{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T21:39:50Z","timestamp":1792532390018,"version":"4.5.0"},"reference-count":74,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T00:00:00Z","timestamp":1788393600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000050","name":"NHLBI","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Blood Red Cells & Iron"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.brci.2026.100132","type":"journal-article","created":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T16:11:40Z","timestamp":1788797500000},"page":"100132","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Selenium-associated BHMT2 and DMGDH loci connect one-carbon metabolism, selenoprotein biology, and red blood cell fragility"],"prefix":"10.1016","volume":"2","author":[{"given":"Daniel","family":"Stephenson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1843-7900","authenticated-orcid":false,"given":"Gregory R.","family":"Keele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7296-4963","authenticated-orcid":false,"given":"Julie A.","family":"Reisz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8566-7119","authenticated-orcid":false,"given":"Travis","family":"Nemkov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-1674-0997","authenticated-orcid":false,"given":"Amy","family":"Argabright","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mars","family":"Stone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steve","family":"Kleinman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael P.","family":"Busch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0526-2088","authenticated-orcid":false,"given":"Philip J.","family":"Norris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2582-3786","authenticated-orcid":false,"given":"Grier P.","family":"Page","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2258-6490","authenticated-orcid":false,"given":"Angelo","family":"D\u2019Alessandro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.brci.2026.100132_bib1","first-page":"27","article-title":"Red blood cell storage lesion: causes and potential clinical consequences","volume":"17","author":"Yoshida","year":"2019","journal-title":"Blood Transfus"},{"issue":"6","key":"10.1016\/j.brci.2026.100132_bib2","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1111\/trf.12992","article-title":"The heritability of hemolysis in stored human red blood cells","volume":"55","author":"Van 't Erve","year":"2015","journal-title":"Transfusion"},{"issue":"6","key":"10.1016\/j.brci.2026.100132_bib3","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1111\/j.1537-2995.2008.01642.x","article-title":"Evaluation of proposed FDA criteria for the evaluation of radiolabeled red cell recovery trials","volume":"48","author":"Dumont","year":"2008","journal-title":"Transfusion"},{"issue":"4","key":"10.1016\/j.brci.2026.100132_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.tmrv.2023.150750","article-title":"Red blood cell storage: from genome to exposome towards personalized transfusion medicine","volume":"37","author":"D'Alessandro","year":"2023","journal-title":"Transfus Med Rev"},{"issue":"8","key":"10.1016\/j.brci.2026.100132_bib5","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1111\/j.1537-2995.2009.02173.x","article-title":"A novel mouse model of red blood cell storage and posttransfusion in vivo survival","volume":"49","author":"Gilson","year":"2009","journal-title":"Transfusion"},{"issue":"15","key":"10.1016\/j.brci.2026.100132_bib6","doi-asserted-by":"crossref","first-page":"2272","DOI":"10.1182\/bloodadvances.2019000605","article-title":"Differences in Steap3 expression are a mechanism of genetic variation of RBC storage and oxidative damage in mice","volume":"3","author":"Howie","year":"2019","journal-title":"Blood Adv"},{"issue":"11","key":"10.1016\/j.brci.2026.100132_bib7","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0259267","article-title":"Blood bank storage of red blood cells increases RBC cytoplasmic membrane order and bending rigidity","volume":"16","author":"Himbert","year":"2021","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.brci.2026.100132_bib8","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1111\/j.1365-3148.2012.01139.x","article-title":"Red blood cell storage and cell morphology","volume":"22","author":"Blasi","year":"2012","journal-title":"Transfus Med"},{"issue":"17","key":"10.1016\/j.brci.2026.100132_bib9","doi-asserted-by":"crossref","first-page":"2285","DOI":"10.1182\/blood.2020008563","article-title":"Rapid