{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T15:52:51Z","timestamp":1792511571219,"version":"4.5.0"},"reference-count":73,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T00:00:00Z","timestamp":1789430400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000050","name":"NHLBI","doi-asserted-by":"publisher","award":["R01HL148151"],"award-info":[{"award-number":["R01HL148151"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"NHLBI","doi-asserted-by":"publisher","award":["R01HL146442"],"award-info":[{"award-number":["R01HL146442"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"NHLBI","doi-asserted-by":"publisher","award":["R01HL161004"],"award-info":[{"award-number":["R01HL161004"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Blood Red Cells &amp; Iron"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.brci.2026.100133","type":"journal-article","created":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T22:22:32Z","timestamp":1789770152000},"page":"100133","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["The red blood cell metabolome maps disease burden, mutation class, and splenectomy status in hereditary spherocytosis"],"prefix":"10.1016","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8566-7119","authenticated-orcid":false,"given":"Travis","family":"Nemkov","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philippe","family":"Connes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6054-2456","authenticated-orcid":false,"given":"Elie","family":"Nader","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-0392-2428","authenticated-orcid":false,"given":"Romain","family":"Carin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4025-7279","authenticated-orcid":false,"given":"Manon","family":"Casabianca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Gauthier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4208-8376","authenticated-orcid":false,"given":"Camille","family":"Boisson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9line","family":"Renoux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Granier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arnaud","family":"Hot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Solene","family":"Poutrel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6785-7709","authenticated-orcid":false,"given":"Giovanna","family":"Cannas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves","family":"Bertrand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2351-9441","authenticated-orcid":false,"given":"Philippe","family":"Joly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2258-6490","authenticated-orcid":false,"given":"Angelo","family":"D\u2019Alessandro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9647","key":"10.1016\/j.brci.2026.100133_bib1","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1016\/S0140-6736(08)61588-3","article-title":"Hereditary spherocytosis","volume":"372","author":"Perrotta","year":"2008","journal-title":"Lancet"},{"issue":"4","key":"10.1016\/j.brci.2026.100133_bib2","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.blre.2013.04.003","article-title":"Hereditary spherocytosis, elliptocytosis, and other red cell membrane disorders","volume":"27","author":"Da Costa","year":"2013","journal-title":"Blood Rev"},{"issue":"1","key":"10.1016\/j.brci.2026.100133_bib3","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/j.1365-2141.1999.01130.x","article-title":"Red blood cell membrane disorders","volume":"104","author":"Tse","year":"1999","journal-title":"Br J Haematol"},{"key":"10.1016\/j.brci.2026.100133_bib4","series-title":"Hereditary Spherocytosis","author":"Zamora","year":"2026"},{"issue":"1","key":"10.1016\/j.brci.2026.100133_bib5","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1186\/s13023-019-1070-0","article-title":"Molecular diagnosis of hereditary spherocytosis by multi-gene target sequencing in Korea: matching with osmotic fragility test and presence of spherocyte","volume":"14","author":"Choi","year":"2019","journal-title":"Orphanet J Rare Dis"},{"key":"10.1016\/j.brci.2026.100133_bib6","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2025.1497588","article-title":"An overview of hereditary spherocytosis and the curative effects of splenectomy","volume":"16","author":"Turpaev","year":"2025","journal-title":"Front Physiol"},{"issue":"7","key":"10.1016\/j.brci.2026.100133_bib7","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1038\/s41594-022-00792-w","article-title":"Architecture of the human erythrocyte ankyrin-1 