{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T18:11:11Z","timestamp":1793211071522,"version":"4.5.0"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T00:00:00Z","timestamp":1747872000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100014188","name":"Ministry of Science and ICT, South Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014188","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS-2021-NR061812"],"award-info":[{"award-number":["RS-2021-NR061812"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thebreastonline.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Breast"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.breast.2025.104508","type":"journal-article","created":{"date-parts":[[2025,5,22]],"date-time":"2025-05-22T19:26:10Z","timestamp":1747941970000},"page":"104508","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Sarcopenia in patients with metastatic breast cancer: A systematic review and meta-analysis"],"prefix":"10.1016","volume":"82","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6073-161X","authenticated-orcid":false,"given":"Min Kyeong","family":"Jang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sungwon","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Raszewski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seho","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sue","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.breast.2025.104508_bib1","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.breast.2022.08.010","article-title":"Current and future burden of breast cancer: Global statistics for 2020 and 2040","volume":"66","author":"Arnold","year":"2022","journal-title":"Breast (Edinb)"},{"key":"10.1016\/j.breast.2025.104508_bib2","unstructured":"Surveillance, Epidemiology, and End Results Program (SEER) Cancer Stat Facts: Female Breast Cancer. National Cancer Institute. Bethesda, MD, https:\/\/seer.cancer.gov\/statfacts\/html\/breast.html. Accessed 2 December 2024."},{"issue":"12","key":"10.1016\/j.breast.2025.104508_bib3","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1016\/j.annonc.2021.09.019","article-title":"ESMO Clinical Practice Guideline for the diagnosis, staging and treatment of patients with metastatic breast cancer","volume":"32","author":"Gennari","year":"2021","journal-title":"Ann Oncol"},{"issue":"6","key":"10.1016\/j.breast.2025.104508_bib4","doi-asserted-by":"crossref","first-page":"2295","DOI":"10.1002\/jcsm.13629","article-title":"Sarcopenia is a prognostic factor of adverse effects and mortality in patients with tumour: a systematic review and meta\u2010analysis","volume":"15","author":"Zhang","year":"2024","journal-title":"Journal of Cachexia, Sarcopenia and Muscle"},{"issue":"1","key":"10.1016\/j.breast.2025.104508_bib5","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1186\/s12885-023-10582-2","article-title":"Sarcopenia as a risk factor of progression-free survival in patients with metastases: a systematic review and meta-analysis","volume":"23","author":"Luo","year":"2023","journal-title":"BMC Cancer"},{"key":"10.1016\/j.breast.2025.104508_bib6","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1007\/s00404-019-05168-y","article-title":"Muscle mass loss in patients with metastatic breast cancer","volume":"300","author":"Solomayer","year":"2019","journal-title":"Arch Gynecol Obstet"},{"issue":"1","key":"10.1016\/j.breast.2025.104508_bib7","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1634\/theoncologist.2017-0255","article-title":"Sarcopenia is associated with quality of life and depression in patients with advanced cancer","volume":"23","author":"Nipp","year":"2018","journal-title":"Oncologist"},{"issue":"5","key":"10.1016\/j.breast.2025.104508_bib8","first-page":"328","article-title":"Prevalence and clinical implications of sarcopenia in breast cancer: a systematic review and meta-analysis","volume":"32","author":"Jang","year":"2024","journal-title":"Support Care Cancer"},{"key":"10.1016\/j.breast.2025.104508_bib9","doi-asserted-by":"crossref","first-page":"93","DOI":"10.14283\/jfa.2019.10","article-title":"Economic impact of hospitalizations in US adults with sarcopenia","volume":"8","author":"Goates","year":"2019","journal-title":"The Journal of frailty & aging"},{"issue":"21","key":"10.1016\/j.breast.2025.104508_bib10","doi-asserted-by":"crossref","first-page":"7964","DOI":"10.1002\/cam4.3428","article-title":"Sarcopenia and adverse health\u2010related outcomes: an umbrella review of meta\u2010analyses of observational studies","volume":"9","author":"Xia","year":"2020","journal-title":"Cancer Med"},{"key":"10.1016\/j.breast.2025.104508_bib11","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1007\/s10549-019-05352-3","article-title":"Muscle composition and outcomes in patients with breast cancer: meta-analysis and systematic review","volume":"177","author":"Aleixo","year":"2019","journal-title":"Breast Cancer Res Treat"},{"key":"10.1016\/j.breast.2025.104508_bib12","article-title":"Evaluation of body computed tomography-determined sarcopenia in breast cancer patients and clinical outcomes: a systematic review","volume":"21","author":"Rossi","year":"2019","journal-title":"Cancer Treat Res Commun"},{"key":"10.1016\/j.breast.2025.104508_bib13","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"bmj"},{"key":"10.1016\/j.breast.2025.104508_bib15","unstructured":"National Heart, Lung, and Blood Institute, Study Quality Assessment Tools. https:\/\/www.nhlbi.nih.gov\/health-topics\/study-quality-assessment-tools. Accessed 29 November 2024."