{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T17:34:30Z","timestamp":1781199270320,"version":"3.54.1"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,7,3]],"date-time":"2023-07-03T00:00:00Z","timestamp":1688342400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thebreastonline.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Breast"],"published-print":{"date-parts":[[2023,10]]},"DOI":"10.1016\/j.breast.2023.07.001","type":"journal-article","created":{"date-parts":[[2023,7,4]],"date-time":"2023-07-04T20:22:30Z","timestamp":1688502150000},"page":"31-41","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"special_numbering":"C","title":["Barrier films for the prevention of acute radiation dermatitis in breast cancer: A systematic review and meta-analysis of randomised controlled trials"],"prefix":"10.1016","volume":"71","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4527-4024","authenticated-orcid":false,"given":"Cas Stefaan","family":"Dejonckheere","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Egon","family":"Dejonckheere","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julian Philipp","family":"Layer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katharina","family":"Layer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo Renato","family":"Sarria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Koch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alina","family":"Abramian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Kaiser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kira","family":"Lindner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Bachmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Anzb\u00f6ck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fred","family":"R\u00f6hner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederic Carsten","family":"Schmeel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonard Christopher","family":"Schmeel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.breast.2023.07.001_bib1","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1001\/jamaoncol.2015.2666","article-title":"Acute and short-term toxic effects of conventionally fractionated vs. hypofractionated whole-breast radiation: a randomized clinical trial","volume":"1","author":"Shaitelman","year":"2015","journal-title":"JAMA Oncol"},{"key":"10.1016\/j.breast.2023.07.001_bib2","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.radonc.2020.02.018","article-title":"Acute radiation-induced skin toxicity in hypofractionated vs. conventional whole-breast irradiation: an objective, randomized multicenter assessment using spectrophotometry","volume":"146","author":"Schmeel","year":"2020","journal-title":"Radiother Oncol J Eur Soc Ther Radiol Oncol"},{"key":"10.1016\/j.breast.2023.07.001_bib3","doi-asserted-by":"crossref","first-page":"E40","DOI":"10.1016\/j.ijrobp.2017.06.688","article-title":"Risk factors for the development of acute radiation dermatitis in breast cancer patients","volume":"99","author":"Parker","year":"2017","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.breast.2023.07.001_bib4","doi-asserted-by":"crossref","DOI":"10.3390\/cancers12092444","article-title":"Objective evaluation of risk factors for radiation dermatitis in whole-breast irradiation using the spectrophotometric L*a*b* colour-space","volume":"12","author":"B\u00f6hner","year":"2020","journal-title":"Cancers"},{"key":"10.1016\/j.breast.2023.07.001_bib5","first-page":"2265","article-title":"Radiation dermatitis assessment tools used in breast cancer: a systematic review of measurement properties","volume":"29","author":"Behroozian","year":"2021","journal-title":"Support Care Cancer"},{"key":"10.1016\/j.breast.2023.07.001_bib6","first-page":"11","article-title":"Risk factors related to acute radiation dermatitis in breast cancer patients after radiotherapy: a systematic review and meta-analysis","author":"Xie","year":"2021","journal-title":"Front Oncol"},{"key":"10.1016\/j.breast.2023.07.001_bib7","first-page":"5343","article-title":"Topical management of acute radiation dermatitis in breast cancer patients: a systematic review and meta-analysis","volume":"37","author":"Haruna","year":"2017","journal-title":"Anticancer Res"},{"key":"10.1016\/j.breast.2023.07.001_bib8","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1007\/s40257-016-0186-4","article-title":"Radiodermatitis: a review of our current understanding","volume":"17","author":"Singh","year":"2016","journal-title":"Am