complex","volume":"29","author":"Vallese","year":"2022","journal-title":"Nat Struct Mol Biol"},{"key":"10.1016\/j.brci.2026.100133_bib8","doi-asserted-by":"crossref","DOI":"10.3324\/haematol.2020.278252","article-title":"The interactome of the N-terminus of band 3 regulates red blood cell metabolism and storage quality","author":"Issaian","year":"2021106112971","journal-title":"Haematologica"},{"issue":"4","key":"10.1016\/j.brci.2026.100133_bib9","doi-asserted-by":"crossref","DOI":"10.1097\/HS9.0000000000000276","article-title":"The complexity of genotype-phenotype correlations in hereditary spherocytosis: a cohort of 95 patients: genotype-phenotype correlation in hereditary spherocytosis","volume":"3","author":"van Vuren","year":"2019","journal-title":"Hemasphere"},{"issue":"1","key":"10.1016\/j.brci.2026.100133_bib10","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-78622-w","article-title":"Identification and functional analysis of novel SPTB and ANK1 mutations in hereditary spherocytosis patients","volume":"14","author":"Panarach","year":"2024","journal-title":"Sci Rep"},{"key":"10.1016\/j.brci.2026.100133_bib11","doi-asserted-by":"crossref","first-page":"815","DOI":"10.3389\/fphys.2019.00815","article-title":"The spectrum of SPTA1-associated hereditary spherocytosis","volume":"10","author":"Chonat","year":"2019","journal-title":"Front Physiol"},{"issue":"1","key":"10.1016\/j.brci.2026.100133_bib12","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1111\/j.1365-2141.1994.tb03266.x","article-title":"Hereditary spherocytosis associated with protein band 3 defect in a Swiss kindred","volume":"86","author":"Reinhart","year":"1994","journal-title":"Br J Haematol"},{"issue":"12","key":"10.1016\/j.brci.2026.100133_bib13","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1182\/blood.2025032915","article-title":"The red blood cell proteome and interactome identify a band 3\u2013BLVRB axis regulating hypoxic metabolic adaptation","volume":"148","author":"Issaian","year":"2026","journal-title":"Blood"},{"issue":"10","key":"10.1016\/j.brci.2026.100133_bib14","doi-asserted-by":"crossref","first-page":"3939","DOI":"10.1182\/blood-2008-07-161166","article-title":"Red cell membrane: past, present, and future","volume":"112","author":"Mohandas","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.brci.2026.100133_bib15","series-title":"GeneReviews","article-title":"EPB42-related hereditary spherocytosis","author":"Kalfa","year":"1993"},{"issue":"3","key":"10.1016\/j.brci.2026.100133_bib16","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1111\/j.1365-2141.1990.tb02594.x","article-title":"A genetic defect of erythrocyte band 4.2 protein associated with hereditary spherocytosis","volume":"74","author":"Ideguchi","year":"1990","journal-title":"Br J Haematol"},{"issue":"13","key":"10.1016\/j.brci.2026.100133_bib17","doi-asserted-by":"crossref","DOI":"10.1172\/JCI146077","article-title":"Multiple-ancestry genome-wide association study identifies 27 loci associated with measures of hemolysis following blood storage","volume":"131","author":"Page","year":"2021","journal-title":"J Clin Invest"},{"issue":"15","key":"10.1016\/j.brci.2026.100133_bib18","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1182\/bloodadvances.2017004820","article-title":"Ethnicity, sex, and age are determinants of red blood cell storage and stress hemolysis: results of the REDS-III RBC-Omics study","volume":"1","author":"Kanias","year":"2017","journal-title":"Blood Adv"},{"issue":"1","key":"10.1016\/j.brci.2026.100133_bib19","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1111\/trf.16141","article-title":"Testosterone replacement therapy in blood donors modulates erythrocyte metabolism and susceptibility to hemolysis in cold storage","volume":"61","author":"Alexander","year":"2021","journal-title":"Transfusion"},{"issue":"2","key":"10.1016\/j.brci.2026.100133_bib20","doi-asserted-by":"crossref","DOI":"10.1111\/acel.14388","article-title":"Arginine metabolism is a biomarker of red blood cell and human aging","volume":"24","author":"Reisz","year":"2025","journal-title":"Aging Cell"},{"issue":"2","key":"10.1016\/j.brci.2026.100133_bib21","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1111\/trf.16168","article-title":"Blood donor obesity is associated with changes in red blood cell metabolism and susceptibility to hemolysis in cold storage and in response to osmotic and oxidative stress","volume":"61","author":"Hazegh","year":"2021","journal-title":"Transfusion"},{"issue":"3","key":"10.1016\/j.brci.2026.100133_bib22","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.146175","article-title":"Blood