase, and calreticulin","volume":"38","author":"Megidish","year":"1999","journal-title":"Biochemistry"},{"key":"10.1016\/j.brainresrev.2004.07.014_bib203","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1038\/sj.cdd.4401020","article-title":"An early increase in the disialoganglioside GD3 contributes to the development of neuronal apoptosis in culture","volume":"9","author":"Melchiorri","year":"2002","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib204","doi-asserted-by":"crossref","first-page":"27299","DOI":"10.1016\/S0021-9258(19)74249-5","article-title":"Fumonisin B1 inhibits sphingosine (sphinganine) N-acyltransferase and de novo sphingolipid biosynthesis in cultured neurons in situ","volume":"268","author":"Merrill","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib205","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/S0014-2999(98)00436-1","article-title":"Discrimination between plasma membrane and intracellular target sites of sphingosylphosphorylcholine","volume":"354","author":"Meyer zu Heringdorf","year":"1998","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib206","doi-asserted-by":"crossref","first-page":"12792","DOI":"10.1073\/pnas.94.24.12792","article-title":"KSR stimulates Raf-1 activity in a kinase-independent manner","volume":"94","author":"Michaud","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib207","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1006\/mcne.2002.1132","article-title":"Fatal shift of signal transduction is an integral part of neuronal differentiation: JNKs realize TNFalpha-mediated apoptosis in neuronlike, but not na\u00efve, PC12 cells","volume":"20","author":"Mielke","year":"2002","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib208","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.brainres.2003.11.067","article-title":"Late onset Tay-Sachs disease in mice with targeted disruption of the Hexa gene: behavioral changes and pathology of the central nervous system","volume":"1001","author":"Miklyaeva","year":"2004","journal-title":"Brain Res."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib209","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1002\/(SICI)1097-4547(19980315)51:6<712::AID-JNR5>3.0.CO;2-E","article-title":"Bipotential roles of ceramide in the growth of hippocampal neurons: promotion of cell survival and dendritic outgrowth in dose- and developmental stage-dependent manners","volume":"51","author":"Mitoma","year":"1998","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib210","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1006\/bbrc.1995.1827","article-title":"Serine palmitoyltransferase is the primary target of a sphingosine-like immunosuppressant, ISP-1\/myriocin","volume":"211","author":"Miyake","year":"1995","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib211","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/S0306-4522(99)00288-2","article-title":"Sphingosine-1-phosphate induces apoptosis of cultured hippocampal neurons that requires protein phosphatases and activator protein-1 complexes","volume":"94","author":"Moore","year":"1999","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainresrev.2004.07.014_bib212","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0006-291X(02)02593-7","article-title":"Ceramide induces neuronal apoptosis through the caspase-9\/caspase-3 pathway","volume":"299","author":"Movsesyan","year":"2002","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib213","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1002\/j.1460-2075.1995.tb07188.x","article-title":"PKC zeta is a molecular switch in signal transduction of TNF-alpha, bifunctionally regulated by ceramide and arachidonic acid","volume":"14","author":"Muller","year":"1995","journal-title":"EMBO J."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib214","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1093\/emboj\/17.3.732","article-title":"Regulation of Raf-1 kinase by TNF via its second messenger ceramide and cross-talk with mitogenic signalling","volume":"17","author":"Muller","year":"1998","journal-title":"EMBO J."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib215","doi-asserted-by":"crossref","first-page":"15884","DOI":"10.1074\/jbc.270.26.15884","article-title":"Identification of heterogeneous ribonucleoprotein A1 as a novel substrate for protein kinase C zeta","volume":"270","author":"Municio","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib216","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/sj.cdd.4400628","article-title":"Ceramide selectively inhibits apoptosis-associated events in NGF-deprived sympathetic neurons","volume":"7","author":"Nair","year":"2000","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib217","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1046\/j.0022-3042.2001.00752.x","article-title":"Ceramide activates microglia to enhance the production\/secretion of brain-derived neurotrophic factor (BDNF) without induction of deleterious factors in vitro","volume":"80","author":"Nakajima","year":"2002","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib218","doi-asserted-by":"crossref","first-page":"525","DOI":"10.7164\/antibiotics.52.525","article-title":"Scyphostatin, a neutral sphingomyelinase inhibitor from a discomycete, Trichopeziza mollissima: taxonomy of the producing organism, fermentation, isolation, and physico-chemical properties","volume":"52","author":"Nara","year":"1999","journal-title":"J. Antibiot. (Tokyo)"},{"key":"10.1016\/j.brainresrev.2004.07.014_bib219","doi-asserted-by":"crossref","first-page":"33368","DOI":"10.1074\/jbc.M403816200","article-title":"Over-expressed GM1 suppresses NGF signals by modulating the intra-cellular localization of NGF receptors and membrane fluidity in PC12 cells","volume":"279","author":"Nishio","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib220","doi-asserted-by":"crossref","first-page":"41259","DOI":"10.1074\/jbc.M304409200","article-title":"Nerve growth factor-induced glutamate release is via p75 receptor, ceramide, and Ca(2+) from ryanodine receptor in developing cerebellar neurons","volume":"278","author":"Numakawa","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib221","first-page":"691","article-title":"Induction of apoptosis by sphingosine in human leukemic HL-60 cells: a possible endogenous modulator of apoptotic DNA fragmentation occurring during phorbol ester-induced differentiation","volume":"55","author":"Ohta","year":"1995","journal-title":"Cancer Res."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib222","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1074\/jbc.C100395200","article-title":"b-Series ganglioside deficiency exhibits no definite changes in the neurogenesis and the sensitivity to Fas-mediated apoptosis but impairs regeneration of the lesioned hypoglossal nerve","volume":"277","author":"Okada","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib223","doi-asserted-by":"crossref","first-page":"9247","DOI":"10.1128\/MCB.20.24.9247-9261.2000","article-title":"Inhibitory regulation of Rac activation, membrane ruffling, and cell migration by the G protein-coupled sphingosine-1-phosphate receptor EDG5 but not EDG1 or EDG3","volume":"20","author":"Okamoto","year":"2000","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib224","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1038\/365557a0","article-title":"Sphingosine-1-phosphate as a second messenger in cell proliferation induced by PDGF and FCS mitogens","volume":"365","author":"Olivera","year":"1993","journal-title":"Nature"},{"key":"10.1016\/j.brainresrev.2004.07.014_bib225","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/S0014-5793(03)00083-8","article-title":"Immunohistochemical and biochemical analyses of GD3, GT1b, and GQ1b ganglioides during neural differentiation of P19 EC cells","volume":"537","author":"Osanai","year":"2003","journal-title":"FEBS Lett."