J Clin Dermatol"},{"key":"10.1016\/j.breast.2023.07.001_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijrobp.2018.07.1984","article-title":"Characterizing the effects of radiation dermatitis on quality of life","volume":"102","author":"Rzepecki","year":"2018","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.breast.2023.07.001_bib10","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.radonc.2021.03.020","article-title":"How do patient-reported outcomes compare with clinician assessments? A prospective study of radiation dermatitis in breast cancer","volume":"159","author":"Behroozian","year":"2021","journal-title":"Radiother Oncol J Eur Soc Ther Radiol Oncol"},{"key":"10.1016\/j.breast.2023.07.001_bib11","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1007\/s40264-015-0287-7","article-title":"Topical corticosteroid-induced skin atrophy: a comprehensive review","volume":"38","author":"Barnes","year":"2015","journal-title":"Drug Saf"},{"key":"10.1016\/j.breast.2023.07.001_bib12","article-title":"Comparison of clinical practice guidelines on radiation dermatitis: a narrative review","author":"Finkelstein","year":"2022","journal-title":"Support Care Cancer"},{"key":"10.1016\/j.breast.2023.07.001_bib13","doi-asserted-by":"crossref","DOI":"10.1007\/s00066-023-02074-w","article-title":"Risk assessment, surveillance, and nonpharmaceutical prevention of acute radiation dermatitis: results of a multicentric survey among the German-speaking radiation oncology community","author":"Layer","year":"2023","journal-title":"Strahlenther Onkol"},{"issue":"S34","key":"10.1016\/j.breast.2023.07.001_bib14","first-page":"S36","article-title":"Use of Hydrofilm and Hydrofilm plus in the community: an assessment","volume":"15","author":"Palfreyman","year":"2010","journal-title":"Br J Community Nurs"},{"key":"10.1016\/j.breast.2023.07.001_bib15","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1259\/bjr\/62011713","article-title":"Mepilex Lite dressings for the management of radiation-induced erythema: a systematic inpatient controlled clinical trial","volume":"83","author":"Diggelmann","year":"2010","journal-title":"Br J Radiol"},{"key":"10.1016\/j.breast.2023.07.001_bib16","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1002\/jmrs.46","article-title":"Protecting the radiation-damaged skin from friction: a mini review","volume":"61","author":"Herst","year":"2014","journal-title":"J Med Radiat Sci"},{"key":"10.1016\/j.breast.2023.07.001_bib17","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.radonc.2014.01.005","article-title":"Prophylactic use of Mepitel Film prevents radiation-induced moist desquamation in an intra-patient randomised controlled clinical trial of 78 breast cancer patients","volume":"110","author":"Herst","year":"2014","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.breast.2023.07.001_bib18","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1080\/0284186X.2018.1441542","article-title":"Prophylactically applied Hydrofilm polyurethane film dressings reduce radiation dermatitis in adjuvant radiation therapy of breast cancer patients","volume":"57","author":"Schmeel","year":"2018","journal-title":"Acta Oncol (Madr)"},{"key":"10.1016\/j.breast.2023.07.001_bib19","doi-asserted-by":"crossref","DOI":"10.3390\/polym11122112","article-title":"Hydrofilm polyurethane films reduce radiation dermatitis severity in hypofractionated whole-breast irradiation: an objective, intrapatient randomized dual-center assessment","volume":"11","author":"Schmeel","year":"2019","journal-title":"Polymers (Basel)"},{"key":"10.1016\/j.breast.2023.07.001_bib20","article-title":"Mepitel film for the prevention of acute radiation dermatitis in breast cancer: a randomized multicenter open-label phase III trial","volume":"22","author":"Behroozian","year":"2022","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.breast.2023.07.001_bib21","doi-asserted-by":"crossref","first-page":"347","DOI":"10.4172\/1948-5956.1000166","article-title":"Randomized intra-patient controlled trial of mepilex lite dressings versus aqueous cream in managing radiation-induced skin reactions post-mastectomy","volume":"4","author":"Paterson","year":"2012","journal-title":"J Cancer Sci Ther"},{"key":"10.1016\/j.breast.2023.07.001_bib22","doi-asserted-by":"crossref","first-page":"l4898","DOI":"10.1136\/bmj.l4898","article-title":"RoB 2: a revised tool for assessing risk of bias in randomised