{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,25]],"date-time":"2026-07-25T03:45:40Z","timestamp":1784951140571,"version":"3.55.0"},"reference-count":94,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T00:00:00Z","timestamp":1769472000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000054","name":"NCI","doi-asserted-by":"publisher","award":["R01CA292482"],"award-info":[{"award-number":["R01CA292482"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"NHLBI","doi-asserted-by":"publisher","award":["R01HL148151"],"award-info":[{"award-number":["R01HL148151"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"NHLBI","doi-asserted-by":"publisher","award":["R01HL146442"],"award-info":[{"award-number":["R01HL146442"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"NHLBI","doi-asserted-by":"publisher","award":["R01HL149714"],"award-info":[{"award-number":["R01HL149714"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"NIA","doi-asserted-by":"publisher","award":["R01AG089069"],"award-info":[{"award-number":["R01AG089069"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"NIA","doi-asserted-by":"publisher","award":["U54AG062319"],"award-info":[{"award-number":["U54AG062319"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Blood Red Cells & Iron"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.brci.2026.100055","type":"journal-article","created":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T23:07:49Z","timestamp":1771456069000},"page":"100055","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Long-distance trail running induces inflammation-associated protein, lipid, and purine oxidation in red blood cells"],"prefix":"10.1016","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8566-7119","authenticated-orcid":false,"given":"Travis","family":"Nemkov","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emeric","family":"Stauffer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8874-2150","authenticated-orcid":false,"given":"Francesca","family":"Cendali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Stephenson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elie","family":"Nader","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e9lanie","family":"Robert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Skinner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9947-2520","authenticated-orcid":false,"given":"Monika","family":"Dzieciatkowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5054-838X","authenticated-orcid":false,"given":"Kirk C.","family":"Hansen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6205-7761","authenticated-orcid":false,"given":"Paul","family":"Robach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6395-0762","authenticated-orcid":false,"given":"Guillaume Y.","family":"Millet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Connes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2258-6490","authenticated-orcid":false,"given":"Angelo","family":"D\u2019Alessandro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.brci.2026.100055_bib1","doi-asserted-by":"crossref","first-page":"332","DOI":"10.3389\/fphys.2013.00332","article-title":"Red blood cells in sports: effects of exercise and training on oxygen supply by red blood cells","volume":"4","author":"Mairb\u00e4url","year":"2013","journal-title":"Front Physiol"},{"key":"10.1016\/j.brci.2026.100055_bib2","article-title":"Red blood cell storage lesion: causes and potential clinical consequences","author":"Yoshida","year":"201917127","journal-title":"Blood Transfus"},{"issue":"4","key":"10.1016\/j.brci.2026.100055_bib3","first-page":"281","article-title":"Protect, repair, destroy or sacrifice: a role of oxidative stress biology in inter-donor variability of blood storage?","volume":"17","author":"D'Alessandro","year":"2019","journal-title":"Blood Transfus"},{"issue":"9","key":"10.1016\/j.brci.2026.100055_bib4","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1038\/s42255-020-0251-4","article-title":"Skeletal muscle energy metabolism during exercise","volume":"2","author":"Hargreaves","year":"2020","journal-title":"Nat Metab"},{"issue":"4","key":"10.1016\/j.brci.2026.100055_bib5","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1002\/ejsc.12073","article-title":"Are