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Lett."},{"key":"10.1016\/j.brainresrev.2011.02.001_bb0620","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S0304-3940(02)00415-9","article-title":"Alpha-lipoic acid prevents ethanol-induced protein oxidation in mouse hippocampal HT22 cells","volume":"328","author":"Pirlich","year":"2002","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.brainresrev.2011.02.001_bb0625","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.tox.2005.06.020","article-title":"Effects of silymarin flavonolignans and synthetic silybin derivatives on estrogen and aryl hydrocarbon receptor activation","volume":"215","author":"Pliskova","year":"2005","journal-title":"Toxicology"},{"key":"10.1016\/j.brainresrev.2011.02.001_bb0630","doi-asserted-by":"crossref","first-page":"462","DOI":"10.5694\/j.1326-5377.1984.tb108163.x","article-title":"The brain: seat of motor control. 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J."},{"key":"10.1016\/j.brainresrev.2011.02.001_bb0645","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1111\/j.1530-0277.2001.tb02292.x","article-title":"In utero ethanol exposure causes mitochondrial dysfunction, which can result in apoptotic cell death in fetal brain: a potential role for 4-hydroxynonenal","volume":"25","author":"Ramachandran","year":"2001","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.brainresrev.2011.02.001_bb0650","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1002\/jnr.10767","article-title":"Ethanol-induced oxidative stress precedes mitochondrially mediated apoptotic death of cultured fetal cortical neurons","volume":"74","author":"Ramachandran","year":"2003","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.brainresrev.2011.02.001_bb0655","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1083\/jcb.133.2.381","article-title":"Alcohol inhibits cell-cell adhesion mediated by human L1","volume":"133","author":"Ramanathan","year":"1996","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.brainresrev.2011.02.001_bb0660","first-page":"977","article-title":"Dose response of ethanol ingestion on antioxidant defense system in rat brain subcellular fractions","volume":"20","author":"Reddy","year":"1999","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.brainresrev.2011.02.001_bb0665","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1055\/s-1999-14085","article-title":"Prevention by a silymarin\/phospholipid compound of ethanol-induced social learning deficits in rats","volume":"65","author":"Reid","year":"1999","journal-title":"Planta Med."},{"key":"10.1016\/j.brainresrev.2011.02.001_bb0670","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1111\/j.1530-0277.1993.tb00857.x","article-title":"Effects of in utero administration of alcohol on glutathione levels in brain and liver","volume":"17","author":"Reyes","year":"1993","journal-title":"Alcohol. Clin. Exp. 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(Phila)"},{"key":"10.1016\/j.brainresrev.2011.02.001_bb0810","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1006\/abbi.1999.1477","article-title":"Cytochrome P4502E (CYP2E) in brain: constitutive expression, induction by ethanol and localization by fluorescence in situ hybridization","volume":"373","author":"Upadhya","year":"2000","journal-title":"Arch. Biochem. 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