{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T13:49:36Z","timestamp":1790948976397,"version":"4.1.0"},"reference-count":55,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Research Reviews"],"published-print":{"date-parts":[[2008,1]]},"DOI":"10.1016\/j.brainresrev.2007.06.021","type":"journal-article","created":{"date-parts":[[2007,8,2]],"date-time":"2007-08-02T07:27:04Z","timestamp":1186039624000},"page":"77-85","source":"Crossref","is-referenced-by-count":83,"title":["Spontaneous rhythmic activity in early chick spinal cord influences distinct motor axon pathfinding decisions"],"prefix":"10.1016","volume":"57","author":[{"given":"M. Gartz","family":"Hanson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise D.","family":"Milner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lynn T.","family":"Landmesser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainresrev.2007.06.021_bib1","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/S0361-9230(00)00403-2","article-title":"Development of lumbar rhythmic networks: from embryonic to neonate locomotor-like patterns in the mouse","volume":"53","author":"Branchereau","year":"2000","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.brainresrev.2007.06.021_bib2","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/j.neuron.2005.09.015","article-title":"Development of precise maps in visual cortex requires patterned spontaneous activity in the retina","volume":"48","author":"Cang","year":"2005","journal-title":"Neuron"},{"key":"10.1016\/j.brainresrev.2007.06.021_bib3","doi-asserted-by":"crossref","first-page":"4943","DOI":"10.1523\/JNEUROSCI.15-07-04943.1995","article-title":"Localization and organization of the central pattern generator for hindlimb locomotion in newborn rat","volume":"15","author":"Cazalets","year":"1995","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainresrev.2007.06.021_bib4","doi-asserted-by":"crossref","first-page":"6929","DOI":"10.1523\/JNEUROSCI.1470-05.2005","article-title":"Evidence for an instructive role of retinal activity in retinotopic map refinement in the superior colliculus of the mouse","volume":"25","author":"Chandrasekaran","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainresrev.2007.06.021_bib6","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1523\/JNEUROSCI.18-01-00294.1998","article-title":"Blockade and recovery of spontaneous rhythmic activity after application of neurotransmitter antagonists to spinal networks of the chick embryo","volume":"85","author":"Chub","year":"1998","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainresrev.2007.06.021_bib5","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1152\/jn.00162.2005","article-title":"Chloride-sensitive MEQ fluorescence in chick embryo motoneurons following manipulations of chloride and during spontaneous network activity","volume":"95","author":"Chub","year":"2006","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.brainresrev.2007.06.021_bib7","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.cell.2005.09.009","article-title":"A hox regulatory network establishes motor neuron pool identity and target-muscle connectivity","volume":"123","author":"Dasen","year":"2005","journal-title":"Cell"},{"key":"10.1016\/j.brainresrev.2007.06.021_bib8","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1038\/386855a0","article-title":"Differential activation of transcription factors induced by Ca2+ response amplitude and duration","volume":"386","author":"Dolmetsch","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.brainresrev.2007.06.021_bib9","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1006\/dbio.2002.0695","article-title":"EphA4 constitutes a population-specific guidance cue for motor neurons","volume":"247","author":"Eberhart","year":"2002","journal-title":"Dev. Biol."},{"key":"10.1016\/j.brainresrev.2007.06.021_bib10","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.tibs.2005.04.004","article-title":"Glycine transporters: essential regulators of neurotransmission","volume":"30","author":"Eulenburg","year":"2005","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.brainresrev.2007.06.021_bib11","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1523\/JNEUROSCI.23-02-00587.2003","article-title":"Characterization of the circuits that generate spontaneous episodes of activity in the early embryonic spinal cord","volume":"23","author":"Hanson","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainresrev.2007.06.021_bib12","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.neuron.2004.08.018","article-title":"Normal patterns of spontaneous activity are required for correct motor axon guidance and the expression of specific guidance