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib226","doi-asserted-by":"crossref","first-page":"2591","DOI":"10.1074\/jbc.273.5.2591","article-title":"Sphingomyelinase and ceramide stimulate the expression of inducible nitric-oxide synthase in rat primary astrocytes","volume":"273","author":"Pahan","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib227","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1046\/j.1471-4159.1999.0730513.x","article-title":"Induction of the manganese superoxide dismutase gene by sphingomyelinase and ceramide","volume":"73","author":"Pahan","year":"1999","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib228","doi-asserted-by":"crossref","first-page":"11830","DOI":"10.1074\/jbc.M009422200","article-title":"Sphingosine 1-phosphate-induced endothelial cell migration requires the expression of EDG-1 and EDG-3 receptors and Rho-dependent activation of alpha vbeta3- and beta1-containing integrins","volume":"276","author":"Paik","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib229","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1128\/MCB.22.2.578-586.2002","article-title":"Role of translation initiation factor 2B in control of cell survival by the phosphatidylinositol 3-kinase\/Akt\/glycogen synthase kinase 3beta signaling pathway","volume":"22","author":"Pap","year":"2002","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib230","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/S0959-4388(02)00363-X","article-title":"Lipid rafts and the control of neurotrophic factor signaling in the nervous system: variations on a theme","volume":"12","author":"Paratcha","year":"2002","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib231","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/S0014-5793(02)03480-4","article-title":"Sphingosine-1-phosphate: dual messenger functions","volume":"531","author":"Payne","year":"2002","journal-title":"FEBS Lett."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib232","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.1046\/j.0953-816x.2001.01585.x","article-title":"Sphingosine-1-phosphate induces proliferation of astrocytes: regulation by intracellular signalling cascades","volume":"13","author":"Pebay","year":"2001","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib233","doi-asserted-by":"crossref","first-page":"1957","DOI":"10.1074\/jbc.M104677200","article-title":"Death-associated protein (DAP) kinase plays a central role in ceramide-induced apoptosis in cultured hippocampal neurons","volume":"277","author":"Pelled","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib234_1","doi-asserted-by":"crossref","first-page":"29496","DOI":"10.1074\/jbc.M302964200","article-title":"Inhibition of calcium uptake via the sarco\/endoplasmic reticulum Ca2+-ATPase in a mouse model of Sandhoff disease and prevention by treatment with N-butyldeoxynojirimycin","volume":"278","author":"Pelled","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib234_2","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1046\/j.1365-2990.2003.00455.x","article-title":"Reduced rates of axonal and dendritic growth in embryonic hippocampal neurones cultured from a mouse model of Sandhoff disease","volume":"29","author":"Pelled","year":"2003","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib235","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/S1388-1981(02)00331-1","article-title":"Ceramide in apoptosis: an overview and current perspectives","volume":"1585","author":"Pettus","year":"2002","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.brainresrev.2004.07.014_bib236","doi-asserted-by":"crossref","first-page":"38206","DOI":"10.1074\/jbc.M304816200","article-title":"Ceramide kinase mediates cytokine- and calcium ionophore-induced arachidonic acid release","volume":"278","author":"Pettus","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib237","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1096\/fj.02-1038com","article-title":"The sphingosine kinase 1\/sphingosine-1-phosphate pathway mediates COX-2 induction and PGE2 production in response to TNF-alpha","volume":"17","author":"Pettus","year":"2003","journal-title":"FASEB J."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib238","doi-asserted-by":"crossref","first-page":"38206","DOI":"10.1074\/jbc.M304816200","article-title":"Ceramide kinase mediates cytokine- and calcium ionophore-induced arachidonic acid release","volume":"278","author":"Pettus","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib239","doi-asserted-by":"crossref","first-page":"11320","DOI":"10.1074\/jbc.M309262200","article-title":"Ceramide 1-phosphate is a direct activator of cytosolic phospholipase A2","volume":"279","author":"Pettus","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib240","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/hmg\/5.1.1","article-title":"Dramatically different phenotypes in mouse models of human Tay-Sachs and Sandhoff diseases","volume":"5","author":"Phaneuf","year":"1996","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib241","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1002\/(SICI)1097-4547(19981015)54:2<206::AID-JNR8>3.0.CO;2-I","article-title":"Ceramide can induce cell death in sensory neurons, whereas ceramide analogues and sphingosine promote survival","volume":"54","author":"Ping","year":"1998","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib242","doi-asserted-by":"crossref","first-page":"8362","DOI":"10.1016\/S0021-9258(17)37202-2","article-title":"N-butyldeoxynojirimycin is a novel inhibitor of glycolipid biosynthesis","volume":"269","author":"Platt","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib243","doi-asserted-by":"crossref","first-page":"27108","DOI":"10.1016\/S0021-9258(18)47132-3","article-title":"N-butyldeoxygalactonojirimycin inhibits glycolipid biosynthesis but does not affect N-linked oligosaccharide processing","volume":"269","author":"Platt","year":"1994","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib244","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0028-3908(01)00163-0","article-title":"TNF-alpha receptors simultaneously activate Ca2+ mobilisation and stress kinases in cultured sensory neurones","volume":"42","author":"Pollock","year":"2002","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.brainresrev.2004.07.014_bib245","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1046\/j.1471-4159.2002.01007.x","article-title":"Ceramide-induced apoptosis of D283 medulloblastoma cells requires mitochondrial respiratory chain activity but occurs independently of caspases and is not sensitive to Bcl-xL overexpression","volume":"82","author":"Poppe","year":"2002","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib246","doi-asserted-by":"crossref","first-page":"3028","DOI":"10.1074\/jbc.272.5.3028","article-title":"Elevation of ceramide within distal neurites inhibits neurite growth in cultured rat sympathetic neurons","volume":"272","author":"Posse de Chaves","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib247","doi-asserted-by":"crossref","first-page":"36207","DOI":"10.1074\/jbc.M104282200","article-title":"Ceramide inhibits axonal growth and nerve growth factor uptake without compromising the viability of sympathetic neurons","volume":"276","author":"Posse de Chaves","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib248","doi-asserted-by":"crossref","first-page":"2388","DOI":"10.1002\/j.1460-2075.1996.tb00595.x","article-title":"Sphingosine-1-phosphate rapidly induces Rho-dependent neurite retraction: action through a specific cell surface receptor","volume":"15","author":"Postma","year":"1996","journal-title":"EMBO J."