{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T08:37:09Z","timestamp":1790066229551,"version":"4.0.1"},"reference-count":48,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,3,1]],"date-time":"2019-03-01T00:00:00Z","timestamp":1551398400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100006279","name":"St. Jude Medical","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006279","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008497","name":"Boston Scientific Corporation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008497","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004374","name":"Medtronic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004374","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["brainstimjrnl.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Stimulation"],"published-print":{"date-parts":[[2019,3]]},"DOI":"10.1016\/j.brs.2018.11.012","type":"journal-article","created":{"date-parts":[[2018,11,27]],"date-time":"2018-11-27T05:57:17Z","timestamp":1543298237000},"page":"344-352","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":61,"title":["Inferior thalamic peduncle deep brain stimulation for treatment-refractory obsessive-compulsive disorder: A phase 1 pilot trial"],"prefix":"10.1016","volume":"12","author":[{"given":"Darrin J.","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert F.","family":"Dallapiazza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3280-6503","authenticated-orcid":false,"given":"Philippe","family":"De Vloo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gavin J.B.","family":"Elias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4131-6784","authenticated-orcid":false,"given":"Anton","family":"Fomenko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre","family":"Boutet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Giacobbe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andres M.","family":"Lozano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.brs.2018.11.012_bib1","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1097\/01.pra.0000300122.76322.ad","article-title":"Obsessive-compulsive disorder: update on assessment and treatment","volume":"13","author":"Bjorgvinsson","year":"2007","journal-title":"J\u00a0Psychiatr Pract"},{"issue":"3","key":"10.1016\/j.brs.2018.11.012_bib2","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.jad.2009.12.001","article-title":"Suicide in patients treated for obsessive-compulsive disorder: a prospective follow-up study","volume":"124","author":"Alonso","year":"2010","journal-title":"J\u00a0Affect Disord"},{"issue":"8","key":"10.1016\/j.brs.2018.11.012_bib3","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1016\/S2215-0366(16)30069-4","article-title":"Pharmacological and psychotherapeutic interventions for management of obsessive-compulsive disorder in adults: a systematic review and network meta-analysis","volume":"3","author":"Skapinakis","year":"2016","journal-title":"Lancet Psychiatry"},{"issue":"8","key":"10.1016\/j.brs.2018.11.012_bib4","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1016\/j.cpr.2004.08.004","article-title":"A\u00a0multidimensional meta-analysis of psychotherapy and pharmacotherapy for obsessive-compulsive disorder","volume":"24","author":"Eddy","year":"2004","journal-title":"Clin Psychol Rev"},{"issue":"1","key":"10.1016\/j.brs.2018.11.012_bib5","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1017\/S1461145704004675","article-title":"Evidence-based pharmacotherapy of obsessive-compulsive disorder","volume":"8","author":"Fineberg","year":"2005","journal-title":"Int J Neuropsychopharmacol"},{"issue":"3","key":"10.1016\/j.brs.2018.11.012_bib6","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1001\/archpsyc.1987.01800150017003","article-title":"Local cerebral glucose metabolic rates in obsessive-compulsive disorder. A comparison with rates in unipolar depression and in normal controls","volume":"44","author":"Baxter","year":"1987","journal-title":"Arch Gen Psychiatr"},{"issue":"6","key":"10.1016\/j.brs.2018.11.012_bib7","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1001\/archpsyc.1989.01810060038007","article-title":"Cerebral glucose metabolism in childhood-onset obsessive-compulsive disorder","volume":"46","author":"Swedo","year":"1989","journal-title":"Arch Gen Psychiatr"},{"issue":"4","key":"10.1016\/j.brs.2018.11.012_bib8","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/0893-133X(89)90028-6","article-title":"Evidence for common alterations in cerebral glucose metabolism in major affective disorders and schizophrenia","volume":"2","author":"Cohen","year":"1989","journal-title":"Neuropsychopharmacology"},{"issue":"1","key":"10.1016\/j.brs.2018.11.012_bib9","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0053241","article-title":"Obsessive compulsive disorder networks: positron emission tomography and neuropsychology provide new insights","volume":"8","author":"Millet","year":"2013","journal-title":"PLoS One"},{"issue":"8","key":"10.1016\/j.brs.2018.11.012_bib10","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1111\/pcn.12195","article-title":"Neurobiological model of obsessive-compulsive disorder: evidence from recent neuropsychological and neuroimaging