molecules","volume":"46","author":"Hanson","year":"2004","journal-title":"Neuron"},{"key":"10.1016\/j.brainresrev.2007.06.021_bib13","doi-asserted-by":"crossref","first-page":"12769","DOI":"10.1523\/JNEUROSCI.4170-06.2006","article-title":"Increasing the frequency of spontaneous rhythmic activity disrupts pool-specific axon fasciculation and pathfinding of embryonic spinal motoneurons","volume":"26","author":"Hanson","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainresrev.2007.06.021_bib14","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1016\/j.neuron.2005.12.003","article-title":"Distinct roles for secreted semaphorin signaling in spinal motor axon guidance","volume":"48","author":"Huber","year":"2005","journal-title":"Neuron"},{"key":"10.1016\/j.brainresrev.2007.06.021_bib15","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.neuron.2006.07.028","article-title":"Spontaneous retinal activity mediates development of ocular dominance columns and binocular receptive fields","volume":"52","author":"Huberman","year":"2006","journal-title":"Neuron"},{"key":"10.1016\/j.brainresrev.2007.06.021_bib16","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1002\/(SICI)1097-4695(19971120)33:6<735::AID-NEU3>3.0.CO;2-A","article-title":"Activity dependent regulation of N-cadherin in DRG neurons: differential regulation of N-cadherin, NCAM, and L1 by distinct patterns of action potentials","volume":"33","author":"Itoh","year":"1997","journal-title":"J. Neurobiol."},{"key":"10.1016\/j.brainresrev.2007.06.021_bib17","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/S0896-6273(03)00292-7","article-title":"Topographic motor projections in the limb imposed by LIM homeodomain protein regulation of ephrin-A: EphA interactions","volume":"38","author":"Kania","year":"2003","journal-title":"Neuron"},{"key":"10.1016\/j.brainresrev.2007.06.021_bib18","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1126\/science.274.5290.1133","article-title":"Synaptic activity and the construction of cortical circuits","volume":"274","author":"Katz","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.brainresrev.2007.06.021_bib19","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1146\/annurev.neuro.29.051605.112910","article-title":"Locomotor circuits in the mammalian spinal cord","volume":"29","author":"Kiehn","year":"2006","journal-title":"Ann. Rev. Neurosci."},{"key":"10.1016\/j.brainresrev.2007.06.021_bib20","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1002\/syn.20286","article-title":"Inhibition of the glycine transported GlyT-1 potentiates the effect of risperidone but not clozapine on glutamatergic transmission in the rat medial prefrontal cortex","volume":"60","author":"Konradsson","year":"2006","journal-title":"Synapse"},{"key":"10.1016\/j.brainresrev.2007.06.021_bib21","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.neuron.2006.02.020","article-title":"Cooperation between GDNF\/Ret and ephrinA\/EphA4 signals for motor\u2013axon pathway selection in the limb","volume":"50","author":"Kramer","year":"2006","journal-title":"Neuron"},{"key":"10.1016\/j.brainresrev.2007.06.021_bib22","doi-asserted-by":"crossref","first-page":"7905","DOI":"10.1523\/JNEUROSCI.20-21-07905.2000","article-title":"Role of bicarbonate and chloride in GABA- and glycine-induced depolarization and [Ca2+]I rise in fetal rat motoneurons in situ","volume":"20","author":"Kulik","year":"2000","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainresrev.2007.06.021_bib23","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1098\/rspb.1981.0079","article-title":"Pathway selection by chick lumbosacral motoneurons during normal development","volume":"214","author":"Lance-Jones","year":"1981","journal-title":"Proc. R. Soc. Lond., B"},{"key":"10.1016\/j.brainresrev.2007.06.021_bib24","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1098\/rspb.1981.0080","article-title":"Pathway selection by embryonic chick lumbosacral motoneurons in an experimentally altered environment","volume":"214","author":"Lance-Jones","year":"1981","journal-title":"Proc. R. Soc. Lond., B"},{"key":"10.1016\/j.brainresrev.2007.06.021_bib25","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1113\/jphysiol.1984.sp015061","article-title":"Activation patterns of embryonic chick hind limb muscles recorded in-ovo and in an isolated spinal cord preparation","volume":"347","author":"Landmesser","year":"1984","journal-title":"J. Physiol. (Lond.)"},{"key":"10.1016\/j.brainresrev.2007.06.021_bib26","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1113\/jphysiol.1984.sp015062","article-title":"The activation patterns of embryonic chick motoneurons projecting to inappropriate muscles","volume":"347","author":"Landmesser","year":"1984","journal-title":"J. Physiol. (Lond.)"