{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T01:00:22Z","timestamp":1783040422990,"version":"3.54.6"},"reference-count":200,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2009,12,1]],"date-time":"2009-12-01T00:00:00Z","timestamp":1259625600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Research Reviews"],"published-print":{"date-parts":[[2009,12]]},"DOI":"10.1016\/j.brainresrev.2009.09.003","type":"journal-article","created":{"date-parts":[[2009,9,11]],"date-time":"2009-09-11T09:35:37Z","timestamp":1252661737000},"page":"33-44","source":"Crossref","is-referenced-by-count":178,"title":["Insight into zinc signaling from dietary zinc deficiency"],"prefix":"10.1016","volume":"62","author":[{"given":"Atsushi","family":"Takeda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruna","family":"Tamano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainresrev.2009.09.003_bib1","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s10571-004-1374-y","article-title":"Dynamics of CNS barriers: evolution, differentiation, and modulation","volume":"25","author":"Abbott","year":"2005","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib2","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1038\/nrn1824","article-title":"Astrocyte\u2013endothelial interactions at the blood\u2013brain barrier","volume":"7","author":"Abbott","year":"2006","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib3","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.jchemneu.2008.07.005","article-title":"Zincergic innervation from the anterior olfactory nucleus to the olfactory bulb displays plastic responses after mitral cell loss","volume":"36","author":"Airado","year":"2008","journal-title":"J. Chem. Neuroanat."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib4","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1001\/archpsyc.1985.01790350067012","article-title":"The dexamethasone suppression test for diagnosis and prognosis in psychiatry","volume":"42","author":"Arana","year":"1985","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.brainresrev.2009.09.003_bib5","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1038\/308734a0","article-title":"Release of endogeneous Zn2+ from brain tissue during activity","volume":"308","author":"Assaf","year":"1984","journal-title":"Nature"},{"key":"10.1016\/j.brainresrev.2009.09.003_bib6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.nbd.2003.12.016","article-title":"The blood\u2013brain barrier: an overview: structure, regulation, and clinical implications","volume":"16","author":"Ballabh","year":"2004","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib7","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1111\/j.1471-4159.2004.02587.x","article-title":"Zinc inhibits glutamate release via activation of pre-synaptic KATP channels and reduces ischaemic damage in rat hippocampus","volume":"90","author":"Bancila","year":"2004","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib8","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1038\/nn1973","article-title":"The hippocampus is necessary for enhancements and impairments of learning following stress","volume":"10","author":"Bangasser","year":"2007","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib9","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.cbpa.2008.02.019","article-title":"Metals in Alzheimer's and Parkinson's diseases","volume":"12","author":"Barnham","year":"2008","journal-title":"Curr. Opin. Chem. Biol."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib10","doi-asserted-by":"crossref","first-page":"301","DOI":"10.3758\/BF03332083","article-title":"Serum corticosterone level predicts the magnitude of hippocampal primed burst potentiation and depression in urethane-anesthetized rats","volume":"19","author":"Bennett","year":"1991","journal-title":"Psychobiology"},{"key":"10.1016\/j.brainresrev.2009.09.003_bib11","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.exger.2007.11.001","article-title":"Brain aging: the zinc connection","volume":"43","author":"Bertoni-Freddari","year":"2008","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib12","doi-asserted-by":"crossref","first-page":"3129","DOI":"10.1523\/JNEUROSCI.20-09-03129.2000","article-title":"Plasma membrane calcium pump isoform I gene expression is repressed by corticosterone and stress in rat hippocampus","volume":"20","author":"Bhargava","year":"2000","journal-title":"J. Neurosci."},{"issue":"Suppl. 2","key":"10.1016\/j.brainresrev.2009.09.003_bib13","doi-asserted-by":"crossref","first-page":"S139","DOI":"10.1079\/BJN2000306","article-title":"Zinc and cognitive development","volume":"85","author":"Bhatnagar","year":"2001","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib14","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1038\/nrn2335","article-title":"The hippocampus and memory: insights from spatial processing","volume":"9","author":"Bird","year":"2008","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib15","doi-asserted-by":"crossref","first-page":"464S","DOI":"10.1093\/ajcn\/68.2.464S","article-title":"Zinc deficiency and child development","volume":"68","author":"Black","year":"1998","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib16","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.jnutbio.2007.06.014","article-title":"Longitudinal changes in zinc transport kinetics, metallothionein and zinc transporter expression in a blood\u2013brain barrier model in response to a moderately excessive zinc environment","volume":"19","author":"Bobilya","year":"2008","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib17","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1523\/JNEUROSCI.15-01-00061.1995","article-title":"Enduring effects of chronic corticosterone treatment on spatial learning, synaptic plasticity, and hippocampal neuropathology in young and mid-aged rats","volume":"15","author":"Bodnoff","year":"1995","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib18","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1038\/sj.jcbfm.9600127","article-title":"The astrocyte\u2013neuron lactate shuttle: a debated but still valuable hypothesis for brain imaging","volume":"25","author":"Bonvento","year":"2005","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib19","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1176\/ajp.157.1.115","article-title":"Hippocampal volume reduction in major depression","volume":"157","author":"Bremner","year":"2000","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.brainresrev.2009.09.003_bib20","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1177\/0960327107070573","article-title":"Metal transporters in intestine and brain: their involvement in metal-associated neurotoxicities","volume":"26","author":"Bressler","year":"2007","journal-title":"Hum. Exp. Toxicol."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib21","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1177\/156482650102200201","article-title":"The importance of zinc in human nutrition and estimation of the global prevalence of zinc deficiency","volume":"22","author":"Brown","year":"2001","journal-title":"Food Nutr. Bull."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib22","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1111\/j.1753-4887.2004.tb00055.x","article-title":"Nutrients for cognitive development in school-aged children","volume":"62","author":"Bryan","year":"2004","journal-title":"Nutr. Rev."