findings","volume":"68","author":"Nakao","year":"2014","journal-title":"Psychiatr Clin Neurosci"},{"issue":"4","key":"10.1016\/j.brs.2018.11.012_bib11","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/s11920-011-0205-3","article-title":"Update on repetitive transcranial magnetic stimulation in obsessive-compulsive disorder: different targets","volume":"13","author":"Blom","year":"2011","journal-title":"Curr Psychiatr Rep"},{"issue":"1","key":"10.1016\/j.brs.2018.11.012_bib12","first-page":"77","article-title":"Dorsal anterior cingulotomy and anterior capsulotomy for severe, refractory obsessive-compulsive disorder: a systematic review of observational studies","volume":"124","author":"Brown","year":"2016","journal-title":"J\u00a0Neurosurg"},{"issue":"1\u20132","key":"10.1016\/j.brs.2018.11.012_bib13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF01402207","article-title":"Treatment of chronic obsessive compulsive states with stereotactic anterior capsulotomy or cingulotomy","volume":"62","author":"Fodstad","year":"1982","journal-title":"Acta Neurochir"},{"issue":"5","key":"10.1016\/j.brs.2018.11.012_bib14","first-page":"1028","article-title":"Deep brain stimulation versus anterior capsulotomy for obsessive-compulsive disorder: a review of the literature","volume":"122","author":"Pepper","year":"2015","journal-title":"J\u00a0Neurosurg"},{"issue":"3","key":"10.1016\/j.brs.2018.11.012_bib15","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.neuron.2013.01.020","article-title":"Probing and regulating dysfunctional circuits using deep brain stimulation","volume":"77","author":"Lozano","year":"2013","journal-title":"Neuron"},{"issue":"10","key":"10.1016\/j.brs.2018.11.012_bib16","doi-asserted-by":"crossref","first-page":"1061","DOI":"10.1001\/archgenpsychiatry.2010.122","article-title":"Deep brain stimulation of the nucleus accumbens for treatment-refractory obsessive-compulsive disorder","volume":"67","author":"Denys","year":"2010","journal-title":"Arch Gen Psychiatr"},{"issue":"1","key":"10.1016\/j.brs.2018.11.012_bib17","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1038\/mp.2008.55","article-title":"Deep brain stimulation of the ventral internal capsule\/ventral striatum for obsessive-compulsive disorder: worldwide experience","volume":"15","author":"Greenberg","year":"2010","journal-title":"Mol Psychiatr"},{"issue":"5","key":"10.1016\/j.brs.2018.11.012_bib18","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1016\/j.biopsych.2004.11.042","article-title":"Deep brain stimulation for refractory obsessive-compulsive disorder","volume":"57","author":"Abelson","year":"2005","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.brs.2018.11.012_bib19","article-title":"Deep brain stimulation for severe treatment-resistant obsessive-compulsive disorder: an open-label case series","author":"Farrand","year":"2017","journal-title":"Aust N Z J Psychiatr"},{"issue":"6","key":"10.1016\/j.brs.2018.11.012_bib20","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1038\/mp.2016.124","article-title":"Long-term electrical stimulation of bed nucleus of stria terminalis for obsessive-compulsive disorder","volume":"22","author":"Raymaekers","year":"2017","journal-title":"Mol Psychiatr"},{"issue":"20","key":"10.1016\/j.brs.2018.11.012_bib21","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1056\/NEJMoa0708514","article-title":"Subthalamic nucleus stimulation in severe obsessive-compulsive disorder","volume":"359","author":"Mallet","year":"2008","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.brs.2018.11.012_bib22","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1016\/j.wneu.2016.10.046","article-title":"Anterior cingulate implant for obsessive-compulsive disorder","volume":"97","author":"De Ridder","year":"2017","journal-title":"World Neurosurg"},{"issue":"3","key":"10.1016\/j.brs.2018.11.012_bib23","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1017\/S1092852916000286","article-title":"The medial forebrain bundle as a target for deep brain stimulation for obsessive-compulsive disorder","volume":"22","author":"Coenen","year":"2017","journal-title":"CNS Spectr"},{"issue":"6","key":"10.1016\/j.brs.2018.11.012_bib24","doi-asserted-by":"crossref","first-page":"e245","DOI":"10.1016\/j.wneu.2012.10.006","article-title":"Deep brain stimulation in the treatment of obsessive-compulsive disorder","volume":"80","author":"Blomstedt","year":"2013","journal-title":"World Neurosurg"},{"issue":"32","key":"10.1016\/j.brs.2018.11.012_bib25","doi-asserted-by":"crossref","first-page":"8368","DOI":"10.1523\/JNEUROSCI.0271-06.2006","article-title":"Reward-related cortical inputs define a large striatal region in primates that interface with associative cortical connections, providing a substrate for incentive-based learning","volume":"26","author":"Haber","year":"2006","journal-title":"J\u00a0Neurosci"},{"issue":"4","key":"10.1016\/j.brs.2018.11.012_bib26","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1038\/mp.2016.1","article-title":"Overshadowed by the amygdala: the bed nucleus of the stria terminalis emerges as key to psychiatric disorders","volume":"21","author":"Lebow","year":"2016","journal-title":"Mol Psychiatr"},{"key":"10.1016\/j.brs.2018.11.012_bib27","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.neuropharm.2017.03.028","article-title":"The