},{"issue":"8","key":"10.1016\/j.breast.2025.104508_bib16","doi-asserted-by":"crossref","first-page":"2920","DOI":"10.1158\/1078-0432.CCR-08-2242","article-title":"Sarcopenia as a determinant of chemotherapy toxicity and time to tumor progression in metastatic breast cancer patients receiving capecitabine treatment","volume":"15","author":"Prado","year":"2009","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.breast.2025.104508_bib17","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.breast.2016.10.014","article-title":"Low muscle attenuation is a prognostic factor for survival in metastatic breast cancer patients treated with first line palliative chemotherapy","volume":"31","author":"Rier","year":"2017","journal-title":"Breast (Edinb)"},{"issue":"3","key":"10.1016\/j.breast.2025.104508_bib18","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1158\/1078-0432.CCR-16-0940","article-title":"Skeletal muscle measures as predictors of toxicity, hospitalization, and survival in patients with metastatic breast cancer receiving taxane-based chemotherapy","volume":"23","author":"Shachar","year":"2017","journal-title":"Clin Cancer Res"},{"issue":"6","key":"10.1016\/j.breast.2025.104508_bib19","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1080\/01635581.2019.1595053","article-title":"Body composition, serum biomarkers of inflammation and quality of life in clinically stable women with estrogen receptor positive metastatic breast cancer","volume":"71","author":"Sheean","year":"2019","journal-title":"Nutr Cancer"},{"key":"10.1016\/j.breast.2025.104508_bib20","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/s10549-020-05617-2","article-title":"Computed tomography-based analyses of baseline body composition parameters and changes in breast cancer patients under treatment with CDK 4\/6 inhibitors","volume":"181","author":"Franzoi","year":"2020","journal-title":"Breast Cancer Res Treat"},{"issue":"1","key":"10.1016\/j.breast.2025.104508_bib21","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s10549-021-06358-6","article-title":"Myosteatosis at diagnosis is adversely associated with 2-year survival in women with estrogen receptor-negative metastatic breast cancer","volume":"190","author":"Sheean","year":"2021","journal-title":"Breast Cancer Res Treat"},{"key":"10.1016\/j.breast.2025.104508_bib22","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.breast.2021.12.014","article-title":"Is sarcopenia a missed factor in the management of patients with metastatic breast cancer?","volume":"61","author":"Deluche","year":"2022","journal-title":"Breast (Edinb)"},{"key":"10.1016\/j.breast.2025.104508_bib23","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2022.987012","article-title":"Do body composition parameters correlate with response to targeted therapy in ER+\/HER2-metastatic breast cancer patients? Role of sarcopenia and obesity","volume":"12","author":"Kripa","year":"2022","journal-title":"Front Oncol"},{"issue":"1","key":"10.1016\/j.breast.2025.104508_bib24","doi-asserted-by":"crossref","first-page":"3385","DOI":"10.1038\/s41598-022-07143-1","article-title":"Computed tomography based analyses of body mass composition in HER2 positive metastatic breast cancer patients undergoing first line treatment with pertuzumab and trastuzumab","volume":"12","author":"Palleschi","year":"2022","journal-title":"Sci Rep"},{"issue":"9","key":"10.1016\/j.breast.2025.104508_bib25","doi-asserted-by":"crossref","first-page":"915","DOI":"10.6004\/jnccn.2023.7045","article-title":"Impact of muscle measures on outcome in patients receiving endocrine therapy for metastatic breast cancer: analysis of ECOG-ACRIN E2112","volume":"21","author":"Ballinger","year":"2023","journal-title":"J Natl Compr Cancer Netw"},{"issue":"1","key":"10.1016\/j.breast.2025.104508_bib26","doi-asserted-by":"crossref","first-page":"688","DOI":"10.3390\/curroncol30010054","article-title":"Poor muscle status, dietary protein intake, exercise levels, quality of life and physical function in women with metastatic breast cancer at chemotherapy commencement and during follow-up","volume":"30","author":"Parkinson","year":"2023","journal-title":"Curr Oncol"},{"key":"10.1016\/j.breast.2025.104508_bib27","doi-asserted-by":"crossref","unstructured":"Camilleri G.M., Delrieu L., Bouleuc C., Pierga J.Y., Cottu P., Berger F., Raynard B., Cyrille S., Marchal T. Prevalence and survival implications of malnutrition and sarcopenia in metastatic breast cancer: a longitudinal analysis. Clin Nutr 2024 Jun 14;43(8):1710-1718.","DOI":"10.1016\/j.clnu.2024.06.014"},{"key":"10.1016\/j.breast.2025.104508_bib28","first-page":"1","article-title":"Body