{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T16:51:10Z","timestamp":1787849470859,"version":"build-2784847793"},"reference-count":118,"publisher":"Elsevier BV","issue":"1-2","license":[{"start":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T00:00:00Z","timestamp":1306886400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Brain Research Reviews"],"published-print":{"date-parts":[[2011,6]]},"DOI":"10.1016\/j.brainresrev.2011.04.003","type":"journal-article","created":{"date-parts":[[2011,4,30]],"date-time":"2011-04-30T21:57:26Z","timestamp":1304200646000},"page":"344-355","source":"Crossref","is-referenced-by-count":30,"title":["Late-life depression and Alzheimer's disease: The glutamatergic system inside of this mirror relationship"],"prefix":"10.1016","volume":"67","author":[{"given":"Vincenza","family":"Frisardi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Panza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akhlaq A.","family":"Farooqui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.brainresrev.2011.04.003_bb0005","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1016\/S0887-8994(01)00383-6","article-title":"Decrease in neuron size in docosahexaenoic acid-deficient brain","volume":"26","author":"Ahmad","year":"2002","journal-title":"Pediatr. Neurol."},{"key":"10.1016\/j.brainresrev.2011.04.003_bb0010","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1001\/archneur.65.11.1509","article-title":"Frequent amyloid deposition without significant cognitive impairment among the elderly","volume":"65","author":"Aizenstein","year":"2008","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.brainresrev.2011.04.003_bb0015","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1176\/ajp.150.11.1693","article-title":"The course of geriatric depression with \u201creversible dementia\u201d: a controlled study","volume":"150","author":"Alexopoulos","year":"1993","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.brainresrev.2011.04.003_bb0020","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1176\/ajp.150.11.1731","article-title":"Plasma and platelet excitatory amino acids in psychiatric disorders","volume":"150","author":"Altamura","year":"1993","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.brainresrev.2011.04.003_bb0025","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.jalz.2010.01.009","article-title":"Alzheimer's disease facts and figures","volume":"6","author":"Alzheimer's Association","year":"2010","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.brainresrev.2011.04.003_bb0030","article-title":"Diagnostic and Statistical Manual of Mental Disorders","author":"American Psychiatric Association Committee on Nomenclature and Statistics","year":"1994"},{"key":"10.1016\/j.brainresrev.2011.04.003_bb0035","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1023\/A:1025063811290","article-title":"Plasticity of glutamate and GABAA receptors in the hippocampus of patients with Alzheimer's disease","volume":"23","author":"Armstrong","year":"2003","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.brainresrev.2011.04.003_bb0040","series-title":"Wiley Encyclopedia of Chemical Biology","first-page":"460","article-title":"Depression: clinical mechanisms","author":"Baker","year":"2009"},{"key":"10.1016\/j.brainresrev.2011.04.003_bb0045","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1111\/j.1471-4159.2007.04487.x","article-title":"Glutamate release from activated microglia requires the oxidative burst and lipid peroxidation","volume":"101","author":"Barger","year":"2007","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainresrev.2011.04.003_bb0050","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.nbd.2010.03.020","article-title":"Depression-like phenotype following chronic CB1 receptor antagonism","volume":"39","author":"Beyer","year":"2010","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.brainresrev.2011.04.003_bb0055","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1017\/S1461145707007924","article-title":"Low GABA concentrations in occipital cortex and anterior cingulate cortex in medication-free, recovered depressed patients","volume":"11","author":"Bhagwagar","year":"2008","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.brainresrev.2011.04.003_bb0060","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1016\/j.neurobiolaging.2007.11.023","article-title":"Role of BDNF Val66Met functional polymorphism in Alzheimer's disease-related depression","volume":"30","author":"Borroni","year":"2009","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.brainresrev.2011.04.003_bb0065","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/S0028-3908(03)00048-0","article-title":"Metabotropic glutamate receptor 5 antagonist-induced stimulation of hypothalamic-pituitary-adrenal axis activity: interaction with serotonergic systems","volume":"44","author":"Bradbury","year":"2003","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.brainresrev.2011.04.003_bb0070","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.jalz.2007.04.381","article-title":"Forecasting the global burden of Alzheimer's disease","volume":"3","author":"Brookmeyer","year":"2007","journal-title":"Alzheimers Dement."