{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T11:08:30Z","timestamp":1785150510254,"version":"3.55.0"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"ADM"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thebreastonline.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Breast"],"published-print":{"date-parts":[[2019,8]]},"DOI":"10.1016\/j.breast.2019.03.011","type":"journal-article","created":{"date-parts":[[2019,3,29]],"date-time":"2019-03-29T06:32:38Z","timestamp":1553841158000},"page":"48-51","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Current knowledge of risk reducing mastectomy: Indications, techniques, results, benefits, harms"],"prefix":"10.1016","volume":"46","author":[{"given":"Andrew D.","family":"Baildam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.breast.2019.03.011_bib1","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1002\/1097-0142(19940201)73:3<643::AID-CNCR2820730323>3.0.CO;2-5","article-title":"Thompson WD Autosomal dominant inheritance for early-onset breast cancer Implications for risk prediction","volume":"73","author":"Claus","year":"1994","journal-title":"Cancer"},{"issue":"7","key":"10.1016\/j.breast.2019.03.011_bib2","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1038\/sj.bjc.6605606","article-title":"Long term outcomes of breast cancer in women aged 30 years or younger, based on family history, pathology and BRCA1\/BRCA2\/TP53 status","volume":"102","author":"Evans","year":"2010","journal-title":"Br J Canc"},{"issue":"3","key":"10.1016\/j.breast.2019.03.011_bib3","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1086\/301749","article-title":"Genetic heterogeneity and penetrance analysis of the BRCA1 and BRCA2 genes in breast cancer families. The Breast Cancer Linkage Consortium","volume":"62","author":"Ford","year":"1998","journal-title":"Am J Hum Genet"},{"issue":"8899","key":"10.1016\/j.breast.2019.03.011_bib4","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1016\/S0140-6736(94)91578-4","article-title":"Risks of cancer in BRCA1-mutation carriers. Breast cancer linkage consortium","volume":"343","author":"Ford","year":"1994","journal-title":"Lancet"},{"key":"10.1016\/j.breast.2019.03.011_bib5","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1186\/1471-2407-8-155","article-title":"Penetrance estimates for BRCA1 and BRCA2 based on genetic testing in a Clinical Cancer Genetics service setting: risks of breast\/0 varian cancer quoted should reflect the cancer burden in the family","volume":"8","author":"Evans","year":"2008","journal-title":"BMC Canc"},{"issue":"5","key":"10.1016\/j.breast.2019.03.011_bib6","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1086\/375033","article-title":"Average risks of breast and ovarian cancer associated with BRCA1 and BRCA2 mutations detected in case series unselected for family History: a combined analysis of 22 studies","volume":"72","author":"Antoniou","year":"2003","journal-title":"Am J Hum Genet"},{"issue":"20","key":"10.1016\/j.breast.2019.03.011_bib7","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1056\/NEJM199705153362001","article-title":"The risk of cancer associated with specific mutations of BRCA1 and BRCA2 among Ashkenazi Jews","volume":"336","author":"Struewing","year":"1997","journal-title":"N\u00a0Engl J Med"},{"issue":"3","key":"10.1016\/j.breast.2019.03.011_bib8","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1002\/1097-0142(19940201)73:3<643::AID-CNCR2820730323>3.0.CO;2-5","article-title":"Autosomal dominant inheritance of early-onset breast cancer. Implications for risk predicition","volume":"73","author":"Claus","year":"1994","journal-title":"Cancer"},{"issue":"12","key":"10.1016\/j.breast.2019.03.011_bib9","doi-asserted-by":"crossref","first-page":"1922","DOI":"10.1016\/S0959-8049(98)00288-3","article-title":"Current policies for surveillance and management in women at risk of breast and ovarian cancer: a survey among 16 European family cancer clinics. European Familial Breast Cancer Collaborative Group","volume":"34","author":"Vasen","year":"1998","journal-title":"Eur J Cancer"},{"issue":"12","key":"10.1016\/j.breast.2019.03.011_bib10","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1136\/jmg.39.12.865","article-title":"Risk assessment and management of high risk familial breast