{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T22:06:09Z","timestamp":1784930769603,"version":"3.55.0"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T00:00:00Z","timestamp":1780531200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thebreastonline.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Breast"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.breast.2026.104832","type":"journal-article","created":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T15:43:31Z","timestamp":1780674211000},"page":"104832","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Pathological complete response and postmastectomy radiation therapy after primary systemic therapy: results from the ReSTORE study"],"prefix":"10.1016","volume":"88","author":[{"given":"Liat","family":"Mizrahi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianna","family":"Valzano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rinat","family":"Bernstein Molho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlotta","family":"Becherini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Visani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Viola","family":"Salvestrini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Mattioli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Rampini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo","family":"Livi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ben","family":"Boursi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Icro","family":"Meattini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orit","family":"Kaidar-Person","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"17","key":"10.1016\/j.breast.2026.104832_bib1","doi-asserted-by":"crossref","first-page":"5365","DOI":"10.7150\/jca.62830","article-title":"Discrepancy of breast and axillary pathologic complete response and outcomes in different subtypes of node-positive breast cancer after neoadjuvant chemotherapy","volume":"12","author":"Chen","year":"2021","journal-title":"J Cancer"},{"issue":"9938","key":"10.1016\/j.breast.2026.104832_bib2","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/S0140-6736(13)62422-8","article-title":"Pathological complete response and long-term clinical benefit in breast cancer: the CTNeoBC pooled analysis","volume":"384","author":"Cortazar","year":"2014","journal-title":"Lancet"},{"key":"10.1016\/j.breast.2026.104832_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.breast.2025.104411","article-title":"Omitting axillary lymph node dissection in breast cancer patients with extensive nodal disease and excellent response to primary systemic therapy using the MARI protocol","volume":"80","author":"van Hemert","year":"2025","journal-title":"Breast"},{"issue":"9","key":"10.1016\/j.breast.2026.104832_bib4","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1016\/S1470-2045(22)00482-X","article-title":"De-escalation of radiotherapy after primary chemotherapy in cT1\u20132N1 breast cancer (RAPCHEM; BOOG 2010\u201303): 5-Year follow-up results of a Dutch, prospective, registry study","volume":"23","author":"de Wild","year":"2022","journal-title":"Lancet Oncol"},{"issue":"21","key":"10.1016\/j.breast.2026.104832_bib5","doi-asserted-by":"crossref","first-page":"2113","DOI":"10.1056\/NEJMoa2414859","article-title":"Omitting regional nodal irradiation after response to neoadjuvant chemotherapy","volume":"392","author":"Mamounas","year":"2025","journal-title":"N Engl J Med"},{"issue":"1","key":"10.1016\/j.breast.2026.104832_bib6","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S1470-2045(17)30777-5","article-title":"Long-term outcomes for neoadjuvant versus adjuvant chemotherapy in early breast cancer: meta-analysis of individual patient data from ten randomised trials","volume":"19","year":"2018","journal-title":"Lancet Oncol"},{"issue":"21","key":"10.1016\/j.breast.2026.104832_bib7","doi-asserted-by":"crossref","first-page":"2113","DOI":"10.1056\/NEJMoa2414859","article-title":"Omitting regional nodal irradiation after response to neoadjuvant chemotherapy","volume":"392","author":"Mamounas","year":"2025","journal-title":"N Engl J Med"},{"key":"10.1016\/j.breast.2026.104832_bib8","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.breast.2022.03.008","article-title":"Oncoplastic breast consortium recommendations for mastectomy and whole breast reconstruction in the setting of post-mastectomy radiation therapy","volume":"63","author":"Weber","year":"2022","journal-title":"Breast"},{"issue":"9935","key":"10.1016\/j.breast.2026.104832_bib9","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1016\/S0140-6736(14)60488-8","article-title":"Effect