trials","volume":"366","author":"Sterne","year":"2019","journal-title":"BMJ"},{"key":"10.1016\/j.breast.2023.07.001_bib23","doi-asserted-by":"crossref","first-page":"n71","DOI":"10.1136\/bmj.n71","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"10.1016\/j.breast.2023.07.001_bib24","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0197-2456(86)90046-2","article-title":"Meta-analysis in clinical trials","volume":"7","author":"DerSimonian","year":"1986","journal-title":"Contr Clin Trials"},{"key":"10.1016\/j.breast.2023.07.001_bib25","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1002\/sim.1186","article-title":"Quantifying heterogeneity in a meta-analysis","volume":"21","author":"Higgins","year":"2002","journal-title":"Stat Med"},{"key":"10.1016\/j.breast.2023.07.001_bib26","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.tipsro.2018.05.004","article-title":"Breast cancer patients report reduced sensitivity and pain using a barrier film during radiotherapy \u2013 a Danish intra-patient randomized multicentre study","volume":"7","author":"M\u00f8ller","year":"2018","journal-title":"Tech Innov Patient Support Radiat Oncol"},{"key":"10.1016\/j.breast.2023.07.001_bib27","doi-asserted-by":"crossref","first-page":"e825","DOI":"10.1016\/j.clbc.2018.06.015","article-title":"Radiation-induced skin toxicity in breast cancer patients: a systematic review of randomized trials","volume":"18","author":"Yee","year":"2018","journal-title":"Clin Breast Cancer"},{"key":"10.1016\/j.breast.2023.07.001_bib28","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1007\/s00066-022-01985-4","article-title":"Hypofractionated radiotherapy after breast-conserving surgery: clinical and dosimetric factors predictive of acute skin toxicity","volume":"199","author":"Ben Amor","year":"2023","journal-title":"Strahlenther Onkol"},{"key":"10.1016\/j.breast.2023.07.001_bib29","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1002\/jmrs.397","article-title":"Mepitel Film is superior to Biafine cream in managing acute radiation-induced skin reactions in head and neck cancer patients: a randomised intra-patient controlled clinical trial","volume":"67","author":"Yan","year":"2020","journal-title":"J Med Radiat Sci"},{"key":"10.1016\/j.breast.2023.07.001_bib30","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1016\/0360-3016(95)00060-C","article-title":"Toxicity criteria of the radiation therapy oncology group (RTOG) and the European organization for research and treatment of cancer (EORTC)","volume":"31","author":"Cox","year":"1995","journal-title":"Int J Radiat Oncol Biol Phys"},{"key":"10.1016\/j.breast.2023.07.001_bib31","unstructured":"Common Terminology Criteria for Adverse Events (CTCAE) Version 5.0 n.d. https:\/\/ctep.cancer.gov\/protocoldevelopment\/electronic_applications\/docs\/ctcae_v5_quick_reference_5x7.pdf."},{"key":"10.1016\/j.breast.2023.07.001_bib32","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.12968\/bjon.1999.8.19.1305","article-title":"Radiation-induced skin reactions. 3: evaluating the RISRAS","volume":"8","author":"Noble-Adams","year":"1999","journal-title":"Br J Nurs"},{"key":"10.1016\/j.breast.2023.07.001_bib33","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1007\/s00066-005-1345-3","article-title":"Spectrophotometric skin measurements correlate with EORTC\/RTOG-common toxicity criteria","volume":"181","author":"Momm","year":"2005","journal-title":"Strahlenther Onkol"},{"key":"10.1016\/j.breast.2023.07.001_bib34","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.radonc.2004.04.011","article-title":"Quantitative assessment of skin erythema due to radiotherapy - evaluation of different measurements","volume":"72","author":"Wengstr\u00f6m","year":"2004","journal-title":"Radiother Oncol J Eur Soc Ther Radiol Oncol Eur Soc Ther Radiol Oncol"},{"key":"10.1016\/j.breast.2023.07.001_bib35","doi-asserted-by":"crossref","DOI":"10.1259\/bjr.20170298","article-title":"The effect of Mepitel Film on acute radiation-induced skin reactions in head and neck cancer patients: a feasibility study","volume":"91","author":"Wooding","year":"2018","journal-title":"Br J Radiol"},{"key":"10.1016\/j.breast.2023.07.001_bib36","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.radonc.2019.07.023","article-title":"A randomized trial (RAREST-01) comparing Mepitel\u00ae Film and standard care for prevention of radiation dermatitis in patients irradiated for locally advanced squamous cell carcinoma of the head-and-neck (SCCHN)","volume":"139","author":"Rades","year":"2019","journal-title":"Radiother Oncol J Eur Soc