pre-race serum blood biomarkers associated with the 24-h ultramarathon race performance?","volume":"24","author":"Amatori","year":"2024","journal-title":"Eur J Sport Sci"},{"issue":"6","key":"10.1016\/j.brci.2026.100055_bib6","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.smhs.2024.11.005","article-title":"Plasma cardiovascular stress biomarkers response to marathon running","volume":"7","author":"Siekierzycka","year":"2024","journal-title":"Sports Med Health Sci"},{"issue":"2","key":"10.1016\/j.brci.2026.100055_bib7","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22020896","article-title":"Acute cycling exercise induces changes in red blood cell deformability and membrane lipid remodeling","volume":"22","author":"Nemkov","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.brci.2026.100055_bib8","doi-asserted-by":"crossref","first-page":"578","DOI":"10.3389\/fphys.2020.00578","article-title":"Metabolomics of endurance capacity in world tour professional cyclists","volume":"11","author":"San-Mill\u00e1n","year":"2020","journal-title":"Front Physiol"},{"key":"10.1016\/j.brci.2026.100055_bib9","first-page":"691","article-title":"Ueber eine neue form von haemoglobinurie beim menschen","volume":"18","author":"Fleischer","year":"1881","journal-title":"Berl Klin Wschr"},{"issue":"5","key":"10.1016\/j.brci.2026.100055_bib10","doi-asserted-by":"crossref","first-page":"119","DOI":"10.17161\/kjm.vol17.22146","article-title":"Foot-strike hemolysis: a scoping review of long-distance runners","volume":"17","author":"Gartner","year":"2024","journal-title":"Kans J Med"},{"issue":"1","key":"10.1016\/j.brci.2026.100055_bib11","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1111\/sms.14241","article-title":"IL-6 signaling in acute exercise and chronic training: potential consequences for health and athletic performance","volume":"33","author":"Nash","year":"2023","journal-title":"Scand J Med Sci Sports"},{"issue":"suppl 1","key":"10.1016\/j.brci.2026.100055_bib12","doi-asserted-by":"crossref","first-page":"S9","DOI":"10.1055\/s-2007-1024743","article-title":"Immunologic mediators as parameters of the reaction to strenuous exercise","volume":"12","author":"Northoff","year":"1991","journal-title":"Int J Sports Med"},{"issue":"1","key":"10.1016\/j.brci.2026.100055_bib13","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/s00421-019-04271-x","article-title":"Impact of a 10 km running trial on eryptosis, red blood cell rheology, and electrophysiology in endurance trained athletes: a pilot study","volume":"120","author":"Nader","year":"2020","journal-title":"Eur J Appl Physiol"},{"issue":"22","key":"10.1016\/j.brci.2026.100055_bib14","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21228531","article-title":"Impact of trail running races on blood viscosity and its determinants: effects of distance","volume":"21","author":"Robert","year":"2020","journal-title":"Int J Mol Sci"},{"issue":"3","key":"10.1016\/j.brci.2026.100055_bib15","doi-asserted-by":"crossref","first-page":"301","DOI":"10.3233\/CH-211121","article-title":"Differential impacts of trail and ultra-trail running on cytokine profiles: an observational study","volume":"78","author":"Skinner","year":"2021","journal-title":"Clin Hemorheol Microcirc"},{"issue":"5","key":"10.1016\/j.brci.2026.100055_bib16","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1016\/j.cell.2020.04.043","article-title":"Molecular choreography of acute exercise","volume":"181","author":"Contrepois","year":"2020","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.brci.2026.100055_bib17","doi-asserted-by":"crossref","DOI":"10.3390\/metabo8010014","article-title":"Untargeted metabolomics profiling of an 80.5 km simulated treadmill ultramarathon","volume":"8","author":"Howe","year":"2018","journal-title":"Metabolites"},{"issue":"1","key":"10.1016\/j.brci.2026.100055_bib18","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-67884-9","article-title":"The unaided recovery of marathon-induced serum metabolome alterations","volume":"10","author":"Stander","year":"2020","journal-title":"Sci Rep"},{"issue":"4","key":"10.1016\/j.brci.2026.100055_bib19","article-title":"Ultramarathon plasma metabolomics: p;hosphatidylcholine