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib23","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1126\/science.271.5247.369","article-title":"Zinc-induced collapse of augmented inhibition by GABA in a temporal lobe epilepsy model","volume":"271","author":"Buhl","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.brainresrev.2009.09.003_bib24","doi-asserted-by":"crossref","first-page":"3605","DOI":"10.1073\/pnas.0637711100","article-title":"Meeting of the minds: metalloneurochemistry","volume":"100","author":"Burdette","year":"2003","journal-title":"Proc Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib25","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/0006-8993(92)91266-H","article-title":"Zinc (Zn2+) blocks voltage gated calcium channels in cultured rat dorsal root ganglion cells","volume":"593","author":"Busselberg","year":"1992","journal-title":"Brain Res"},{"key":"10.1016\/j.brainresrev.2009.09.003_bib26","doi-asserted-by":"crossref","first-page":"93","DOI":"10.3233\/JAD-2005-8202","article-title":"Zinc dyshomeostasis: a key modulator of neuronal injury","volume":"8","author":"Capasso","year":"2005","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib27","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1017\/S0033291700013775","article-title":"Cerebrospinal fluid and plasma free cortisol concentrations in depression","volume":"6","author":"Carroll","year":"1976","journal-title":"Psychol. Med."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib28","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1001\/archpsyc.1981.01780260017001","article-title":"A specific laboratory test for the diagnosis of melancholia: standardization, validation and clinical utility","volume":"38","author":"Carroll","year":"1981","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.brainresrev.2009.09.003_bib29","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1124\/mol.51.6.1015","article-title":"Differential sensitivity of recombinant N-methyl-d-aspartate receptor subtypes to zinc inhibition","volume":"51","author":"Chen","year":"1997","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib30","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1146\/annurev.ne.13.030190.001131","article-title":"The role of glutamate neurotoxicity in hypoxic-ischemic neuronal death","volume":"13","author":"Choi","year":"1990","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib31","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1146\/annurev.neuro.21.1.347","article-title":"Zinc and brain injury","volume":"21","author":"Choi","year":"1998","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib32","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0896-6273(00)80763-1","article-title":"Identification and mechanism of action of two histidine residues underlying high-affinity Zn2+ inhibition of the NMDA receptor","volume":"23","author":"Choi","year":"1999","journal-title":"Neuron"},{"key":"10.1016\/j.brainresrev.2009.09.003_bib33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/taap.1993.1037","article-title":"Differential expression of the metallothionein gene in liver and brain of mice and rats","volume":"119","author":"Choudhuri","year":"1993","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib34","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1093\/jn\/135.5.1002","article-title":"Zinc deficiency is associated with increased brain zinc import and LIV-1 expression and decreased ZnT-1 expression in neonatal rats","volume":"135","author":"Chowanadisai","year":"2005","journal-title":"J. Nutr."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib35","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1001\/jama.267.9.1244","article-title":"The concepts of stress and stress system disorders: overview of physical and behavioral homeostasis","volume":"267","author":"Chrousos","year":"1992","journal-title":"J. Am. Med. Assoc."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib36","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1016\/S0031-9384(03)00041-6","article-title":"Water maze performance and changes in serum corticosterone levels in zinc-deprived and pair-fed rats","volume":"78","author":"Chu","year":"2003","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib37","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/0006-8993(83)90062-8","article-title":"Divalent transition metal ions (Cu2+ and Zn2+) in the brains of epileptogenic and normal mice","volume":"280","author":"Chung","year":"1983","journal-title":"Brain Res."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib38","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.neuroscience.2003.11.031","article-title":"Chronic corticosterone affects brain weight, and mitochondrial, but not glial volume fraction in hippocampal area CA3","volume":"124","author":"Coburn-Litvak","year":"2004","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainresrev.2009.09.003_bib39","doi-asserted-by":"crossref","first-page":"6154","DOI":"10.1073\/pnas.0501431102","article-title":"Zinc inhibition of gamma-aminobutyric acid transporter 4 (GAT4) reveals a link between excitatory and inhibitory neurotransmission","volume":"102","author":"Cohen-Kfir","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib40","first-page":"889","article-title":"Zinc nutrition and growth retardation","volume":"5","author":"Cole","year":"2008","journal-title":"Pediatr. Endocrinol. Rev."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib200","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.1073\/pnas.96.4.1716","article-title":"Elimination of zinc from synaptic vesicles in the intact mouse brain by disruption of the ZnT3 gene","volume":"96","author":"Cole","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.brainresrev.2009.09.003_bib41","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0920-1211(99)00121-7","article-title":"Seizures and neuronal damage in mice lacking vesicular zinc","volume":"39","author":"Cole","year":"2000","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib42","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0006-8993(00)03220-0","article-title":"Removing zinc from synaptic vesicles does not impair spatial learning, memory, or sensorimotor functions in the mouse","volume":"891","author":"Cole","year":"2001","journal-title":"Brain Res."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib43","first-page":"143","article-title":"Excitatory amino acid receptors in the vertebrate central nervous system","volume":"40","author":"Collingridge","year":"1989","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib44","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.ejphar.2003.08.067","article-title":"Zn2+ transporters and Zn2+ homeostasis in neurons","volume":"479","author":"Colvin","year":"2003","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib45","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.brainres.2008.08.040","article-title":"Zinc deficiency impairs neuronal precursor cell proliferation and induces apoptosis via p53-mediated mechanisms","volume":"1237","author":"Corniola","year":"2008","journal-title":"Brain Res."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib46","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1113\/jphysiol.2005.089458","article-title":"Cell type-specific action of seizure-induced intracellular zinc accumulation in the rat hippocampus","volume":"566","author":"C\u00f4t\u00e9","year":"2005","journal-title":"J. Physiol."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib47","doi-asserted-by":"crossref","first-page":"24085","DOI":"10.1074\/jbc.R600011200","article-title":"Mammalian zinc transport, trafficking, and signals","volume":"281","author":"Cousins","year":"2006","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib48","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0301-0082(00)00067-8","article-title":"Glutamate uptake","volume":"65","author":"Danbolt","year":"2001","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib49","doi-asserted-by":"crossref","first-page":"2650","DOI":"10.4049\/jimmunol.124.6.2650","article-title":"Further characterization of the role of corticosterone in the loss of humoral immunity in zinc-deficient A\/J mice as determined by adrenalectomy","volume":"124","author":"DePasquale-Jardieu","year":"1980","journal-title":"J. Immunol."