clearance of storage-induced microerythrocytes alters transfusion recovery","volume":"137","author":"Roussel","year":"2021","journal-title":"Blood"},{"issue":"9","key":"10.1016\/j.brci.2026.100132_bib10","doi-asserted-by":"crossref","DOI":"10.1172\/JCI183099","article-title":"Proteostasis and metabolic dysfunction characterize a subset of storage-induced senescent erythrocytes targeted for posttransfusion clearance","volume":"135","author":"Peltier","year":"2025","journal-title":"J Clin Invest"},{"key":"10.1016\/j.brci.2026.100132_bib11","article-title":"Genetic architecture of the red blood cell proteome in genetically diverse mice reveals central role of hemoglobin beta cysteine redox status in maintaining circulating glutathione pools","author":"Keele","year":"2025","journal-title":"bioRxiv"},{"issue":"7","key":"10.1016\/j.brci.2026.100132_bib12","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1182\/blood.2024026109","article-title":"Ferroptosis regulates hemolysis in stored murine and human red blood cells","volume":"145","author":"D\u2019Alessandro","year":"2025","journal-title":"Blood"},{"issue":"3","key":"10.1016\/j.brci.2026.100132_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.brci.2025.100020","article-title":"GPX4 regulates lipid peroxidation and ferroptosis of stored red blood cells","volume":"1","author":"Stephenson","year":"2025","journal-title":"Blood Red Cells Iron"},{"issue":"14","key":"10.1016\/j.brci.2026.100132_bib14","doi-asserted-by":"crossref","first-page":"2401","DOI":"10.1016\/j.cell.2022.06.003","article-title":"Ferroptosis turns 10: emerging mechanisms, physiological functions, and therapeutic applications","volume":"185","author":"Stockwell","year":"2022","journal-title":"Cell"},{"issue":"12","key":"10.1016\/j.brci.2026.100132_bib15","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1182\/blood.2025032915","article-title":"The red blood cell proteome and interactome identify a Band 3-BLVRB axis regulating hypoxic metabolic adaptation","volume":"148","author":"Issaian","year":"2026","journal-title":"Blood"},{"issue":"13","key":"10.1016\/j.brci.2026.100132_bib16","doi-asserted-by":"crossref","DOI":"10.1172\/JCI146077","article-title":"Multiple-ancestry genome-wide association study identifies 27 loci associated with measures of hemolysis following blood storage","volume":"131","author":"Page","year":"2021","journal-title":"J Clin Invest"},{"key":"10.1016\/j.brci.2026.100132_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.102073","article-title":"Red blood cells contain enzymatically active GPx4 whose abundance anticorrelates with hemolysis during blood bank storage","volume":"46","author":"Stolwijk","year":"2021","journal-title":"Redox Biol"},{"issue":"1","key":"10.1016\/j.brci.2026.100132_bib18","doi-asserted-by":"crossref","first-page":"107","DOI":"10.3324\/haematol.2011.051789","article-title":"Time-course investigation of SAGM-stored leukocyte-filtered red bood cell concentrates: from metabolism to proteomics","volume":"97","author":"D'Alessandro","year":"2012","journal-title":"Haematologica"},{"issue":"3","key":"10.1016\/j.brci.2026.100132_bib19","first-page":"376","article-title":"Storing red blood cells with vitamin C and N-acetylcysteine prevents oxidative stress-related lesions: a metabolomics overview","volume":"12","author":"Pallotta","year":"2014","journal-title":"Blood Transfus"},{"key":"10.1016\/j.brci.2026.100132_bib20","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2022.833242","article-title":"High-throughput metabolomics platform for the rapid data-driven development of novel additive solutions for blood storage","volume":"13","author":"Nemkov","year":"2022","journal-title":"Front Physiol"},{"issue":"10","key":"10.1016\/j.brci.2026.100132_bib21","doi-asserted-by":"crossref","first-page":"2248","DOI":"10.1111\/trf.12106","article-title":"Addition of ascorbic acid solution to stored murine red blood cells increases posttransfusion recovery and decreases microparticles and alloimmunization","volume":"53","author":"Stowell","year":"2013","journal-title":"Transfusion"},{"issue":"5","key":"10.1016\/j.brci.2026.100132_bib22","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1159\/000486605","article-title":"Vitamin E analogue protects red blood cells against storage-induced oxidative damage","volume":"45","author":"Antosik","year":"2018","journal-title":"Transfus Med