{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T02:16:51Z","timestamp":1780107411064,"version":"3.54.0"},"reference-count":21,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,8,1]],"date-time":"2016-08-01T00:00:00Z","timestamp":1470009600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thebreastonline.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Breast"],"published-print":{"date-parts":[[2016,8]]},"DOI":"10.1016\/j.breast.2016.04.003","type":"journal-article","created":{"date-parts":[[2016,6,18]],"date-time":"2016-06-18T10:42:32Z","timestamp":1466246552000},"page":"174-177","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Aromatase inhibitors decrease radiation-induced lung fibrosis: Results of an experimental study"],"prefix":"10.1016","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5509-2270","authenticated-orcid":false,"given":"A.Y.","family":"Altinok","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Yildirim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Altug","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Sut","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Ober","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.M.","family":"Ozsahin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Azria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.S.","family":"Bese","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.breast.2016.04.003_bib1","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S1470-2045(07)70385-6","article-title":"Effect of anastrozole and tamoxifen as adjuvant treatment for early-stage breast cancer: 100-month analysis of the ATAC trial","volume":"9","author":"Forbes","year":"2008","journal-title":"Lancet Oncol"},{"issue":"5","key":"10.1016\/j.breast.2016.04.003_bib2","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1200\/JCO.2006.08.8617","article-title":"Five years of letrozole compared with tamoxifen as initial adjuvant therapy for postmenopausal women with endocrine-responsive early breast cancer: update of study BIG 1-98","volume":"25","author":"Coates","year":"2007","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.breast.2016.04.003_bib3","first-page":"3","article-title":"2006 Update of the early breast cancer trialists' collaborative group overview of radiation therapy for early breast cancer","author":"Whelan","year":"2007","journal-title":"ASCO Educ Bookl"},{"key":"10.1016\/j.breast.2016.04.003_bib4","doi-asserted-by":"crossref","first-page":"2268","DOI":"10.1200\/JCO.2005.02.8738","article-title":"Study of failure pattern among high-risk breast cancer patients with or without postmastectomy radiotherapy in addition to adjuvant systemic therapy: long-term results from the Danish Breast Cancer Cooperative Group DBCG 82b and c randomized studies","volume":"24","author":"Nielsen","year":"2006","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.breast.2016.04.003_bib5","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1093\/jnci\/djh297","article-title":"Locoregional radiation therapy in patients with high-risk breast cancer receiving adjuvant chemotherapy: 20-year results of the British Columbia randomized trial","volume":"97","author":"Ragaz","year":"2005","journal-title":"J\u00a0Natl Cancer Inst"},{"issue":"1","key":"10.1016\/j.breast.2016.04.003_bib6","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1186\/bcr969","article-title":"Letrozole sensitizes breast cancer cells to ionizing radiation","volume":"7","author":"Azria","year":"2005","journal-title":"Breast Cancer Res"},{"key":"10.1016\/j.breast.2016.04.003_bib7","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/S1470-2045(03)01191-4","article-title":"Effects of radiation on normal tissue: consequences and mechanisms","volume":"4","author":"Stone","year":"2003","journal-title":"Lancet Oncol"},{"issue":"3","key":"10.1016\/j.breast.2016.04.003_bib8","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1016\/j.breast.2005.04.016","article-title":"The effects of tamoxifen on radiation-induced pulmonary fibrosis in Wistar albino rats: results of an experimental study","volume":"15","author":"Bese","year":"2006","journal-title":"Breast"},{"key":"10.1016\/j.breast.2016.04.003_bib9","doi-asserted-by":"crossref","first-page":"15","DOI":"10.2307\/3578634","article-title":"The pulmonary response to sublethal thoracic irradiation in the rat","volume":"36","author":"Ward","year":"1993","journal-title":"Radiat Res"},{"key":"10.1016\/j.breast.2016.04.003_bib10","series-title":"Biostatistics: a foundation for