},{"key":"10.1016\/j.brainresrev.2007.06.021_bib27","doi-asserted-by":"crossref","first-page":"17816","DOI":"10.1073\/pnas.0509030102","article-title":"Fast non-invasive activation and inhibition of neural and network activity by vertebrate rhodopsin and green algae channelrhodopsin","volume":"102","author":"Li","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.brainresrev.2007.06.021_bib28","doi-asserted-by":"crossref","first-page":"3601","DOI":"10.1523\/JNEUROSCI.4290-04.2005","article-title":"Modeling spontaneous activity in the developing spinal cord using activity-dependent variations in intracellular chloride","volume":"25","author":"Marchetti","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainresrev.2007.06.021_bib29","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1016\/S0896-6273(03)00790-6","article-title":"Retinotopic map refinement requires spontaneous retinal waves during a brief critical period of development","volume":"40","author":"McLaughlin","year":"2003","journal-title":"Neuron"},{"key":"10.1016\/j.brainresrev.2007.06.021_bib30","doi-asserted-by":"crossref","first-page":"3007","DOI":"10.1523\/JNEUROSCI.19-08-03007.1999","article-title":"Cholinergic and GABAergic inputs drive patterned spontaneous motoneuron activity before target contact","volume":"19","author":"Milner","year":"1999","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainresrev.2007.06.021_bib31","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/S0896-6273(01)00217-3","article-title":"Electrical activity modulates growth cone guidance by diffusible factors","volume":"4","author":"Ming","year":"2001","journal-title":"Neuron"},{"key":"10.1016\/j.brainresrev.2007.06.021_bib32","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1152\/physrev.00017.2004","article-title":"Ion channel development, spontaneous activity, and activity-dependent development in nerve and muscle cells","volume":"85","author":"Moody","year":"2004","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.brainresrev.2007.06.021_bib33","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.neuron.2006.03.009","article-title":"Spike timing-dependent LTP\/LTD mediates visual experience-dependent plasticity in a developing retinotectal system","volume":"50","author":"Mu","year":"2006","journal-title":"Neuron"},{"key":"10.1016\/j.brainresrev.2007.06.021_bib34","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1113\/jphysiol.1996.sp021755","article-title":"Spontaneous motoneuronal activity mediated by glycine and GABA in the spinal cord of rat fetuses in vitro","volume":"497","author":"Nishimaru","year":"1996","journal-title":"J. Physiol. (Lond.)"},{"key":"10.1016\/j.brainresrev.2007.06.021_bib35","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s004410000343","article-title":"Neurotransmitters as early signals for central nervous system development","volume":"305","author":"Nguyen","year":"2001","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.brainresrev.2007.06.021_bib36","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/S0959-4388(99)80012-9","article-title":"The origin of spontaneous activity in developing networks of the vertebrate nervous system","volume":"9","author":"O'Donovan","year":"1999","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.brainresrev.2007.06.021_bib38","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1002\/(SICI)1097-4695(199810)37:1<131::AID-NEU10>3.0.CO;2-H","article-title":"Mechanisms of spontaneous activity in developing spinal networks","volume":"37","author":"O'Donovan","year":"1998","journal-title":"J. Neurobiol."},{"key":"10.1016\/j.brainresrev.2007.06.021_bib37","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.ceca.2005.01.012","article-title":"Calcium imaging of network function in the developing spinal cord","volume":"37","author":"O'Donovan","year":"2005","journal-title":"Cell Calcium"},{"key":"10.1016\/j.brainresrev.2007.06.021_bib39","doi-asserted-by":"crossref","first-page":"2108","DOI":"10.1126\/science.279.5359.2108","article-title":"Competition in retinogeniculate patterning driven by spontaneous activity","volume":"279","author":"Penn","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.brainresrev.2007.06.021_bib40","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1152\/jn.00539.2002","article-title":"Ontogeny of rhythmic motor patterns in the embryonic rat spinal cord","volume":"89","author":"Ren","year":"2003","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.brainresrev.2007.06.021_bib41","doi-asserted-by":"crossref","first-page":"R18","DOI":"10.1016\/S0960-9822(02)01318-0","article-title":"The role of activity in development of the visual system","volume":"12","author":"Sengpiel","year":"2002","journal-title":"Curr. Biol."},{"key":"10.1016\/j.brainresrev.2007.06.021_bib43","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1146\/annurev.neuro.25.112701.142916","article-title":"Transcriptional codes and the control of neuronal identity","volume":"25","author":"Shirasaki","year":"2002","journal-title":"Ann. Rev. Neurosci."