cancer","volume":"39","author":"Evans","year":"2002","journal-title":"J\u00a0Med Genet"},{"issue":"24","key":"10.1016\/j.breast.2019.03.011_bib11","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1093\/jnci\/81.24.1879","article-title":"Projecting individualized probabilities of developing breast cancer for white females who are being examined annually","volume":"81","author":"Gail","year":"1989","journal-title":"J\u00a0Nat Cancer Inst"},{"issue":"8","key":"10.1016\/j.breast.2019.03.011_bib12","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1038\/sj.bjc.6604305","article-title":"The BOADICEA model of genentic susceptibility to breast and ovarian cancer: updates and extensions","volume":"98","author":"Antoniou","year":"2008","journal-title":"Br J Canc"},{"issue":"7","key":"10.1016\/j.breast.2019.03.011_bib13","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1002\/sim.1668","article-title":"A\u00a0breast cancer prediction model incorporating familial and personal risk factors","volume":"23","author":"Tyrer","year":"2004","journal-title":"Stat Med"},{"key":"10.1016\/j.breast.2019.03.011_bib14","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1053\/ejso.2000.0986","article-title":"Preventative mastectomy for women at high risk of breast cancer","volume":"26","author":"Lalloo","year":"2002","journal-title":"Eur J Surg Oncol"},{"issue":"4","key":"10.1016\/j.breast.2019.03.011_bib15","doi-asserted-by":"crossref","DOI":"10.1136\/jmg.2008.062232","article-title":"Risk reducing mastectomy oucomes in 10 European centres","volume":"46","author":"Evans","year":"2009","journal-title":"J\u00a0Med Genet"},{"issue":"3","key":"10.1016\/j.breast.2019.03.011_bib16","volume":"32A","author":"Evans","year":"1996","journal-title":"Cancer Genetics Clinics Eor J Cancer"},{"issue":"3","key":"10.1016\/j.breast.2019.03.011_bib17","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1038\/sj.ejhg.5200418","article-title":"Physicians' attitudes towards mammography and prophylactic surgery for hereditary breast\/ovarian cancer risk and subsequently published guidelines","volume":"8","author":"Julian-Renier","year":"2000","journal-title":"Eur J Hum Genet"},{"issue":"4","key":"10.1016\/j.breast.2019.03.011_bib18","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1002\/1097-0142(20010815)92:4<959::AID-CNCR1406>3.0.CO;2-V","article-title":"Women's attitudes towards preventive strategies for hereditary breast or ovarian carcinoma differ from one country to another: differences among English, French and Canadian women","volume":"92","author":"Julian-Renier","year":"2001","journal-title":"Cancer"},{"issue":"9033","key":"10.1016\/j.breast.2019.03.011_bib19","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1016\/S0140-6736(05)64963-X","article-title":"Fictitious breast cancer family history","volume":"348","author":"Evans","year":"1996","journal-title":"Lancet"},{"issue":"3","key":"10.1016\/j.breast.2019.03.011_bib20","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1200\/JCO.2006.07.3890","article-title":"Quality of life after contralateral prophylactic mastectomy in newly-diagnosed high-risk breast cancer patients who underwent BRCA1\/2 testing","volume":"25","author":"Tercyak","year":"2007","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.breast.2019.03.011_bib21","series-title":"Breast Surgery, a companion to specialist surgical practice","first-page":"127","article-title":"The genetics of breast cancer, risk-reducing surgery and prevention","author":"Evans","year":"2014"},{"key":"10.1016\/j.breast.2019.03.011_bib22","doi-asserted-by":"crossref","first-page":"3171","DOI":"10.1245\/s10434-012-2528-7","article-title":"Surgical delay of the nipple-areolar complex: a powerful technique to maximize nipple viability following nipple-sparing mastectomy","volume":"19","author":"Jensen","year":"2012","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.breast.2019.03.011_bib23","doi-asserted-by":"crossref","first-page":"3102","DOI":"10.1245\/s10434-011-1908-8","article-title":"Prophylactic and therapeutic mastectomy in BRCA mutation carriers: can the nipple be preserved?","volume":"18","author":"Reynolds","year":"2011","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.breast.2019.03.011_bib24","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1245\/s10434-014-3883-3","article-title":"Nipple-sparing