levels associated with running performance","volume":"8","author":"H\u00f8eg","year":"2020","journal-title":"Sports (Basel)"},{"key":"10.1016\/j.brci.2026.100055_bib20","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2013.00332","article-title":"Red blood cells in sports: Effects of exercise and training on oxygen supply by red blood cells","volume":"4","author":"Mairb\u00e4url","year":"2013","journal-title":"Front Physiol"},{"key":"10.1016\/j.brci.2026.100055_bib21","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/978-1-4939-9236-2_2","article-title":"High-throughput metabolomics: isocratic and gradient mass spectrometry-based methods","volume":"1978","author":"Nemkov","year":"2019","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.brci.2026.100055_bib22","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/978-1-4939-9236-2_8","article-title":"Untargeted and semi-targeted lipid analysis of biological samples using mass spectrometry-based metabolomics","volume":"1978","author":"Reisz","year":"2019","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.brci.2026.100055_bib23","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2022.828087","article-title":"Inductively-coupled plasma mass spectrometry-novel insights from an old technology into stressed red blood cell physiology","volume":"13","author":"Stephenson","year":"2022","journal-title":"Front Physiol"},{"issue":"2","key":"10.1016\/j.brci.2026.100055_bib24","first-page":"182","article-title":"Red blood cell proteomics update: is there more to discover?","volume":"15","author":"D'Alessandro","year":"2017","journal-title":"Blood Transfus"},{"issue":"8","key":"10.1016\/j.brci.2026.100055_bib25","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1038\/s41596-022-00710-w","article-title":"Using MetaboAnalyst 5.0 for LC-HRMS spectra processing, multi-omics integration and covariate adjustment of global metabolomics data","volume":"17","author":"Pang","year":"2022","journal-title":"Nat Protoc"},{"issue":"11","key":"10.1016\/j.brci.2026.100055_bib26","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1101\/gr.1239303","article-title":"Cytoscape: a software environment for integrated models of biomolecular interaction networks","volume":"13","author":"Shannon","year":"2003","journal-title":"Genome Res"},{"issue":"8","key":"10.1016\/j.brci.2026.100055_bib27","doi-asserted-by":"crossref","first-page":"2628","DOI":"10.1093\/bioinformatics\/btz931","article-title":"ShinyGO: a graphical gene-set enrichment tool for animals and plants","volume":"36","author":"Ge","year":"2020","journal-title":"Bioinformatics"},{"issue":"14","key":"10.1016\/j.brci.2026.100055_bib28","doi-asserted-by":"crossref","first-page":"1830","DOI":"10.1093\/bioinformatics\/btt285","article-title":"Pathview: an R\/Bioconductor package for pathway-based data integration and visualization","volume":"29","author":"Luo","year":"2013","journal-title":"Bioinformatics"},{"issue":"5","key":"10.1016\/j.brci.2026.100055_bib29","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.3390\/antiox12051058","article-title":"Metabolic functions of biliverdin IX\u03b2 reductase in redox-regulated hematopoietic cell fate","volume":"12","author":"Bahou","year":"2023","journal-title":"Antioxidants"},{"issue":"18 pt B","key":"10.1016\/j.brci.2026.100055_bib30","doi-asserted-by":"crossref","first-page":"3234","DOI":"10.1016\/j.jmb.2018.06.015","article-title":"Biliverdin reductase B dynamics are coupled to coenzyme binding","volume":"430","author":"Paukovich","year":"2018","journal-title":"J Mol Biol"},{"issue":"6","key":"10.1016\/j.brci.2026.100055_bib31","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20211314","article-title":"CD36, a signaling receptor and fatty acid transporter that regulates immune cell metabolism and fate","volume":"219","author":"Chen","year":"2022","journal-title":"J Exp Med"},{"issue":"9","key":"10.1016\/j.brci.2026.100055_bib32","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1249\/00005768-199109000-00006","article-title":"Plasma creatine kinase activity and exercise-induced muscle damage in older men","volume":"23","author":"Manfredi","year":"1991","journal-title":"Med Sci Sports