{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T06:18:45Z","timestamp":1785824325741,"version":"3.56.0"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,10,4]],"date-time":"2022-10-04T00:00:00Z","timestamp":1664841600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thebreastonline.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Breast"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1016\/j.breast.2022.10.003","type":"journal-article","created":{"date-parts":[[2022,10,5]],"date-time":"2022-10-05T05:38:16Z","timestamp":1664948296000},"page":"118-125","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"special_numbering":"C","title":["Imaging of lumpectomy surface with large field-of-view confocal laser scanning microscope for intraoperative margin assessment - POLARHIS study"],"prefix":"10.1016","volume":"66","author":[{"given":"Mariana-Felicia","family":"Sandor","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatrice","family":"Schwalbach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viktoria","family":"Hofmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona-Elena","family":"Istrate","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zlatna","family":"Schuller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Ionescu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Heimann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moira","family":"Ragazzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2781-2178","authenticated-orcid":false,"given":"Michael P.","family":"Lux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.breast.2022.10.003_bib1","series-title":"World cancer report 2008","author":"Boyle","year":"2008"},{"key":"10.1016\/j.breast.2022.10.003_bib2","doi-asserted-by":"crossref","first-page":"16","DOI":"10.5455\/aim.2013.21.16-19","article-title":"Criteria and procedures for breast conserving surgery","volume":"21","author":"Fajdic","year":"2013","journal-title":"Acta Inf Med"},{"key":"10.1016\/j.breast.2022.10.003_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0074028","article-title":"Intraoperative ultrasound guidance is associated with clear lumpectomy margins for breast cancer: a systematic review and meta-analysis","volume":"8","author":"Pan","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.breast.2022.10.003_bib4","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1245\/s10434-010-1280-0","article-title":"Resection margins in ultrasound-guided breast-conserving surgery\u201d Ann","volume":"18","author":"Olsha","year":"2011","journal-title":"Surg Oncol"},{"key":"10.1016\/j.breast.2022.10.003_bib5","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1007\/s11307-017-1054-1","article-title":"Optical surgical navigation for precision in tumor resections","volume":"19","author":"Harmsen","year":"2017","journal-title":"Mol Imag Biol"},{"key":"10.1016\/j.breast.2022.10.003_bib6","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1245\/s10434-020-08731-z","article-title":"Lowering Re-excision rates after breast-conserving surgery: unraveling the intersection between surgeon case volumes and techniques","volume":"28","author":"Baliski","year":"2021","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.breast.2022.10.003_bib7","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1001\/jamasurg.2014.926","article-title":"Repeat surgery after breast conservation for the treatment of stage 0 to II breast carcinoma: a report from the national cancer data base, 2004-2010","volume":"149","author":"Wilke","year":"2014","journal-title":"JAMA Surg"},{"key":"10.1016\/j.breast.2022.10.003_bib8","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.breast.2016.10.023","article-title":"Over surgery in breast cancer","volume":"31","author":"MacNeill","year":"2017","journal-title":"Breast"},{"key":"10.1016\/j.breast.2022.10.003_bib9","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/j.amjsurg.2009.05.027","article-title":"Impact of initial surgical margins and residual cancer upon re-excision on outcome of patients with localized breast cancer","volume":"198","author":"Kouzminova","year":"2009","journal-title":"Am J Surg"},{"key":"10.1016\/j.breast.2022.10.003_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s40137-016-0136-3","article-title":"Advances in intraoperative margin assessment for breast cancer","volume":"4","author":"Keating","year":"2016","journal-title":"Curr Surg Reports"},{"key":"10.1016\/j.breast.2022.10.003_bib11","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1245\/s10434-016-5756-4","article-title":"Intraoperative