donor exposome and impact of common drugs on red blood cell metabolism","volume":"6","author":"Nemkov","year":"2021","journal-title":"JCI Insight"},{"issue":"1","key":"10.1016\/j.brci.2026.100133_bib23","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1111\/trf.14987","article-title":"Intradonor reproducibility and changes in hemolytic variables during red blood cell storage: results of recall phase of the REDS-III RBC-Omics study","volume":"59","author":"Lanteri","year":"2019","journal-title":"Transfusion"},{"issue":"4","key":"10.1016\/j.brci.2026.100133_bib24","doi-asserted-by":"crossref","first-page":"516","DOI":"10.3324\/haematol.2011.052845","article-title":"Diagnostic power of laboratory tests for hereditary spherocytosis: a comparison study in 150 patients grouped according to molecular and clinical characteristics","volume":"97","author":"Bianchi","year":"2012","journal-title":"Haematologica"},{"issue":"1","key":"10.1016\/j.brci.2026.100133_bib25","doi-asserted-by":"crossref","first-page":"10","DOI":"10.5045\/br.2018.53.1.10","article-title":"Cryohemolysis, erythrocyte osmotic fragility, and supplementary hematimetric indices in the diagnosis of hereditary spherocytosis","volume":"53","author":"Emilse","year":"2018","journal-title":"Blood Res"},{"issue":"1","key":"10.1016\/j.brci.2026.100133_bib26","doi-asserted-by":"crossref","first-page":"6771","DOI":"10.1038\/s41598-019-43200-y","article-title":"Impact of surface-area-to-volume ratio, internal viscosity and membrane viscoelasticity on red blood cell deformability measured in isotonic condition","volume":"9","author":"Renoux","year":"2019","journal-title":"Sci Rep"},{"key":"10.1016\/j.brci.2026.100133_bib27","doi-asserted-by":"crossref","first-page":"641384","DOI":"10.3389\/fphys.2021.641384","article-title":"Ektacytometry analysis of post-splenectomy red blood cell properties identifies cell membrane stability test as a novel biomarker of membrane health in hereditary spherocytosis","volume":"12","author":"Berrevoets","year":"2021","journal-title":"Front Physiol"},{"issue":"7","key":"10.1016\/j.brci.2026.100133_bib28","doi-asserted-by":"crossref","first-page":"793","DOI":"10.3390\/metabo13070793","article-title":"Red blood cell metabolism in vivo and in vitro","volume":"13","author":"D\u2019Alessandro","year":"2023","journal-title":"Metabolites"},{"issue":"3","key":"10.1016\/j.brci.2026.100133_bib29","doi-asserted-by":"crossref","DOI":"10.1111\/apha.14081","article-title":"Erythrocyte metabolism","volume":"240","author":"Chatzinikolaou","year":"2024","journal-title":"Acta Physiol (Oxf)"},{"issue":"24","key":"10.1016\/j.brci.2026.100133_bib30","doi-asserted-by":"crossref","first-page":"2517","DOI":"10.1182\/blood.2024023983","article-title":"Genetic regulation of carnitine metabolism controls lipid damage repair and aging RBC hemolysis in vivo and in vitro","volume":"143","author":"Nemkov","year":"2024","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.brci.2026.100133_bib31","first-page":"75","article-title":"Red blood cell subpopulations in freshly drawn blood: application of proteomics and metabolomics to a decades-long biological issue","volume":"11","author":"D\u2019Alessandro","year":"2013","journal-title":"Blood Transfus"},{"issue":"11","key":"10.1016\/j.brci.2026.100133_bib32","doi-asserted-by":"crossref","first-page":"2633","DOI":"10.1111\/trf.16017","article-title":"Donor-dependent aging of young and old red blood cell subpopulations: metabolic and functional heterogeneity","volume":"60","author":"Mykhailova","year":"2020","journal-title":"Transfusion"},{"issue":"7","key":"10.1016\/j.brci.2026.100133_bib33","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1182\/blood.2024026109","article-title":"Ferroptosis regulates hemolysis in stored murine and human red blood cells","volume":"145","author":"D\u2019Alessandro","year":"2025","journal-title":"Blood"},{"issue":"9","key":"10.1016\/j.brci.2026.100133_bib34","doi-asserted-by":"crossref","DOI":"10.1172\/JCI183099","article-title":"Proteostasis and metabolic dysfunction characterize a subset of storage-induced senescent erythrocytes targeted for post-transfusion clearance","volume":"135","author":"Peltier","year":"2025","journal-title":"J Clin Invest"},{"issue":"9","key":"10.1016\/j.brci.2026.100133_bib35","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1016\/j.cmet.2024.06.007","article-title":"Biological and genetic determinants of glycolysis: phosphofructokinase isoforms