},{"key":"10.1016\/j.brainresrev.2011.04.003_bb0075","doi-asserted-by":"crossref","first-page":"345","DOI":"10.31887\/DCNS.2008.10.3\/mabutters","article-title":"Pathways linking late-life depression to persistent cognitive impairment and dementia","volume":"10","author":"Butters","year":"2008","journal-title":"Dialogues Clin. Neurosci."},{"key":"10.1016\/j.brainresrev.2011.04.003_bb0080","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1111\/j.1471-4159.2009.06335.x","article-title":"Docosahexaenoic acid promotes hippocampal neuronal development and synaptic function","volume":"111","author":"Cao","year":"2009","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainresrev.2011.04.003_bb0085","doi-asserted-by":"crossref","first-page":"S29","DOI":"10.1097\/01.psy.0000162254.61556.d5","article-title":"Depression, the autonomic nervous system, and coronary heart disease","volume":"67","author":"Carney","year":"2005","journal-title":"Psychosom. Med."},{"key":"10.1016\/j.brainresrev.2011.04.003_bb0090","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1046\/j.1471-4159.2000.0750889.x","article-title":"Regulation of neurotransmitter release by metabotropic glutamate receptors","volume":"75","author":"Cartmell","year":"2000","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainresrev.2011.04.003_bb0095","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1126\/science.1083968","article-title":"Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene","volume":"301","author":"Caspi","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.brainresrev.2011.04.003_bb0100","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2174\/157488906775245318","article-title":"Non-monoamine-based approach for the treatment of depression and anxiety disorders","volume":"1","author":"Chaki","year":"2006","journal-title":"Recent Patents C. N. S. Drug Discov."},{"key":"10.1016\/j.brainresrev.2011.04.003_bb0105","doi-asserted-by":"crossref","first-page":"15653","DOI":"10.1073\/pnas.0507901102","article-title":"Altered cortical glutamatergic and GABAergic signal transmission with glial involvement in depression","volume":"102","author":"Choudary","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.brainresrev.2011.04.003_bb0110","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/0166-2236(95)93868-X","article-title":"Memories of NMDA receptors and LTP","volume":"18","author":"Collingridge","year":"1995","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.brainresrev.2011.04.003_bb0115","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/j.neuropharm.2009.12.004","article-title":"From synapse to nucleus: novel targets for treating depression","volume":"5","author":"Covington","year":"2010","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.brainresrev.2011.04.003_bb0120","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/S1054-3589(10)58016-5","article-title":"GABAB receptors and depression: current status","volume":"58","author":"Cryan","year":"2010","journal-title":"Adv. Pharmacol."},{"key":"10.1016\/j.brainresrev.2011.04.003_bb0125","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/S0889-1591(02)00005-3","article-title":"Questions raised by the cytokine hypothesis of depression","volume":"16","author":"de Beaurepaire","year":"2002","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.brainresrev.2011.04.003_bb0130","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1152\/physrev.00023.2009","article-title":"Proteases and proteolysis in Alzheimer disease: a multifactorial view on the disease process","volume":"90","author":"De Strooper","year":"2010","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.brainresrev.2011.04.003_bb0135","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/j.euroneuro.2008.05.003","article-title":"Cannabinoid receptor 1 (CNR1) gene: impact on antidepressant treatment response and emotion processing in major depression","volume":"18","author":"Domschke","year":"2008","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.brainresrev.2011.04.003_bb0140","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s00429-008-0189-x","article-title":"Brain structural and functional abnormalities in mood disorders: implications for neurocircuitry models of depression","volume":"213","author":"Drevets","year":"2008","journal-title":"Brain Struct. Funct."