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib249","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/S0014-5793(97)00981-2","article-title":"Involvement of a ceramide activated protein phosphatase in the differentiation of neuroblastoma Neuro2a cells","volume":"414","author":"Prinetti","year":"1997","journal-title":"FEBS Lett."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib250","doi-asserted-by":"crossref","first-page":"21136","DOI":"10.1074\/jbc.M010666200","article-title":"Changes in the lipid turnover, composition, and organization, as sphingolipid-enriched membrane domains, in rat cerebellar granule cells developing in vitro","volume":"276","author":"Prinetti","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib251","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1023\/A:1020217309987","article-title":"Sphingolipid metabolism and caveolin expression in gonadotropin-releasing hormone-expressing GN11 and gonadotropin-releasing hormone-secreting GT1-7 neuronal cells","volume":"27","author":"Prioni","year":"2002","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib252","doi-asserted-by":"crossref","first-page":"19777","DOI":"10.1074\/jbc.M300466200","article-title":"Ceramide stabilizes beta-site amyloid precursor protein-cleaving enzyme 1 and promotes amyloid beta-peptide biogenesis","volume":"278","author":"Puglielli","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib253","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0006-8993(76)90245-6","article-title":"Distortion of neuronal geometry and formation of aberrant synapses in neuronal storage disease","volume":"116","author":"Purpura","year":"1976","journal-title":"Brain Res."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib254","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1055\/s-2007-973664","article-title":"Upregulation of Bcl-2 and elevation of ceramide in Batten disease","volume":"28","author":"Puranam","year":"1997","journal-title":"Neuropediatrics"},{"key":"10.1016\/j.brainresrev.2004.07.014_bib255","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1042\/0264-6021:3490385","article-title":"Sphingosine 1-phosphate signalling in mammalian cells","volume":"349","author":"Pyne","year":"2000","journal-title":"Biochem. J."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib256","doi-asserted-by":"crossref","first-page":"21388","DOI":"10.1074\/jbc.272.34.21388","article-title":"Implication of mitochondrial hydrogen peroxide generation in ceramide-induced apoptosis","volume":"272","author":"Quillet-Mary","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib257","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0014-5793(02)02472-9","article-title":"Bcl-2 overexpression prevents apoptosis induced by ceramidase inhibitors in malignant melanoma and HaCaT keratinocytes","volume":"516","author":"Raisova","year":"2002","journal-title":"FEBS Lett."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib258","doi-asserted-by":"crossref","first-page":"10777","DOI":"10.1074\/jbc.272.16.10777","article-title":"Divergence in signal transduction pathways of PDGF and EGF receptors: involvement of sphingosine-1-phosphate in PDGF but not EGF signaling","volume":"272","author":"Rani","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib259","doi-asserted-by":"crossref","first-page":"21375","DOI":"10.1074\/jbc.271.35.21375","article-title":"c-Jun is a downstream target for ceramide-activated protein phosphatase in A431 cells","volume":"271","author":"Reyes","year":"1996","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib260","doi-asserted-by":"crossref","first-page":"26868","DOI":"10.1074\/jbc.270.45.26868","article-title":"A mediator role of ceramide in the regulation of neuroblastoma Neuro2a cell differentiation","volume":"270","author":"Riboni","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib261","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0163-7827(97)00008-8","article-title":"The role of sphingolipids in the process of signal transduction","volume":"36","author":"Riboni","year":"1997","journal-title":"Prog. Lipid Res."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib262","doi-asserted-by":"crossref","first-page":"12797","DOI":"10.1074\/jbc.M011570200","article-title":"Basic fibroblast growth factor-induced proliferation of primary astrocytes: evidence for the involvement of sphingomyelin biosynthesis","volume":"276","author":"Riboni","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib263","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1023\/A:1020236419556","article-title":"Metabolic formation of ceramide-1-phosphate in cerebellar granule cells: evidence for the phosphorylation of ceramide by different metabolic pathways","volume":"27","author":"Riboni","year":"2002","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib264","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0014-5793(97)01277-5","article-title":"Activation of sphingosine kinase in pheochromocytoma PC12 neuronal cells in response to trophic factors","volume":"417","author":"Rius","year":"1997","journal-title":"FEBS Lett."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib265","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1046\/j.1460-9568.1999.00574.x","article-title":"Cells defective in sphingolipids biosynthesis express low amounts of muscle nicotinic acetylcholine receptor","volume":"11","author":"Roccamo","year":"1999","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib266","series-title":"Glycobiology of the Brain","first-page":"19","article-title":"Gangliosides and brain development","author":"Rosner","year":"1994"},{"key":"10.1016\/j.brainresrev.2004.07.014_bib267","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1111\/j.1749-6632.1998.tb09672.x","article-title":"Significance of gangliosides in neuronal differentiation of neuroblastoma cells and neurite growth in tissue culture","volume":"845","author":"Rosner","year":"1998","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib268","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S1043-6618(03)00050-1","article-title":"Intracellular signal transduction pathways activated by ceramide and its metabolites","volume":"47","author":"Ruvolo","year":"2003","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib269","doi-asserted-by":"crossref","first-page":"20296","DOI":"10.1074\/jbc.274.29.20296","article-title":"Ceramide induces Bcl2 dephosphorylation via a mechanism involving mitochondrial PP2A","volume":"274","author":"Ruvolo","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib270","doi-asserted-by":"crossref","first-page":"11754","DOI":"10.1074\/jbc.M011400200","article-title":"Ceramide regulates protein synthesis by a novel mechanism involving the cellular PKR activator RAX","volume":"276","author":"Ruvolo","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib271","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1002\/glia.10047","article-title":"Trisialoganglioside GT1b induces in vivo degeneration of nigral dopaminergic neurons: role of microglia","volume":"38","author":"Ryu","year":"2002","journal-title":"Glia"},{"key":"10.1016\/j.brainresrev.2004.07.014_bib272","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/S0169-328X(97)00268-4","article-title":"Molecular cloning and developmental expression of a rat homologue of death-associated protein kinase in the nervous system","volume":"52","author":"Sakagami","year":"1997","journal-title":"Mol. Brain Res."