Exerc"},{"issue":"5","key":"10.1016\/j.brci.2026.100055_bib33","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1182\/blood.2023022052","article-title":"Regulation of kynurenine metabolism by blood donor genetics and biology impacts red cell hemolysis in vitro and in vivo","volume":"143","author":"Nemkov","year":"2024","journal-title":"Blood"},{"key":"10.1016\/j.brci.2026.100055_bib34","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.1004545","article-title":"Kynurenine serves as useful biomarker in acute, Long- and Post-COVID-19 diagnostics","volume":"13","author":"Bizjak","year":"2022","journal-title":"Front Immunol"},{"issue":"1","key":"10.1016\/j.brci.2026.100055_bib35","doi-asserted-by":"crossref","first-page":"9959","DOI":"10.1038\/s41598-022-14292-w","article-title":"Urine metabolomics links dysregulation of the tryptophan-kynurenine pathway to inflammation and severity of COVID-19","volume":"12","author":"Dewulf","year":"2022","journal-title":"Sci Rep"},{"issue":"14","key":"10.1016\/j.brci.2026.100055_bib36","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.140327","article-title":"COVID-19 infection alters kynurenine and fatty acid metabolism, correlating with IL-6 levels and renal status","volume":"5","author":"Thomas","year":"2020","journal-title":"JCI Insight"},{"issue":"26","key":"10.1016\/j.brci.2026.100055_bib37","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abm9138","article-title":"Immunomodulatory actions of a kynurenine-derived endogenous electrophile","volume":"8","author":"Carre\u00f1o","year":"2022","journal-title":"Sci Adv"},{"key":"10.1016\/j.brci.2026.100055_bib38","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/513518","article-title":"Triggers, inhibitors, mechanisms, and significance of eryptosis: the suicidal erythrocyte death","volume":"2015","author":"Lang","year":"2015","journal-title":"Biomed Res Int"},{"issue":"5","key":"10.1016\/j.brci.2026.100055_bib39","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1111\/sms.13059","article-title":"Eryptosis and hemorheological responses to maximal exercise in athletes: comparison between running and cycling","volume":"28","author":"Nader","year":"2018","journal-title":"Scand J Med Sci Sports"},{"key":"10.1016\/j.brci.2026.100055_bib40","article-title":"Decoding the metabolic landscape of pathophysiological stress-induced cell death in anucleate red blood cells","author":"Nemkov","year":"2020182130","journal-title":"Blood Transfus"},{"key":"10.1016\/j.brci.2026.100055_bib41","article-title":"Hypoxia-mediated impaired erythrocyte Lands' Cycle is pathogenic for sickle cell disease","volume":"6","author":"Wu","year":"2016","journal-title":"Sci Rep"},{"issue":"8","key":"10.1016\/j.brci.2026.100055_bib42","first-page":"2639","article-title":"Functional and multi-omics signatures of mitapivat efficacy upon activation of pyruvate kinase in red blood cells from patients with sickle cell disease","volume":"109","author":"D'Alessandro","year":"2024","journal-title":"Haematologica"},{"issue":"2","key":"10.1016\/j.brci.2026.100055_bib43","doi-asserted-by":"crossref","first-page":"361","DOI":"10.3324\/haematol.2017.178608","article-title":"Hypoxia modulates the purine salvage pathway and decreases red blood cell and supernatant levels of hypoxanthine during refrigerated storage","volume":"103","author":"Nemkov","year":"2018","journal-title":"Haematologica"},{"issue":"10","key":"10.1016\/j.brci.2026.100055_bib44","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1681\/ASN.0000000000000195","article-title":"Erythrocyte ENT1-AMPD3 axis is an essential purinergic hypoxia sensor and energy regulator combating CKD in a mouse model","volume":"34","author":"Chen","year":"2023","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.brci.2026.100055_bib45","doi-asserted-by":"crossref","first-page":"175","DOI":"10.3389\/fmed.2017.00175","article-title":"Metabolism of citrate and other carboxylic acids in erythrocytes as a function of oxygen saturation and refrigerated storage","volume":"4","author":"Nemkov","year":"2017","journal-title":"Front Med"},{"key":"10.1016\/j.brci.2026.100055_bib46","article-title":"Donor sex, age and ethnicity impact stored red blood cell antioxidant metabolism through mechanisms in part explained by glucose 6-phosphate