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib50","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/aps.2009.24","article-title":"Molecular mechanisms of excitotoxicity and their relevance to pathogenesis of neurodegenerative diseases","volume":"30","author":"Dong","year":"2009","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib51","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1016\/0140-6736(93)90754-5","article-title":"Extracellular hippocampal glutamate and spontaneous seizure in the conscious human brain","volume":"341","author":"During","year":"1993","journal-title":"Lancet"},{"key":"10.1016\/j.brainresrev.2009.09.003_bib52","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/0006-8993(83)90284-6","article-title":"Alterations in the postnatal development of the cerebellar cortex due to zinc deficiency. I. Impaired acquisition of granule cells","volume":"271","author":"Dvergsten","year":"1983","journal-title":"Brain Res."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib53","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/0165-3806(84)90057-9","article-title":"Alterations in the postnatal development of the cerebellar cortex due to zinc deficiency. II. Impaired maturation of Purkinje cells","volume":"318","author":"Dvergsten","year":"1984","journal-title":"Brain Res."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib54","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1007\/BF02795528","article-title":"Biochemical characterization of a metallothionein-like protein in rat brain","volume":"11","author":"Ebadi","year":"1986","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib55","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1111\/j.1471-4159.1992.tb08345.x","article-title":"Corticosterone enhances kainic acid-induced calcium elevation in cultured hippocampal neurons","volume":"59","author":"Elliott","year":"1992","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib56","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/0006-8993(93)90245-I","article-title":"Corticosterone impairs hippocampal neuronal calcium regulation\u2014possible mediating mechanisms","volume":"602","author":"Elliott","year":"1993","journal-title":"Brain Res."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib57","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/j.metabol.2004.01.009","article-title":"Regulation of metabolic rate and substrate utilization by zinc deficiency","volume":"53","author":"Evans","year":"2004","journal-title":"Metabolism"},{"key":"10.1016\/j.brainresrev.2009.09.003_bib58","doi-asserted-by":"crossref","first-page":"249","DOI":"10.2174\/138955709787316001","article-title":"Antiglucocorticoids, neurogenesis and depression","volume":"9","author":"Fitzsimons","year":"2009","journal-title":"Mini. Rev. Med. Chem."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib59","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1080\/07315724.1995.10718467","article-title":"Possible roles for glucocorticoids and apoptosis in the suppression of lymphopoiesis during zinc deficiency: a review","volume":"14","author":"Fraker","year":"1995","journal-title":"J. Am. Coll. Nutr."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib60","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0074-7742(08)60279-2","article-title":"Neurobiology of zinc and zinc-containing neurons","volume":"31","author":"Frederickson","year":"1989","journal-title":"Int. Rev. Neurobiol."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib61","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/S0079-6123(08)61242-X","article-title":"Zinc-containing neurons in hippocampus and related CNS structures","volume":"83","author":"Frederickson","year":"1990","journal-title":"Prog. Brain Res."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib62","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1159\/000109536","article-title":"Zinc-containing neurons","volume":"3","author":"Frederickson","year":"1994","journal-title":"Biol. Signals"},{"key":"10.1016\/j.brainresrev.2009.09.003_bib63","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1023\/A:1012934207456","article-title":"Synaptically released zinc: physiological functions and pathological effects","volume":"14","author":"Frederickson","year":"2001","journal-title":"BioMetals"},{"key":"10.1016\/j.brainresrev.2009.09.003_bib64","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1038\/nrn1671","article-title":"The neurobiology of zinc in health and disease","volume":"6","author":"Frederickson","year":"2005","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib65","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.expneurol.2005.08.030","article-title":"Concentrations of extracellular free zinc (pZn)e in the central nervous system during simple anesthetization, ischemia and reperfusion","volume":"198","author":"Frederickson","year":"2006","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib66","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/0006-8993(90)90806-M","article-title":"Effects of dietary zinc status on seizure susceptibility and hippocampal zinc content in the El (epilepsy) mouse","volume":"529","author":"Fukahori","year":"1990","journal-title":"Brain Res"},{"key":"10.1016\/j.brainresrev.2009.09.003_bib67","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0955-2863(01)00220-0","article-title":"Decreased food intake rather than zinc deficiency is associated with changes in plasma leptin, metabolic rate, and activity levels in zinc deficient rats","volume":"13","author":"Gaetke","year":"2002","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib68","first-page":"E760","article-title":"Regulation of metallothionein concentrations in rat brain: effect of glucocorticoids, zinc, copper, and endotoxin","volume":"266","author":"Gasull","year":"1994","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib69","doi-asserted-by":"crossref","first-page":"614S","DOI":"10.1093\/ajcn\/85.2.614S","article-title":"Nutrition and the developing brain: nutrient priorities and measurement","volume":"85","author":"Georgieff","year":"2007","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib70","doi-asserted-by":"crossref","first-page":"2263","DOI":"10.1093\/jn\/125.suppl_8.2263S","article-title":"Developmental zinc deficiency and behavior","volume":"125","author":"Golub","year":"1995","journal-title":"J. Nutr."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib71","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.bbr.2004.05.013","article-title":"Effect of repeated corticosterone injections and restraint stress on anxiety and depression-like behavior in male rats","volume":"156","author":"Gregus","year":"2005","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib72","doi-asserted-by":"crossref","first-page":"2589","DOI":"10.1046\/j.1471-4159.1996.66062589.x","article-title":"Modulation of 45Ca2+ influx into cells stably expressing recombinant human NMDA receptors by ligands acting at distinct recognition sites","volume":"66","author":"Grimwood","year":"1996","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib73","doi-asserted-by":"crossref","first-page":"1344S","DOI":"10.1093\/jn\/130.5.1344S","article-title":"Human zinc deficiency","volume":"130","author":"Hambidge","year":"2000","journal-title":"J. Nutr."