{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,9]],"date-time":"2026-11-09T16:38:05Z","timestamp":1794242285060,"version":"4.9.0"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,10,1]],"date-time":"2016-10-01T00:00:00Z","timestamp":1475280000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institute of Health","doi-asserted-by":"publisher","award":["1R21NR012288-01A"],"award-info":[{"award-number":["1R21NR012288-01A"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institute of Health","doi-asserted-by":"publisher","award":["P60 MD000538-03"],"award-info":[{"award-number":["P60 MD000538-03"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thebreastonline.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Breast"],"published-print":{"date-parts":[[2016,10]]},"DOI":"10.1016\/j.breast.2016.06.023","type":"journal-article","created":{"date-parts":[[2016,7,24]],"date-time":"2016-07-24T08:27:56Z","timestamp":1469348876000},"page":"231-240","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":54,"special_numbering":"C","title":["Precision assessment of heterogeneity of lymphedema phenotype, genotypes and risk prediction"],"prefix":"10.1016","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3891-0109","authenticated-orcid":false,"given":"Mei R.","family":"Fu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yvette P.","family":"Conley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah","family":"Axelrod","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amber A.","family":"Guth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jason","family":"Fletcher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Zagzag","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.breast.2016.06.023_bib1","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1158\/1055-9965.EPI-06-0168","article-title":"The epidemiology of arm and hand swelling in premenopausal breast cancer survivors","volume":"16","author":"Paskett","year":"2007","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"3","key":"10.1016\/j.breast.2016.06.023_bib2","first-page":"118","article-title":"Post-breast cancer lymphedema: incidence increases from 12 to 30 to 60 months","volume":"43","author":"Armer","year":"2010","journal-title":"Lymphology"},{"key":"10.1016\/j.breast.2016.06.023_bib3","series-title":"Breast cancer facts & figures 2015\u20132016","author":"American Cancer Society (ACS)","year":"2015"},{"key":"10.1016\/j.breast.2016.06.023_bib4","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/j.jpainsymman.2009.04.030","article-title":"Breast cancer survivors' experiences of lymphedema-related symptoms","volume":"38","author":"Fu","year":"2009","journal-title":"J\u00a0Pain Symp Manage"},{"key":"10.1016\/j.breast.2016.06.023_bib5","first-page":"161","article-title":"Minimal limb volume change has a significant impact on breast cancer survivors","volume":"42","author":"Cormier","year":"2009","journal-title":"Lymphology"},{"key":"10.1016\/j.breast.2016.06.023_bib6","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.jamcollsurg.2012.11.004","article-title":"Trends in risk reduction practices for the prevention of lymphedema in the first 12 months after breast cancer surgery","volume":"216","author":"McLaughlin","year":"2013","journal-title":"J\u00a0Am Coll Surg"},{"key":"10.1016\/j.breast.2016.06.023_bib7","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1002\/pon.3201","article-title":"Psychosocial impact of lymphedema: a systematic review of literature from 2004 to 2011","volume":"22","author":"Fu","year":"2013","journal-title":"Psycho-oncology"},{"issue":"2","key":"10.1016\/j.breast.2016.06.023_bib8","first-page":"59","article-title":"Factors associated with the development of arm lymphedema following breast cancer treatment: a match pair case-control study","volume":"35","author":"Johansson","year":"2002","journal-title":"Lymphology"},{"issue":"7","key":"10.1016\/j.breast.2016.06.023_bib9","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1245\/s10434-009-0452-2","article-title":"The risk of developing arm lymphedema among breast cancer survivors: a meta-analysis of treatment factors","volume":"16","author":"Tsai","year":"2009","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.breast.2016.06.023_bib10","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1097\/NNR.0b013e31818c3de2","article-title":"Predictors of lymphedema in patients with breast cancer undergoing axillary lymph node dissection in Hong Kong","volume":"57","author":"Mak","year":"2008","journal-title":"Nurs Res"},{"issue":"3","key":"10.1016\/j.breast.2016.06.023_bib11","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1097\/01.sla.0000245472.47748.ec","article-title":"Morbidity of sentinel lymph node biopsy (SLN) alone versus SLN and completion axillary