dehydrogenase levels and activity","author":"D\u2019Alessandro","year":"202110651290","journal-title":"Haematologica"},{"issue":"5","key":"10.1016\/j.brci.2026.100055_bib47","doi-asserted-by":"crossref","first-page":"2270","DOI":"10.1172\/JCI133530","article-title":"Donor glucose-6-phosphate dehydrogenase deficiency decreases blood quality for transfusion","volume":"130","author":"Francis","year":"2020","journal-title":"J Clin Invest"},{"issue":"12","key":"10.1016\/j.brci.2026.100055_bib48","doi-asserted-by":"crossref","first-page":"2978","DOI":"10.1111\/trf.14936","article-title":"Methylation of protein aspartates and deamidated asparagines as a function of blood bank storage and oxidative stress in human red blood cells","volume":"58","author":"Reisz","year":"2018","journal-title":"Transfusion"},{"issue":"29","key":"10.1016\/j.brci.2026.100055_bib49","doi-asserted-by":"crossref","first-page":"12089","DOI":"10.1074\/jbc.M117.787622","article-title":"Domain alternation and active site remodeling are conserved structural features of ubiquitin E1","volume":"292","author":"Lv","year":"2017","journal-title":"J Biol Chem"},{"issue":"1 suppl","key":"10.1016\/j.brci.2026.100055_bib50","first-page":"100","article-title":"Trace elements and inflammatory response: implications for nutritional support","volume":"11","author":"Shenkin","year":"1995","journal-title":"Nutrition"},{"issue":"2","key":"10.1016\/j.brci.2026.100055_bib51","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/0005-2736(79)90214-1","article-title":"The effect of copper on erythrocyte deformability: a possible mechanism of hemolysis in acute copper intoxication","volume":"550","author":"Adams","year":"1979","journal-title":"Biochim Biophys Acta"},{"issue":"1","key":"10.1016\/j.brci.2026.100055_bib52","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1111\/j.1600-0838.2012.01481.x","article-title":"Hemolysis induced by an extreme mountain ultra-marathon is not associated with a decrease in total red blood cell volume","volume":"24","author":"Robach","year":"2014","journal-title":"Scand J Med Sci Sports"},{"issue":"1","key":"10.1016\/j.brci.2026.100055_bib53","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1172\/JCI90837","article-title":"Prolonged red cell storage before transfusion increases extravascular hemolysis","volume":"127","author":"Rapido","year":"2017","journal-title":"J Clin Invest"},{"issue":"3","key":"10.1016\/j.brci.2026.100055_bib54","doi-asserted-by":"crossref","first-page":"143","DOI":"10.3109\/10408363.2011.600228","article-title":"Hemolyzed specimens: a major challenge for emergency departments and clinical laboratories","volume":"48","author":"Lippi","year":"2011","journal-title":"Crit Rev Clin Lab Sci"},{"issue":"2","key":"10.1016\/j.brci.2026.100055_bib55","first-page":"86","article-title":"Creatine in density-fractionated red cells, a useful indicator of erythropoietic dynamics and of hypoxia past and present","volume":"66","author":"Syllm-Rapoport","year":"1981","journal-title":"Acta Haematol"},{"issue":"1","key":"10.1016\/j.brci.2026.100055_bib56","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/0005-2736(80)90426-5","article-title":"Creatine and creatinine transport in old and young human red blood cells","volume":"600","author":"Ku","year":"1980","journal-title":"Biochim Biophys Acta"},{"issue":"6","key":"10.1016\/j.brci.2026.100055_bib57","doi-asserted-by":"crossref","first-page":"3077","DOI":"10.1073\/pnas.95.6.3077","article-title":"Phosphatidylserine exposure and red cell viability in red cell aging and in hemolytic anemia","volume":"95","author":"Boas","year":"1998","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"10.1016\/j.brci.2026.100055_bib58","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1152\/jappl.1983.54.3.827","article-title":"Impaired red cell filterability with elimination of old red blood cells during a 100-km race","volume":"54","author":"Reinhart","year":"1983","journal-title":"J Appl Physiol"},{"issue":"2","key":"10.1016\/j.brci.2026.100055_bib59","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1152\/japplphysiol.00580.2006","article-title":"Exercise-induced hemolysis is caused by protein modification and most evident during the early