margin management in breast-conserving surgery: a systematic review of the literature","volume":"25","author":"Gray","year":"2018","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.breast.2022.10.003_bib12","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1002\/jso.24890","article-title":"The impact of preoperative magnetic resonance imaging and lumpectomy cavity shavings on re-excision rate in pure ductal carcinoma in situ\u2014a single institution's experience","volume":"117","author":"So","year":"2018","journal-title":"J Surg Oncol"},{"key":"10.1016\/j.breast.2022.10.003_bib13","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1038\/modpathol.2013.158","article-title":"Fluorescence confocal microscopy for pathologists","volume":"27","author":"Ragazzi","year":"2014","journal-title":"Mod Pathol"},{"key":"10.1016\/j.breast.2022.10.003_bib14","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1097\/PAP.0000000000000114","article-title":"Ex Vivo (fluorescence) confocal microscopy in surgical pathology: state of the art","volume":"23","author":"Ragazzi","year":"2016","journal-title":"Adv Anat Pathol"},{"key":"10.1016\/j.breast.2022.10.003_bib15","doi-asserted-by":"crossref","DOI":"10.1117\/1.JBO.18.10.106016","article-title":"Feasibility of confocal fluorescence microscopy for real-time evaluation of neoplasia in fresh human breast tissue","volume":"18","author":"Dobbs","year":"2013","journal-title":"J Biomed Opt"},{"key":"10.1016\/j.breast.2022.10.003_bib16","first-page":"159","volume":"26","author":"Weisman","year":"2015","journal-title":"J Breast Dis"},{"key":"10.1016\/j.breast.2022.10.003_bib17","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1111\/jdv.15243","article-title":"Diagnostic accuracy of a new ex vivo confocal laser scanning microscope compared to H&E-stained paraffin slides for micrographic surgery of basal cell carcinoma","volume":"33","author":"Peters","year":"2019","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"10.1016\/j.breast.2022.10.003_bib18","doi-asserted-by":"crossref","first-page":"e91","DOI":"10.1002\/ski2.91","article-title":"Ex vivo confocal microscopy for surgical margin assessment: a histology\u2010compared study on 109 specimens","volume":"2","author":"Grizzetti","year":"2022","journal-title":"Skin Health Dis"},{"key":"10.1016\/j.breast.2022.10.003_bib19","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/s13000-019-0835-z","article-title":"Correction to: comparative analysis of confocal microscopy on fresh breast core needle biopsies and conventional histology","volume":"14","author":"Elfgen","year":"2019","journal-title":"Diagn Pathol"},{"key":"10.1016\/j.breast.2022.10.003_bib20","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/s10549-015-3543-8","article-title":"Imaging breast cancer morphology using probe-based confocal laser endomicroscopy: towards a real-time intraoperative imaging tool for cavity scanning","volume":"153","author":"Chang","year":"2015","journal-title":"Breast Cancer Res Treat"},{"key":"10.1016\/j.breast.2022.10.003_bib21","series-title":"Histological assessment of large fresh breast surgical specimens with ultra-fast slide-free confocal microscopy: a feasibility study","volume":"481","author":"Mathieu","year":"2022"},{"key":"10.1016\/j.breast.2022.10.003_bib22","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S0002-9610(02)01012-7","article-title":"Surgical margins in patients with early-stage breast cancer treated with breast conservation therapy","volume":"184","author":"Singletary","year":"2002","journal-title":"Am J Surg"},{"key":"10.1016\/j.breast.2022.10.003_bib23","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1002\/lsm.20865","article-title":"Autofluorescence and diffuse reflectance spectroscopy and spectral imaging for breast surgical margin analysis","volume":"42","author":"Keller","year":"2010","journal-title":"Laser Surg Med"},{"key":"10.1016\/j.breast.2022.10.003_bib24","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.amjsurg.2008.06.024","article-title":"A prospective, randomized, controlled, multicenter study of a real-time, intraoperative probe for positive margin detection in breast-conserving surgery","volume":"196","author":"Allweis","year":"2008","journal-title":"Am J Surg"},{"key":"10.1016\/j.breast.2022.10.003_bib25","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1007\/s10549-017-4475-2","article-title":"Performance characteristics of