},{"key":"10.1016\/j.brainresrev.2011.04.003_bb0145","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1038\/sj.npp.1301178","article-title":"The anticonvulsants lamotrigine, riluzole, and valproate differentially regulate AMPA receptor membrane localization: relationship to clinical effects in mood disorders","volume":"32","author":"Du","year":"2006","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.brainresrev.2011.04.003_bb0150","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.neuropharm.2008.06.022","article-title":"Role of metabotropic glutamate receptors in the control of neuroendocrine function","volume":"55","author":"Durand","year":"2008","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.brainresrev.2011.04.003_bb0155","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1002\/(SICI)1096-9861(20000626)422:2<159::AID-CNE1>3.0.CO;2-1","article-title":"Localisation of cannabinoid receptors in the rat brain using antibodies to the intracellular C-terminal tail of CB(1)","volume":"422","author":"Egertova","year":"2000","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.brainresrev.2011.04.003_bb0160","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1016\/j.psyneuen.2009.04.011","article-title":"GluR5-mediated signalling reduces hypothalamo-pituitary-adrenocortical stress responses at the paraventricular nucleus and median eminence","volume":"34","author":"Evanson","year":"2009","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.brainresrev.2011.04.003_bb0165","series-title":"Hot Topics in Neural Membrane Lipidology","first-page":"173","article-title":"Excitotoxicity-mediated neurochemical changes in neurological disorders","author":"Farooqui","year":"2009"},{"key":"10.1016\/j.brainresrev.2011.04.003_bb0170","series-title":"Neurochemical Aspects of Neurotraumatic and Neurodegenerative Diseases","first-page":"249","article-title":"Neurochemical Aspects of Neurodegenerative diseases","author":"Farooqui","year":"2010"},{"key":"10.1016\/j.brainresrev.2011.04.003_bb0175","first-page":"208","article-title":"Elevated activities of lipases and lysophospholipases in Alzheimer's disease","volume":"1","author":"Farooqui","year":"1990","journal-title":"Dementia"},{"key":"10.1016\/j.brainresrev.2011.04.003_bb0180","series-title":"Neurochemical Aspects of Excitotoxicity","first-page":"37","article-title":"Multiplicity of glutamate receptors in brain","author":"Farooqui","year":"2008"},{"key":"10.1016\/j.brainresrev.2011.04.003_bb0185","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/S0006-3223(99)00092-X","article-title":"Essential fatty acids, lipid membrane abnormalities, and the diagnosis and treatment of schizophrenia","volume":"47","author":"Fenton","year":"2000","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.brainresrev.2011.04.003_bb0190","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1186\/1471-2377-10-87","article-title":"Behavioural symptoms in patients with Alzheimer's disease and their association with cognitive impairment","volume":"10","author":"Fern\u00e1ndez","year":"2010","journal-title":"BMC Neurol."},{"key":"10.1016\/j.brainresrev.2011.04.003_bb0195","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1111\/j.1476-5381.2008.00088.x","article-title":"The endocannabinoid system as a target for the treatment of motor dysfunction","volume":"156","author":"Fern\u00e1ndez-Ruiz","year":"2009","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.brainresrev.2011.04.003_bb0200","doi-asserted-by":"crossref","first-page":"715","DOI":"10.3233\/JAD-2010-100942","article-title":"Nutraceutical properties of mediterranean diet and cognitive decline: possible underlying mechanisms","volume":"22","author":"Frisardi","year":"2010","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.brainresrev.2011.04.003_bb0205","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.biopsych.2006.01.024","article-title":"Low cerebrospinal fluid glutamate and glycine in refractory affective disorder","volume":"61","author":"Frye","year":"2007","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.brainresrev.2011.04.003_bb0210","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1159\/000127022","article-title":"Stimulation of the amygdala by glutamate facilitates corticotropin-releasing factor release from the median eminence and activation of the hypothalamic-pituitary-adrenal axis in stressed rats","volume":"62","author":"Gabr","year":"1995","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.brainresrev.2011.04.003_bb0215","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1177\/1073858410361780","article-title":"Corticotropin-releasing hormone, glutamate, and \u03b3-aminobutyric acid in depression","volume":"17","author":"Gao","year":"2011","journal-title":"Neuroscientist"},{"key":"10.1016\/j.brainresrev.2011.04.003_bb0220","doi-asserted-by":"crossref","first-page":"3759","DOI":"10.1113\/jphysiol.2008.155655","article-title":"Synaptic integration and plasticity of new neurons in the adult hippocampus","volume":"586","author":"Ge","year":"2008","journal-title":"J. Physiol."