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib74","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1111\/j.1748-1716.1981.tb06920.x","article-title":"Extracellular ion concentrations during spreading depression and ischemia in the rat brain cortex","volume":"113","author":"Hansen","year":"1980","journal-title":"Acta Physiol. Scand."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib75","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/0165-6147(90)90116-P","article-title":"Excitatory amino acids and synaptic transmission: the evidence for a physiological function","volume":"11","author":"Headley","year":"1990","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib76","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1212\/WNL.33.10.1350","article-title":"Cerebrospinal fluid trace element content in dementia: clinical, radiologic, and pathologic correlations","volume":"33","author":"Hershey","year":"1983","journal-title":"Neurology"},{"key":"10.1016\/j.brainresrev.2009.09.003_bib77","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S0022-4731(83)80033-8","article-title":"The dexamethasone suppression test in depressed patients: clinical and biochemical aspects","volume":"19","author":"Holsboer","year":"1983","journal-title":"J. Steroid Biochem."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib78","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0079-6123(07)00008-8","article-title":"Synaptic plasticity in learning and memory: stress effects in the hippocampus","volume":"169","author":"Howland","year":"2008","journal-title":"Prog. Brain Res."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib79","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1007\/BF00965899","article-title":"The selective inhibition of hippocampal glutamic acid decarboxylase in zinc-induced epileptic seizures","volume":"7","author":"Itoh","year":"1982","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib80","doi-asserted-by":"crossref","first-page":"7181","DOI":"10.1523\/JNEUROSCI.1258-06.2006","article-title":"Zinc modulates bidirectional hippocampal plasticity by effects on NMDA receptors","volume":"26","author":"Izumi","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib81","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.brainres.2007.02.080","article-title":"Chronic food restriction in young rats results in depression- and anxiety-like behaviors with decreased expression of serotonin reuptake transporter","volume":"30","author":"Jahng","year":"2007","journal-title":"Brain Res."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib82","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1113\/jphysiol.2002.020172","article-title":"Zn2+ currents are mediated by calcium-permeable AMPA\/kainite channels in cultured murine hippocampal neurons","volume":"543","author":"Jia","year":"2002","journal-title":"J. Physiol. (Lond.)"},{"key":"10.1016\/j.brainresrev.2009.09.003_bib83","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1002\/bies.20718","article-title":"The blood\u2013CSF barrier explained: when development is not immaturity","volume":"30","author":"Johansson","year":"2008","journal-title":"BioEssays."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib84","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.bbr.2005.11.019","article-title":"Effect of different doses of corticosterone on depression-like behavior and HPA axis responses to a novel stressor","volume":"168","author":"Johnson","year":"2006","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib85","doi-asserted-by":"crossref","first-page":"6847","DOI":"10.1523\/JNEUROSCI.23-17-06847.2003","article-title":"Evidence for chelatable zinc in the extracellular space of the hippocampus, but little evidence for synaptic release of Zn","volume":"23","author":"Kay","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib86","doi-asserted-by":"crossref","first-page":"8527","DOI":"10.1073\/pnas.89.18.8527","article-title":"Hippocampal glucocorticoid receptor activation enhances voltage-dependent Ca2+ conductances: relevance to brain aging","volume":"89","author":"Kerr","year":"1992","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib87","doi-asserted-by":"crossref","first-page":"1360S","DOI":"10.1093\/jn\/130.5.1360S","article-title":"Zinc homeostasis in humans","volume":"130","author":"King","year":"2000","journal-title":"J. Nutr."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib88","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1093\/jn\/132.5.974","article-title":"Apoptosis plays a distinct role in the loss of precursor lymphocytes during zinc deficiency in mice","volume":"132","author":"King","year":"2002","journal-title":"J. Nutr."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib89","doi-asserted-by":"crossref","first-page":"15218","DOI":"10.1073\/pnas.0607131103","article-title":"Synaptically released zinc gates long-term potentiation in fear conditioning pathways","volume":"103","author":"Kodirov","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib90","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1126\/science.272.5264.1013","article-title":"The role of zinc in selective neuronal death after transient global cerebral ischemia","volume":"272","author":"Koh","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.brainresrev.2009.09.003_bib91","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.abb.2007.02.017","article-title":"The zinc\/thiolate redox biochemistry of metallothionein and the control of zinc ion fluctuations in cell signaling","volume":"463","author":"Krezel","year":"2007","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib92","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1126\/science.6494926","article-title":"Prolonged Ca2+-dependent afterhyperpolarizations in hippocampal neurons of aged rats","volume":"226","author":"Landfield","year":"1984","journal-title":"Science"},{"key":"10.1016\/j.brainresrev.2009.09.003_bib93","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0306-4522(02)00570-5","article-title":"Lack of vesicular zinc in mossy fibers does not affect synaptic excitability of CA3 pyramidal cells in zinc transporter 3 knockout mice","volume":"116","author":"Lopantsev","year":"2003","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainresrev.2009.09.003_bib94","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1034\/j.1399-5618.2002.01144.x","article-title":"Stress and depression: possible links to neuron death in the hippocampus","volume":"4","author":"Lee","year":"2002","journal-title":"Bipolar Disord."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib95","doi-asserted-by":"crossref","first-page":"A7","DOI":"10.1038\/399a007","article-title":"The changing landscape of ischaemic brain injury mechanisms","volume":"399","author":"Lee","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.brainresrev.2009.09.003_bib96","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1301\/nr.2003.jul.247-249","article-title":"Zinc regulation of food intake: new insights on the role of neuropeptide Y","volume":"61","author":"Levenson","year":"2003","journal-title":"Nutr. Rev."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib97","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1111\/j.1753-4887.2006.tb00171.x","article-title":"Zinc: the new antidepressant?","volume":"64","author":"Levenson","year":"2006","journal-title":"Nutr. Rev."