Hemother"},{"issue":"20","key":"10.1016\/j.brci.2026.100132_bib23","doi-asserted-by":"crossref","DOI":"10.3390\/nu15204456","article-title":"Low-dose dietary fish oil improves RBC deformability without improving post-transfusion recovery in mice","volume":"15","author":"Kim","year":"2023","journal-title":"Nutrients"},{"key":"10.1016\/j.brci.2026.100132_bib24","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2022.868578","article-title":"Deuterated linoleic acid attenuates the RBC storage lesion in a mouse model of poor RBC storage","volume":"13","author":"Kim","year":"2022","journal-title":"Front Physiol"},{"key":"10.1016\/j.brci.2026.100132_bib25","doi-asserted-by":"crossref","DOI":"10.1182\/blood.2024023983","article-title":"Genetic regulation of carnitine metabolism controls lipid damage repair and aging RBC hemolysis in vivo and in vitro","author":"Nemkov","year":"2024143242517","journal-title":"Blood"},{"issue":"3","key":"10.1016\/j.brci.2026.100132_bib26","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1152\/physrev.00039.2013","article-title":"Selenoproteins: molecular pathways and physiological roles","volume":"94","author":"Labunskyy","year":"2014","journal-title":"Physiol Rev"},{"issue":"11","key":"10.1016\/j.brci.2026.100132_bib27","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1016\/j.bbagen.2009.05.014","article-title":"Eukaryotic selenoproteins and selenoproteomes","volume":"1790","author":"Lobanov","year":"2009","journal-title":"Biochim Biophys Acta"},{"issue":"15","key":"10.1016\/j.brci.2026.100132_bib28","doi-asserted-by":"crossref","first-page":"2457","DOI":"10.1007\/s00018-009-0032-4","article-title":"The human selenoproteome: recent insights into functions and regulation","volume":"66","author":"Reeves","year":"2009","journal-title":"Cell Mol Life Sci"},{"issue":"11","key":"10.1016\/j.brci.2026.100132_bib29","doi-asserted-by":"crossref","first-page":"2971","DOI":"10.3324\/haematol.2020.278252","article-title":"The interactome of the N-terminus of band 3 regulates red blood cell metabolism and storage quality","volume":"106","author":"Issaian","year":"2021","journal-title":"Haematologica"},{"issue":"5","key":"10.1016\/j.brci.2026.100132_bib30","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/j.clnu.2013.01.005","article-title":"Erythrocyte selenium concentration as a marker of selenium status","volume":"32","author":"Stefanowicz","year":"2013","journal-title":"Clin Nutr"},{"issue":"4","key":"10.1016\/j.brci.2026.100132_bib31","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1093\/ajcn\/41.4.735","article-title":"Selenium repletion and glutathione peroxidase--differential effects on plasma and red blood cell enzyme activity","volume":"41","author":"Cohen","year":"1985","journal-title":"Am J Clin Nutr"},{"issue":"3","key":"10.1016\/j.brci.2026.100132_bib32","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1111\/j.1365-2141.1978.tb01111.x","article-title":"In vivo and in vitro variations of human erythrocyte glutathione peroxidase activity as result of cells ageing, selenium availability and peroxide activation","volume":"39","author":"Perona","year":"1978","journal-title":"Br J Haematol"},{"key":"10.1016\/j.brci.2026.100132_bib33","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.freeradbiomed.2018.03.035","article-title":"Selenium versus sulfur: reversibility of chemical reactions and resistance to permanent oxidation in proteins and nucleic acids","volume":"127","author":"Maroney","year":"2018","journal-title":"Free Radic Biol Med"},{"issue":"8","key":"10.1016\/j.brci.2026.100132_bib34","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1089\/ars.2010.3323","article-title":"The regulation of erythropoiesis by selenium in mice","volume":"14","author":"Kaushal","year":"2011","journal-title":"Antioxid Redox Signal"},{"issue":"2","key":"10.1016\/j.brci.2026.100132_bib35","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1007\/s12011-020-02162-3","article-title":"Dietary selenium deficiency facilitated reduced stomatin and phosphatidylserine externalization, increasing erythrocyte osmotic fragility in mice","volume":"199","author":"Duan","year":"2021","journal-title":"Biol Trace Elem Res"},{"issue":"4","key":"10.1016\/j.brci.2026.100132_bib36","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1080\/07315724.1983.10719930","article-title":"Red blood cell and serum selenium concentrations as influenced by age and selected diseases","volume":"2","author":"Miller","year":"1983","journal-title":"J