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib273","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1006\/mcne.1999.0813","article-title":"Inhibition of PKB\/Akt1 by C2-ceramide involves activation of ceramide-activated protein phosphatase in PC12 cells","volume":"15","author":"Salinas","year":"2000","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib274","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/ng1095-170","article-title":"Mouse models of Tay-Sachs and Sandhoff diseases differ in neurologic phenotype and ganglioside metabolism","volume":"11","author":"Sango","year":"1995","journal-title":"Nat. Genet."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib275","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1038\/ng1196-348","article-title":"Mice lacking both subunits of lysosomal beta-hexosaminidase display gangliosidosis and mucopolysaccharidosis","volume":"14","author":"Sango","year":"1996","journal-title":"Nat. Genet."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib276","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1046\/j.1365-2990.2002.00366.x","article-title":"Lysosomal storage results in impaired survival but normal neurite outgrowth in dorsal root ganglion neurones from a mouse model of Sandhoff disease","volume":"28","author":"Sango","year":"2002","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib277","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1006\/bbrc.1997.7666","article-title":"Exogenous sphingosine 1-phosphate induces neurite retraction possibly through a cell surface receptor in PC12 cells","volume":"240","author":"Sato","year":"1997","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib278","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/S0169-328X(00)00262-X","article-title":"Differential roles of Edg-1 and EDG-5, sphingosine 1-phosphate receptors, in the signaling pathways in C6 glioma cells","volume":"85","author":"Sato","year":"2000","journal-title":"Mol. Brain Res."},{"issue":"2","key":"10.1016\/j.brainresrev.2004.07.014_bib279","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1006\/excr.2001.5437","article-title":"Acid sphingomyelinase activation requires caspase-8 but not p53 nor reactive oxygen species during Fas-induced apoptosis in human glioma cells","volume":"273","author":"Sawada","year":"2002","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib280","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1182\/blood.V93.1.217","article-title":"Ceramide and cyclic adenosine monophosphate (cAMP) induce cAMP response element binding protein phosphorylation via distinct signaling pathways while having opposite effects on myeloid cell survival","volume":"93","author":"Scheid","year":"1999","journal-title":"Blood"},{"key":"10.1016\/j.brainresrev.2004.07.014_bib281","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1042\/0264-6021:3620183","article-title":"Re-evaluation of primary structure, topology, and localization of Scamper, a putative intracellular Ca2+ channel activated by sphingosylphosphocholine","volume":"362","author":"Schnurbus","year":"2002","journal-title":"Biochem. J."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib282","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/S1570-9639(02)00453-3","article-title":"DAPK catalytic activity in the hippocampus increases during the recovery phase in an animal model of brain hypoxic\u2013ischemic injury","volume":"1600","author":"Schumacher","year":"2002","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.brainresrev.2004.07.014_bib283","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/S0076-6879(00)12928-3","article-title":"Use of affinity chromatography and TID-ceramide photoaffinity labeling for detection of ceramide-binding proteins","volume":"312","author":"Schutze","year":"2000","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib284","doi-asserted-by":"crossref","first-page":"2929","DOI":"10.1523\/JNEUROSCI.17-09-02929.1997","article-title":"Distinct roles for ceramide and glucosylceramide at different stages of neuronal growth","volume":"17","author":"Schwarz","year":"1997","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib285","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1002\/(SICI)1097-4547(19990215)55:4<514::AID-JNR11>3.0.CO;2-V","article-title":"Differential responses of oligodendrocytes to tumor necrosis factor and other pro-apoptotic agents: role of ceramide in apoptosis","volume":"55","author":"Scurlock","year":"1999","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib286","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1023\/B:GLYC.0000016739.32089.55","article-title":"A turn in the road: how studies on the pharmacology of glucosylceramide synthase inhibitors led to the identification of a lysosomal phospholipase A2 with ceramide transacylase activity","volume":"20","author":"Shayman","year":"2004","journal-title":"Glycoconj. J."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib287","doi-asserted-by":"crossref","first-page":"7532","DOI":"10.1073\/pnas.96.13.7532","article-title":"Mice lacking complex gangliosides develop Wallerian degeneration and myelination defects","volume":"96","author":"Sheikh","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib288","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/S0006-8993(98)01354-7","article-title":"Protective effects of the TNF-ceramide pathway against glutamate neurotoxicity on cultured mesencephalic neurons","volume":"819","author":"Shinpo","year":"1999","journal-title":"Brain Res."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib289","doi-asserted-by":"crossref","first-page":"48733","DOI":"10.1074\/jbc.M011072200","article-title":"Sphingosine 1-phosphate activates nuclear factor-kappa B through Edg receptors. Activation through Edg-3 and EDG-5, but not Edg-1, in human embryonic kidney 293 cells","volume":"276","author":"Siehler","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib290","doi-asserted-by":"crossref","first-page":"8141","DOI":"10.1074\/jbc.272.13.8141","article-title":"TAK1 mediates the ceramide signaling to stress-activated protein kinase\/c-Jun N-terminal kinase","volume":"272","author":"Shirakabe","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib291","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1038\/sj.cdd.4401027","article-title":"Disialoganglioside GD3 is released by microglia and induces oligodendrocyte apoptosis","volume":"9","author":"Simon","year":"2002","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib292","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/S0962-8924(00)01847-X","article-title":"Jamming the endosomal system: lipid rafts and lysosomal storage diseases","volume":"10","author":"Simons","year":"2000","journal-title":"Trends Cell Biol."