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Neurophysiol."},{"key":"10.1016\/j.brainresrev.2007.05.010_bib101","series-title":"The Human Nervous System","first-page":"1125","article-title":"Pain system","author":"Willis","year":"2004"},{"key":"10.1016\/j.brainresrev.2007.05.010_bib100","doi-asserted-by":"crossref","first-page":"7675","DOI":"10.1073\/pnas.96.14.7675","article-title":"A visceral pain pathway in the dorsal column of the spinal cord","volume":"96","author":"Willis","year":"1999","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.brainresrev.2007.05.010_bib102","doi-asserted-by":"crossref","unstructured":"Willis, W.D., Westlund, K.N., Carlton, S.M., 2004. Pain system. In: The Rat Nervous System, 3rd edition, Paxinos, G. 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