mastectomy in BRCA1\/2 mutation carriers: an interim analysis and review of the literature","volume":"22","author":"Yao","year":"2015","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.breast.2019.03.011_bib25","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1245\/s10434-014-4007-9","article-title":"Safely expanding the use of nipple sparing mastectomy in BRCA mutation carriers","volume":"22","author":"Cyr","year":"2015","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.breast.2019.03.011_bib26","doi-asserted-by":"crossref","first-page":"3764","DOI":"10.1245\/s10434-015-4648-3","article-title":"The nipple is just another margin","volume":"22","author":"Coopey","year":"2015","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.breast.2019.03.011_bib27","doi-asserted-by":"crossref","first-page":"3324","DOI":"10.1245\/s10434-015-4761-3","article-title":"Long-term psychosocial functioning in women with bilateral prophylactic mastectomy: does preservation of the nipple-areolar complex make a difference?","volume":"22","author":"Metcalfe","year":"2015","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.breast.2019.03.011_bib28","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1007\/s10549-008-0238-4","article-title":"Does nipple preservation in mastectomy improve satisfaction with cosmetic results, psychological adjustment, body image and sexuality?","volume":"118","author":"Didier","year":"2009","journal-title":"Breast Canc Res Treat"},{"issue":"3","key":"10.1016\/j.breast.2019.03.011_bib29","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1097\/PRS.0000000000004635","article-title":"Novel approach for risk-reducing mastectomy: first-stage implant placement and subsequent second-stage mastectomy","volume":"142","author":"Lim","year":"2018","journal-title":"Plast Reconstr Surg"},{"key":"10.1016\/j.breast.2019.03.011_bib30","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1136\/bmj.317.7170.1402","article-title":"Prophylactic mastectomy: deliverance or delusion?","volume":"317","author":"Fentiman","year":"1998","journal-title":"BMJ"},{"key":"10.1016\/j.breast.2019.03.011_bib31","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1136\/bmj.317.7170.1402","article-title":"Editorial Comment - prophylactic mastectomy: deliverance or delusion?","volume":"317","author":"Milne","year":"1998","journal-title":"BMJ"},{"key":"10.1016\/j.breast.2019.03.011_bib32","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1056\/NEJM199901143400201","article-title":"Efficacy of bilateral prophylactic mastectomy in women with a family history of breast cancer","volume":"340","author":"Hartmann","year":"1999","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.breast.2019.03.011_bib33","series-title":"Bilateral prophylactic mastectomy in BRCA1\/2 mutation carriers","author":"Hartmann","year":"2000"},{"key":"10.1016\/j.breast.2019.03.011_bib34","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1200\/JCO.2004.04.188","article-title":"Bilateral prophylactic mastectomy reduces breast cancer risk in BRCA1 and BRCA2 mutation carriers: the PROSE study group","volume":"22","author":"Rebbeck","year":"2004","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.breast.2019.03.011_bib35","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1093\/jnci\/93.21.1633","article-title":"Efficacy of bilateral prophylactic mastectomy in BRCA1 and BRCA2 gene mutation carriers","volume":"93","author":"Hartmann","year":"2001","journal-title":"J\u00a0Natl Cancer Inst"},{"issue":"3","key":"10.1016\/j.breast.2019.03.011_bib36","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1056\/NEJM200107193450301","article-title":"Breast cancer after prophylactic mastectomy in women with a BRCA1 or BRCA2 mutation","volume":"345","author":"Meijers-Heijboer","year":"2001","journal-title":"N\u00a0Engl J Med"},{"issue":"11","key":"10.1016\/j.breast.2019.03.011_bib37","first-page":"875","article-title":"Bilateral prophylactic oophorectomy and bilateral prophylactic mastectomy in a prospective cohort of unaffected BRCA1 or BRCA2 mutation carriers","volume":"7","author":"Friebel","year":"2007","journal-title":"Clin Breast Canc"},{"issue":"4","key":"10.1016\/j.breast.2019.03.011_bib38","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1136\/jmg.2008.062232","article-title":"Risk-reducing