analysis in the health sciences","first-page":"273","author":"Daniel","year":"1995"},{"issue":"34","key":"10.1016\/j.breast.2016.04.003_bib11","doi-asserted-by":"crossref","DOI":"10.1200\/JCO.2005.03.6194","article-title":"The irreversibility of radiation-induced fibrosis: fact or folklore?","volume":"23","author":"Anscher","year":"2005","journal-title":"JCO"},{"key":"10.1016\/j.breast.2016.04.003_bib12","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1053\/srao.2000.9424","article-title":"The physical parameters and molecular events associated with radiation-induced lung toxicity","volume":"10","author":"Vujaskovic","year":"2000","journal-title":"Semin Radiat Oncol"},{"key":"10.1016\/j.breast.2016.04.003_bib13","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1016\/S0360-3016(98)00154-0","article-title":"Plasma transforming growth factor beta 1 as a predictor or radiation pneumonitis","volume":"41","author":"Anscher","year":"1998","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.breast.2016.04.003_bib14","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1677\/erc.0.0090197","article-title":"Interactions between radiotherapy and endocrine therapy in breast cancer","volume":"9","author":"Moral","year":"2002","journal-title":"Endocrine-Relat Cancer"},{"issue":"48","key":"10.1016\/j.breast.2016.04.003_bib15","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/0092-8674(87)90193-0","article-title":"Evidence that transforming growth factor beta is a hormonally regulated negative growth factor in human breast cancer cells","author":"Knabbe","year":"1987","journal-title":"Cell"},{"key":"10.1016\/j.breast.2016.04.003_bib16","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/bjc.1990.307","article-title":"Anti-oestrogens induce the secretion of active transforming growth factor beta from human fetal fibroblasts","volume":"62","author":"Colletta","year":"1990","journal-title":"Br J Cancer"},{"key":"10.1016\/j.breast.2016.04.003_bib17","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0167-8140(02)00136-6","article-title":"Effects of tamoxifen on pulmonary fibrosis after cobalt-60 radiotherapy in breast cancer patients","volume":"64","author":"Koc","year":"2002","journal-title":"Radiother Oncol"},{"issue":"4","key":"10.1016\/j.breast.2016.04.003_bib18","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/j.ijrobp.2010.03.044","article-title":"The role of systemic therapy in the development of lung sequelae after conformal radiotherapy in breast cancer patients","volume":"80","author":"Varga","year":"2011","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.breast.2016.04.003_bib19","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/S1470-2045(10)70013-9","article-title":"Concurrent or sequential adjuvant letrozole and radiotherapy after conservative surgery for early-stage breast cancer (CO-HORT): a phase 2 randomised trial","volume":"11","author":"Azria","year":"2010","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.breast.2016.04.003_bib20","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1093\/annonc\/mdv602","article-title":"Concurrent or sequential letrozole with adjuvant breast radiotherapy: final results of the CO-HO-RT phase II randomized trial","volume":"27","author":"Bourgier","year":"2016","journal-title":"Ann Oncol"},{"key":"10.1016\/j.breast.2016.04.003_bib21","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1269\/jrr.42.21","article-title":"Radioprotectors in radiotherapy","volume":"42","author":"Nairi","year":"2001","journal-title":"J\u00a0Radiat Res"}],"container-title":["The Breast"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960977616300339?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960977616300339?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T08:37:19Z","timestamp":1760776639000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960977616300339"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,8]]},"references-count":21,"alternative-id":["S0960977616300339"],"URL":"https:\/\/doi.org\/10.1016\/j.breast.2016.04.003","relation":{},"ISSN":["0960-9776"],"issn-type":[{"value":"0960-9776","type":"print"}],"subject":[],"published":{"date-parts":[[2016,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Aromatase inhibitors decrease radiation-induced lung fibrosis: Results of an experimental study","name":"articletitle","label":"Article Title"},{"value":"The Breast","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.breast.2016.04.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}