},{"key":"10.1016\/j.brainresrev.2011.04.003_bb0225","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/S0006-3223(02)01480-4","article-title":"New insights into the role of cortisol and the glucocorticoid receptor in severe depression","volume":"52","author":"Gold","year":"2002","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.brainresrev.2011.04.003_bb0230","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1038\/nn1471","article-title":"Dopaminergic modulation of limbic and cortical drive of nucleus accumbens in goal-directed behavior","volume":"8","author":"Goto","year":"2005","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.brainresrev.2011.04.003_bb0235","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/BF03035129","article-title":"Late life depression","volume":"251","author":"Gottfries","year":"2001","journal-title":"Eur. Arch. Psychiatry Clin. Neurosci."},{"key":"10.1016\/j.brainresrev.2011.04.003_bb0240","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.neuint.2009.02.018","article-title":"Inhibition of astroglial glutamate transport by polyunsaturated fatty acids: evidence for a signalling role of docosahexaenoic acid","volume":"54","author":"Grintal","year":"2009","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.brainresrev.2011.04.003_bb0245","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1177\/1073858406296716","article-title":"Endocannabinoids and synaptic function in the CNS","volume":"13","author":"Hashimotodani","year":"2007","journal-title":"Neuroscientist"},{"key":"10.1016\/j.brainresrev.2011.04.003_bb0250","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1001\/archpsyc.64.2.193","article-title":"Reduced prefrontal glutamate\/glutamine and gamma-aminobutyric acid levels in major depression determined using proton magnetic resonance spectroscopy","volume":"64","author":"Hasler","year":"2007","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.brainresrev.2011.04.003_bb0255","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1007\/s00702-010-0438-z","article-title":"Neuroinflammatory processes in Alzheimer's disease","volume":"117","author":"Heneka","year":"2010","journal-title":"J. Neural Transm."},{"key":"10.1016\/j.brainresrev.2011.04.003_bb0260","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1016\/S0140-6736(05)79168-6","article-title":"Fish consumption and major depression","volume":"351","author":"Hibbeln","year":"1998","journal-title":"Lancet"},{"key":"10.1016\/j.brainresrev.2011.04.003_bb0265","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1055\/s-2007-993211","article-title":"Serum endocannabinoid content is altered in females with depressive disorders: a preliminary report","volume":"41","author":"Hill","year":"2008","journal-title":"Pharmacopsychiatry"},{"key":"10.1016\/j.brainresrev.2011.04.003_bb0270","doi-asserted-by":"crossref","first-page":"e4328","DOI":"10.1371\/journal.pone.0004328","article-title":"Regulation of kainate receptor subunit mRNA by stress and corticosteroids in the rat hippocampus","volume":"4","author":"Hunter","year":"2009","journal-title":"P.Lo.S. ONE"},{"key":"10.1016\/j.brainresrev.2011.04.003_bb0275","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1111\/j.1471-4159.2004.02548.x","article-title":"Differential expression of N-methyl-d-aspartate receptor NR2 isoforms in Alzheimer's disease","volume":"90","author":"Hynd","year":"2004","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainresrev.2011.04.003_bb0280","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1080\/13854040600910018","article-title":"Functional near infrared spectroscopy (fNIRS): an emerging neuroimaging technology with important applications for the study of brain disorders","volume":"21","author":"Irani","year":"2007","journal-title":"Clin. Neuropsychol."},{"key":"10.1016\/j.brainresrev.2011.04.003_bb0285","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S1474-4422(09)70299-6","article-title":"Hypothetical model of dynamic biomarkers of the Alzheimer's pathological cascade","volume":"9","author":"Jack","year":"2010","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.brainresrev.2011.04.003_bb0290","doi-asserted-by":"crossref","first-page":"97","DOI":"10.3233\/JAD-2007-11113","article-title":"Alterations in expression of glutamatergic transporters and receptors in sporadic Alzheimer's disease","volume":"11","author":"Jacob","year":"2007","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.brainresrev.2011.04.003_bb0295","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1038\/npp.2009.19","article-title":"CNR1 gene is associated with high neuroticism and low agreeableness and interacts with recent negative life events to predict current depressive symptoms","volume":"34","author":"Juhasz","year":"2009","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.brainresrev.2011.04.003_bb0300","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1152\/jn.00840.2009","article-title":"Kainate