{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T00:27:40Z","timestamp":1791764860402,"version":"4.3.4"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,2,1]],"date-time":"2018-02-01T00:00:00Z","timestamp":1517443200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Beijing Municipal Science and Technology Commission, China","award":["D131100002213001"],"award-info":[{"award-number":["D131100002213001"]}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thebreastonline.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Breast"],"published-print":{"date-parts":[[2018,2]]},"DOI":"10.1016\/j.breast.2017.08.003","type":"journal-article","created":{"date-parts":[[2017,10,23]],"date-time":"2017-10-23T11:39:05Z","timestamp":1508758745000},"page":"18-27","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Effects of the Chinese medicine Yi Shen Jian Gu granules on aromatase inhibitor-associated musculoskeletal symptoms: A randomized, controlled clinical trial"],"prefix":"10.1016","volume":"37","author":[{"given":"Nan","family":"Peng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingwei","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guowang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongmei","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weiru","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cong","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rencun","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.breast.2017.08.003_bib1","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1056\/NEJMoa040331","article-title":"A\u00a0randomized trial of exemestane after two to three years of tamoxifen therapy in postmenopausal women with primary breast cancer","volume":"350","author":"Coombes","year":"2004","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.breast.2017.08.003_bib2","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/S0140-6736(04)17666-6","article-title":"Results of the ATAC (Arimidex, Tamoxifen, Alone or in Combination) trial after completion of 5 years' adjuvant treatment for breast cancer","volume":"365","author":"Howell","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.breast.2017.08.003_bib3","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1056\/NEJMoa0810818","article-title":"Letrozole therapy alone or in sequence with tamoxifen in women with breast cancer","volume":"361","author":"Mouridsen","year":"2009","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.breast.2017.08.003_bib4","doi-asserted-by":"crossref","first-page":"3877","DOI":"10.1200\/JCO.2007.10.7573","article-title":"Prevalence of joint symptoms in postmenopausal women taking aromatase inhibitors for early-stage breast cancer","volume":"25","author":"Crew","year":"2007","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.breast.2017.08.003_bib5","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1007\/s10549-012-2114-5","article-title":"Adherence to adjuvant hormonal therapy among breast cancer survivors in clinical practice: a systematic review","volume":"134","author":"Murphy","year":"2012","journal-title":"Breast Cancer Res Treat"},{"key":"10.1016\/j.breast.2017.08.003_bib6","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1007\/s10549-010-1132-4","article-title":"Early discontinuation and non-adherence to adjuvant hormonal therapy are associated with increased mortality in women with breast cancer","volume":"126","author":"Hershman","year":"2011","journal-title":"Breast Cancer Res Treat"},{"key":"10.1016\/j.breast.2017.08.003_bib7","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1345\/aph.1R369","article-title":"Effect of concurrent prescription antiarthralgia pharmacotherapy on persistence to aromatase inhibitors in treatment-naive postmenopausal females","volume":"47","author":"Hashem","year":"2013","journal-title":"Ann Pharmacother"},{"key":"10.1016\/j.breast.2017.08.003_bib8","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/s10549-011-1644-6","article-title":"Vitamin D and aromatase inhibitor-induced musculoskeletal symptoms (AIMSS): a phase II, double-blind, placebo-controlled, randomized trial","volume":"129","author":"Rastelli","year":"2011","journal-title":"Breast Cancer Res Treat"},{"key":"10.1016\/j.breast.2017.08.003_bib9","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1200\/JCO.2014.57.1547","article-title":"Randomized