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib98","doi-asserted-by":"crossref","first-page":"8015","DOI":"10.1523\/JNEUROSCI.21-20-08015.2001","article-title":"Induction of mossy fiber\u2192CA3 long-term potentiation requires translocation of synaptically released Zn2+","volume":"21","author":"Li","year":"2001","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib99","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1056\/NEJM199403033300907","article-title":"Excitatory amino acids as a final common pathway for neurologic disorders","volume":"330","author":"Lipton","year":"1994","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib100","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1002\/1098-2396(200011)38:2<187::AID-SYN10>3.0.CO;2-R","article-title":"Endogenous Zn(2+) is required for the induction of long-term potentiation at rat hippocampal mossy fiber-CA3 synapses","volume":"38","author":"Lu","year":"2000","journal-title":"Synapse"},{"key":"10.1016\/j.brainresrev.2009.09.003_bib101","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/0165-0327(94)90117-1","article-title":"Hypozincemia in depression","volume":"31","author":"Maes","year":"1994","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib102","doi-asserted-by":"crossref","first-page":"2304","DOI":"10.1242\/jeb.02208","article-title":"Neuron\u2013glia metabolic coupling and plasticity","volume":"209","author":"Magistretti","year":"2006","journal-title":"J. Exp. Biol."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib103","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1007\/s10522-006-9048-4","article-title":"Zinc status, psychological and nutritional assessment in old people recruited in five European countries: Zincage study","volume":"7","author":"Marcellini","year":"2006","journal-title":"Biogerontology"},{"key":"10.1016\/j.brainresrev.2009.09.003_bib104","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cccn.2003.12.008","article-title":"Peripheral markers of blood\u2013brain barrier damage","volume":"342","author":"Marchi","year":"2004","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.brainresrev.2009.09.003_bib105","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1089\/ars.2006.8.1419","article-title":"Zinc coordination environments in proteins as redox sensors and signal transducers","volume":"8","author":"Maret","year":"2006","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib106","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/j.exger.2007.10.005","article-title":"Possible roles of zinc nutriture in the fetal origins of disease","volume":"43","author":"Maret","year":"2008","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib107","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/0197-4580(84)90081-2","article-title":"Brain trace element concentrations in aging","volume":"5","author":"Markesbery","year":"1984","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.brainresrev.2009.09.003_bib108","doi-asserted-by":"crossref","first-page":"3347","DOI":"10.1002\/jnr.21444","article-title":"The glutamate\u2013glutamine cycle is not stoichiometric: fates of glutamate in brain","volume":"85","author":"McKenna","year":"2007","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib109","doi-asserted-by":"crossref","first-page":"1007S","DOI":"10.1093\/jn\/130.4.1007S","article-title":"Glutamate as a neurotransmitter in the brain: review of physiology and pathology","volume":"130","author":"Meldrum","year":"2000","journal-title":"J. Nutr."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib110","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1002\/jnr.20714","article-title":"Inhibition of presynaptic activity by zinc released from mossy fiber terminals during tetanic stimulation","volume":"83","author":"Minami","year":"2006","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib111","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.pneurobio.2005.04.005","article-title":"Brain, aging and neurodegeneration: role of zinc ion availability","volume":"75","author":"Mocchegiani","year":"2005","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib112","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1016\/S0140-6736(96)07492-2","article-title":"Alternative projections of mortality and disability by cause 1990-2020: global burden of disease study","volume":"349","author":"Murray","year":"1997","journal-title":"Lancet"},{"key":"10.1016\/j.brainresrev.2009.09.003_bib113","doi-asserted-by":"crossref","first-page":"13995","DOI":"10.1523\/JNEUROSCI.4645-08.2008","article-title":"Enhanced plasticity in zincergic, cortical circuits after exposure to enriched environments","volume":"28","author":"Nakashima","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib114","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.brainresrev.2008.10.003","article-title":"Zinc and cortical plasticity","volume":"59","author":"Nakashima","year":"2009","journal-title":"Brain Res. Rev."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib115","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.2460\/javma.1984.184.12.1480","article-title":"Zinc deficiency in sheep and goats: three field cases","volume":"184","author":"Nelson","year":"1984","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib116","doi-asserted-by":"crossref","first-page":"12230","DOI":"10.1073\/pnas.0505408102","article-title":"Blockade of calcium-permeable AMPA receptors protects hippocampal neurons against global ischemia-induced death","volume":"102","author":"Noh","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib117","first-page":"713","article-title":"Zinc and depression. An update","volume":"57","author":"Nowak","year":"2005","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib118","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0301-0082(96)00049-4","article-title":"Altered glutamatergic transmission in neurological disorders: from high extracellular glutamate to excessive synaptic efficacy","volume":"51","author":"Obrenovitch","year":"1997","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib119","doi-asserted-by":"crossref","first-page":"611","DOI":"10.3945\/jn.108.096370","article-title":"Orally administered zinc increases food intake via vagal stimulation in rats","volume":"139","author":"Ohinata","year":"2009","journal-title":"J. Nutr."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib120","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1007\/s00424-003-1070-7","article-title":"Efflux and compartmentalization of zinc by members of the SLC30 family of solute carriers","volume":"447","author":"Palmiter","year":"2004","journal-title":"Pflugers Arch."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib121","doi-asserted-by":"crossref","first-page":"14934","DOI":"10.1073\/pnas.93.25.14934","article-title":"ZnT-3, a putative transporter of zinc into synaptic vesicles","volume":"93","author":"Palmiter","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib122","doi-asserted-by":"crossref","first-page":"5711","DOI":"10.1523\/JNEUROSCI.17-15-05711.1997","article-title":"High-affinity zinc inhibition of NMDA NR1\u2013NR2A receptors","volume":"17","author":"Paoletti","year":"1997","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib123","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1002\/hipo.450030210","article-title":"Effects of glucocorticoids on hippocampal long-term potentiation","volume":"3","author":"Pavlides","year":"1993","journal-title":"Hippocampus"},{"key":"10.1016\/j.brainresrev.2009.09.003_bib124","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.1002\/glia.20528","article-title":"Activity-dependent regulation of energy metabolism by astrocytes: an update","volume":"55","author":"Pellerin","year":"2007","journal-title":"Glia"},{"key":"10.1016\/j.brainresrev.2009.09.003_bib125","doi-asserted-by":"crossref","first-page":"361S","DOI":"10.1093\/jn\/130.2.361S","article-title":"Behavioral data and methodology issues in studies of zinc nutrition in humans","volume":"130","author":"Penland","year":"2000","journal-title":"J. Nutr."