},{"key":"10.1016\/j.brainresrev.2007.06.021_bib42","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/j.neuron.2006.04.030","article-title":"FGF as a target derived chemoattractant for developing motor axons genetically programmed by the LIM code","volume":"50","author":"Shirasaki","year":"2006","journal-title":"Neuron"},{"key":"10.1016\/j.brainresrev.2007.06.021_bib44","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/S0896-6273(02)00577-9","article-title":"An instructive role for retinal waves in the development of retinogeniculate connectivity","volume":"33","author":"Stellwagen","year":"2002","journal-title":"Neuron"},{"key":"10.1016\/j.brainresrev.2007.06.021_bib45","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/0896-6273(92)90125-W","article-title":"Polysialic acid influences specific pathfinding by avian motoneurons","volume":"8","author":"Tang","year":"1992","journal-title":"Neuron"},{"key":"10.1016\/j.brainresrev.2007.06.021_bib46","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/0896-6273(94)90356-5","article-title":"Polysialic acid regulates growth cone behavior during sorting of motor axons in the plexus region","volume":"13","author":"Tang","year":"1994","journal-title":"Neuron"},{"key":"10.1016\/j.brainresrev.2007.06.021_bib47","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1038\/nn1376","article-title":"High frequency, synchronized bursting drives eye-specific segregation of retinogeniculate projections","volume":"8","author":"Torborg","year":"2005","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.brainresrev.2007.06.021_bib48","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.pneurobio.2005.09.002","article-title":"Spontaneous patterned retinal activity and the refinement of retinal projections","volume":"76","author":"Torborg","year":"2005","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.brainresrev.2007.06.021_bib49","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1006\/mcne.2000.0871","article-title":"Specific frequencies of spontaneous Ca2+ transients upregulate GAD 67 transcripts in embryonic spinal neurons","volume":"16","author":"Watt","year":"2000","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.brainresrev.2007.06.021_bib50","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1152\/jn.2001.86.3.1481","article-title":"Mechanisms that initiate spontaneous network activity in the developing chick spinal cord","volume":"86","author":"Wenner","year":"2001","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.brainresrev.2007.06.021_bib51","doi-asserted-by":"crossref","first-page":"11024","DOI":"10.1073\/pnas.191352298","article-title":"Calcium regulation of neuronal gene expression","volume":"98","author":"West","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.brainresrev.2007.06.021_bib52","doi-asserted-by":"crossref","first-page":"2821","DOI":"10.1152\/jn.2000.84.6.2821","article-title":"Properties of rhythmic activity generated by the isolated spinal cord of the neonatal mouse","volume":"84","author":"Whelan","year":"2000","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.brainresrev.2007.06.021_bib54","doi-asserted-by":"crossref","first-page":"3935","DOI":"10.1523\/JNEUROSCI.12-10-03935.1992","article-title":"Early development of glycine- and GABA-mediated synapses in rat spinal cord","volume":"12","author":"Wu","year":"1992","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainresrev.2007.06.021_bib53","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/83976","article-title":"Spaced stimuli stabilize MAPK pathway activation and its effects on dendritic morphology","volume":"4","author":"Wu","year":"2001","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.brainresrev.2007.06.021_bib55","doi-asserted-by":"crossref","first-page":"2101","DOI":"10.1152\/jn.01095.2003","article-title":"Multiple spontaneous rhythmic activity patterns generated by the embryonic mouse spinal cord occur within a specific developmental time window","volume":"91","author":"Yvert","year":"2004","journal-title":"J. Neurophysiol."}],"container-title":["Brain Research Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165017307001270?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165017307001270?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T13:39:06Z","timestamp":1556717946000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165017307001270"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,1]]},"references-count":55,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,1]]}},"alternative-id":["S0165017307001270"],"URL":"https:\/\/doi.org\/10.1016\/j.brainresrev.2007.06.021","relation":{},"ISSN":["0165-0173"],"issn-type":[{"value":"0165-0173","type":"print"}],"subject":[],"published":{"date-parts":[[2008,1]]}}}