exercise trial of aromatase inhibitor-induced arthralgia in breast cancer survivors","volume":"33","author":"Irwin","year":"2015","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.breast.2017.08.003_bib10","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1200\/JCO.2009.23.4708","article-title":"Randomized, blinded, sham-controlled trial of acupuncture for the management of aromatase inhibitor-associated joint symptoms in women with early-stage breast cancer","volume":"28","author":"Crew","year":"2010","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.breast.2017.08.003_bib11","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1093\/annonc\/mdt037","article-title":"Aromatase inhibitor-induced arthralgia: a review","volume":"24","author":"Niravath","year":"2013","journal-title":"Ann Oncol"},{"key":"10.1016\/j.breast.2017.08.003_bib12","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s10549-009-0692-7","article-title":"Effect of a switch of aromatase inhibitors on musculoskeletal symptoms in postmenopausal women with hormone-receptor-positive breast cancer: the ATOLL (articular tolerance of letrozole) study","volume":"120","author":"Briot","year":"2010","journal-title":"Breast Cancer Res Treat"},{"key":"10.1016\/j.breast.2017.08.003_bib13","first-page":"141","article-title":"Traditional Chinese medicine in the treatment of symptoms in patients with advanced cancer","volume":"2","author":"Ling","year":"2013","journal-title":"Ann Palliat Med"},{"key":"10.1016\/j.breast.2017.08.003_bib14","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.soncn.2011.11.007","article-title":"Traditional Chinese Medicine for cancer-related symptoms","volume":"28","author":"Smith","year":"2012","journal-title":"Semin Oncol Nurs"},{"key":"10.1016\/j.breast.2017.08.003_bib15","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1007\/s00296-010-1370-0","article-title":"Traditional Chinese medicine in the treatment of rheumatoid arthritis: a general review","volume":"30","author":"Zhang","year":"2010","journal-title":"Rheumatol Int"},{"key":"10.1016\/j.breast.2017.08.003_bib16","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1007\/s11655-015-2432-7","article-title":"Diagnosis and management of knee osteoarthritis: Chinese medicine expert consensus (2015)","volume":"22","author":"Chen","year":"2016","journal-title":"Chin J Integr Med"},{"key":"10.1016\/j.breast.2017.08.003_bib17","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1177\/1534735407305705","article-title":"Chinese herbal medicine for cancer pain","volume":"6","author":"Xu","year":"2007","journal-title":"Integr Cancer Ther"},{"key":"10.1016\/j.breast.2017.08.003_bib18","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1142\/S0192415X16500373","article-title":"Traditional Chinese medications for knee osteoarthritis pain: a meta-analysis of randomized controlled trials","volume":"44","author":"Chen","year":"2016","journal-title":"Am J Chin Med"},{"key":"10.1016\/j.breast.2017.08.003_bib19","series-title":"Oncology of traditional Chinese medicine","author":"Zhou","year":"2011"},{"key":"10.1016\/j.breast.2017.08.003_bib20","series-title":"Basic theory of traditional Chinese medicine","author":"Sun","year":"2002"},{"key":"10.1016\/j.breast.2017.08.003_bib21","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/0304-3959(96)03147-8","article-title":"The Chinese version of the Brief Pain Inventory (BPI-C): its development and use in a study of cancer pain","volume":"67","author":"Wang","year":"1996","journal-title":"Pain"},{"key":"10.1016\/j.breast.2017.08.003_bib22","first-page":"1833","article-title":"Validation study of WOMAC: a health status instrument for measuring clinically important patient relevant outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip or knee","volume":"15","author":"Bellamy","year":"1988","journal-title":"J\u00a0Rheumatol"},{"key":"10.1016\/j.breast.2017.08.003_bib23","doi-asserted-by":"crossref","first-page":"1409","DOI":"10.1093\/rheumatology\/keh360","article-title":"Development of the M-SACRAH, a modified, shortened version of SACRAH (score for the assessment and quantification of chronic rheumatoid Affections of the hands)","volume":"43","author":"Sautner","year":"2004","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.breast.2017.08.003_bib24","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1200\/JCO.1997.15.3.974","article-title":"Reliability