Am Coll Nutr"},{"issue":"8","key":"10.1016\/j.brci.2026.100132_bib37","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph19084908","article-title":"Reference ranges of selenium in plasma and whole blood for child-bearing-aged women in China","volume":"19","author":"Cao","year":"2022","journal-title":"Int J Environ Res Public Health"},{"key":"10.1016\/j.brci.2026.100132_bib38","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2022.828087","article-title":"Inductively-coupled plasma mass spectrometry-novel insights from an old technology into stressed red blood cell physiology","volume":"13","author":"Stephenson","year":"2022","journal-title":"Front Physiol"},{"key":"10.1016\/j.brci.2026.100132_bib39","article-title":"A population-scale red blood cell proteome reveals genetically encoded aging clocks predictive of hemolysis and blood donor activity","author":"Dzieciatkowska","year":"2026","journal-title":"bioRxiv"},{"issue":"1","key":"10.1016\/j.brci.2026.100132_bib40","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1111\/trf.14979","article-title":"Heterogeneity of blood processing and storage additives in different centers impacts stored red blood cell metabolism as much as storage time: lessons from REDS-III-Omics","volume":"59","author":"D'Alessandro","year":"2019","journal-title":"Transfusion"},{"issue":"15","key":"10.1016\/j.brci.2026.100132_bib41","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1182\/bloodadvances.2017004820","article-title":"Ethnicity, sex, and age are determinants of red blood cell storage and stress hemolysis: results of the REDS-III RBC-Omics study","volume":"1","author":"Kanias","year":"2017","journal-title":"Blood Adv"},{"key":"10.1016\/j.brci.2026.100132_bib42","article-title":"Evidence for structural protein damage and membrane lipid remodeling in red blood cells from COVID-19 patients","author":"Thomas","year":"2020","journal-title":"medRxiv"},{"key":"10.1016\/j.brci.2026.100132_bib43","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/978-1-4939-9236-2_8","article-title":"Untargeted and semi-targeted lipid analysis of biological samples using mass spectrometry-based metabolomics","volume":"1978","author":"Reisz","year":"2019","journal-title":"Methods Mol Biol"},{"issue":"5","key":"10.1016\/j.brci.2026.100132_bib44","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1111\/trf.16869","article-title":"The Recipient Epidemiology and Donor Evaluation Study-IV-Pediatric (REDS-IV-P): a research program striving to improve blood donor safety and optimize transfusion outcomes across the lifespan","volume":"62","author":"Josephson","year":"2022","journal-title":"Transfusion"},{"issue":"1","key":"10.1016\/j.brci.2026.100132_bib45","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1111\/trf.14987","article-title":"Intradonor reproducibility and changes in hemolytic variables during red blood cell storage: results of recall phase of the REDS-III RBC-Omics study","volume":"59","author":"Lanteri","year":"2019","journal-title":"Transfusion"},{"issue":"12","key":"10.1016\/j.brci.2026.100132_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2022.102706","article-title":"Genome-wide metabolite quantitative trait loci analysis (mQTL) in red blood cells from volunteer blood donors","volume":"298","author":"Moore","year":"2022","journal-title":"J Biol Chem"},{"issue":"9","key":"10.1016\/j.brci.2026.100132_bib47","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1016\/j.cmet.2024.06.007","article-title":"Biological and genetic determinants of glycolysis: phosphofructokinase isoforms boost energy status of stored red blood cells and transfusion outcomes","volume":"36","author":"Nemkov","year":"2024","journal-title":"Cell Metab"},{"issue":"14","key":"10.1016\/j.brci.2026.100132_bib48","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.187792","article-title":"Donor genetics and storage conditions influence mitochondrial DNA and extracellular vesicle levels in RBC units","volume":"10","author":"Deng","year":"2025","journal-title":"JCI Insight"},{"key":"10.1016\/j.brci.2026.100132_bib49","article-title":"Reticulocytes in donor RBC units enhance RBC alloimmunization","author":"Thomas","year":"2023","journal-title":"bioRxiv"},{"issue":"5","key":"10.1016\/j.brci.2026.100132_bib50","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1093\/hmg\/ddu546","article-title":"Genome-wide association study of selenium concentrations","volume":"24","author":"Cornelis","year":"2015","journal-title":"Hum