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib293","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1083\/jcb.151.1.143","article-title":"Assembly of myelin by association of proteolipid protein with cholesterol- and galactosylceramide-rich membrane domains","volume":"151","author":"Simons","year":"2000","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib294","doi-asserted-by":"crossref","first-page":"7289","DOI":"10.1128\/MCB.19.11.7289","article-title":"Caveolins, liquid-ordered domains, and signal transduction","volume":"19","author":"Smart","year":"1999","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib295","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1016\/S0028-3908(03)00284-3","article-title":"Inhibition of rat sympathetic neuron apoptosis by ceramide. Role of p75 NTR in ceramide generation","volume":"45","author":"Song","year":"2003","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.brainresrev.2004.07.014_bib296","doi-asserted-by":"crossref","first-page":"25851","DOI":"10.1074\/jbc.R200007200","article-title":"Sphingosine 1-phosphate, a key cell signaling molecule","volume":"277","author":"Spiegel","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib297","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/nrm1103","article-title":"Sphingosine-1-phosphate: an enigmatic signalling lipid","author":"Spiegel","year":"2003","journal-title":"Nat. Rev., Mol. Cell Biol."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib298","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/j.1749-6632.1998.tb09658.x","article-title":"Sphingosine-1-phosphate in cell growth and cell death","volume":"845","author":"Spiegel","year":"1998","journal-title":"Ann. N.Y. Acad. Sci."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib299","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1006\/mcne.2002.1129","article-title":"Oligodendroglial expression of Edg-2 receptor: developmental analysis and pharmacological responses to lysophosphatidic acid","volume":"20","author":"Stankoff","year":"2002","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib300","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1002\/(SICI)1098-1136(199908)27:2<110::AID-GLIA2>3.0.CO;2-C","article-title":"Cytosolic phospholipase A2 is induced in reactive glia following different forms of neurodegeneration","volume":"27","author":"Stephenson","year":"1999","journal-title":"Glia"},{"key":"10.1016\/j.brainresrev.2004.07.014_bib301","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/S1044-7431(02)00028-3","article-title":"Ceramide-induced neuronal apoptosis is associated with dephosphorylation of Akt, BAD, FKHR, GSK-3beta, and induction of the mitochondrial-dependent intrinsic caspase pathway","volume":"22","author":"Stoica","year":"2003","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib302","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1023\/B:NERE.0000021236.32785.37","article-title":"Activation of cell cycle regulatory proteins in the apoptosis of terminally differentiated oligodendrocytes","volume":"29","author":"Strazza","year":"2004","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib303","doi-asserted-by":"crossref","first-page":"32943","DOI":"10.1074\/jbc.273.49.32943","article-title":"Ceramide regulates the transcription of cyclooxygenase-2. Evidence for involvement of extracellular signal-regulated kinase\/c-Jun N-terminal kinase and p38 mitogen-activated protein kinase pathways","volume":"273","author":"Subbaramaiah","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib304","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/0005-2760(75)90176-9","article-title":"Ceramidase and ceramide synthesis in human kidney and cerebellum. Description of a new alkaline ceramidase","volume":"398","author":"Sugita","year":"1975","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.brainresrev.2004.07.014_bib305","doi-asserted-by":"crossref","first-page":"23294","DOI":"10.1074\/jbc.M201535200","article-title":"Ceramide kinase, a novel lipid kinase. Molecular cloning and functional characterization","volume":"277","author":"Sugiura","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib306","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/S0014-5793(99)01628-2","article-title":"Nerve growth factor stimulates MAPK via the low affinity receptor p75(LNTR)","volume":"463","author":"Susen","year":"1999","journal-title":"FEBS Lett."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib307","doi-asserted-by":"crossref","first-page":"10662","DOI":"10.1073\/pnas.93.20.10662","article-title":"Mice with disrupted GM2\/GD2 synthase gene lack complex gangliosides but exhibit only subtle defects in their nervous system","volume":"93","author":"Takamiya","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib308","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1007\/BF00309622","article-title":"Neuropathology of mice with targeted disruption of Hexa gene, a model of Tay-Sachs disease","volume":"89","author":"Taniike","year":"1995","journal-title":"Acta Neuropathol. (Berl.)"},{"key":"10.1016\/j.brainresrev.2004.07.014_bib309","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1023\/A:1021008626887","article-title":"Ceramide induces apoptosis to immature cerebellar granule cells in culture","volume":"24","author":"Taniwaki","year":"1999","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib310","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0304-3940(00)01054-5","article-title":"Sphingomyelinase metabolites control survival and apoptotic death in SH-SY5Y neuroblastoma cells","volume":"285","author":"Tavarini","year":"2000","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib311","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1016\/S0306-4522(02)00791-1","article-title":"Edg-8 receptors are preferentially expressed in oligodendrocyte lineage cells of the rat CNS","volume":"116","author":"Terai","year":"2003","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainresrev.2004.07.014_bib312","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1002\/jnr.10816","article-title":"Regulation of sphingomyelinases in cells of the oligodendrocyte lineage","volume":"75","author":"Testai","year":"2004","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib313","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0079-6123(08)61941-X","article-title":"Gangliosides turnover and neural cells function: a new perspective","volume":"101","author":"Tettamanti","year":"1994","journal-title":"Prog. Brain Res."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib314","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/0929-7855(96)00535-4","article-title":"Sphingoid bioregulators in the differentiation of cells of neural origin","volume":"14","author":"Tettamanti","year":"1996","journal-title":"J. Lipid Mediators Cell Signal."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib315","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/S0300-9084(03)00047-6","article-title":"Salvage pathways in glycosphingolipid metabolism","volume":"85","author":"Tettamanti","year":"2003","journal-title":"Biochimie"},{"key":"10.1016\/j.brainresrev.2004.07.014_bib316","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0090-6980(01)00107-1","article-title":"Physiological responses to lysophosphatidic acid and related glycero-phospholipids","volume":"64","author":"Tigyi","year":"2001","journal-title":"Prostaglandins Other Lipid Mediat."