lymph node dissection after breast cancer surgery: a prospective Swiss multicenter study on 659 patients","volume":"245","author":"Langer","year":"2007","journal-title":"Ann Surg"},{"issue":"5","key":"10.1016\/j.breast.2016.06.023_bib12","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1016\/j.jamcollsurg.2007.12.022","article-title":"Axillary reverse mapping: mapping and preserving arm lymphatics may be important in preventing lymphedema during sentinel lymph node biopsy","volume":"206","author":"Boneti","year":"2008","journal-title":"J\u00a0Am Coll Surg"},{"issue":"32","key":"10.1016\/j.breast.2016.06.023_bib13","doi-asserted-by":"crossref","first-page":"5213","DOI":"10.1200\/JCO.2008.16.3725","article-title":"Prevalence of lymphedema in women with breast cancer 5 years after sentinel lymph node biopsy or axillary dissection: objective measurements","volume":"26","author":"McLaughlin","year":"2008","journal-title":"J\u00a0Clin Oncol"},{"issue":"5","key":"10.1016\/j.breast.2016.06.023_bib14","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1111\/j.1075-122X.2004.21411.x","article-title":"Lymphedema of the arm and breast in irradiated breast cancer patients: risks in an era of dramatically changing axillary surgery","volume":"10","author":"Goffman","year":"2004","journal-title":"Breast J"},{"issue":"6","key":"10.1016\/j.breast.2016.06.023_bib15","first-page":"433","article-title":"Lymphatics at the crossroads of angiogenesis and lymphangiogenesis","volume":"204","author":"Scavelli","year":"2004","journal-title":"J\u00a0Anat"},{"issue":"11","key":"10.1016\/j.breast.2016.06.023_bib16","doi-asserted-by":"crossref","first-page":"1868","DOI":"10.1038\/oby.2006.216","article-title":"Interleukin-6 gene polymorphism -174G\/C influences plasma lipid levels in women","volume":"14","author":"Henningsson","year":"2006","journal-title":"Obesity"},{"key":"10.1016\/j.breast.2016.06.023_bib17","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1016\/j.bbi.2008.05.009","article-title":"Cytokine gene polymorphisms and fatigue in breast cancer survivors","volume":"22","author":"Collado-Hidalgo","year":"2008","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.breast.2016.06.023_bib18","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1002\/jcla.20152","article-title":"Proinflammatory cytokine gene polymorphisms among Hashimoto's thyroiditis patients","volume":"20","author":"Chen","year":"2006","journal-title":"J\u00a0Clin Lab Anal"},{"issue":"7","key":"10.1016\/j.breast.2016.06.023_bib19","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1172\/JCI2629","article-title":"The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis","volume":"102","author":"Fishman","year":"1998","journal-title":"J\u00a0Clin Invest"},{"issue":"7","key":"10.1016\/j.breast.2016.06.023_bib20","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1517\/14712598.3.7.1061","article-title":"The therapeutic potential of interleukin-6 in treating obesity","volume":"3","author":"Wallenius","year":"2003","journal-title":"Expert Opin Biol Ther"},{"issue":"8","key":"10.1016\/j.breast.2016.06.023_bib21","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1034\/j.1600-0714.2003.00168.x","article-title":"Expression of vascular endothelial growth factor-C correlates with the lymphatic microvessel density and the nodal status in oral squamous cell cancer","volume":"32","author":"Sedivy","year":"2003","journal-title":"J\u00a0Oral Pathol Med"},{"issue":"1","key":"10.1016\/j.breast.2016.06.023_bib22","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1089\/lrb.2011.0024","article-title":"Possible genetic predisposition to lymphedema after breast cancer","volume":"10","author":"Newman","year":"2012","journal-title":"Lymphatic Res Bio"},{"issue":"1","key":"10.1016\/j.breast.2016.06.023_bib23","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1089\/lrb.2013.0024","article-title":"Cytokine candidate genes predict the development of secondary lymphedema following breast cancer surgery","volume":"12","author":"Leung","year":"2014","journal-title":"Lymphatic Res Bio"},{"issue":"4","key":"10.1016\/j.breast.2016.06.023_bib24","doi-asserted-by":"crossref","first-page":"e60164","DOI":"10.1371\/journal.pone.0060164","article-title":"Lymphatic and angiogentic candidate genes predict the development of development of secondary lymphedema following breast cancer surgery","volume":"8","author":"Miaskowski","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.breast.2016.06.023_bib25","doi-asserted-by":"crossref","first-page":"345","DOI":"10.2147\/BCTT.S87854","article-title":"Symptom reporting in detecting breast cancer-related lymphedema","volume":"7","author":"Fu","year":"2015","journal-title":"Breast Cancer Targets