and validity of the functional assessment of cancer therapy-breast quality-of-life instrument","volume":"15","author":"Brady","year":"1997","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.breast.2017.08.003_bib25","doi-asserted-by":"crossref","first-page":"34","DOI":"10.3816\/CBC.2009.n.006","article-title":"Aromatase inhibitor-related musculoskeletal symptoms: is preventing osteoporosis the key to eliminating these symptoms?","volume":"9","author":"Muslimani","year":"2009","journal-title":"Clin Breast Cancer"},{"key":"10.1016\/j.breast.2017.08.003_bib26","doi-asserted-by":"crossref","first-page":"4932","DOI":"10.1200\/JCO.2009.23.3270","article-title":"Aromatase inhibitor-associated arthralgias","volume":"27","author":"Chlebowski","year":"2009","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.breast.2017.08.003_bib27","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1007\/s10549-010-0757-7","article-title":"Aromatase inhibitor-induced arthralgia in early breast cancer: what do we know and how can we find out more?","volume":"120","author":"Din","year":"2010","journal-title":"Breast Cancer Res Treat"},{"key":"10.1016\/j.breast.2017.08.003_bib28","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1093\/annonc\/mdt037","article-title":"Aromatase inhibitor-induced arthralgia: a review","volume":"24","author":"Niravath","year":"2013","journal-title":"Ann Oncol"},{"key":"10.1016\/j.breast.2017.08.003_bib29","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1248\/bpb.17.262","article-title":"Anti-inflammatory activities of methanolic extract and alkaloidal components from Corydalis tuber","volume":"17","author":"Kubo","year":"1994","journal-title":"Biol Pharm Bull"},{"key":"10.1016\/j.breast.2017.08.003_bib30","first-page":"2161","article-title":"Analgesic effect of Corydalis yanhusuo in a rat model of trigeminal neuropathic pain","volume":"30","author":"Huang","year":"2010","journal-title":"Nan Fang Yi Ke Da Xue Xue Bao"},{"key":"10.1016\/j.breast.2017.08.003_bib31","first-page":"694","article-title":"Metabolomics study of anti-inflammatory action of Radix Paeoniae Rubra and Radix Paeoniae Alba by ultraperformance liquid chromatography-mass spectrometry","volume":"36","author":"Yang","year":"2011","journal-title":"Zhongguo Zhong Yao Za Zhi"},{"key":"10.1016\/j.breast.2017.08.003_bib32","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/s10549-011-1644-6","article-title":"Vitamin D and aromatase inhibitor-induced musculoskeletal symptoms (AIMSS): a phase II, double-blind, placebo-controlled, randomized trial","volume":"129","author":"Rastelli","year":"2011","journal-title":"Breast Cancer Res Treat"},{"key":"10.1016\/j.breast.2017.08.003_bib33","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1007\/s10549-010-1075-9","article-title":"Vitamin D threshold to prevent aromatase inhibitor-induced arthralgia: a prospective cohort study","volume":"125","author":"Prieto-Alhambra","year":"2011","journal-title":"Breast Cancer Res Treat"},{"key":"10.1016\/j.breast.2017.08.003_bib34","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1056\/NEJM200105243442106","article-title":"Is the placebo powerless? An analysis of clinical trials comparing placebo with no treatment","volume":"344","author":"Hrobjartsson","year":"2001","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.breast.2017.08.003_bib35","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1002\/jclp.20129","article-title":"The placebo is powerful: estimating placebo effects in medicine and psychotherapy from randomized clinical trials","volume":"61","author":"Wampold","year":"2005","journal-title":"J\u00a0Clin Psychol"},{"key":"10.1016\/j.breast.2017.08.003_bib36","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1200\/JCO.2015.61.1004","article-title":"The power of the placebo in symptom management","volume":"33","author":"Henry","year":"2015","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.breast.2017.08.003_bib37","doi-asserted-by":"crossref","first-page":"1910","DOI":"10.1200\/JCO.2014.59.5595","article-title":"Randomized multicenter placebo-controlled trial of Omega-3 fatty acids for the control of aromatase inhibitor-induced musculoskeletal pain: SWOG