boost energy status of stored red blood cells and transfusion outcomes","volume":"36","author":"Nemkov","year":"2024","journal-title":"Cell Metab"},{"issue":"7","key":"10.1016\/j.brci.2026.100133_bib36","doi-asserted-by":"crossref","DOI":"10.1097\/HS9.0000000000000591","article-title":"Metabolic fingerprint in hereditary spherocytosis correlates with red blood cell characteristics and clinical severity","volume":"5","author":"van Dooijeweert","year":"2021","journal-title":"Hemasphere"},{"issue":"5","key":"10.1016\/j.brci.2026.100133_bib37","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1182\/blood.2023022052","article-title":"Regulation of kynurenine metabolism by blood donor genetics and biology impacts red cell hemolysis in vitro and in vivo","volume":"143","author":"Nemkov","year":"2024","journal-title":"Blood"},{"issue":"5","key":"10.1016\/j.brci.2026.100133_bib38","doi-asserted-by":"crossref","first-page":"e41","DOI":"10.1111\/bjh.19444","article-title":"Red blood cell senescence and vascular function in patients with hereditary spherocytosis with and without splenectomy","volume":"204","author":"Casabianca","year":"2024","journal-title":"Br J Haematol"},{"key":"10.1016\/j.brci.2026.100133_bib39","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.551441","article-title":"Association between nitric oxide, oxidative stress, eryptosis, red blood cell microparticles, and vascular function in sickle cell anemia","volume":"11","author":"Nader","year":"2020","journal-title":"Front Immunol"},{"issue":"11","key":"10.1016\/j.brci.2026.100133_bib40","doi-asserted-by":"crossref","first-page":"3086","DOI":"10.3324\/haematol.2023.282684","article-title":"Increased retention of functional mitochondria in mature sickle red blood cells is associated with increased sickling tendency, hemolysis and oxidative stress","volume":"108","author":"Esperti","year":"2023","journal-title":"Haematologica"},{"issue":"4","key":"10.1016\/j.brci.2026.100133_bib41","doi-asserted-by":"crossref","first-page":"H789","DOI":"10.1152\/ajpheart.00334.2025","article-title":"Persisting elevation of total hemoglobin mass after altitude training in elite swimmers: a potential role of prolonged erythrocyte survival","volume":"329","author":"Carin","year":"2025","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"8","key":"10.1016\/j.brci.2026.100133_bib42","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1002\/rcm.7834","article-title":"A three-minute method for high-throughput quantitative metabolomics and quantitative tracing experiments of central carbon and nitrogen pathways","volume":"31","author":"Nemkov","year":"2017","journal-title":"Rapid Commun Mass Spectrom"},{"key":"10.1016\/j.brci.2026.100133_bib43","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/978-1-4939-9236-2_2","article-title":"High-throughput metabolomics: isocratic and gradient mass spectrometry-based methods","volume":"1978","author":"Nemkov","year":"2019","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.brci.2026.100133_bib44","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2022.833242","article-title":"High-throughput metabolomics platform for the rapid data-driven development of novel additive solutions for blood storage","volume":"13","author":"Nemkov","year":"2022","journal-title":"Front Physiol"},{"issue":"5","key":"10.1016\/j.brci.2026.100133_bib45","doi-asserted-by":"crossref","DOI":"10.15252\/embr.202255373","article-title":"pH regulates hematopoietic stem cell potential via polyamines","volume":"24","author":"Kumar","year":"2023","journal-title":"EMBO Rep"},{"key":"10.1016\/j.brci.2026.100133_bib46","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2019.01329","article-title":"Blood rheology: key parameters, impact on blood flow, role in sickle cell disease and effects of exercise","volume":"10","author":"Nader","year":"2019","journal-title":"Front Physiol"},{"key":"10.1016\/j.brci.2026.100133_bib47","article-title":"Long-distance trail running induces inflammatory-associated protein, lipid, and purine oxidation in red blood cells","author":"Nemkov","year":"2025","journal-title":"bioRxiv"},{"issue":"3","key":"10.1016\/j.brci.2026.100133_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.brci.2025.100020","article-title":"GPX4 regulates lipid peroxidation and ferroptosis of stored red blood cells","volume":"1","author":"Stephenson","year":"2025","journal-title":"Blood Red Cells Iron"},{"issue":"1","key":"10.1016\/j.brci.2026.100133_bib49","article-title":"Hypoxia-mediated impaired erythrocyte Lands\u2019 cycle is