specimen radiography for margin assessment for ductal carcinoma in situ: a systematic review","volume":"166","author":"Versteegden","year":"2017","journal-title":"Breast Cancer Res Treat"},{"key":"10.1016\/j.breast.2022.10.003_bib26","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1007\/s10549-019-05476-6","article-title":"Efficacy of intraoperative specimen radiography as margin assessment tool in breast conserving surgery","volume":"179","author":"Funk","year":"2020","journal-title":"Breast Cancer Res Treat"},{"key":"10.1016\/j.breast.2022.10.003_bib27","series-title":"Breast carcinoma detection in ex-vivo fresh human breast surgical specimens using fast slide-free confocal microscopy scanner: the HIBISCUSS project","author":"Conversano","year":"2022"},{"key":"10.1016\/j.breast.2022.10.003_bib28","doi-asserted-by":"crossref","first-page":"1473","DOI":"10.1111\/bjd.17507","article-title":"Diagnostic accuracy of ex vivo fluorescence confocal microscopy in Mohs surgery of basal cell carcinomas: a prospective study on 753 margins","volume":"180","author":"Longo","year":"2019","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.breast.2022.10.003_bib29","doi-asserted-by":"crossref","first-page":"S307","DOI":"10.21037\/tcr.2017.08.33","article-title":"Current controversies in the treatment of ductal carcinoma in situ of the breast","volume":"7","author":"Garganese","year":"2018","journal-title":"Transl Cancer Res"},{"key":"10.1016\/j.breast.2022.10.003_bib30","first-page":"78","year":"2020"},{"key":"10.1016\/j.breast.2022.10.003_bib31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/cancers12030609","article-title":"Ductal carcinoma in situ of the breast: an update with emphasis on radiological and morphological features as predictive prognostic factors","volume":"12","author":"Salvatorelli","year":"2020","journal-title":"Cancers"},{"key":"10.1016\/j.breast.2022.10.003_bib32","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.breast.2015.12.014","article-title":"The role of specimen radiography in breast-conserving therapy of ductal carcinoma in situ","volume":"26","author":"Lange","year":"2016","journal-title":"Breast"},{"key":"10.1016\/j.breast.2022.10.003_bib33","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1016\/S1470-2045(13)70442-X","article-title":"Economic burden of cancer across the European Union: a population-based cost analysis","volume":"14","author":"Luengo-Fernandez","year":"2013","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.breast.2022.10.003_bib34","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1159\/000509127","article-title":"Analysis of oncological second opinions in a certified university breast and gynecological cancer center regarding consensus between the first and second opinion and conformity with the guidelines","volume":"16","author":"Lux","year":"2021","journal-title":"Breast Care"},{"key":"10.1016\/j.breast.2022.10.003_bib35","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1055\/s-0030-1271117","article-title":"Finanzierung und finanzielle Probleme von Leistungen und Strukturen im Fachgebiet Gyn\u00e4kologie und Geburtshilfe im Jahr 2011 allgemeine Aspekte und geburtshilfliche Versorgung: II. Artikel der Finanzierungskommission der DGGG e.V. Teil I","volume":"71","author":"Beckmann","year":"2011","journal-title":"Geburtshilfe Frauenheilkd"},{"key":"10.1016\/j.breast.2022.10.003_bib36","unstructured":"aG-DRG-Report-Browser 2021. https:\/\/www.g-drg.de\/Datenbrowser_und_Begleitforschung\/G-DRG-Report-Browser\/aG-DRG-Report-Browser_2021."}],"container-title":["The Breast"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960977622001680?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960977622001680?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T08:45:53Z","timestamp":1760777153000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960977622001680"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":36,"alternative-id":["S0960977622001680"],"URL":"https:\/\/doi.org\/10.1016\/j.breast.2022.10.003","relation":{},"ISSN":["0960-9776"],"issn-type":[{"value":"0960-9776","type":"print"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Imaging of lumpectomy surface with large field-of-view confocal laser scanning microscope for intraoperative margin assessment - POLARHIS study","name":"articletitle","label":"Article Title"},{"value":"The Breast","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.breast.2022.10.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}