Mol Genet"},{"issue":"2","key":"10.1016\/j.brci.2026.100132_bib51","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1093\/jn\/nxaa355","article-title":"Genome-wide association study of response to selenium supplementation and circulating selenium concentrations in adults of European descent","volume":"151","author":"Batai","year":"2021","journal-title":"J Nutr"},{"issue":"19","key":"10.1016\/j.brci.2026.100132_bib52","doi-asserted-by":"crossref","first-page":"3998","DOI":"10.1093\/hmg\/ddt239","article-title":"Genome-wide association study identifies loci affecting blood copper, selenium and zinc","volume":"22","author":"Evans","year":"2013","journal-title":"Hum Mol Genet"},{"issue":"4","key":"10.1016\/j.brci.2026.100132_bib53","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines10040891","article-title":"The selenoprotein glutathione peroxidase 4: from molecular mechanisms to novel therapeutic opportunities","volume":"10","author":"Weaver","year":"2022","journal-title":"Biomedicines"},{"issue":"7","key":"10.1016\/j.brci.2026.100132_bib54","article-title":"Red blood cell metabolism in vivo and in vitro","volume":"13","author":"D'Alessandro","year":"2023","journal-title":"Metabolites"},{"issue":"23","key":"10.1016\/j.brci.2026.100132_bib55","doi-asserted-by":"crossref","first-page":"4645","DOI":"10.1016\/j.molcel.2024.10.027","article-title":"PRDX6 contributes to selenocysteine metabolism and ferroptosis resistance","volume":"84","author":"Chen","year":"2024","journal-title":"Mol Cell"},{"issue":"23","key":"10.1016\/j.brci.2026.100132_bib56","doi-asserted-by":"crossref","first-page":"4629","DOI":"10.1016\/j.molcel.2024.10.028","article-title":"PRDX6 dictates ferroptosis sensitivity by directing cellular selenium utilization","volume":"84","author":"Ito","year":"2024","journal-title":"Mol Cell"},{"key":"10.1016\/j.brci.2026.100132_bib57","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1016\/j.freeradbiomed.2025.06.036","article-title":"Novel role of peroxiredoxin 6 in ferroptosis: bridging selenium transport with enzymatic functions","volume":"238","author":"Pal","year":"2025","journal-title":"Free Radic Biol Med"},{"issue":"2","key":"10.1016\/j.brci.2026.100132_bib58","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.stem.2025.12.018","article-title":"Activation of a branched-chain amino acid rheostat restores replication-dependent hematopoietic stem cell fitness","volume":"33","author":"Bartram","year":"2026","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.brci.2026.100132_bib59","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.exphem.2023.10.001","article-title":"The multifaceted role of mitochondria in HSC fate decisions: energy and beyond","volume":"128","author":"Filippi","year":"2023","journal-title":"Exp Hematol"},{"issue":"12","key":"10.1016\/j.brci.2026.100132_bib60","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.3324\/haematol.2017.171074","article-title":"Folate dietary insufficiency and folic acid supplementation similarly impair metabolism and compromise hematopoiesis","volume":"102","author":"Henry","year":"2017","journal-title":"Haematologica"},{"issue":"10","key":"10.1016\/j.brci.2026.100132_bib61","doi-asserted-by":"crossref","first-page":"2726","DOI":"10.3324\/haematol.2020.266676","article-title":"Protein-L-isoaspartate O-methyltransferase is required for in vivo control of oxidative damage in red blood cells","volume":"106","author":"D'Alessandro","year":"2021","journal-title":"Haematologica"},{"issue":"12","key":"10.1016\/j.brci.2026.100132_bib62","doi-asserted-by":"crossref","first-page":"2978","DOI":"10.1111\/trf.14936","article-title":"Methylation of protein aspartates and deamidated asparagines as a function of blood bank storage and oxidative stress in human red blood cells","volume":"58","author":"Reisz","year":"2018","journal-title":"Transfusion"},{"issue":"4","key":"10.1016\/j.brci.2026.100132_bib63","doi-asserted-by":"crossref","DOI":"10.1002\/hem3.70361","article-title":"Improved red blood cell storage quality of blood from donors carrying the hypermorphic PIMT I120 variant","volume":"10","author":"Bevers","year":"2026","journal-title":"Hemasphere"},{"issue":"1","key":"10.1016\/j.brci.2026.100132_bib64","first-page":"75","article-title":"Red blood cell subpopulations in freshly drawn blood: application of proteomics and metabolomics to a decades-long biological issue","volume":"11","author":"D'Alessandro","year":"2013","journal-title":"Blood