{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T10:13:30Z","timestamp":1778926410564,"version":"3.51.4"},"reference-count":25,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T00:00:00Z","timestamp":1774742400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thebreastonline.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Breast"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.breast.2026.104779","type":"journal-article","created":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T23:56:09Z","timestamp":1775260569000},"page":"104779","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Chemotherapy is associated with differential survival outcomes in apocrine carcinoma: A nationwide cohort study from the Japanese National Clinical Database\u2013Breast Cancer Registry"],"prefix":"10.1016","volume":"87","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8935-0768","authenticated-orcid":false,"given":"Yoshiya","family":"Horimoto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiraku","family":"Kumamaru","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyoko","family":"Orimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3450-4533","authenticated-orcid":false,"given":"Takashi","family":"Ishikawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naoko","family":"Kinukawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takayuki","family":"Iwamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naruto","family":"Taira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takanori","family":"Ishida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.breast.2026.104779_bib1","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1038\/s12276-023-01030-z","article-title":"Genomic characteristics of triple negative apocrine carcinoma: a comparison to triple negative breast cancer","volume":"55","author":"Kim","year":"2023","journal-title":"Exp Mol Med"},{"key":"10.1016\/j.breast.2026.104779_bib2","series-title":"Carcinoma with apocrine differentiation","author":"Provenzano","year":"2019"},{"issue":"11","key":"10.1016\/j.breast.2026.104779_bib3","first-page":"1393","article-title":"Apocrine carcinoma of the breast: a comprehensive review","volume":"28","author":"Vranic","year":"2013","journal-title":"Histol Histopathol"},{"issue":"4","key":"10.1016\/j.breast.2026.104779_bib4","doi-asserted-by":"crossref","first-page":"e576","DOI":"10.1016\/j.clbc.2021.12.009","article-title":"An update on the molecular and clinical characteristics of apocrine carcinoma of the breast","volume":"22","author":"Vranic","year":"2022","journal-title":"Clin Breast Cancer"},{"issue":"28","key":"10.1016\/j.breast.2026.104779_bib5","doi-asserted-by":"crossref","first-page":"3994","DOI":"10.1038\/sj.onc.1209415","article-title":"An estrogen receptor-negative breast cancer subset characterized by a hormonally regulated transcriptional program and response to androgen","volume":"25","author":"Doane","year":"2006","journal-title":"Oncogene"},{"issue":"2","key":"10.1016\/j.breast.2026.104779_bib6","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1007\/s10549-022-06578-4","article-title":"HER2-positive apocrine carcinoma of the breast: a population-based analysis of treatment and outcome","volume":"193","author":"Skenderi","year":"2022","journal-title":"Breast Cancer Res Treat"},{"issue":"15","key":"10.1016\/j.breast.2026.104779_bib7","doi-asserted-by":"crossref","first-page":"24579","DOI":"10.18632\/oncotarget.15597","article-title":"Dose invasive apocrine adenocarcinoma has worse prognosis than invasive ductal carcinoma of breast: evidence from SEER database","volume":"8","author":"Zhang","year":"2017","journal-title":"Oncotarget"},{"issue":"2","key":"10.1016\/j.breast.2026.104779_bib8","doi-asserted-by":"crossref","first-page":"296","DOI":"10.7150\/jca.22280","article-title":"The clinicopathological features and survival outcomes of different histological subtypes in triple-negative breast cancer","volume":"9","author":"Liao","year":"2018","journal-title":"J Cancer"},{"key":"10.1016\/j.breast.2026.104779_bib9","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.breast.2020.07.003","article-title":"Prognosis of selected triple negative apocrine breast cancer patients who did not receive adjuvant chemotherapy","volume":"53","author":"Montagna","year":"2020","journal-title":"Breast"},{"issue":"6","key":"10.1016\/j.breast.2026.104779_bib10","doi-asserted-by":"crossref","DOI":"10.3390\/jcm11061607","article-title":"Triple-negative apocrine breast carcinoma has better prognosis despite poor response to neoadjuvant chemotherapy","volume":"11","author":"Hu","year":"2022","journal-title":"J Clin Med"},{"issue":"8","key":"10.1016\/j.breast.2026.104779_bib11","doi-asserted-by":"crossref","first-page":"e892","DOI":"10.1016\/j.clbc.2022.08.006","article-title":"Disease behavior and treatment response of special histological types of triple-negative breast cancer","volume":"22","author":"Bonadio","year":"2022","journal-title":"Clin Breast Cancer"},{"issue":"6","key":"10.1016\/j.breast.2026.104779_bib12","doi-asserted-by":"crossref","first-page":"551","DOI":"10.14740\/wjon1694","article-title":"Clinicopathological characteristics and prognosis of triple-negative apocrine carcinoma: a case-control study","volume":"14","author":"Suzuki","year":"2023","journal-title":"World J Oncol"},{"issue":"18","key":"10.1016\/j.breast.2026.104779_bib13","doi-asserted-by":"crossref","first-page":"7523","DOI":"10.1002\/cam4.2634","article-title":"Prognosis