{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T16:51:39Z","timestamp":1786985499117,"version":"build-2736575974"},"reference-count":35,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T00:00:00Z","timestamp":1359676800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2013,2,1]],"date-time":"2013-02-01T00:00:00Z","timestamp":1359676800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,10,10]],"date-time":"2019-10-10T00:00:00Z","timestamp":1570665600000},"content-version":"vor","delay-in-days":2442,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thebreastonline.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Breast"],"published-print":{"date-parts":[[2013,2]]},"DOI":"10.1016\/j.breast.2012.10.009","type":"journal-article","created":{"date-parts":[[2012,11,5]],"date-time":"2012-11-05T21:16:42Z","timestamp":1352150202000},"page":"19-23","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"title":["Implication of breast cancer phenotype for patients with leptomeningeal carcinomatosis"],"prefix":"10.1016","volume":"22","author":[{"given":"Davis","family":"Torrej\u00f3n","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mafalda","family":"Oliveira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Cortes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gessami","family":"Sanchez-Olle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"G\u00f3mez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meritxell","family":"Bellet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Saura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicente","family":"Peg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Rovira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serena","family":"Di Cosimo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.breast.2012.10.009_bib1","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0733-8619(02)00032-4","article-title":"Leptomeningeal metastases","volume":"21","author":"Kesari","year":"2003","journal-title":"Neurol Clin"},{"key":"10.1016\/j.breast.2012.10.009_bib2","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1002\/jso.2930230311","article-title":"Breast carcinoma: pattern of metastasis at autopsy","volume":"23","author":"Lee","year":"1983","journal-title":"J\u00a0Surg Oncol"},{"key":"10.1016\/j.breast.2012.10.009_bib3","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.1002\/1097-0142(19831215)52:12<2349::AID-CNCR2820521231>3.0.CO;2-B","article-title":"Central nervous system metastasis from breast carcinoma. Autopsy study","volume":"52","author":"Tsukada","year":"1983","journal-title":"Cancer"},{"issue":"1","key":"10.1016\/j.breast.2012.10.009_bib4","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/s11060-007-9340-4","article-title":"Breast cancer leptomeningeal metastasis\u2013the role of multimodality treatment","volume":"84","author":"Rudnicka","year":"2007","journal-title":"J\u00a0Neurooncol"},{"key":"10.1016\/j.breast.2012.10.009_bib5","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1023\/A:1005803918194","article-title":"Carcinomatous meningitis secondary to breast cancer: predictors of response to combined modality therapy","volume":"35","author":"Chamberlain","year":"1997","journal-title":"J\u00a0Neurooncol"},{"issue":"6","key":"10.1016\/j.breast.2012.10.009_bib6","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1097\/CCO.0b013e32833de986","article-title":"Leptomeningeal metastasis","volume":"22","author":"Chamberlain","year":"2010","journal-title":"Curr Opin Oncol"},{"key":"10.1016\/j.breast.2012.10.009_bib7","doi-asserted-by":"crossref","DOI":"10.1093\/annonc\/mdq232","article-title":"Survival of breast cancer patients with meningeal carcinomatosis","author":"Gauthier","year":"2010","journal-title":"Ann Oncol"},{"issue":"20","key":"10.1016\/j.breast.2012.10.009_bib8","doi-asserted-by":"crossref","first-page":"3271","DOI":"10.1200\/JCO.2009.25.9820","article-title":"Metastatic behavior of breast cancer subtypes","volume":"28","author":"Kennecke","year":"2010","journal-title":"J\u00a0Clin Oncol"},{"issue":"2","key":"10.1016\/j.breast.2012.10.009_bib9","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/s11060-008-9768-1","article-title":"Meningeal carcinomatosis in HER2-overexpressing breast cancers","volume":"93","author":"Bidard","year":"2009","journal-title":"J\u00a0Neurooncol"},{"issue":"6","key":"10.1016\/j.breast.2012.10.009_bib10","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1002\/1097-0142(19910315)67:6<1685::AID-CNCR2820670635>3.0.CO;2-M","article-title":"Meningeal carcinomatosis in breast cancer. Prognostic factors and influence of treatment","volume":"67","author":"Boogerd","year":"1991","journal-title":"Cancer"},{"key":"10.1016\/j.breast.2012.10.009_bib11","doi-asserted-by":"crossref","DOI":"10.1007\/s11060-010-0524-y","article-title":"Meningeal carcinomatosis in breast cancer: prognostic factors and outcome","author":"de Azevedo","year":"2011","journal-title":"J\u00a0Neurooncol"},{"issue":"12","key":"10.1016\/j.breast.2012.10.009_bib12","doi-asserted-by":"crossref","first-page":"3135","DOI":"10.1002\/1097-0142(19941215)74:12<3135::AID-CNCR2820741212>3.0.CO;2-8","article-title":"Carcinomatous meningitis in patients with breast cancer. An aggressive disease variant","volume":"74","author":"Jayson","year":"1994","journal-title":"Cancer"},{"key":"10.1016\/j.breast.2012.10.009_bib13","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1200\/JCO.2006.09.2775","article-title":"American Society of Clinical Oncology\/College of American Pathologists guideline recommendations for human epidermal growth factor receptor 2 testing in breast cancer","volume":"25","author":"Wolff","year":"2007","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.breast.2012.10.009_bib14","doi-asserted-by":"crossref","DOI":"10.1200\/jco.2011.29.15_suppl.1073","article-title":"Breast cancer carcinomatous meningitis: differences in survival depending on biological subtype, performance status, and treatment methods","volume":"29","author":"Niwinska","year":"2011","journal-title":"J\u00a0Clin Oncol"},{"issue":"7s","key":"10.1016\/j.breast.2012.10.009_bib15","article-title":"Pathological characteristics and prognosis of a cohort of 74 patients (pts) with breast cancer (BC) with neoplastic meningitis (NM)","volume":"28","author":"Kotecki","year":"2010","journal-title":"J\u00a0Clin Oncol"},{"issue":"9","key":"10.1016\/j.breast.2012.10.009_bib16","first-page":"810","article-title":"The diagnostic accuracy of magnetic resonance imaging and cerebrospinal fluid cytology in leptomeningeal metastasis","volume":"246","author":"Straathof","year":"1999","journal-title":"J\u00a0Neurol"},{"issue":"1","key":"10.1016\/j.breast.2012.10.009_bib17","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1002\/ana.410380111","article-title":"Neuroimaging and cerebrospinal fluid cytology in the diagnosis of leptomeningeal metastasis","volume":"38","author":"Freilich","year":"1995","journal-title":"Ann Neurol"},{"issue":"3","key":"10.1016\/j.breast.2012.10.009_bib18","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1007\/BF01059954","article-title":"Comparative spine imaging in leptomeningeal metastases","volume":"23","author":"Chamberlain","year":"1995","journal-title":"J\u00a0Neurooncol"},{"issue":"17","key":"10.1016\/j.breast.2012.10.009_bib19","doi-asserted-by":"crossref","first-page":"3608","DOI":"10.1200\/JCO.2004.01.175","article-title":"CNS smetastases in breast cancer","volume":"22","author":"Lin","year":"2004","journal-title":"J\u00a0Clin Oncol"},{"issue":"10","key":"10.1016\/j.breast.2012.10.009_bib20","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1200\/JCO.2009.24.9284","article-title":"Breast cancer subtypes and the risk of local and regional relapse","volume":"28","author":"Voduc","year":"2010","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.breast.2012.10.009_bib21","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1093\/annonc\/mdi371","article-title":"Isolated central nervous system metastases in patients with HER2-overexpressing advanced breast cancer treated with first-line trastuzumab-based therapy","volume":"16","author":"Burstein","year":"2005","journal-title":"Ann Oncol"},{"key":"10.1016\/j.breast.2012.10.009_bib22","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1002\/ijc.2910490504","article-title":"Association od c-erbB-2 protein over-expression with high rate of cell proliferation, increased risk of visceral metastasis and poor long-term survival in breast cancer","volume":"49","author":"Kallioniemi","year":"1991","journal-title":"Int J Cancer"},{"key":"10.1016\/j.breast.2012.10.009_bib23","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1097\/01.cad.0000236313.50833.ee","article-title":"Ratio of trastuzumab levels in serum and cerebrospinal fluid altered in HER2- positive breast cancer patients with brain metastases and impairment of blood- brain barrier","volume":"18","author":"Stemmler","year":"2007","journal-title":"Anticancer Drugs"},{"key":"10.1016\/j.breast.2012.10.009_bib24","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1093\/annonc\/mdp019","article-title":"Intrathecal trastuzumab and thiotepa for leptomeningeal spread of breast