of radiotherapy after mastectomy and axillary surgery on 10-year recurrence and 20-year breast cancer mortality: meta-analysis of individual patient data for 8135 women in 22 randomised trials","volume":"383","author":"McGale","year":"2014","journal-title":"Lancet"},{"issue":"11","key":"10.1016\/j.breast.2026.104832_bib10","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1093\/bjs\/znac283","article-title":"Long-term outcomes of implant-based immediate breast reconstruction with and without radiotherapy: a population-based study","volume":"109","author":"de Boniface","year":"2022","journal-title":"Br J Surg"},{"issue":"7","key":"10.1016\/j.breast.2026.104832_bib11","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1245\/s10434-018-6486-6","article-title":"Eighth edition of the AJCC cancer staging manual: breast cancer","volume":"25","author":"Giuliano","year":"2018","journal-title":"Ann Surg Oncol"},{"issue":"1","key":"10.1016\/j.breast.2026.104832_bib12","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.radonc.2014.11.030","article-title":"ESTRO consensus guideline on target volume delineation for elective radiation therapy of early stage breast cancer","volume":"114","author":"Offersen","year":"2015","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.breast.2026.104832_bib13","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.radonc.2021.07.015","article-title":"Tricks and tips for target volume definition and delineation in breast cancer: lessons learned from ESTRO breast courses","volume":"162","author":"Kaidar-Person","year":"2021","journal-title":"Radiother Oncol"},{"issue":"1","key":"10.1016\/j.breast.2026.104832_bib14","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.clon.2020.09.004","article-title":"Postmastectomy radiation therapy planning after immediate implant-based reconstruction using the European society for radiotherapy and oncology-advisory committee in radiation oncology practice consensus guidelines for target volume delineation","volume":"33","author":"Kaidar-Person","year":"2021","journal-title":"Clin Oncol"},{"key":"10.1016\/j.breast.2026.104832_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.breast.2024.103791","article-title":"Locoregional recurrence in studies of primary systemic therapy in early invasive breast cancer","volume":"77","author":"Chen","year":"2024","journal-title":"Breast"},{"key":"10.1016\/j.breast.2026.104832_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.radonc.2025.110962","article-title":"An additional peril of pathologic complete response","volume":"209","author":"Kaidar-Person","year":"2025","journal-title":"Radiother Oncol"},{"issue":"32","key":"10.1016\/j.breast.2026.104832_bib17","doi-asserted-by":"crossref","first-page":"3960","DOI":"10.1200\/JCO.2011.40.8369","article-title":"Predictors of locoregional recurrence after neoadjuvant chemotherapy: results from combined analysis of National surgical adjuvant breast and bowel project B-18 and B-27","volume":"30","author":"Mamounas","year":"2012","journal-title":"J Clin Oncol"},{"issue":"2","key":"10.1016\/j.breast.2026.104832_bib18","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1007\/s11547-023-01743-1","article-title":"Optimising of axillary therapy in breast cancer: lessons from the past to plan for a better future","volume":"129","author":"Kaidar-Person","year":"2024","journal-title":"Radiol Med"},{"key":"10.1016\/j.breast.2026.104832_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.radonc.2024.110563","article-title":"The EORTC 22922\/10925 trial investigating regional nodal irradiation in stage I-III breast cancer: outcomes according to locoregional and systemic therapies","volume":"201","author":"Kaidar-Person","year":"2024","journal-title":"Radiother Oncol"},{"key":"10.1016\/j.breast.2026.104832_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijrobp.2026.02.235","article-title":"Integration of breast reconstruction and radiation: how the proton-photon debate exposes methodological gaps, analytical bias, and lack of consensus","author":"Naoum","year":"2026","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"1\u20132","key":"10.1016\/j.breast.2026.104832_bib21","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1111\/ans.70371","article-title":"Selective Pectoralis muscle denervation reduces capsular contracture in sub-pectoral breast reconstruction. long-term retrospective Case- control study","volume":"96","author":"Bernini","year":"2026","journal-title":"ANZ J Surg"},{"issue":"3","key":"10.1016\/j.breast.2026.104832_bib22","doi-asserted-by":"crossref","first-page":"297","DOI":"10.21037\/gs-23-432","article-title":"Pre-pectoral breast reconstruction with tissue expander entirely covered by acellular dermal matrix: feasibility, safety and histological features resulting from the first 64 procedures","volume":"13","author":"Bernini","year":"2024","journal-title":"Gland Surg"},{"key":"10.1016\/j.breast.2026.104832_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.ctrv.2021.102236","article-title":"Breast reconstruction and radiation therapy: an Italian expert Delphi consensus statements and critical review","volume":"99","author":"Meattini","year":"2021","journal-title":"Cancer Treat Rev"},{"key":"10.1016\/j.breast.2026.104832_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.radonc.2023.109698","article-title":"Mapping the location of local and regional recurrences according to breast cancer surgery and radiation therapy: results from EORTC 22922\/10925","volume":"185","author":"Kaidar-Person","year":"2023","journal-title":"Radiother Oncol"},{"issue":"7","key":"10.1016\/j.breast.2026.104832_bib25","doi-asserted-by":"crossref","first-page":"2288","DOI":"10.1245\/s10434-020-08516-4","article-title":"Residual glandular breast tissue after mastectomy: a systematic review","volume":"27","author":"Kaidar-Person","year":"2020","journal-title":"Ann Surg Oncol"},{"issue":"2","key":"10.1016\/j.breast.2026.104832_bib26","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1007\/s10549-020-05774-4","article-title":"Spatial location of local recurrences after mastectomy: a systematic review","volume":"183","author":"Kaidar-Person","year":"2020","journal-title":"Breast Cancer Res Treat"},{"issue":"1","key":"10.1016\/j.breast.2026.104832_bib27","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s10549-022-06545-z","article-title":"Three-year follow-up of de-escalated axillary treatment after neoadjuvant systemic therapy in clinically node-positive breast cancer: the MARI-protocol","volume":"193","author":"van Loevezijn","year":"2022","journal-title":"Breast Cancer Res Treat"},{"issue":"4","key":"10.1016\/j.breast.2026.104832_bib28","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2024-084488","article-title":"Protocol for the development of a core outcome set and reporting guidelines for locoregional treatment in neoadjuvant systemic breast cancer treatment trials: the PRECEDENT project","volume":"14","author":"Potter","year":"2024","journal-title":"BMJ Open"},{"key":"10.1016\/j.breast.2026.104832_bib29","article-title":"Essential requirements for reporting radiation therapy in breast cancer clinical trials: an international multi-disciplinary consensus endorsed by the European society for Radiotherapy and Oncology (ESTRO)","author":"Kaidar-Person","year":"2023","journal-title":"Radiother Oncol"},{"issue":"28","key":"10.1016\/j.breast.2026.104832_bib30","doi-asserted-by":"crossref","first-page":"4414","DOI":"10.1200\/JCO.2007.10.6823","article-title":"Measurement of residual breast cancer burden to predict survival after neoadjuvant chemotherapy","volume":"25","author":"Symmans","year":"2007","journal-title":"J Clin Oncol"},{"issue":"1","key":"10.1016\/j.breast.2026.104832_bib31","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/S1470-2045(21)00589-1","article-title":"Residual cancer burden after neoadjuvant chemotherapy and long-term survival outcomes in breast cancer: a multicentre pooled analysis of 5161 patients","volume":"23","author":"Yau","year":"2022","journal-title":"Lancet Oncol"}],"container-title":["The Breast"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960977626001426?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0960977626001426?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T21:32:07Z","timestamp":1784928727000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0960977626001426"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":31,"alternative-id":["S0960977626001426"],"URL":"https:\/\/doi.org\/10.1016\/j.breast.2026.104832","relation":{},"ISSN":["0960-9776"],"issn-type":[{"value":"0960-9776","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pathological complete response and postmastectomy radiation therapy after primary systemic therapy: results from the ReSTORE study","name":"articletitle","label":"Article Title"},{"value":"The Breast","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.breast.2026.104832","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"104832"}}