phase of an ultraendurance race","volume":"102","author":"Yusof","year":"2007","journal-title":"J Appl Physiol"},{"issue":"5","key":"10.1016\/j.brci.2026.100055_bib60","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1249\/MSS.0000000000003621","article-title":"Accelerated red blood cell turnover following extreme mountain ultramarathon?","volume":"57","author":"Krumm","year":"2025","journal-title":"Med Sci Sports Exerc"},{"issue":"9","key":"10.1016\/j.brci.2026.100055_bib61","article-title":"Proteostasis and metabolic dysfunction characterize a subset of storage-induced senescent erythrocytes targeted for posttransfusion clearance","volume":"135","author":"Gautier","year":"2025","journal-title":"J Clin Invest"},{"key":"10.1016\/j.brci.2026.100055_bib62","doi-asserted-by":"crossref","first-page":"73","DOI":"10.3389\/fimmu.2017.00073","article-title":"From the cradle to the grave: the role of macrophages in erythropoiesis and erythrophagocytosis","volume":"8","author":"Klei","year":"2017","journal-title":"Front Immunol"},{"issue":"1","key":"10.1016\/j.brci.2026.100055_bib63","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1152\/japplphysiol.00631.2001","article-title":"Footstrike is the major cause of hemolysis during running","volume":"94","author":"Telford","year":"2003","journal-title":"J Appl Physiol"},{"key":"10.1016\/j.brci.2026.100055_bib64","doi-asserted-by":"crossref","DOI":"10.1007\/s40279-025-02279-2","article-title":"Erythrocyte glycolytic and redox metabolism affects muscle oxygenation and exercise performance: a randomized double-blind crossover study in men","author":"Chatzinikolaou","year":"202555123157","journal-title":"Sports Med"},{"issue":"2","key":"10.1016\/j.brci.2026.100055_bib65","doi-asserted-by":"crossref","first-page":"129","DOI":"10.3177\/jnsv.33.129","article-title":"Comparison of effects of vegetable protein diet and animal protein diet on the initiation of anemia during vigorous physical training (sports anemia) in dogs and rats","volume":"33","author":"Yamada","year":"1987","journal-title":"J Nutr Sci Vitaminol (Tokyo)"},{"issue":"4","key":"10.1016\/j.brci.2026.100055_bib66","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1007\/s00421-005-0010-y","article-title":"Haemolysis caused by alterations of alpha- and beta-spectrin after 10 to 35 min of severe exercise","volume":"95","author":"Beneke","year":"2005","journal-title":"Eur J Appl Physiol"},{"issue":"1","key":"10.1016\/j.brci.2026.100055_bib67","doi-asserted-by":"crossref","first-page":"9","DOI":"10.2165\/00007256-199519010-00002","article-title":"Exercise, training and red blood cell turnover","volume":"19","author":"Smith","year":"1995","journal-title":"Sports Med"},{"issue":"3","key":"10.1016\/j.brci.2026.100055_bib68","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1172\/JCI110297","article-title":"Exercise-induced hemolysis in xerocytosis. Erythrocyte dehydration and shear sensitivity","volume":"68","author":"Platt","year":"1981","journal-title":"J Clin Invest"},{"issue":"6","key":"10.1016\/j.brci.2026.100055_bib69","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1152\/jappl.1981.50.6.1255","article-title":"Erythrocyte volume, plasma volume, and acid-base changes in exercise and heat dehydration","volume":"50","author":"van Beaumont","year":"1981","journal-title":"J Appl Physiol"},{"issue":"5","key":"10.1016\/j.brci.2026.100055_bib70","doi-asserted-by":"crossref","first-page":"421","DOI":"10.3233\/CH-1985-5505","article-title":"Influence of lactate on the insulin action on red blood cell filterability","volume":"5","author":"Lipovac","year":"2016","journal-title":"Clin Hemorheol Microcirc"},{"issue":"1","key":"10.1016\/j.brci.2026.100055_bib71","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1007\/s004210050126","article-title":"Lactate\/H+ uptake by red blood cells during exercise alters their physical properties","volume":"75","author":"Smith","year":"1997","journal-title":"Eur J Appl Physiol Occup Physiol"},{"issue":"4","key":"10.1016\/j.brci.2026.100055_bib72","first-page":"311","article-title":"Opposite effects of in vitro lactate on erythrocyte deformability in athletes and untrained subjects","volume":"31","author":"Connes","year":"2004","journal-title":"Clin