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib317","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1074\/jbc.273.1.242","article-title":"Sphingosine inhibits voltage-operated calcium channels in GH4C1 cells","volume":"273","author":"Titievsky","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib318","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1023\/A:1020219915922","article-title":"Lysophospholipid receptors in the nervous system","volume":"27","author":"Toman","year":"2002","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib319","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1089\/neu.2000.17.891","article-title":"Role of ceramide in neuronal cell death and differentiation","volume":"17","author":"Toman","year":"2000","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.brainresrev.2004.07.014_bib320","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1042\/bj20031637","article-title":"Ceramide 1-phosphate enhances calcium entry through voltage-operated calcium channels by a protein kinase C-dependent mechanism in GH 4C 1 rat pituitary cells","volume":"380","author":"Tornquist","year":"2004","journal-title":"Biochem. J."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib321","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/BF02736923","article-title":"Involvement of lipid mediators on cytokine signaling and induction of secretory phospholipase A2 in immortalized astrocytes (DITNC)","volume":"12","author":"Tong","year":"1999","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib322","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/S0166-2236(02)02215-4","article-title":"Lipid rafts in neuronal signaling and function","volume":"25","author":"Tsui-Pierchala","year":"2002","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib323","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1093\/oxfordjournals.jbchem.a135140","article-title":"Bioactive gangliosides. IV: ganglioside GQ1b\/Ca2+ dependent protein kinase activity exists in the plasma membrane fraction of neuroblastoma cell line, GOTO","volume":"97","author":"Tsuji","year":"1985","journal-title":"J. Biochem. (Tokyo)"},{"key":"10.1016\/j.brainresrev.2004.07.014_bib324","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1086\/381055","article-title":"Mutation of CERKL, a novel human ceramide kinase gene, causes autosomal recessive retinitis pigmentosa (RP26)","volume":"74","author":"Tuson","year":"2004","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib325","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1093\/oxfordjournals.jbchem.a123549","article-title":"Effects of an inhibitor of glucosylceramide synthase on glycosphingolipid synthesis and neurite outgrowth in murine neuroblastoma cell lines","volume":"110","author":"Uemura","year":"1991","journal-title":"J. Biochem. (Tokyo)"},{"key":"10.1016\/j.brainresrev.2004.07.014_bib326","doi-asserted-by":"crossref","first-page":"9657","DOI":"10.1021\/bi010535k","article-title":"Structural requirements of ceramide and sphingosine based inhibitors of mitochondrial ceramidase","volume":"40","author":"Usta","year":"2001","journal-title":"Biochemistry"},{"key":"10.1016\/j.brainresrev.2004.07.014_bib327","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/0006-8993(94)91444-3","article-title":"Nuclear and cytoplasmic Ca2+ signals in developing rat dorsal root ganglion neurons studied in excised tissue","volume":"635","author":"Utzscheneider","year":"1994","journal-title":"Brain Res."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib328","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1083\/jcb.142.1.229","article-title":"Dual actions of sphingosine-1-phosphate: extracellular through the Gi-coupled receptor Edg-1 and intracellular to regulate proliferation and survival","volume":"142","author":"Van Brocklyn","year":"1998","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib329","doi-asserted-by":"crossref","first-page":"4626","DOI":"10.1074\/jbc.274.8.4626","article-title":"Sphingosine 1-phosphate-induced cell rounding and neurite retraction are mediated by the G protein-coupled receptor H218","volume":"274","author":"Van Brocklyn","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib330","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0304-3835(02)00050-2","article-title":"Sphingosine-1-phosphate stimulates human glioma cell proliferation through Gi-coupled receptors: role of ERK MAP kinase and phosphatidylinositol 3-kinase b","volume":"181","author":"Van Brocklyn","year":"2002","journal-title":"Cancer Lett."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib331","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0304-3835(03)00334-3","article-title":"Sphingosine-1-phosphate stimulates motility and invasiveness of human glioblastoma multiforme cells","volume":"199","author":"Van Brocklyn","year":"2003","journal-title":"Cancer Lett."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib332","doi-asserted-by":"crossref","first-page":"5341","DOI":"10.1016\/S0021-9258(18)53324-X","article-title":"Ganglioside metabolism. Enzymology, topology, and regulation","volume":"268","author":"van Echten","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib333","doi-asserted-by":"crossref","first-page":"2535","DOI":"10.1016\/S0024-3205(01)01049-9","article-title":"Sphingosine kinase-mediated calcium signaling by muscarinic acetylcholine receptors","volume":"68","author":"van Koppen","year":"2001","journal-title":"Life Sci."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib334","doi-asserted-by":"crossref","first-page":"12649","DOI":"10.1074\/jbc.M109111200","article-title":"Involvement of sphingosine kinase in TNF-alpha-stimulated tetrahydrobiopterin biosynthesis in C6 glioma cells","volume":"277","author":"Vann","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib335","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/380075a0","article-title":"Requirement for ceramide-initiated SAPK\/JNK signalling in stress-induced apoptosis","volume":"380","author":"Verheij","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.brainresrev.2004.07.014_bib336","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/S0014-5793(99)00836-4","article-title":"Sphingosine inhibits nitric oxide synthase from cerebellar granule cells differentiated in vitro","volume":"454","author":"Viani","year":"1999","journal-title":"FEBS Lett."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib337","doi-asserted-by":"crossref","first-page":"9592","DOI":"10.1074\/jbc.M207729200","article-title":"Ceramide in nitric oxide inhibition of glioma cell growth. Evidence for the involvement of ceramide traffic","volume":"278","author":"Viani","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib338","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/S1044-7431(02)00031-3","article-title":"Lipid rafts mediate the interaction between myelin-associated glycoprotein (MAG) on myelin and MAG-receptors on neurons","volume":"22","author":"Vinson","year":"2003","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib339","doi-asserted-by":"crossref","first-page":"L98","DOI":"10.1152\/ajplung.2001.281.1.L98","article-title":"Sphingomyelin metabolites inhibit sphingomyelin synthase and CTP: phosphocholine cytidylyltransferase","volume":"281","author":"Vivekananda","year":"2001","journal-title":"Am. J. Physiol., Lung Cell. Mol. Physiol."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib340","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1515\/BC.2001.033","article-title":"Anencephaly: structural characterization of gangliosides in defined brain regions","volume":"382","author":"Vukelic","year":"2001","journal-title":"Biol. Chem."