receptor-induced ectopic spiking of CA3 pyramidal neurons initiates network bursts in neonatal hippocampus","volume":"104","author":"Juuri","year":"2010","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.brainresrev.2011.04.003_bb0305","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1002\/gps.2550","article-title":"Neuropsychiatric symptoms and Quality of Life in patients with very mild and mild Alzheimer's disease","volume":"26","author":"Karttunen","year":"2011","journal-title":"Int. J. Geriatr. Psychiatry"},{"key":"10.1016\/j.brainresrev.2011.04.003_bb0310","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/BF02257411","article-title":"Phencyclidine disrupts long- but not short-term memory within a spatial learning task","volume":"111","author":"Kesner","year":"1993","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.brainresrev.2011.04.003_bb0315","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1196\/annals.1332.006","article-title":"Microglia as a potential bridge between the amyloid beta-peptide and tau","volume":"1035","author":"Kitazawa","year":"2004","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.brainresrev.2011.04.003_bb0320","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1080\/10401230701653435","article-title":"Neuroimaging approaches in mood disorders: technique and clinical implications","volume":"19","author":"Konarski","year":"2007","journal-title":"Ann. Clin. Psychiatry"},{"key":"10.1016\/j.brainresrev.2011.04.003_bb0325","doi-asserted-by":"crossref","first-page":"S71","DOI":"10.1038\/sj.mp.4001021","article-title":"Glutamate and GABA systems as targets for novel antidepressant and mood-stabilizing treatments","volume":"7","author":"Krystal","year":"2002","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.brainresrev.2011.04.003_bb0330","first-page":"1026","article-title":"Metabolic, hormonal, and hemodynamic changes induced by metabotropic excitatory amino acid agonist (1S, 3R)-ACPD","volume":"268","author":"Lang","year":"1995","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.brainresrev.2011.04.003_bb0335","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/S0092-8674(03)00122-3","article-title":"Phosphorylation of the AMPA receptor GluR1 subunit is required for synaptic plasticity and retention of spatial memory","volume":"112","author":"Lee","year":"2003","journal-title":"Cell"},{"key":"10.1016\/j.brainresrev.2011.04.003_bb0340","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1016\/j.pnpbp.2007.12.009","article-title":"Neural correlates of affective processing in response to sad and angry facial stimuli in patients with major depressive disorder","volume":"32","author":"Lee","year":"2008","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.brainresrev.2011.04.003_bb0345","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1358\/dot.2007.43.10.1122223","article-title":"Psychopathology of depression","volume":"43","author":"Leonard","year":"2007","journal-title":"Drugs Today (Barc)"},{"key":"10.1016\/j.brainresrev.2011.04.003_bb0350","doi-asserted-by":"crossref","first-page":"205","DOI":"10.2174\/157339510791823835","article-title":"The concept of depression as a dysfunction of the immune system","volume":"6","author":"Leonard","year":"2010","journal-title":"Curr. Immunol. Rev."},{"key":"10.1016\/j.brainresrev.2011.04.003_bb0355","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.biopsych.2010.03.018","article-title":"A meta-analytic review of polyunsaturated fatty acid compositions in patients with depression","volume":"68","author":"Lin","year":"2010","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.brainresrev.2011.04.003_bb0360","first-page":"287","article-title":"The cytokine hypothesis of depression: inflammation, oxidative & nitrosative stress (IO&NS) and leaky gut as new targets for adjunctive treatments in depression","volume":"29","author":"Maes","year":"2008","journal-title":"Neuro Endocrinol. Lett."},{"key":"10.1016\/j.brainresrev.2011.04.003_bb0365","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1038\/87865","article-title":"The cellular neurobiology of depression","volume":"7","author":"Manji","year":"2001","journal-title":"Nat. Med."},{"key":"10.1016\/j.brainresrev.2011.04.003_bb0370","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1196\/annals.1418.005","article-title":"Glutamate and neurotrophic factors in neuronal plasticity and disease","volume":"1144","author":"Mattson","year":"2008","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.brainresrev.2011.04.003_bb0375","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1159\/000026491","article-title":"Plasma and platelet amino acid concentrations in patients affected by major depression and under fluvoxamine treatment","volume":"37","author":"Mauri","year":"1998","journal-title":"Neuropsychobiology"},{"key":"10.1016\/j.brainresrev.2011.04.003_bb0380","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1002\/ajmg.b.20086","article-title":"Association between interleukin 1-beta promoter (\u2212511) polymorphism and depressive symptoms in Alzheimer's disease","volume":"124B","author":"McCulley","year":"2004","journal-title":"Am. J. Med. Genet. B Neuropsychiatr. Genet."