{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T11:43:52Z","timestamp":1787312632385,"version":"build-2736575974"},"reference-count":23,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,16]],"date-time":"2025-03-16T00:00:00Z","timestamp":1742083200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003052","name":"Korea Ministry of Trade Industry and Energy","doi-asserted-by":"publisher","award":["RS-2024-00508422"],"award-info":[{"award-number":["RS-2024-00508422"]}],"id":[{"id":"10.13039\/501100003052","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thebreastonline.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Breast"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.breast.2025.104449","type":"journal-article","created":{"date-parts":[[2025,3,17]],"date-time":"2025-03-17T20:26:02Z","timestamp":1742243162000},"page":"104449","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Comparison of oncological outcomes of premenopausal with ovarian function suppression versus postmenopausal women in ER+\/HER2- breast cancer"],"prefix":"10.1016","volume":"81","author":[{"given":"Min Jung","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-Jung","family":"Jung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong-Ho","family":"Cheun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eunhye","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong-Kyu","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han-Byoel","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyeong-Gon","family":"Moon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7310-0764","authenticated-orcid":false,"given":"Wonshik","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.breast.2025.104449_bib1","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1056\/NEJMoa1804710","article-title":"Adjuvant chemotherapy guided by a 21-gene expression assay in breast cancer","volume":"379","author":"Sparano","year":"2018","journal-title":"N Engl J Med"},{"key":"10.1016\/j.breast.2025.104449_bib2","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1200\/JCO.2007.15.1068","article-title":"Development of the 21-gene assay and its application in clinical practice and clinical trials","volume":"26","author":"Sparano","year":"2008","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.breast.2025.104449_bib3","doi-asserted-by":"crossref","first-page":"2336","DOI":"10.1056\/NEJMoa2108873","article-title":"21-gene assay to inform chemotherapy benefit in node-positive breast cancer","volume":"385","author":"Kalinsky","year":"2021","journal-title":"N Engl J Med"},{"key":"10.1016\/j.breast.2025.104449_bib4","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1016\/S0140-6736(00)02292-3","article-title":"Is chemotherapy alone adequate for young patients with oestrogen-receptor-positive breast cancer?","volume":"355","author":"Aebi","year":"2000","journal-title":"Lancet"},{"key":"10.1016\/j.breast.2025.104449_bib5","doi-asserted-by":"crossref","first-page":"3324","DOI":"10.1200\/JCO.2007.14.2471","article-title":"Young age at diagnosis correlates with worse prognosis and defines a subset of breast cancers with shared patterns of gene expression","volume":"26","author":"Anders","year":"2008","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.breast.2025.104449_bib6","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1186\/s13058-014-0427-5","article-title":"Biology of breast cancer in young patients","volume":"16","author":"Azim","year":"2014","journal-title":"Breast Cancer Res"},{"key":"10.1016\/j.breast.2025.104449_bib7","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0007695","article-title":"Breast cancer in young patients: poor survival despite intensive treatment","volume":"4","author":"Fredholm","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.breast.2025.104449_bib8","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.critrevonc.2007.09.001","article-title":"Impact of aging on the biology of breast cancer","volume":"66","author":"Benz","year":"2008","journal-title":"Crit Rev Oncol Hematol"},{"key":"10.1016\/j.breast.2025.104449_bib9","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1200\/JCO.2005.03.0783","article-title":"Tamoxifen after adjuvant chemotherapy for premenopausal patients with lymph node-positive breast cancer: International Breast Cancer Study Group Trial 13\u201393","volume":"24","author":"International Breast Cancer Study Group","year":"2006","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.breast.2025.104449_bib10","doi-asserted-by":"crossref","first-page":"341","DOI":"10.4048\/jbc.2016.19.4.341","article-title":"Role of ovarian function suppression in premenopausal patients with early breast cancer","volume":"19","author":"Park","year":"2016","journal-title":"J Breast Cancer"},{"key":"10.1016\/j.breast.2025.104449_bib11","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1200\/JCO.2015.65.9573","article-title":"Adjuvant endocrine therapy for patients with hormone receptor-positive breast cancer: American Society of Clinical Oncology clinical practice guideline update on ovarian