in triple-negative apocrine carcinomas of the breast: a population-based study","volume":"8","author":"Wu","year":"2019","journal-title":"Cancer Med"},{"issue":"6","key":"10.1016\/j.breast.2026.104779_bib14","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0157368","article-title":"Refinement of triple-negative breast cancer molecular subtypes: implications for neoadjuvant chemotherapy selection","volume":"11","author":"Lehmann","year":"2016","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.breast.2026.104779_bib16","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/s12282-024-01545-x","article-title":"Survival trends and patient characteristics between 2004 and 2016 for breast cancer in Japan based on the national clinical database-breast cancer registry","volume":"31","author":"Iwamoto","year":"2024","journal-title":"Breast Cancer"},{"key":"10.1016\/j.breast.2026.104779_bib17","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.ejca.2022.05.017","article-title":"Prognostic impact of postoperative radiotherapy in patients with breast cancer and with pT1-2 and 1-3 lymph node metastases: a retrospective cohort study based on the Japanese breast cancer registry","volume":"172","author":"Yamada","year":"2022","journal-title":"Eur J Cancer"},{"issue":"10","key":"10.1016\/j.breast.2026.104779_bib18","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.0040296","article-title":"The strengthening the reporting of observational studies in epidemiology (STROBE) statement: guidelines for reporting observational studies","volume":"4","author":"von Elm","year":"2007","journal-title":"PLoS Med"},{"issue":"22","key":"10.1016\/j.breast.2026.104779_bib19","doi-asserted-by":"crossref","first-page":"3867","DOI":"10.1200\/JCO.22.02864","article-title":"Human epidermal growth factor receptor 2 testing in breast cancer: ASCO-college of American pathologists guideline update","volume":"41","author":"Wolff","year":"2023","journal-title":"J Clin Oncol"},{"issue":"10","key":"10.1016\/j.breast.2026.104779_bib20","doi-asserted-by":"crossref","first-page":"5610","DOI":"10.1245\/s10434-021-10518-9","article-title":"Apocrine breast cancer: unique features of a predominantly triple-negative breast cancer","volume":"28","author":"Saridakis","year":"2021","journal-title":"Ann Surg Oncol"},{"issue":"6","key":"10.1016\/j.breast.2026.104779_bib21","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.21037\/gs-22-248","article-title":"Tumor-infiltrating lymphocytes status, programmed death-ligand 1 expression, and clinicopathological features of 41 cases of pure apocrine carcinoma of the breast: a retrospective study based on clinical pathological analysis and different immune statuses","volume":"11","author":"Xiao","year":"2022","journal-title":"Gland Surg"},{"issue":"9","key":"10.1016\/j.breast.2026.104779_bib22","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1038\/s41416-019-0420-y","article-title":"Molecular apocrine tumours in EORTC 10994\/BIG 1-00 phase III study: pathological response after neoadjuvant chemotherapy and clinical outcomes","volume":"120","author":"Bonnefoi","year":"2019","journal-title":"Br J Cancer"},{"issue":"2","key":"10.1016\/j.breast.2026.104779_bib23","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1056\/NEJMoa1703643","article-title":"Adjuvant pertuzumab and trastuzumab in early HER2-Positive breast cancer","volume":"377","author":"von Minckwitz","year":"2017","journal-title":"N Engl J Med"},{"issue":"9555","key":"10.1016\/j.breast.2026.104779_bib24","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/S0140-6736(07)60028-2","article-title":"2-year follow-up of trastuzumab after adjuvant chemotherapy in HER2-positive breast cancer: a randomised controlled trial","volume":"369","author":"Smith","year":"2007","journal-title":"Lancet"},{"issue":"3","key":"10.1016\/j.breast.2026.104779_bib25","doi-asserted-by":"crossref","DOI":"10.1186\/bcr3421","article-title":"Molecular apocrine breast cancers are aggressive estrogen receptor negative tumors overexpressing either HER2 or GCDFP15","volume":"15","author":"Lehmann-Che","year":"2013","journal-title":"Breast Cancer Res"},{"issue":"29","key":"10.1016\/j.breast.2026.104779_bib26","doi-asserted-by":"crossref","first-page":"4660","DOI":"10.1038\/sj.onc.1208561","article-title":"Identification of molecular apocrine breast tumours by microarray analysis","volume":"24","author":"Farmer","year":"2005","journal-title":"Oncogene"}],"container-title":["The Breast"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960977626000895?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960977626000895?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T09:59:04Z","timestamp":1778925544000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960977626000895"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":25,"alternative-id":["S0960977626000895"],"URL":"https:\/\/doi.org\/10.1016\/j.breast.2026.104779","relation":{},"ISSN":["0960-9776"],"issn-type":[{"value":"0960-9776","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chemotherapy is associated with differential survival outcomes in apocrine carcinoma: A nationwide cohort study from the Japanese National Clinical Database\u2013Breast Cancer Registry","name":"articletitle","label":"Article Title"},{"value":"The Breast","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.breast.2026.104779","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"104779"}}