},{"key":"10.1016\/j.brainresrev.2011.04.003_bb0385","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/j.plefa.2006.07.010","article-title":"Role of omega-3 fatty acids in brain development and function: potential implications for the pathogenesis and prevention of psychopathology","volume":"75","author":"McNamara","year":"2006","journal-title":"Prostaglandins Leukot. Essent. Fatty Acids"},{"key":"10.1016\/j.brainresrev.2011.04.003_bb0390","doi-asserted-by":"crossref","first-page":"1007S","DOI":"10.1093\/jn\/130.4.1007S","article-title":"Glutamate as a neurotransmitter in the brain: review of physiology and pathology","volume":"130","author":"Meldrum","year":"2000","journal-title":"J. Nutr."},{"key":"10.1016\/j.brainresrev.2011.04.003_bb0395","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1017\/S0033291703007931","article-title":"Metabolic changes within the left dorsolateral prefrontal cortex occurring with electroconvulsive therapy in patients with treatment resistant unipolar depression","volume":"33","author":"Michael","year":"2003","journal-title":"Psychol. Med."},{"key":"10.1016\/j.brainresrev.2011.04.003_bb0400","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1016\/j.pnpbp.2006.03.036","article-title":"Correlation between plasma levels of glutamate, alanine and serine with severity of depression","volume":"30","author":"Mitani","year":"2006","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.brainresrev.2011.04.003_bb0405","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1111\/j.1600-0447.2009.01529.x","article-title":"An update on the role of glutamate in the pathophysiology of depression","volume":"122","author":"Mitchell","year":"2010","journal-title":"Acta Psychiatr. Scand."},{"key":"10.1016\/j.brainresrev.2011.04.003_bb0410","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/0304-3940(93)90641-W","article-title":"Prefrontal cortex regulates burst firing and transmitter release in rat mesolimbic dopamine neurons studied in vivo","volume":"157","author":"Murase","year":"1993","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.brainresrev.2011.04.003_bb0415","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1001\/archpsyc.63.5.530","article-title":"Depression and risk for Alzheimer's disease: systematic review, meta-analysis, and meta-regression analysis","volume":"63","author":"Ownby","year":"2006","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.brainresrev.2011.04.003_bb0420","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1124\/pr.57.2.7","article-title":"The molecular pharmacology and cell biology of alpha-amino-3-hydroxy-5- methyl-4-isoxazolepropionic acid receptors","volume":"57","author":"Palmer","year":"2005","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.brainresrev.2011.04.003_bb0425","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.pharmthera.2007.04.007","article-title":"Metabotropic glutamate receptor ligands as possible anxiolytic and antidepressant drugs","volume":"115","author":"Palucha","year":"2007","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.brainresrev.2011.04.003_bb0430","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1097\/JGP.0b013e3181b0fa13","article-title":"Late-life depression, mild cognitive impairment, and dementia: possible continuum?","volume":"18","author":"Panza","year":"2010","journal-title":"Am. J. Geriatr. Psychiatry"},{"key":"10.1016\/j.brainresrev.2011.04.003_bb0435","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.tins.2008.06.006","article-title":"The HPA axis in major depression: classical theories and new developments","volume":"31","author":"Pariante","year":"2007","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.brainresrev.2011.04.003_bb0440","doi-asserted-by":"crossref","first-page":"2821","DOI":"10.1111\/j.1460-9568.2008.06266.x","article-title":"Adaptations in endocannabinoid signaling in response to repeated homotypic stress: a novel mechanism for stress habituation","volume":"27","author":"Patel","year":"2008","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.brainresrev.2011.04.003_bb0445","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1001\/archneur.63.7.936","article-title":"Age and apolipoprotein E*4 allele effects on cerebrospinal fluid beta-amyloid 42 in adults with normal cognition","volume":"63","author":"Peskind","year":"2006","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.brainresrev.2011.04.003_bb0450","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0925-4927(03)00003-9","article-title":"Effective electroconvulsive therapy reverses glutamate\/glutamine