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib126","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1080\/07315724.1997.10718684","article-title":"A preliminary report: effects of zinc and micronutrient repletion on growth and neuropsychological function of urban Chinese children","volume":"16","author":"Penland","year":"1997","journal-title":"J. Am. Coll. Nutr."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib127","doi-asserted-by":"crossref","first-page":"353","DOI":"10.2119\/2008-00033.Prasad","article-title":"Zinc in human health: effect of zinc on immune cells","volume":"14","author":"Prasad","year":"2008","journal-title":"Mol. Med."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib128","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1111\/j.1471-4159.2008.05700.x","article-title":"Mechanisms of Zn2+ efflux in cultured cortical neurons","volume":"107","author":"Qin","year":"2008","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib129","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.brainres.2004.01.013","article-title":"Hippocampal mossy fiber calcium transients are maintained during long-term potentiation and are inhibited by endogenous zinc","volume":"1004","author":"Quinta-Ferreira","year":"2004","journal-title":"Brain Res."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib130","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainres.2005.04.006","article-title":"Tetanically released zinc inhibits hippocampal mossy fiber calcium, zinc and synaptic responses","volume":"1047","author":"Quinta-Ferreira","year":"2005","journal-title":"Brain Res."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib131","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/0896-6273(90)90199-P","article-title":"Zinc has opposite effects on NMDA and non-NMDA receptors expressed in Xenopus oocytes","volume":"4","author":"Rassendren","year":"1990","journal-title":"Neuron"},{"key":"10.1016\/j.brainresrev.2009.09.003_bib132","doi-asserted-by":"crossref","first-page":"470S","DOI":"10.1093\/ajcn\/68.2.470S","article-title":"Effects of repletion with zinc and other micronutrients on neuropsychologic performance and growth of Chinese children","volume":"68","author":"Sandstead","year":"1998","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib133","doi-asserted-by":"crossref","first-page":"496S","DOI":"10.1093\/jn\/130.2.496S","article-title":"History of zinc as related to brain function","volume":"130","author":"Sandstead","year":"2000","journal-title":"J. Nutr."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib134","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1007\/PL00007533","article-title":"Basal activity of the hypothalamic\u2013pituitary\u2013adrenal axis and cognitive function in anorexia nervosa","volume":"250","author":"Seed","year":"2000","journal-title":"Eur. Arch. Psychiatry Clin. Neurosci."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib135","doi-asserted-by":"crossref","first-page":"87","DOI":"10.2174\/1566524043479211","article-title":"Rethinking the excitotoxic ionic milieu: the emerging role of Zn(2+) in ischemic neuronal injury","volume":"4","author":"Sensi","year":"2004","journal-title":"Curr. Mol. Med."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib136","doi-asserted-by":"crossref","first-page":"9554","DOI":"10.1523\/JNEUROSCI.17-24-09554.1997","article-title":"Measurement of intracellular free zinc in living cortical neurons: routes of entry","volume":"15","author":"Sensi","year":"1997","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib137","doi-asserted-by":"crossref","first-page":"6157","DOI":"10.1073\/pnas.1031598100","article-title":"Modulation of mitochondrial function by endogenous Zn2+ pools","volume":"100","author":"Sensi","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib138","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1111\/j.1528-1157.1985.tb05398.x","article-title":"A review of mouse mutants as genetic models of epilepsy","volume":"26","author":"Seyfried","year":"1985","journal-title":"Epilepsia"},{"issue":"5S Suppl","key":"10.1016\/j.brainresrev.2009.09.003_bib139","doi-asserted-by":"crossref","first-page":"1493S","DOI":"10.1093\/jn\/130.5.1493S","article-title":"Neurobiology of zinc-influenced eating behavior","volume":"130","author":"Shay","year":"2000","journal-title":"J. Nutr."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib140","doi-asserted-by":"crossref","first-page":"3908","DOI":"10.1073\/pnas.93.9.3908","article-title":"Hippocampal atrophy in recurrent major depression","volume":"93","author":"Sheline","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib141","doi-asserted-by":"crossref","first-page":"5034","DOI":"10.1523\/JNEUROSCI.19-12-05034.1999","article-title":"Depression duration but not age predicts hippocampal volume loss in medically healthy women with recurrent major depression","volume":"19","author":"Sheline","year":"1999","journal-title":"J. Neurosci."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib142","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/S0092-8674(02)01116-9","article-title":"Identification of a signaling network in lateral nucleus of amygdala important for inhibiting memory specifically related to learned fear","volume":"111","author":"Shumyatsky","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.brainresrev.2009.09.003_bib143","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/0301-0082(94)90082-5","article-title":"Modulation of inhibitory and excitatory amino acid receptor ion channels by zinc","volume":"42","author":"Smart","year":"1994","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib144","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1007\/s00702-008-0115-7","article-title":"Antidepressant-like activity of zinc: further behavioral and molecular evidence","volume":"115","author":"Sowa-Ku\u0107ma","year":"2008","journal-title":"J. Neural. Transm."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib145","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1016\/0006-3223(92)90079-F","article-title":"Hippocampal formation volume, memory dysfunction, and cortisol levels in patients with Cushing's syndrome","volume":"32","author":"Starkman","year":"1992","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.brainresrev.2009.09.003_bib146","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.1111\/j.1471-4159.1992.tb10047.x","article-title":"Glucocorticoids exacerbate kainic acid-induced extracellular accumulation of excitatory amino acids in the rat hippocampus","volume":"58","author":"Stein-Behrens","year":"1992","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib147","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/0006-8993(86)90045-4","article-title":"Kindled seizure induction alters and is altered by zinc absorption","volume":"383","author":"Sterman","year":"1986","journal-title":"Brain Res."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib148","series-title":"Nutritional modulation of neural function","first-page":"307","article-title":"Zinc and seizure mechanisms","author":"Sterman","year":"1988"},{"key":"10.1016\/j.brainresrev.2009.09.003_bib149","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.neuroscience.2007.09.025","article-title":"Amyloid plaques arise from zinc-enriched cortical layers in APP\/PS1 transgenic mice and are paradoxically enlarged with dietary zinc deficiency","volume":"150","author":"Stoltenberg","year":"2007","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainresrev.2009.09.003_bib150","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1172\/JCI30077","article-title":"Hypoglycemic neuronal death is triggered by glucose reperfusion and activation of neuronal NADPH oxidase","volume":"117","author":"Suh","year":"2007","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib151","doi-asserted-by":"crossref","unstructured":"Suh, S.W., Won, S.J., Hamby, A.M., Fan, Y., Sheline, C.T., Tamano, H., Takeda, A., Liu, J., 2009. Decreased brain zinc availability reduces hippocampal neurogenesis in mice and rats. J. Cereb. Blood Flow Metab. 