pathogenic for sickle cell disease","volume":"6","author":"Wu","year":"2016","journal-title":"Sci Rep"},{"issue":"2","key":"10.1016\/j.brci.2026.100133_bib50","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.cmet.2021.12.019","article-title":"Erythrocyte transglutaminase-2 combats hypoxia and chronic kidney disease by promoting oxygen delivery and carnitine homeostasis","volume":"34","author":"Xu","year":"2022","journal-title":"Cell Metab"},{"issue":"6","key":"10.1016\/j.brci.2026.100133_bib51","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1016\/j.kint.2021.08.024","article-title":"Proteinuric chronic kidney disease is associated with altered red blood cell lifespan, deformability and metabolism","volume":"100","author":"Bissinger","year":"2021","journal-title":"Kidney Int"},{"issue":"8","key":"10.1016\/j.brci.2026.100133_bib52","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0269619","article-title":"The bending rigidity of the red blood cell cytoplasmic membrane","volume":"17","author":"Himbert","year":"2022","journal-title":"PLoS One"},{"issue":"11","key":"10.1016\/j.brci.2026.100133_bib53","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0259267","article-title":"Blood bank storage of red blood cells increases RBC cytoplasmic membrane order and bending rigidity","volume":"16","author":"Himbert","year":"2021","journal-title":"PLoS One"},{"issue":"20","key":"10.1016\/j.brci.2026.100133_bib54","doi-asserted-by":"crossref","DOI":"10.3390\/nu15204456","article-title":"Low-dose dietary fish oil improves RBC deformability without improving post-transfusion recovery in mice","volume":"15","author":"Kim","year":"2023","journal-title":"Nutrients"},{"issue":"3","key":"10.1016\/j.brci.2026.100133_bib55","doi-asserted-by":"crossref","DOI":"10.3390\/cells11030503","article-title":"Eryptosis: programmed death of nucleus-free, iron-filled blood cells","volume":"11","author":"Dreischer","year":"2022","journal-title":"Cells"},{"issue":"16","key":"10.1016\/j.brci.2026.100133_bib56","doi-asserted-by":"crossref","DOI":"10.3390\/ijms26167722","article-title":"Not-so-rare defects of RBC lipidic composition: four new cases of flippase deficiency due to ATP11C mutations","volume":"26","author":"Fermo","year":"2025","journal-title":"Int J Mol Sci"},{"issue":"1","key":"10.1016\/j.brci.2026.100133_bib57","doi-asserted-by":"crossref","DOI":"10.1002\/hem3.70288","article-title":"Hypomorphic ATP11c is a novel regulator of decreased efficacy of transfused red blood cells in humans and mice","volume":"10","author":"Zimring","year":"2026","journal-title":"Hemasphere"},{"issue":"8045","key":"10.1016\/j.brci.2026.100133_bib58","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1038\/s41586-024-08264-5","article-title":"Haematological setpoints are a stable and patient-specific deep phenotype","volume":"637","author":"Foy","year":"2025","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.brci.2026.100133_bib59","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.3324\/haematol.2020.246603","article-title":"Donor sex, age and ethnicity impact stored red blood cell antioxidant metabolism through mechanisms in part explained by glucose 6-phosphate dehydrogenase levels and activity","volume":"106","author":"D\u2019Alessandro","year":"2021","journal-title":"Haematologica"},{"issue":"10","key":"10.1016\/j.brci.2026.100133_bib60","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2020.101630","article-title":"Metabolome changes during in vivo red cell aging reveal disruption of key metabolic pathways","volume":"23","author":"Jamshidi","year":"2020","journal-title":"iScience"},{"key":"10.1016\/j.brci.2026.100133_bib61","article-title":"Reticulocytes in donor RBC units enhance RBC alloimmunization","author":"Thomas","year":"2023","journal-title":"bioRxiv"},{"issue":"2","key":"10.1016\/j.brci.2026.100133_bib62","first-page":"130","article-title":"Decoding the metabolic landscape of pathophysiological stress-induced cell death in anucleate red blood cells","volume":"18","author":"Nemkov","year":"2020","journal-title":"Blood Transfus"},{"issue":"2","key":"10.1016\/j.brci.2026.100133_bib63","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1021\/acs.jproteome.1c00912","article-title":"Irradiation causes alterations of polyamine, purine, and sulfur metabolism in red blood cells and multiple organs","volume":"21","author":"Kalani Roy","year":"2022","journal-title":"J Proteome Res"},{"issue":"17","key":"10.1016\/j.brci.2026.100133_bib64","doi-asserted-by":"crossref","first-page":"4464","DOI":"10.1016\/j.cell.2021.07.021","article-title":"Erythroid