deficit in the left anterior cingulum of unipolar depressed patients","volume":"122","author":"Pfleiderer","year":"2003","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.brainresrev.2011.04.003_bb0455","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1016\/j.bcp.2007.09.021","article-title":"Mood disorders: regulation by metabotropic glutamate receptors","volume":"75","author":"Pilc","year":"2008","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.brainresrev.2011.04.003_bb0460","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1097\/01.nrl.0000252947.15389.a9","article-title":"Contribution of depression to cognitive impairment and dementia in older adults","volume":"13","author":"Potter","year":"2007","journal-title":"Neurologist"},{"key":"10.1016\/j.brainresrev.2011.04.003_bb0465","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/S0006-3223(01)01080-0","article-title":"Reductions in neuronal and glial density characterize the dorsolateral prefrontal cortex in bipolar disorder","volume":"49","author":"Rajkowska","year":"2001","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.brainresrev.2011.04.003_bb0470","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1111\/j.1471-4159.2007.04832.x","article-title":"GABA(A) receptors in aging and Alzheimer's disease","volume":"103","author":"Rissman","year":"2007","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainresrev.2011.04.003_bb0475","article-title":"Neuroglial roots of neurodegenerative diseases?","author":"Rodr\u00edguez","year":"2010","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.brainresrev.2011.04.003_bb0480","first-page":"1","article-title":"Remodelling by earlylife stress of NMDA receptor-dependent synaptic plasticity in a gene\u2013environment rat model of depression","volume":"31","author":"Ryan","year":"2008","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.brainresrev.2011.04.003_bb0485","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1001\/archpsyc.56.11.1043","article-title":"Reduced cortical c-aminobutyric acid levels in depressed patients determined by proton magnetic resonance spectroscopy","volume":"56","author":"Sanacora","year":"1999","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.brainresrev.2011.04.003_bb0490","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1001\/archpsyc.61.7.705","article-title":"Subtype-specific alterations of gammaaminobutyric acid and glutamate in patients with major depression","volume":"61","author":"Sanacora","year":"2004","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.brainresrev.2011.04.003_bb0495","doi-asserted-by":"crossref","first-page":"12320","DOI":"10.1073\/pnas.231475998","article-title":"Depression, antidepressants, and the shrinking hippocampus","volume":"98","author":"Sapolsky","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.brainresrev.2011.04.003_bb0500","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/S0028-3908(03)00027-3","article-title":"Endogenous activation of group-II metabotropic glutamate receptors inhibits the hypothalamic-pituitary-adrenocortical axis","volume":"44","author":"Scaccianoce","year":"2003","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.brainresrev.2011.04.003_bb0505","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1006\/phrs.2000.0806","article-title":"Current perspectives on the development of non-biogenic aminebased antidepressants","volume":"43","author":"Skolnick","year":"2001","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.brainresrev.2011.04.003_bb0510","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1093\/ajcn\/72.5.1241","article-title":"Effects of polyunsaturated fatty acids on psychiatric disorders","volume":"72","author":"Su","year":"2000","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.brainresrev.2011.04.003_bb0515","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/j.stem.2009.10.003","article-title":"Imbalance between GABAergic and glutamatergic transmission impairs adult neurogenesis in an animal model of Alzheimer's disease","volume":"5","author":"Sun","year":"2009","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.brainresrev.2011.04.003_bb0520","doi-asserted-by":"crossref","first-page":"3182","DOI":"10.1073\/pnas.052712799","article-title":"Involvement of striatal and extrastriatal DARPP-32 in biochemical and behavioural effects of fluoxetine (Prozac)","volume":"99","author":"Svenningsson","year":"2002","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.brainresrev.2011.04.003_bb0525","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1038\/nature05028","article-title":"NMDA-receptor-mediated, cell-specific integration of new neurons in adult dentate gyrus","volume":"442","author":"Tashiro","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.brainresrev.2011.04.003_bb0530","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1177\/0269881107081510","article-title":"Differential