suppression","volume":"34","author":"Burstein","year":"2016","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.breast.2025.104449_bib12","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1056\/NEJMoa1803164","article-title":"Tailoring adjuvant endocrine therapy for premenopausal breast cancer","volume":"379","author":"Francis","year":"2018","journal-title":"N Engl J Med"},{"key":"10.1016\/j.breast.2025.104449_bib13","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1056\/NEJMoa1404037","article-title":"Adjuvant exemestane with ovarian suppression in premenopausal breast cancer","volume":"371","author":"Pagani","year":"2014","journal-title":"N Engl J Med"},{"key":"10.1016\/j.breast.2025.104449_bib14","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1056\/NEJMoa1412379","article-title":"Adjuvant ovarian suppression in premenopausal breast cancer","volume":"372","author":"Francis","year":"2015","journal-title":"N Engl J Med"},{"key":"10.1016\/j.breast.2025.104449_bib15","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1200\/JCO.22.01065","article-title":"Adjuvant endocrine therapy in premenopausal breast cancer: 12-year results from SOFT","volume":"41","author":"Francis","year":"2023","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.breast.2025.104449_bib16","first-page":"93","article-title":"The Eighth Edition AJCC Cancer Staging Manual: Continuing to build a bridge from a population-based to a more \u201cpersonalized\u201d approach to cancer staging","volume":"67","author":"Amin","year":"2017","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.breast.2025.104449_bib17","doi-asserted-by":"crossref","first-page":"1112","DOI":"10.1245\/s10434-009-0334-7","article-title":"Ki-67 expression gives additional prognostic information on St. Gallen 2007 and Adjuvant! Online risk categories in early breast cancer","volume":"16","author":"Jung","year":"2009","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.breast.2025.104449_bib18","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.ejca.2021.04.038","article-title":"Chemotherapy-induced ovarian failure in young patients with early breast cancer: prospective analysis of four randomised neoadjuvant\/adjuvant breast cancer trials","volume":"152","author":"Furlanetto","year":"2021","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.breast.2025.104449_bib19","doi-asserted-by":"crossref","first-page":"301","DOI":"10.4048\/jbc.2014.17.4.301","article-title":"Unique features of young age breast cancer and its management","volume":"17","author":"Lee","year":"2014","journal-title":"J Breast Cancer"},{"key":"10.1016\/j.breast.2025.104449_bib20","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1158\/1078-0432.CCR-11-2599","article-title":"Elucidating prognosis and biology of breast cancer arising in young patients using gene expression profiling","volume":"18","author":"Azim","year":"2012","journal-title":"Clin Cancer Res"},{"issue":"16_suppl","key":"10.1016\/j.breast.2025.104449_bib21","doi-asserted-by":"crossref","first-page":"3017","DOI":"10.1200\/JCO.2024.42.16_suppl.3017","article-title":"Association between stromal tumor-infiltrating lymphocytes (TILs) and pathologic complete response (pCR) in patients with early breast cancer (BC) treated with neoadjuvant chemotherapy and HER2-directed therapies in NSABP B-41","volume":"42","author":"Schlam","year":"2024","journal-title":"J Clin Oncol"},{"issue":"16_suppl","key":"10.1016\/j.breast.2025.104449_bib22","doi-asserted-by":"crossref","first-page":"TPS618","DOI":"10.1200\/JCO.2023.41.16_suppl.TPS618","article-title":"Prospective single-arm study of endocrine therapies with ovarian function suppression in premenopausal patients with node-positive early breast cancer with low genomic risk (INTERSTELLAR trial, KBCSG-25)","volume":"41","author":"Ahn","year":"2023","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.breast.2025.104449_bib23","doi-asserted-by":"crossref","first-page":"3948","DOI":"10.1200\/JCO.2014.55.6993","article-title":"Phase III comparison of tamoxifen versus tamoxifen plus ovarian function suppression in premenopausal patients with node-negative, hormone receptor-positive breast cancer (E-3193, INT-0142): a trial of the Eastern Cooperative Oncology Group","volume":"32","author":"Tevaarwerk","year":"2014","journal-title":"J Clin Oncol"}],"container-title":["The Breast"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960977625004667?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960977625004667?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T02:55:25Z","timestamp":1763607325000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960977625004667"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":23,"alternative-id":["S0960977625004667"],"URL":"https:\/\/doi.org\/10.1016\/j.breast.2025.104449","relation":{},"ISSN":["0960-9776"],"issn-type":[{"value":"0960-9776","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comparison of oncological outcomes of premenopausal with ovarian function suppression versus postmenopausal women in ER+\/HER2- breast cancer","name":"articletitle","label":"Article Title"},{"value":"The Breast","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.breast.2025.104449","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"104449"}}