29, 1579\u20131588.","DOI":"10.1038\/jcbfm.2009.80"},{"key":"10.1016\/j.brainresrev.2009.09.003_bib152","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1016\/0166-2236(94)90040-X","article-title":"Triggering and execution of neuronal death in brain ischaemia: two phases of glutamate release by different mechanisms","volume":"17","author":"Szatkowski","year":"1994","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib153","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0165-0173(00)00044-8","article-title":"Movement of zinc and its functional significance in the brain","volume":"34","author":"Takeda","year":"2000","journal-title":"Brain Res. Rev."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib154","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1023\/A:1012982123386","article-title":"Zinc homeostasis and functions of zinc in the brain","volume":"14","author":"Takeda","year":"2001","journal-title":"BioMetals"},{"key":"10.1016\/j.brainresrev.2009.09.003_bib155","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1248\/yakushi.124.577","article-title":"Essential trace metals and brain function","volume":"124","author":"Takeda","year":"2004","journal-title":"Yakugaku Zasshi"},{"key":"10.1016\/j.brainresrev.2009.09.003_bib156","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/0006-8993(94)91891-0","article-title":"Brain uptake of trace metals, zinc and manganese, in rats","volume":"640","author":"Takeda","year":"1994","journal-title":"Brain Res."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib157","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/S0006-8993(09)90032-4","article-title":"Localization in rat brain of the trace metals, zinc and manganese, after intracerebroventricular injection","volume":"658","author":"Takeda","year":"1994","journal-title":"Brain Res."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib158","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/0006-8993(95)00916-E","article-title":"Biological half-lives of zinc and manganese in rat brain","volume":"695","author":"Takeda","year":"1995","journal-title":"Brain Res."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib159","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/S0006-8993(00)02027-8","article-title":"Relationship between brain zinc and transient learning impairment of adult rats fed zinc-deficient diet","volume":"859","author":"Takeda","year":"2000","journal-title":"Brain Res."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib160","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1002\/1097-4547(20010301)63:5<447::AID-JNR1040>3.0.CO;2-C","article-title":"Zinc homeostasis in the brain of adult rats fed zinc-deficient diet","volume":"63","author":"Takeda","year":"2001","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib161","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1002\/jnr.10600","article-title":"Release of glutamate and GABA in the hippocampus under zinc deficiency","volume":"72","author":"Takeda","year":"2003","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib162","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1046\/j.1471-4159.2003.01803.x","article-title":"Susceptibility to kainate-induced seizures under dietary zinc deficiency","volume":"85","author":"Takeda","year":"2003","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib163","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S0920-1211(03)00063-9","article-title":"Zinc movement in the brain under kainite-induced seizures","volume":"54","author":"Takeda","year":"2003","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib164","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.eplepsyres.2003.11.003","article-title":"Inhibitory function of zinc against excitation of hippocampal glutamatergic neurons","volume":"57","author":"Takeda","year":"2003","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib201","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1002\/jnr.10846","article-title":"Differential effects of zinc on glutamatergic and GABAergic neurotransmitter systems in the hippocampus","volume":"75","author":"Takeda","year":"2004","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib165","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.neuint.2004.10.003","article-title":"Zinc homeostasis in the hippocampus of zinc-deficient young adult rats","volume":"46","author":"Takeda","year":"2005","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib166","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.eplepsyres.2005.07.011","article-title":"Involvement of unusual glutamate release in kainate-induced seizures in zinc-deficient adult rats","volume":"66","author":"Takeda","year":"2005","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib167","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/j.neuint.2005.07.009","article-title":"Increase in hippocampal cell death after treatment with kainate in zinc deficiency","volume":"47","author":"Takeda","year":"2005","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib168","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1007\/s10534-005-6145-9","article-title":"Responsiveness to kainate in young rats after 2-week zinc deprivation","volume":"19","author":"Takeda","year":"2006","journal-title":"BioMetals"},{"key":"10.1016\/j.brainresrev.2009.09.003_bib169","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1016\/j.neuint.2006.06.005","article-title":"Impairment of GABAergic neurotransmitter system in the amygdala of young rats after 4-week zinc deprivation","volume":"49","author":"Takeda","year":"2006","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib170","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbr.2006.11.023","article-title":"Anxiety-like behavior of young rats after 2-week zinc deprivation","volume":"177","author":"Takeda","year":"2007","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib171","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1002\/jnr.21233","article-title":"Role of zinc influx via AMPA\/kainate receptor activation in metabotropic glutamate receptor-mediated calcium release","volume":"85","author":"Takeda","year":"2007","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib172","doi-asserted-by":"crossref","first-page":"3666","DOI":"10.1002\/jnr.21449","article-title":"Negative modulation of presynaptic activity by zinc released from Schaffer collaterals","volume":"85","author":"Takeda","year":"2007","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib173","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/j.neuint.2006.08.015","article-title":"Response of hippocampal mossy fiber zinc to excessive glutamate release","volume":"50","author":"Takeda","year":"2007","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib174","doi-asserted-by":"crossref","first-page":"2909","DOI":"10.1002\/jnr.21732","article-title":"Attenuation of hippocampal mossy fiber long-term potentiation by low micromolar concentrations of zinc","volume":"86","author":"Takeda","year":"2008","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib175","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/j.lfs.2008.02.005","article-title":"Enhancement of social isolation-induced aggressive behavior of young mice by zinc deficiency","volume":"82","author":"Takeda","year":"2008","journal-title":"Life Sci."