Hemorheol Microcirc"},{"issue":"2","key":"10.1016\/j.brci.2026.100055_bib73","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/S0021-9258(18)70453-5","article-title":"Metabolism of glycerolipides; a comparison of lecithin and triglyceride synthesis","volume":"231","author":"Lands","year":"1958","journal-title":"J Biol Chem"},{"issue":"18","key":"10.1016\/j.brci.2026.100055_bib74","doi-asserted-by":"crossref","first-page":"12673","DOI":"10.1016\/S0021-9258(18)42330-7","article-title":"Role of carnitine and carnitine palmitoyltransferase as integral components of the pathway for membrane phospholipid fatty acid turnover in intact human erythrocytes","volume":"267","author":"Arduini","year":"1992","journal-title":"J Biol Chem"},{"issue":"26","key":"10.1016\/j.brci.2026.100055_bib75","doi-asserted-by":"crossref","first-page":"2395","DOI":"10.1016\/0024-3205(90)90483-8","article-title":"Effect of L-carnitine and acetyl-L-carnitine on the human erythrocyte membrane stability and deformability","volume":"47","author":"Arduini","year":"1990","journal-title":"Life Sci"},{"issue":"1","key":"10.1016\/j.brci.2026.100055_bib76","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/S0006-291X(05)81500-1","article-title":"Acyl-trafficking in membrane phospholipid fatty acid turnover: the transfer of fatty acid from the acyl-L-carnitine pool to membrane phospholipids in intact human erythrocytes","volume":"187","author":"Arduini","year":"1992","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.brci.2026.100055_bib77","doi-asserted-by":"crossref","DOI":"10.1182\/blood.2024023983","article-title":"Genetic regulation of carnitine metabolism controls lipid damage repair and aging RBC hemolysis in vivo and in vitro","author":"Nemkov","year":"2024143242517","journal-title":"Blood"},{"issue":"10","key":"10.1016\/j.brci.2026.100055_bib78","doi-asserted-by":"crossref","first-page":"2586","DOI":"10.1093\/jn\/125.10.2586","article-title":"Pantothenic acid uptake and metabolism by red blood cells of rats","volume":"125","author":"Annous","year":"1995","journal-title":"J Nutr"},{"issue":"685","key":"10.1016\/j.brci.2026.100055_bib79","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abn5135","article-title":"Vitamin B5 and succinyl-CoA improve ineffective erythropoiesis in SF3B1-mutated myelodysplasia","volume":"15","author":"Mian","year":"2023","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.brci.2026.100055_bib80","first-page":"163","article-title":"Vitamin supplementation and athletic performance","volume":"30","author":"Williams","year":"1989","journal-title":"Int J Vitamin Nutr Res Suppl"},{"issue":"6","key":"10.1016\/j.brci.2026.100055_bib81","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1007\/s004210050364","article-title":"Physiological and performance responses to supplementation with thiamin and pantothenic acid derivatives","volume":"77","author":"Webster","year":"1998","journal-title":"Eur J Appl Physiol Occup Physiol"},{"issue":"4","key":"10.1016\/j.brci.2026.100055_bib82","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1165\/rcmb.2024-0178LE","article-title":"Red blood cell metabolic responses during acute hypoxic exercise in healthy adults","volume":"72","author":"Forbes","year":"2025","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.brci.2026.100055_bib83","first-page":"355","article-title":"Lipid peroxidation: its measurement, occurrence, and significance in animal tissues","volume":"2","author":"Barber","year":"1967","journal-title":"Adv Gerontol Res"},{"issue":"4","key":"10.1016\/j.brci.2026.100055_bib84","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1016\/j.cmet.2018.12.023","article-title":"Polyunsaturated fatty acid desaturation is a mechanism for glycolytic NAD(+) recycling","volume":"29","author":"Kim","year":"2019","journal-title":"Cell Metab"},{"key":"10.1016\/j.brci.2026.100055_bib85","doi-asserted-by":"crossref","DOI":"10.1111\/trf.16402","article-title":"Fatty acid desaturase activity in mature red blood cells and implications for blood storage quality","author":"Thomas","year":"20216161867","journal-title":"Transfusion"},{"issue":"6","key":"10.1016\/j.brci.2026.100055_bib86","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1249\/MSS.0000000000003653","article-title":"Effects