Ther"},{"issue":"6","key":"10.1016\/j.breast.2016.06.023_bib26","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1097\/00006199-200311000-00004","article-title":"Predicting breast cancer-related lymphedema using self-reported symptoms","volume":"52","author":"Armer","year":"2003","journal-title":"Nurs Res"},{"key":"10.1016\/j.breast.2016.06.023_bib27","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1245\/s10434-010-0941-3","article-title":"The effect of providing information about lymphedema on the cognitive and symptom outcomes of breast cancer survivors","volume":"17","author":"Fu","year":"2010","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.breast.2016.06.023_bib28","first-page":"326","article-title":"Patterns of obesity and lymph fluid level during the first year of breast cancer treatment: a prospective study","volume":"5","author":"Fu","year":"2015","journal-title":"J\u00a0Pers Med"},{"issue":"4","key":"10.1016\/j.breast.2016.06.023_bib29","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1089\/lrb.2005.3.208","article-title":"A\u00a0comparison of four diagnostic criteria for lymphedema in a post-breast cancer population","volume":"3","author":"Armer","year":"2005","journal-title":"Lymphatic Res Bio"},{"issue":"11","key":"10.1016\/j.breast.2016.06.023_bib30","doi-asserted-by":"crossref","first-page":"3481","DOI":"10.1245\/s10434-014-3761-z","article-title":"Proactive approach to lymphedema risk reduction: a prospective study","volume":"21","author":"Fu","year":"2014","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.breast.2016.06.023_bib31","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.ejon.2015.05.002","article-title":"Psychometric properties of the breast cancer and lymphedema symptom experience index: the Chinese version","volume":"20","author":"Shi","year":"2016","journal-title":"Euro J Oncol Nurs"},{"issue":"10","key":"10.1016\/j.breast.2016.06.023_bib32","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1038\/sj.ejhg.5201875","article-title":"Tag SNP selection for candidate gene association studies using HapMap and gene resequencing data","volume":"15","author":"Xu","year":"2007","journal-title":"Euro J Hum Genet"},{"issue":"6","key":"10.1016\/j.breast.2016.06.023_bib33","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1086\/430507","article-title":"(2005). Rational inferences about departures from Hardy-Weinberg equilibrium","volume":"76","author":"Wittke-Thompson","year":"2005","journal-title":"Amer J Hum Genet"},{"issue":"5","key":"10.1016\/j.breast.2016.06.023_bib34","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1086\/429864","article-title":"A\u00a0note on exact tests of Hardy-Weinberg equilibrium","volume":"76","author":"Wigginton","year":"2005","journal-title":"Amer J Hum Genet"},{"issue":"3","key":"10.1016\/j.breast.2016.06.023_bib35","first-page":"134","article-title":"The Effects of symptomatic seroma on lymphedema symptoms following breast cancer treatment","volume":"44","author":"Fu","year":"2011","journal-title":"Lymphology"},{"issue":"5","key":"10.1016\/j.breast.2016.06.023_bib36","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1186\/1479-7364-2-5-310","article-title":"Detecting multiple associations in genome-wide studies","volume":"2","author":"Dudbridge","year":"2006","journal-title":"Hum Genomics"},{"key":"10.1016\/j.breast.2016.06.023_bib37","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1016\/S0140-6736(05)67531-9","article-title":"What makes a good genetic association study?","volume":"366","author":"Hattersley","year":"2005","journal-title":"Lancet"},{"issue":"s6","key":"10.1016\/j.breast.2016.06.023_bib38","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1188\/14.CJON.S3.68-79","article-title":"Putting evidence into practice: cancer-related lymphedema","volume":"18","author":"Fu","year":"2014","journal-title":"Clin J Onco Nurs"}],"container-title":["The Breast"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960977616301060?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960977616301060?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T08:38:09Z","timestamp":1760776689000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960977616301060"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,10]]},"references-count":38,"alternative-id":["S0960977616301060"],"URL":"https:\/\/doi.org\/10.1016\/j.breast.2016.06.023","relation":{},"ISSN":["0960-9776"],"issn-type":[{"value":"0960-9776","type":"print"}],"subject":[],"published":{"date-parts":[[2016,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Precision assessment of heterogeneity of lymphedema phenotype, genotypes and risk prediction","name":"articletitle","label":"Article Title"},{"value":"The Breast","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.breast.2016.06.023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}