cancer","volume":"20","author":"Ferrario","year":"2009","journal-title":"Ann Oncol"},{"key":"10.1016\/j.breast.2012.10.009_bib25","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1007\/s10549-011-1417-2","article-title":"Complete response in HER2+ leptomeningeal carcinomatosis from breast cancer with intrathecal trastuzumab","volume":"127","author":"Oliveiram","year":"2011","journal-title":"Breast Cancer Res Treat"},{"key":"10.1016\/j.breast.2012.10.009_bib26","first-page":"1373","article-title":"Application of intrathecal trastuzumab (herceptintrade mark) for treatment of meningeal carcinomatosis in HER2- overexpressing metastatic breast cancer","volume":"15","author":"Stemmler","year":"2006","journal-title":"Oncol Rep"},{"issue":"2","key":"10.1016\/j.breast.2012.10.009_bib27","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1054\/bjoc.2000.1574","article-title":"Intrathecal treatment of neoplastic meningitis due to breast cancer with a slow-release formulation of cytarabine","volume":"84","author":"Jaeckle","year":"2001","journal-title":"Br J Cancer"},{"issue":"9","key":"10.1016\/j.breast.2012.10.009_bib28","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/S1470-2045(10)70034-6","article-title":"Intrathecal chemotherapy for treatment of leptomeningeal dissemination of metastatic tumours","volume":"11","author":"Beauchesne","year":"2010","journal-title":"Lancet Oncol"},{"issue":"11","key":"10.1016\/j.breast.2012.10.009_bib29","first-page":"1838","article-title":"Liposomal cytarabine given concomitantly with radiotherapy in a patient with leptomeningeal metastasis from breast cancer","volume":"255","author":"Glas","year":"2008","journal-title":"J\u00a0Neurol"},{"issue":"12","key":"10.1016\/j.breast.2012.10.009_bib30","first-page":"5191","article-title":"Neoplastic meningitis from breast cancer: feasibility and activity of long-term intrathecal liposomal ara-c combined with dose-dense temozolmide","volume":"29","author":"Hoffmann","year":"2009","journal-title":"Anticancer Res"},{"issue":"31","key":"10.1016\/j.breast.2012.10.009_bib31","doi-asserted-by":"crossref","first-page":"5278","DOI":"10.1200\/JCO.2008.19.8481","article-title":"Human epidermal growth factor receptor 2-positive breast cancer and central nervous system metastases","volume":"27","author":"Leyland-Jones","year":"2009","journal-title":"J\u00a0Clin Oncol"},{"issue":"1","key":"10.1016\/j.breast.2012.10.009_bib32","doi-asserted-by":"crossref","first-page":"R20","DOI":"10.1186\/bcr1870","article-title":"Breast cancer subtypes and survival in patients with brain metastases","volume":"10","author":"Nam","year":"2008","journal-title":"Breast Cancer Res"},{"issue":"3","key":"10.1016\/j.breast.2012.10.009_bib33","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1097\/COC.0b013e31815a43c4","article-title":"Extended survival in women with brain metastases from HER2 overexpressing breast cancer","volume":"31","author":"Church","year":"2008","journal-title":"Am J Clin Oncol"},{"issue":"3","key":"10.1016\/j.breast.2012.10.009_bib34","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/s11060-007-9420-5","article-title":"Trastuzumab prolongs overall survival in patients with brain metastases from HER2 positive breast cancer","volume":"85","author":"Bartsch","year":"2007","journal-title":"J\u00a0Neurooncol"},{"issue":"2","key":"10.1016\/j.breast.2012.10.009_bib35","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1093\/annonc\/mdq689","article-title":"Validation of the Institut Curie simplified prognostic score for breast cancer meningeal carcinomatosis","volume":"22","author":"Bidard","year":"2011","journal-title":"Ann Oncol"}],"container-title":["The Breast"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S096097761200210X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S096097761200210X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T08:29:12Z","timestamp":1760776152000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S096097761200210X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,2]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2013,2]]}},"alternative-id":["S096097761200210X"],"URL":"https:\/\/doi.org\/10.1016\/j.breast.2012.10.009","relation":{},"ISSN":["0960-9776"],"issn-type":[{"value":"0960-9776","type":"print"}],"subject":[],"published":{"date-parts":[[2013,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Implication of breast cancer phenotype for patients with leptomeningeal carcinomatosis","name":"articletitle","label":"Article Title"},{"value":"The Breast","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.breast.2012.10.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}