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib341","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/0009-3084(80)90057-2","article-title":"Analogs of ceramide that inhibit glucocerebroside synthetase in mouse brain","volume":"26","author":"Vunnam","year":"1980","journal-title":"Chem. Phys. Lipids"},{"key":"10.1016\/j.brainresrev.2004.07.014_bib342","doi-asserted-by":"crossref","first-page":"10954","DOI":"10.1073\/pnas.97.20.10954","article-title":"Microglial activation precedes acute neurodegeneration in Sandhoff disease and is suppressed by bone marrow transplantation","volume":"97","author":"Wada","year":"2000","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib343","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1038\/sj.cdd.4400848","article-title":"C2-ceramide signaling in glioma cells: synergistic enhancement of CD95-mediated, caspase-dependent apoptosis","volume":"8","author":"Wagenknecht","year":"2001","journal-title":"Cell Death Differ."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib344","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1093\/cercor\/10.10.1028","article-title":"Gangliosides as modulators of dendritogenesis in normal and storage disease-affected pyramidal neurons","volume":"10","author":"Walkley","year":"2000","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.brainresrev.2004.07.014_bib345","doi-asserted-by":"crossref","first-page":"14486","DOI":"10.1016\/S0021-9258(18)98712-0","article-title":"Inhibition of sphingolipid biosynthesis by fumonisins. Implications for diseases associated with Fusarium moniliforme","volume":"266","author":"Wang","year":"1991","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib346","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1002\/(SICI)1097-4547(19990201)55:3<293::AID-JNR4>3.0.CO;2-9","article-title":"Atypical PKC zeta is activated by ceramide, resulting in coactivation of NF-kappaB\/JNK kinase and cell survival","volume":"55","author":"Wang","year":"1999","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib347","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/S0014-5793(99)01024-8","article-title":"Antagonistic effect of ganglioside GM1 and GM3 on the activity and conformation of sarcoplasmic reticulum Ca(2+)-ATPase","volume":"457","author":"Wang","year":"1999","journal-title":"FEBS Lett."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib348","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1016\/S0163-7827(03)00015-8","article-title":"Pleiotropic actions of sphingosine-1-phosphate","volume":"42","author":"Watterson","year":"2003","journal-title":"Prog. Lipid Res."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib349","first-page":"3654","article-title":"Inhibition of melanoma tumor growth by a novel inhibitor of glucosylceramide synthase","volume":"63","author":"Weiss","year":"2003","journal-title":"Cancer Res."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib350","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1177\/153537020322801108","article-title":"Tetrahydrobiopterin and nitric oxide: mechanistic and pharmacological aspects","volume":"228","author":"Werner","year":"2003","journal-title":"Exp. Biol. Med."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib351","doi-asserted-by":"crossref","first-page":"22689","DOI":"10.1074\/jbc.270.39.22689","article-title":"Ceramide activates the stress-activated protein kinases","volume":"270","author":"Westwick","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib352","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1046\/j.1471-4159.1996.66041418.x","article-title":"Staurosporine induces programmed cell death in embryonic neurons and activation of the ceramide pathway","volume":"66","author":"Wiesner","year":"1996","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib353","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1046\/j.0953-816x.2001.01581.x","article-title":"Ceramide-induced apoptosis in cortical neurons is mediated by an increase in p38 phosphorylation and not by the decrease in ERK phosphorylation","volume":"13","author":"Willaime","year":"2001","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib354","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S0006-8993(01)02452-0","article-title":"Stimulation of astrocyte-enriched culture with C2 ceramide increases proenkephalin mRNA: involvement of cAMP-response element binding protein and mitogen activated protein kinases","volume":"903","author":"Won","year":"2001","journal-title":"Brain Res."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib355","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1111\/j.1471-4159.1991.tb02567.x","article-title":"Stimulation of neurite outgrowth in neuroblastoma cells by neuraminidase: putative role of GM1 ganglioside in differentiation J","volume":"56","author":"Wu","year":"1991","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib356","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/BF02815354","article-title":"Inhibition of neurite outgrowth of neuroblastoma Neuro-2a cells by cholera toxin B-subunit and anti-GM1 antibody","volume":"21","author":"Wu","year":"1994","journal-title":"Mol. Chem. Neuropathol."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib357","doi-asserted-by":"crossref","first-page":"3739","DOI":"10.1523\/JNEUROSCI.15-05-03739.1995","article-title":"Induced and spontaneous neuritogenesis are associated with enhanced expression of ganglioside GM1 in the nuclear membrane","volume":"15","author":"Wu","year":"1995","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib358","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0165-3806(00)00150-4","article-title":"Comparison of ganglioside profiles in nuclei and whole cells of NG108-15 and NG-CR72 lines: changes in response to different neuritogenic stimuli","volume":"126","author":"Wu","year":"2001","journal-title":"Dev. Brain Res."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib359","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1073\/pnas.011523698","article-title":"Cerebellar neurons lacking complex gangliosides degenerate in the presence of depolarizing levels of potassium","volume":"98","author":"Wu","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib360","doi-asserted-by":"crossref","first-page":"4785","DOI":"10.1210\/en.142.11.4785","article-title":"Ceramide inhibits the inwardly rectifying potassium current in GH(3) lactotrophs","volume":"142","author":"Wu","year":"2001","journal-title":"Endocrinology"},{"key":"10.1016\/j.brainresrev.2004.07.014_bib361","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1126\/science.270.5240.1326","article-title":"Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis","volume":"270","author":"Xia","year":"1995","journal-title":"Science"},{"issue":"10","key":"10.1016\/j.brainresrev.2004.07.014_bib362","doi-asserted-by":"crossref","first-page":"7996","DOI":"10.1074\/jbc.M111423200","article-title":"Sphingosine kinase interacts with TRAF2 and dissects tumor necrosis factor-alpha signaling","volume":"277","author":"Xia","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib363","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1046\/j.1471-4159.1997.69031020.x","article-title":"Ceramide selectively decreases tau levels in differentiated PC12 cells through modulation of calpain