composition measures as a determinant of Alpelisib related toxicity","volume":"7","author":"Shachar","year":"2024","journal-title":"Breast Cancer Res Treat"},{"issue":"5","key":"10.1016\/j.breast.2025.104508_bib29","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1007\/s00280-024-04641-z","article-title":"Visceral obesity and sarcopenia as predictors of efficacy and hematological toxicity in patients with metastatic breast cancer treated with CDK 4\/6 inhibitors","volume":"93","author":"Y\u00fccel","year":"2024","journal-title":"Cancer Chemother Pharmacol"},{"issue":"8","key":"10.1016\/j.breast.2025.104508_bib30","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1002\/jpen.2415","article-title":"Prevalence of sarcopenia in patients with solid tumors: a meta\u2010analysis based on 81,814 patients","volume":"46","author":"Surov","year":"2022","journal-title":"J Parenter Enteral Nutr"},{"issue":"3","key":"10.1016\/j.breast.2025.104508_bib31","doi-asserted-by":"crossref","first-page":"596","DOI":"10.3390\/cancers16030596","article-title":"Sarcopenia in breast Cancer patients: a systematic review and Meta-analysis","volume":"16","author":"Roberto","year":"2024","journal-title":"Cancers"},{"issue":"15","key":"10.1016\/j.breast.2025.104508_bib32","doi-asserted-by":"crossref","first-page":"3918","DOI":"10.3390\/cancers13153918","article-title":"The role of chronic inflammation in the development of breast cancer","volume":"13","author":"Danforth","year":"2021","journal-title":"Cancers"},{"key":"10.1016\/j.breast.2025.104508_bib33","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2021.811288","article-title":"Association between systemic inflammation and malnutrition with survival in patients with cancer sarcopenia\u2014a prospective multicenter study","volume":"8","author":"Ruan","year":"2022","journal-title":"Front Nutr"},{"issue":"4","key":"10.1016\/j.breast.2025.104508_bib34","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1016\/j.clnu.2017.07.010","article-title":"Prevalence and predictive value of pre-therapeutic sarcopenia in cancer patients: a systematic review","volume":"37","author":"Pamoukdjian","year":"2018","journal-title":"Clin Nutr"},{"key":"10.1016\/j.breast.2025.104508_bib35","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.tipsro.2020.10.001","article-title":"Sarcopenia in cancer: risking more than muscle loss","volume":"16","author":"Anjanappa","year":"2020","journal-title":"Technical innovations & patient support in radiation oncology"},{"key":"10.1016\/j.breast.2025.104508_bib36","doi-asserted-by":"crossref","first-page":"S34","DOI":"10.1016\/j.afos.2021.02.005","article-title":"Different definitions of sarcopenia and mortality in cancer: a meta-analysis","volume":"7","author":"Li","year":"2021","journal-title":"Osteoporosis and sarcopenia"},{"issue":"1","key":"10.1016\/j.breast.2025.104508_bib37","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1186\/s12885-022-09443-1","article-title":"Skeletal muscle loss during neoadjuvant chemotherapy predicts poor prognosis in patients with breast cancer","volume":"22","author":"Amitani","year":"2022","journal-title":"BMC Cancer"},{"key":"10.1016\/j.breast.2025.104508_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.nut.2021.111345","article-title":"Sarcopenia and prognosis of advanced cancer patients receiving immune checkpoint inhibitors: a comprehensive systematic review and meta-analysis","volume":"90","author":"Deng","year":"2021","journal-title":"Nutrition"},{"key":"10.1016\/j.breast.2025.104508_bib39","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.breast.2020.11.014","article-title":"Impact of body mass index on overall survival in patients with metastatic breast cancer","volume":"55","author":"Saleh","year":"2021","journal-title":"Breast (Edinb)"},{"issue":"1","key":"10.1016\/j.breast.2025.104508_bib40","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1002\/jcsm.13161","article-title":"Predictive validity of current sarcopenia definitions (EWGSOP2, SDOC, and AWGS2) for clinical outcomes: a scoping review","volume":"14","author":"Stuck","year":"2023","journal-title":"Journal of cachexia, sarcopenia and muscle"}],"container-title":["The Breast"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960977625005259?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960977625005259?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T03:11:13Z","timestamp":1769656273000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960977625005259"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":39,"alternative-id":["S0960977625005259"],"URL":"https:\/\/doi.org\/10.1016\/j.breast.2025.104508","relation":{},"ISSN":["0960-9776"],"issn-type":[{"value":"0960-9776","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sarcopenia in patients with metastatic breast cancer: A systematic review and meta-analysis","name":"articletitle","label":"Article Title"},{"value":"The Breast","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.breast.2025.104508","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"104508"}}