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib176","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.neuint.2007.06.021","article-title":"Hippocampal calcium dyshomeostasis and long-term potentiation in 2-week zinc deficiency","volume":"52","author":"Takeda","year":"2008","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib177","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.neuint.2008.07.009","article-title":"Attenuation of abnormal glutamate release in zinc deficiency by zinc and Yokukansan","volume":"53","author":"Takeda","year":"2008","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib178","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.neuroscience.2008.10.009","article-title":"Positive modulation of long-term potentiation at hippocampal CA1 synapses by low micromolar concentrations of zinc","volume":"158","author":"Takeda","year":"2009","journal-title":"Neuroscience"},{"key":"10.1016\/j.brainresrev.2009.09.003_bib179","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.eplepsyres.2008.09.009","article-title":"Abnormal calcium mobilization in hippocampal slices of epileptic animals fed a zinc-deficient diet","volume":"83","author":"Takeda","year":"2009","journal-title":"Epilepsy Res."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib180","doi-asserted-by":"crossref","unstructured":"Tamano, H., Kan, F., Kawamura, M., Oku, N., Takeda, A., 2009. Behavior in the forced swim test and neurochemical changes in the hippocampus in young rats after 2-week zinc deprivation. Neurochem. Int. 55, 536\u2013541.","DOI":"10.1016\/j.neuint.2009.05.011"},{"key":"10.1016\/j.brainresrev.2009.09.003_bib181","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.physbeh.2008.06.017","article-title":"Zinc deficiency induces depression-like symptoms in adult rats","volume":"95","author":"Tassabehji","year":"2008","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib182","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1002\/cne.21071","article-title":"Synapse loss from chronically elevated glucocorticoids: relationship to neuropil volume and cell number in hippocampal area CA3","volume":"498","author":"Tata","year":"2006","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib183","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1054\/npep.2002.0897","article-title":"Diverse functions of neuropeptide Y revealed using genetically modified animals","volume":"36","author":"Thorsell","year":"2002","journal-title":"Neuropeptides"},{"key":"10.1016\/j.brainresrev.2009.09.003_bib184","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1083\/jcb.200204066","article-title":"Mossy fiber Zn2+ spillover modulates heterosynaptic N-methyl-d-aspartate receptor activity in hippocampal CA3 circuits","volume":"158","author":"Ueno","year":"2002","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib185","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1006\/mcne.2002.1159","article-title":"Developmental expression of ZnT3 in mouse brain: correlation between the vesicular zinc transporter protein and chelatable vesicular zinc (CVZ) cells. Glial and neuronal CVZ cells interact","volume":"21","author":"Valente","year":"2002","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib186","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1006\/exnr.2002.7876","article-title":"Postnatal development of zinc-rich terminal fields in the brain of the rat","volume":"174","author":"Valente","year":"2002","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib187","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1152\/physrev.1993.73.1.79","article-title":"The biological basis of zinc physiology","volume":"73","author":"Vallee","year":"1993","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib188","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0896-6273(00)81149-6","article-title":"The actions of synaptically released zinc at hippocampal mossy fiber synapses","volume":"26","author":"Vogt","year":"2000","journal-title":"Neuron"},{"key":"10.1016\/j.brainresrev.2009.09.003_bib189","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/S0896-6273(02)01170-4","article-title":"Glial glutamate transporters mediate a functional metabolic crosstalk between neurons and astrocytes in the mouse developing cortex","volume":"37","author":"Voutsinos-Porche","year":"2003","journal-title":"Neuron"},{"key":"10.1016\/j.brainresrev.2009.09.003_bib190","first-page":"65","article-title":"Zinc and brain function","volume":"380","author":"Wallwork","year":"1993","journal-title":"Prog. Clin. Biol. Res."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib191","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/S0031-9384(97)88988-3","article-title":"Elevated blood copper\/zinc ratios in assaultive young males","volume":"62","author":"Walsh","year":"1997","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib192","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/S0165-6147(00)01541-8","article-title":"Zn(2+): a novel ionic mediator of neural injury in brain disease","volume":"21","author":"Weiss","year":"2000","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib193","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1038\/328640a0","article-title":"Micromolar concentrations of Zn2+ antagonize NMDA and GABA responses of hippocampal neurons","volume":"328","author":"Westbrook","year":"1987","journal-title":"Nature"},{"key":"10.1016\/j.brainresrev.2009.09.003_bib194","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1016\/0006-3223(87)90013-8","article-title":"The effect of age on baseline and postdexamethasone cortisol levels in major depressive disorder","volume":"22","author":"Whiteford","year":"1987","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.brainresrev.2009.09.003_bib195","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1007\/s00726-008-0195-6","article-title":"Zinc deficiency induces enhanced depression-like behaviour and altered limbic activation reversed by antidepressant treatment in mice","volume":"36","author":"Whittle","year":"2009","journal-title":"Amino Acids"},{"key":"10.1016\/j.brainresrev.2009.09.003_bib196","doi-asserted-by":"crossref","first-page":"2868","DOI":"10.1210\/en.140.6.2868","article-title":"Daily changes in hypothalamic gene expression of neuropeptide Y, galanin, proopiomelanocortin, and adipocyte leptin gene expression and secretion: effects of food restriction","volume":"140","author":"Xu","year":"1999","journal-title":"Endocrinology"},{"key":"10.1016\/j.brainresrev.2009.09.003_bib197","doi-asserted-by":"crossref","first-page":"223","DOI":"10.3233\/JAD-2006-102-309","article-title":"Blood\u2013brain barrier flux of aluminum, manganese, iron and other metals suspected to contribute to metal-induced neurodegeneration","volume":"10","author":"Yokel","year":"2006","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.brainresrev.2009.09.003_bib198","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.ejphar.2007.12.005","article-title":"A mouse model of depression induced by repeated corticosterone injections","volume":"581","author":"Zhao","year":"2008","journal-title":"Eur. J. Pharmacol."}],"container-title":["Brain Research Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016501730900085X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016501730900085X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,12]],"date-time":"2025-02-12T03:13:25Z","timestamp":1739330005000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S016501730900085X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,12]]},"references-count":200,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2009,12]]}},"alternative-id":["S016501730900085X"],"URL":"https:\/\/doi.org\/10.1016\/j.brainresrev.2009.09.003","relation":{},"ISSN":["0165-0173"],"issn-type":[{"value":"0165-0173","type":"print"}],"subject":[],"published":{"date-parts":[[2009,12]]}}}