mitochondrial retention triggers myeloid-dependent type I interferon in human SLE","volume":"184","author":"Caielli","year":"2021","journal-title":"Cell"},{"issue":"9","key":"10.1016\/j.brci.2026.100133_bib65","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1038\/s41577-021-00524-z","article-title":"The cGAS\u2013STING pathway as a therapeutic target in inflammatory diseases","volume":"21","author":"Decout","year":"2021","journal-title":"Nat Rev Immunol"},{"issue":"22","key":"10.1016\/j.brci.2026.100133_bib66","doi-asserted-by":"crossref","first-page":"3116","DOI":"10.1182\/blood.2020009063","article-title":"Circulating mitochondrial DNA is a proinflammatory DAMP in sickle cell disease","volume":"137","author":"Tumburu","year":"2021","journal-title":"Blood"},{"issue":"23","key":"10.1016\/j.brci.2026.100133_bib67","doi-asserted-by":"crossref","first-page":"2581","DOI":"10.1182\/blood-2017-12-822619","article-title":"Increased erythrophagocytosis induces ferroptosis in red pulp macrophages in a mouse model of transfusion","volume":"131","author":"Youssef","year":"2018","journal-title":"Blood"},{"issue":"17","key":"10.1016\/j.brci.2026.100133_bib68","doi-asserted-by":"crossref","first-page":"2285","DOI":"10.1182\/blood.2020008563","article-title":"Rapid clearance of storage-induced microerythrocytes alters transfusion recovery","volume":"137","author":"Roussel","year":"2021","journal-title":"Blood"},{"issue":"8","key":"10.1016\/j.brci.2026.100133_bib69","doi-asserted-by":"crossref","first-page":"2639","DOI":"10.3324\/haematol.2023.284831","article-title":"Functional and multi-omics signatures of mitapivat efficacy upon activation of pyruvate kinase in red blood cells from patients with sickle cell disease","volume":"109","author":"D\u2019Alessandro","year":"2024","journal-title":"Haematologica"},{"issue":"20","key":"10.1016\/j.brci.2026.100133_bib70","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.172656","article-title":"Mitapivat reprograms the RBC metabolome and improves anemia in a mouse model of hereditary spherocytosis","volume":"8","author":"Matte","year":"2023","journal-title":"JCI Insight"},{"issue":"1","key":"10.1016\/j.brci.2026.100133_bib71","doi-asserted-by":"crossref","DOI":"10.1016\/j.brci.2025.100005","article-title":"Ex vivo activation of pyruvate kinase improves red blood cell metabolism and hydration in hereditary spherocytosis","volume":"1","author":"de Wilde","year":"2025","journal-title":"Blood Red Cells Iron"},{"issue":"7","key":"10.1016\/j.brci.2026.100133_bib72","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2023-083691","article-title":"Designing a single-arm phase 2 clinical trial of mitapivat for adult patients with erythrocyte membranopathies (SATISFY): a framework for interventional trials in rare anaemias - pilot study protocol","volume":"14","author":"Glenth\u00f8j","year":"2024","journal-title":"BMJ Open"},{"key":"10.1016\/j.brci.2026.100133_bib73","series-title":"Paper presented at: EHA 2025 Congress, European Hematology Association","article-title":"SATISFY: mitapivat in adults with erythrocyte membranopathies and congenital dyserythropoietic anemia type II: a EuroBloodNet, multicenter, single-arm, phase 2 study","author":"Doeven","year":"2025"}],"container-title":["Blood Red Cells &amp; Iron"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S3050598426000880?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S3050598426000880?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T15:33:35Z","timestamp":1792510415000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S3050598426000880"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":73,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,12]]}},"alternative-id":["S3050598426000880"],"URL":"https:\/\/doi.org\/10.1016\/j.brci.2026.100133","relation":{},"ISSN":["3050-5984"],"issn-type":[{"value":"3050-5984","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The red blood cell metabolome maps disease burden, mutation class, and splenectomy status in hereditary spherocytosis","name":"articletitle","label":"Article Title"},{"value":"Blood Red Cells & Iron","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brci.2026.100133","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 American Society of Hematology. Published by Elsevier Inc. Licensed under Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0), permitting only noncommercial, nonderivative use with attribution. All other rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"100133"}}