S0927","volume":"33","author":"Hershman","year":"2015","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.breast.2017.08.003_bib38","doi-asserted-by":"crossref","first-page":"1104","DOI":"10.1200\/JCO.2014.57.1547","article-title":"Randomized exercise trial of aromatase inhibitor-induced arthralgia in breast cancer survivors","volume":"33","author":"Irwin","year":"2015","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.breast.2017.08.003_bib39","first-page":"38","article-title":"Tai chi for well-being of breast cancer survivors with aromatase inhibitor-associated arthralgias: a feasibility study","volume":"19","author":"Galantino","year":"2013","journal-title":"Altern Ther Health Med"},{"key":"10.1016\/j.breast.2017.08.003_bib40","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1002\/pon.3756","article-title":"Pilot study of Iyengar yoga for management of aromatase inhibitor-associated arthralgia in women with breast cancer","volume":"24","author":"Jacobsen","year":"2015","journal-title":"Psychooncology"},{"key":"10.1016\/j.breast.2017.08.003_bib41","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1200\/JCO.2009.23.4708","article-title":"Randomized, blinded, sham-controlled trial of acupuncture for the management of aromatase inhibitor-associated joint symptoms in women with early-stage breast cancer","volume":"28","author":"Crew","year":"2010","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.breast.2017.08.003_bib42","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.ejca.2013.09.022","article-title":"A\u00a0randomised trial of electro-acupuncture for arthralgia related to aromatase inhibitor use","volume":"50","author":"Mao","year":"2014","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.breast.2017.08.003_bib43","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/s10549-011-1644-6","article-title":"Vitamin D and aromatase inhibitor-induced musculoskeletal symptoms (AIMSS): a phase II, double-blind, placebo-controlled, randomized trial","volume":"129","author":"Rastelli","year":"2011","journal-title":"Breast Cancer Res Treat"},{"key":"10.1016\/j.breast.2017.08.003_bib44","first-page":"1077","article-title":"Phase II study of glucosamine with chondroitin on aromatase inhibitor-associated joint symptoms in women with breast cancer","volume":"21","author":"Greenlee","year":"2013","journal-title":"Support Care Cancer"},{"key":"10.1016\/j.breast.2017.08.003_bib45","first-page":"2331","article-title":"Short-term and low-dose prednisolone administration reduces aromatase inhibitor-induced arthralgia in patients with breast cancer","volume":"32","author":"Kubo","year":"2012","journal-title":"Anticancer Res"},{"key":"10.1016\/j.breast.2017.08.003_bib46","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1097\/COC.0b013e3181cae782","article-title":"Immunological therapies can relieve aromatase inhibitor-related joint symptoms in breast cancer survivors","volume":"33","author":"Zhang","year":"2010","journal-title":"Am J Clin Oncol"},{"key":"10.1016\/j.breast.2017.08.003_bib47","doi-asserted-by":"crossref","first-page":"5469","DOI":"10.1002\/cncr.26230","article-title":"Pilot study of duloxetine for treatment of aromatase inhibitor-associated musculoskeletal symptoms","volume":"117","author":"Henry","year":"2011","journal-title":"Cancer"}],"container-title":["The Breast"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960977617305520?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960977617305520?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T08:37:50Z","timestamp":1760776670000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960977617305520"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,2]]},"references-count":47,"alternative-id":["S0960977617305520"],"URL":"https:\/\/doi.org\/10.1016\/j.breast.2017.08.003","relation":{},"ISSN":["0960-9776"],"issn-type":[{"value":"0960-9776","type":"print"}],"subject":[],"published":{"date-parts":[[2018,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of the Chinese medicine Yi Shen Jian Gu granules on aromatase inhibitor-associated musculoskeletal symptoms: A randomized, controlled clinical trial","name":"articletitle","label":"Article Title"},{"value":"The Breast","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.breast.2017.08.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 The Authors. Published by Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}