Transfus"},{"issue":"3","key":"10.1016\/j.brci.2026.100132_bib65","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S1568-1637(03)00011-4","article-title":"Aging as war between chemical and biochemical processes: protein methylation and the recognition of age-damaged proteins for repair","volume":"2","author":"Clarke","year":"2003","journal-title":"Ageing Res Rev"},{"issue":"6","key":"10.1016\/j.brci.2026.100132_bib66","doi-asserted-by":"crossref","first-page":"501","DOI":"10.2174\/1570159X18666200106152631","article-title":"Selenium and neurological diseases: focus on peripheral pain and TRP channels","volume":"18","author":"Naz\u0131ro\u011flu","year":"2020","journal-title":"Curr Neuropharmacol"},{"issue":"3","key":"10.1016\/j.brci.2026.100132_bib67","doi-asserted-by":"crossref","first-page":"282","DOI":"10.2174\/1570159X14666151223100011","article-title":"Selenium in the therapy of neurological diseases. Where is it going?","volume":"14","author":"Dominiak","year":"2016","journal-title":"Curr Neuropharmacol"},{"issue":"11","key":"10.1016\/j.brci.2026.100132_bib68","doi-asserted-by":"crossref","first-page":"5296","DOI":"10.1002\/alz.13115","article-title":"The role of PIMT in Alzheimer's disease pathogenesis: a novel hypothesis","volume":"19","author":"D'Alessandro","year":"2023","journal-title":"Alzheimers Dement"},{"issue":"20","key":"10.1016\/j.brci.2026.100132_bib69","doi-asserted-by":"crossref","first-page":"5263","DOI":"10.1111\/j.1742-4658.2007.06048.x","article-title":"Accumulation of altered aspartyl residues in erythrocyte proteins from patients with Down's syndrome","volume":"274","author":"Galletti","year":"2007","journal-title":"Febs j"},{"issue":"2","key":"10.1016\/j.brci.2026.100132_bib70","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1046\/j.1537-2995.1997.37297203519.x","article-title":"Addition of L-carnitine to additive solution-suspended red cells stored at 4 degrees C reduces in vitro hemolysis and improves in vivo viability","volume":"37","author":"Arduini","year":"1997","journal-title":"Transfusion"},{"issue":"1","key":"10.1016\/j.brci.2026.100132_bib71","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.tmrv.2003.10.003","article-title":"L-carnitine and its possible role in red cell and platelet storage","volume":"18","author":"Sweeney","year":"2004","journal-title":"Transfus Med Rev"},{"issue":"2","key":"10.1016\/j.brci.2026.100132_bib72","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.cmet.2021.12.019","article-title":"Erythrocyte transglutaminase-2 combats hypoxia and chronic kidney disease by promoting oxygen delivery and carnitine homeostasis","volume":"34","author":"Xu","year":"2022","journal-title":"Cell Metab"},{"issue":"7","key":"10.1016\/j.brci.2026.100132_bib73","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1194\/jlr.R082578","article-title":"The phospholipase A(2) activity of peroxiredoxin 6","volume":"59","author":"Fisher","year":"2018","journal-title":"J Lipid Res"},{"issue":"10","key":"10.1016\/j.brci.2026.100132_bib74","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1182\/blood.2026034666","article-title":"Precision transfusion medicine in the omics era","volume":"148","author":"D'Alessandro","year":"2026","journal-title":"Blood"}],"container-title":["Blood Red Cells & Iron"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S3050598426000879?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S3050598426000879?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T21:06:27Z","timestamp":1792530387000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S3050598426000879"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":74,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["S3050598426000879"],"URL":"https:\/\/doi.org\/10.1016\/j.brci.2026.100132","relation":{},"ISSN":["3050-5984"],"issn-type":[{"value":"3050-5984","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Selenium-associated BHMT2 and DMGDH loci connect one-carbon metabolism, selenoprotein biology, and red blood cell fragility","name":"articletitle","label":"Article Title"},{"value":"Blood Red Cells & Iron","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brci.2026.100132","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 American Society of Hematology. Published by Elsevier Inc. Licensed under Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0), permitting only noncommercial, nonderivative use with attribution. All other rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"100132"}}