effects of citalopram and reboxetine on cortical Glx measured with proton MR spectroscopy","volume":"22","author":"Taylor","year":"2008","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.brainresrev.2011.04.003_bb0535","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1007\/s11064-007-9518-3","article-title":"Innovative approaches for the treatment of depression: targeting the HPA axis","volume":"33","author":"Thomson","year":"2008","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.brainresrev.2011.04.003_bb0540","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/j.neuron.2005.08.023","article-title":"GABAergic excitation promotes neuronal differentiation in adult hippocampal progenitor cells","volume":"47","author":"Tozuka","year":"2005","journal-title":"Neuron"},{"key":"10.1016\/j.brainresrev.2011.04.003_bb0545","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1016\/j.neuint.2006.10.007","article-title":"Glutamate-glutamine cycling in Alzheimer's disease","volume":"50","author":"Walton","year":"2007","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.brainresrev.2011.04.003_bb0550","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1038\/35069076","article-title":"Endogenous cannabinoids mediate retrograde signalling at hippocampal synapses","volume":"410","author":"Wilson","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.brainresrev.2011.04.003_bb0555","doi-asserted-by":"crossref","first-page":"3280","DOI":"10.1021\/pr1002214","article-title":"Brain phosphoproteome obtained by a FASP-based method reveals plasma membrane protein topology","volume":"9","author":"Wi\u015bniewski","year":"2010","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.brainresrev.2011.04.003_bb0560","series-title":"Chapter V, categories F00\u2013F99: Mental, Behavioural, and Developmental Disorders, Clinical Description and Diagnostic Guidelines","article-title":"International Statistical Classification of Diseases and Related Health Problems, 10th Revision (ICD-10)","author":"World Health Organization","year":"1992"},{"key":"10.1016\/j.brainresrev.2011.04.003_bb0565","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1038\/25147","article-title":"Calcium promotes cell survival through CaM-k kinase activation of the protein-kinase-B pathway","volume":"396","author":"Yano","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.brainresrev.2011.04.003_bb0570","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/j.pnpbp.2006.03.012","article-title":"Neurochemical alterations of the brain in bipolar disorder and their implications for pathophysiology: a systematic review of the in vivo proton magnetic resonance spectroscopy findings","volume":"30","author":"Yildiz-Yesiloglu","year":"2006","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.brainresrev.2011.04.003_bb0575","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.1046\/j.1471-4159.1997.68031261.x","article-title":"Synaptic vesicle ultrastructural changes in the rat hippocampus induced by a combination of alpha-linolenate deficiency and a learning task","volume":"68","author":"Yoshida","year":"1997","journal-title":"J. Neurochem."},{"key":"10.1016\/j.brainresrev.2011.04.003_bb0580","doi-asserted-by":"crossref","first-page":"293","DOI":"10.3109\/10673229.2010.511059","article-title":"Glutamatergic modulators: the future of treating mood disorders?","volume":"18","author":"Zarate","year":"2010","journal-title":"Harv. Rev. Psychiatry"},{"key":"10.1016\/j.brainresrev.2011.04.003_bb0585","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.brainres.2004.10.034","article-title":"Glutamate agonists activate the hypothalamic-pituitary-adrenal axis through hypothalamic periventricular nucleus, but not through vasopressinergic neurons","volume":"1031","author":"Zelena","year":"2005","journal-title":"Brain Res."},{"key":"10.1016\/j.brainresrev.2011.04.003_bb0590","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.cell.2008.01.033","article-title":"Mechanisms and functional implications of adult neurogenesis","volume":"132","author":"Zhao","year":"2008","journal-title":"Cell"}],"container-title":["Brain Research Reviews"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165017311000245?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0165017311000245?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,11,22]],"date-time":"2021-11-22T11:35:32Z","timestamp":1637580932000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0165017311000245"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,6]]},"references-count":118,"journal-issue":{"issue":"1-2","published-print":{"date-parts":[[2011,6]]}},"alternative-id":["S0165017311000245"],"URL":"https:\/\/doi.org\/10.1016\/j.brainresrev.2011.04.003","relation":{},"ISSN":["0165-0173"],"issn-type":[{"value":"0165-0173","type":"print"}],"subject":[],"published":{"date-parts":[[2011,6]]}}}