of three different distance\/elevation gain ultra-trail races on red blood cell oxidative stress and senescence, and blood rheology","volume":"57","author":"Carin","year":"2025","journal-title":"Med Sci Sports Exerc"},{"key":"10.1016\/j.brci.2026.100055_bib87","doi-asserted-by":"crossref","DOI":"10.1016\/j.jtemb.2023.127316","article-title":"Alterations in plasma and erythrocyte membrane fatty acid composition following exposure to toxic copper level affect membrane deformability and fluidity in female Wistar rats","volume":"80","author":"Adele","year":"2023","journal-title":"J Trace Elem Med Biol"},{"issue":"38","key":"10.1016\/j.brci.2026.100055_bib88","doi-asserted-by":"crossref","first-page":"9574","DOI":"10.1073\/pnas.1806501115","article-title":"Mechanics of diseased red blood cells in human spleen and consequences for hereditary blood disorders","volume":"115","author":"Li","year":"2018","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"10.1016\/j.brci.2026.100055_bib89","doi-asserted-by":"crossref","first-page":"4766","DOI":"10.1038\/s41467-019-12739-9","article-title":"Trisomy 21 activates the kynurenine pathway via increased dosage of interferon receptors","volume":"10","author":"Powers","year":"2019","journal-title":"Nat Commun"},{"key":"10.1016\/j.brci.2026.100055_bib90","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.bbi.2022.07.011","article-title":"C-Reactive protein and the kynurenic acid to quinolinic acid ratio are independently associated with white matter integrity in major depressive disorder","volume":"105","author":"Zheng","year":"2022","journal-title":"Brain Behav Immun"},{"issue":"11","key":"10.1016\/j.brci.2026.100055_bib91","doi-asserted-by":"crossref","first-page":"4455","DOI":"10.1021\/acs.jproteome.0c00606","article-title":"Evidence of structural protein damage and membrane lipid remodeling in red blood cells from COVID-19 patients","volume":"19","author":"Thomas","year":"2020","journal-title":"J Proteome Res"},{"issue":"23","key":"10.1016\/j.brci.2026.100055_bib92","doi-asserted-by":"crossref","DOI":"10.3390\/ijms232315332","article-title":"SARS-CoV-2 altered hemorheological and hematological parameters during one-month observation period in critically ill COVID-19 patients","volume":"23","author":"Bizjak","year":"2022","journal-title":"Int J Mol Sci"},{"issue":"3","key":"10.1016\/j.brci.2026.100055_bib93","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1002\/ajh.26440","article-title":"Increased blood viscosity and red blood cell aggregation in patients with COVID-19","volume":"97","author":"Nader","year":"2022","journal-title":"Am J Hematol"},{"issue":"3","key":"10.1016\/j.brci.2026.100055_bib94","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1097\/MOH.0000000000000863","article-title":"Red blood cell metabolism: a window on systems health towards clinical metabolomics","volume":"32","author":"D\u2019Alessandro","year":"2025","journal-title":"Curr Opin Hematol"}],"container-title":["Blood Red Cells & Iron"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S3050598426000107?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S3050598426000107?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T08:29:15Z","timestamp":1781857755000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S3050598426000107"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":94,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["S3050598426000107"],"URL":"https:\/\/doi.org\/10.1016\/j.brci.2026.100055","relation":{},"ISSN":["3050-5984"],"issn-type":[{"value":"3050-5984","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Long-distance trail running induces inflammation-associated protein, lipid, and purine oxidation in red blood cells","name":"articletitle","label":"Article Title"},{"value":"Blood Red Cells & Iron","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brci.2026.100055","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 American Society of Hematology. Published by Elsevier Inc. Licensed under Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0), permitting only noncommercial, nonderivative use with attribution. All other rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"100055"}}