I","volume":"69","author":"Xie","year":"1997","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib364","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1002\/glia.10180","article-title":"Sphingosine 1-phosphate induces the production of glial cell line-derived neurotrophic factor and cellular proliferation in astrocytes","volume":"41","author":"Yamagata","year":"2003","journal-title":"Glia"},{"key":"10.1016\/j.brainresrev.2004.07.014_bib365","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1046\/j.0014-2956.2002.00029.x","article-title":"DAP kinase activity is critical for C(2)-ceramide-induced apoptosis in PC12 cells","volume":"269","author":"Yamamoto","year":"2002","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib366","doi-asserted-by":"crossref","first-page":"9975","DOI":"10.1073\/pnas.91.21.9975","article-title":"Targeted disruption of the Hexa gene results in mice with biochemical and pathologic features of Tay-Sachs disease","volume":"91","author":"Yamanaka","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib367","doi-asserted-by":"crossref","first-page":"9142","DOI":"10.1073\/pnas.96.16.9142","article-title":"A vital role for glycosphingolipid synthesis during development and differentiation","volume":"96","author":"Yamashita","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"2","key":"10.1016\/j.brainresrev.2004.07.014_bib368","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0306-4522(99)00582-5","article-title":"Ceramide-induced sustained depression of synaptic currents mediated by ionotropic glutamate receptors in the hippocampus: an essential role of postsynaptic protein phosphatases","volume":"96","author":"Yang","year":"2000","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainresrev.2004.07.014_bib369","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/378307a0","article-title":"Phosphorylation of Raf by ceramide-activated protein kinase","volume":"378","author":"Yao","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.brainresrev.2004.07.014_bib370","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1021\/bi9515533","article-title":"N,N-dimethylsphingosine inhibition of sphingosine kinase and sphingosine 1-phosphate activity in human platelets","volume":"35","author":"Yatomi","year":"1996","journal-title":"Biochemistry"},{"key":"10.1016\/j.brainresrev.2004.07.014_bib371","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0960-894X(02)00888-0","article-title":"Synthesis of non-competitive inhibitors of sphingomyelinases with significant activity","volume":"13","author":"Yokomatsu","year":"2003","journal-title":"Bioorg. Med. Chem. Lett."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib372","doi-asserted-by":"crossref","first-page":"6921","DOI":"10.1074\/jbc.273.12.6921","article-title":"Ceramide formation leads to caspase-3 activation during hypoxic PC12 cell death. Inhibitory effects of Bcl-2 on ceramide formation and caspase-3 activation","volume":"273","author":"Yoshimura","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib373","doi-asserted-by":"crossref","first-page":"38532","DOI":"10.1074\/jbc.M006631200","article-title":"Lysophosphatidic acid-induced Ca2+ mobilization requires intracellular sphingosine 1-phosphate production. Potential involvement of endogenous EDG-4 receptors","volume":"275","author":"Young","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib374","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1006\/scdb.2000.0213","article-title":"Intracellular sphingosine 1-phosphate production: a novel pathway for Ca2+ release","volume":"12","author":"Young","year":"2001","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib375","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S0079-6123(08)61938-X","article-title":"Development regulation of ganglioside metabolism","volume":"101","author":"Yu","year":"1994","journal-title":"Prog. Brain Res."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib376","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1046\/j.1471-4159.1999.0730933.x","article-title":"Role of the outward delayed rectifier K+ current in ceramide-induced caspase activation and apoptosis in cultured cortical neurons","volume":"73","author":"Yu","year":"1999","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib377","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1385\/JMN:15:2:85","article-title":"Pivotal role for acidic sphingomyelinase in cerebral ischemia-induced ceramide cytokine production, and neuronal apoptosis","volume":"15","author":"Yu","year":"2000","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib378","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/S0021-9258(19)40197-X","article-title":"Sphingosine stimulates cellular proliferation via a protein kinase C-independent pathway","volume":"265","author":"Zhang","year":"1990","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib379","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1083\/jcb.114.1.155","article-title":"Sphingosine-1-phosphate, a novel lipid, involved in cellular proliferation","volume":"114","author":"Zhang","year":"1991","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib380","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1002\/(SICI)1097-4547(19961001)46:1<114::AID-JNR14>3.0.CO;2-5","article-title":"Activation of C-jun N-terminal kinase\/stress-activated protein kinase in primary glial cultures","volume":"46","author":"Zhang","year":"1996","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib381","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0092-8674(00)80183-X","article-title":"Kinase suppressor of Ras is ceramide-activated protein kinase","volume":"89","author":"Zhang","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.brainresrev.2004.07.014_bib382","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1113\/jphysiol.2002.024265","article-title":"Ceramide, a putative second messenger for nerve growth factor, modulates the TTX-resistant Na(+) current and delayed rectifier K(+) current in rat sensory neurons","volume":"544","author":"Zhang","year":"2002","journal-title":"J. Physiol."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib383","doi-asserted-by":"crossref","first-page":"16568","DOI":"10.1074\/jbc.273.26.16568","article-title":"Inhibition of Akt kinase by cell-permeable ceramide and its implications for ceramide-induced apoptosis","volume":"273","author":"Zhou","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresrev.2004.07.014_bib384","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1006\/bbrc.2000.4248","article-title":"Ceramide induces the dephosphorylation and inhibition of constitutively activated Akt in PTEN negative U87mg cells","volume":"280","author":"Zinda","year":"2001","journal-title":"Biochem. Biophys. Res. Commun."}],"container-title":["Brain Research Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165017304001122?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165017304001122?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,1,14]],"date-time":"2024-01-14T09:51:09Z","timestamp":1705225869000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165017304001122"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,11]]},"references-count":385,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2004,11]]}},"alternative-id":["S0165017304001122"],"URL":"https:\/\/doi.org\/10.1016\/j.brainresrev.2004.07.014","relation":{},"ISSN":["0165-0173"],"issn-type":[{"value":"0165-0173","type":"print"}],"subject":[],"published":{"date-parts":[[2004,11]]}}}