mastectomy: outcomes in 10 European centres","volume":"46","author":"Evans","year":"2009","journal-title":"J\u00a0Med Genet"},{"issue":"1\u20133","key":"10.1016\/j.breast.2019.03.011_bib39","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1155\/1999\/605917","article-title":"Utilisation of prophylactic mastectomy in 10 European centres","volume":"15","author":"Evans","year":"1999","journal-title":"Dis Markers"},{"key":"10.1016\/j.breast.2019.03.011_bib40","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1245\/s10434-014-3532-x","article-title":"MRI volumetric analysis of breast fibroglandular tissue to assess risk of the spared nipple in BRCA1 and BRCA2 mutation carriers","volume":"21","author":"Baltzer","year":"2014","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.breast.2019.03.011_bib41","doi-asserted-by":"crossref","first-page":"3324","DOI":"10.1245\/s10434-015-4761-3","article-title":"Long term psychosocial functioning in women with bilateral prophylactic mastectomy: does preservation of the nipple-areolar complex make a difference?","volume":"22","author":"Metcalfe","year":"2015","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.breast.2019.03.011_bib42","doi-asserted-by":"crossref","first-page":"3943","DOI":"10.1200\/JCO.2007.13.9568","article-title":"Psychological reactions, quality of life and body image after bilateral prophylactic mastectomy in women at high risk for breast cancer: a prospective 1-year follow-up study","volume":"26","author":"Brandberg","year":"2008","journal-title":"J\u00a0Clin Oncol"},{"key":"10.1016\/j.breast.2019.03.011_bib43","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1007\/s10689-012-9588-5","article-title":"Body image issues after bilateral prophylactic mastectomy with breast reconstruction in healthy women at risk fro hereditary breast cancer","volume":"12","author":"Gopie","year":"2013","journal-title":"Fam Cancer"},{"key":"10.1016\/j.breast.2019.03.011_bib44","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1002\/pon.726","article-title":"Psychosocial functioning in women who have undergone bilateral prophylactic mastectomy","volume":"13","author":"Metcalfe","year":"2004","journal-title":"Psycho Oncol"},{"key":"10.1016\/j.breast.2019.03.011_bib45","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1023\/A:1015269620265","article-title":"One-year follow-up of women opting for presymptomatic testing for BRCA1 and BRCA2: emotional impact of the test outcome and decisions on risk management (surveillance of prophylactic surgery)","volume":"73","author":"Lodder","year":"2002","journal-title":"Breast Canc Res Treat"},{"key":"10.1016\/j.breast.2019.03.011_bib46","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1007\/s10549-011-1941-0","article-title":"Long-term follow-up of Jewish women with a BRCA1 and BRCA2 mutationwho underwent population genetic screening","volume":"133","author":"Metcalfe","year":"2012","journal-title":"Breast Canc Res Treat"},{"key":"10.1016\/j.breast.2019.03.011_bib47","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1158\/1055-9965.EPI-11-0991","article-title":"Long term psychosocial outcomes of BRCA1\/BRCA2 testing: differences across affected status and risk-reducing surgery choice","volume":"21","author":"Graves","year":"2012","journal-title":"Cancer Epidemiol Biomark Prev"}],"container-title":["The Breast"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960977619304801?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960977619304801?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T08:41:14Z","timestamp":1760776874000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960977619304801"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8]]},"references-count":47,"alternative-id":["S0960977619304801"],"URL":"https:\/\/doi.org\/10.1016\/j.breast.2019.03.011","relation":{},"ISSN":["0960-9776"],"issn-type":[{"value":"0960-9776","type":"print"}],"subject":[],"published":{"date-parts":[[2019,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Current knowledge of risk reducing mastectomy: Indications, techniques, results, benefits, harms","name":"articletitle","label":"Article Title"},{"value":"The Breast","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.breast.2019.03.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}