Ther Radiol Oncol"},{"key":"10.1016\/j.breast.2023.07.001_bib37","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1186\/1471-2407-14-53","article-title":"Prevention and treatment of acute radiation-induced skin reactions: a systematic review and meta-analysis of randomized controlled trials","volume":"14","author":"Chan","year":"2014","journal-title":"BMC Cancer"},{"key":"10.1016\/j.breast.2023.07.001_bib38","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.breast.2019.05.012","article-title":"Mepitel Film and Mepilex Lite for the prophylaxis and treatment of skin toxicities from breast radiation","volume":"46","author":"Wan","year":"2019","journal-title":"Breast"},{"key":"10.1016\/j.breast.2023.07.001_bib39","doi-asserted-by":"crossref","first-page":"E225","DOI":"10.1188\/20.ONF.E225-E236","article-title":"Radiodermatitis in patients with cancer: systematic review and meta-analysis","volume":"47","author":"Ginex","year":"2020","journal-title":"Oncol Nurs Forum"},{"key":"10.1016\/j.breast.2023.07.001_bib40","article-title":"Effectiveness of semi-permeable dressings to treat radiation-induced skin reactions. A systematic review","volume":"26","author":"Fern\u00e1ndez-Castro","year":"2017","journal-title":"Eur J Cancer Care"},{"key":"10.1016\/j.breast.2023.07.001_bib41","first-page":"219","article-title":"Barrier films and dressings for the prevention of acute radiation dermatitis: a systematic review and meta-analysis","volume":"31","author":"Robijns","year":"2023","journal-title":"Support Care Cancer"},{"key":"10.1016\/j.breast.2023.07.001_bib42","doi-asserted-by":"crossref","first-page":"e172","DOI":"10.1016\/S1470-2045(23)00067-0","article-title":"Multinational Association of Supportive Care in Cancer (MASCC) clinical practice guidelines for the prevention and management of acute radiation dermatitis: international Delphi consensus-based recommendations","volume":"24","author":"Behroozian","year":"2023","journal-title":"Lancet Oncol"},{"key":"10.1016\/j.breast.2023.07.001_bib43","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1001\/jamadermatol.2022.1736","article-title":"Efficacy of epigallocatechin-3-gallate in preventing dermatitis in patients with breast cancer receiving postoperative radiotherapy: a double-blind, placebo-controlled, phase 2 randomized clinical trial","volume":"158","author":"Zhao","year":"2022","journal-title":"JAMA Dermatol"},{"key":"10.1016\/j.breast.2023.07.001_bib44","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1002\/lsm.23475","article-title":"Photobiomodulation therapy for the prevention of acute radiation dermatitis in breast cancer patients undergoing hypofractioned whole-breast irradiation (LABRA trial)","volume":"54","author":"Robijns","year":"2022","journal-title":"Laser Surg Med"},{"issue":"9","key":"10.1016\/j.breast.2023.07.001_bib45","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.3390\/pharmaceutics14091767","article-title":"Non-invasive physical plasma for preventing radiation dermatitis in breast cancer: a first-in-human feasibility study","volume":"14","author":"Dejonckheere","year":"2022","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.breast.2023.07.001_bib46","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1001\/jamaoncol.2022.1479","article-title":"Effect of supine vs prone breast radiotherapy on acute toxic effects of the skin among women with large breast size: a randomized clinical trial","volume":"8","author":"Vesprini","year":"2022","journal-title":"JAMA Oncol"}],"container-title":["The Breast"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960977623005167?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960977623005167?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T08:46:45Z","timestamp":1760777205000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960977623005167"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":46,"alternative-id":["S0960977623005167"],"URL":"https:\/\/doi.org\/10.1016\/j.breast.2023.07.001","relation":{},"ISSN":["0960-9776"],"issn-type":[{"value":"0960-9776","type":"print"}],"subject":[],"published":{"date-parts":[[2023,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Barrier films for the prevention of acute radiation dermatitis in breast cancer: A systematic review and meta-analysis of randomised controlled trials","name":"articletitle","label":"Article Title"},{"value":"The Breast","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.breast.2023.07.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}