bed nucleus of the stria terminalis in drug-associated behavior and affect: a circuit-based perspective","volume":"122","author":"Vranjkovic","year":"2017","journal-title":"Neuropharmacology"},{"issue":"14","key":"10.1016\/j.brs.2018.11.012_bib28","doi-asserted-by":"crossref","first-page":"3855","DOI":"10.1523\/JNEUROSCI.4957-05.2006","article-title":"Behavioral and anatomical interactions between dopamine and corticotropin-releasing factor in the rat","volume":"26","author":"Meloni","year":"2006","journal-title":"J\u00a0Neurosci"},{"issue":"15","key":"10.1016\/j.brs.2018.11.012_bib29","doi-asserted-by":"crossref","first-page":"5338","DOI":"10.1523\/JNEUROSCI.4793-11.2012","article-title":"Pathways for emotions and attention converge on the thalamic reticular nucleus in primates","volume":"32","author":"Zikopoulos","year":"2012","journal-title":"J\u00a0Neurosci"},{"issue":"6","key":"10.1016\/j.brs.2018.11.012_bib30","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1080\/13803395.2012.666231","article-title":"Orbitofrontal cortex biases attention to emotional events","volume":"34","author":"Hartikainen","year":"2012","journal-title":"J\u00a0Clin Exp Neuropsychol"},{"issue":"3\u20134","key":"10.1016\/j.brs.2018.11.012_bib31","first-page":"S30","article-title":"Electrical stimulation of the inferior thalamic peduncle in the treatment of major depression and obsessive compulsive disorders","volume":"80","author":"Jimenez","year":"2013","journal-title":"World Neurosurg"},{"issue":"10","key":"10.1016\/j.brs.2018.11.012_bib32","doi-asserted-by":"crossref","DOI":"10.1038\/tp.2017.66","article-title":"Deep brain stimulation for treatment-resistant major depressive disorder: a comparison of two targets and long-term follow-up","volume":"7","author":"Raymaekers","year":"2017","journal-title":"Transl Psychiat"},{"key":"10.1016\/j.brs.2018.11.012_bib33","series-title":"Diagnostic and statistical manual of mental disorders","author":"American Psychiatric Association","year":"2000"},{"key":"10.1016\/j.brs.2018.11.012_bib34","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.neuroimage.2014.12.002","article-title":"Lead-DBS: a toolbox for deep brain stimulation electrode localizations and visualizations","volume":"107","author":"Horn","year":"2015","journal-title":"Neuroimage"},{"issue":"1","key":"10.1016\/j.brs.2018.11.012_bib35","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.media.2007.06.004","article-title":"Symmetric diffeomorphic image registration with cross-correlation: evaluating automated labeling of elderly and neurodegenerative brain","volume":"12","author":"Avants","year":"2008","journal-title":"Med Image Anal"},{"issue":"1","key":"10.1016\/j.brs.2018.11.012_bib36","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1002\/ana.24974","article-title":"Connectivity Predicts deep brain stimulation outcome in Parkinson disease","volume":"82","author":"Horn","year":"2017","journal-title":"Ann Neurol"},{"issue":"7","key":"10.1016\/j.brs.2018.11.012_bib37","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1162\/jocn.2007.19.7.1081","article-title":"Improving lesion-symptom mapping","volume":"19","author":"Rorden","year":"2007","journal-title":"J\u00a0Cognit Neurosci"},{"issue":"2","key":"10.1016\/j.brs.2018.11.012_bib38","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1038\/sj.npp.1301408","article-title":"Deep brain stimulation to reward circuitry alleviates anhedonia in refractory major depression","volume":"33","author":"Schlaepfer","year":"2008","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.brs.2018.11.012_bib39","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.conb.2014.08.008","article-title":"Striatal circuits, habits, and implications for obsessive-compulsive disorder","volume":"30","author":"Burguiere","year":"2015","journal-title":"Curr Opin Neurobiol"},{"issue":"8","key":"10.1016\/j.brs.2018.11.012_bib40","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/j.biopsych.2004.12.039","article-title":"Brain activation of patients with obsessive-compulsive disorder during neuropsychological and symptom provocation tasks before and after symptom improvement: a functional magnetic resonance imaging study","volume":"57","author":"Nakao","year":"2005","journal-title":"Biol Psychiatry"},{"issue":"7","key":"10.1016\/j.brs.2018.11.012_bib41","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/0006-3223(94)00305-M","article-title":"Regional 133 xenon cerebral blood flow and cerebral 99mTc-HMPAO uptake in patients with obsessive-compulsive disorder before and during treatment","volume":"38","author":"Rubin","year":"1995","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.brs.2018.11.012_bib42","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1196\/annals.1401.029","article-title":"Orbitofrontal cortex function and structure in depression","volume":"1121","author":"Drevets","year":"2007","journal-title":"Ann N Y Acad Sci"},{"issue":"10","key":"10.1016\/j.brs.2018.11.012_bib43","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.1016\/j.neuropsychologia.2009.03.018","article-title":"An initial investigation of the orbitofrontal cortex hyperactivity in obsessive-compulsive disorder: exaggerated representations of anticipated aversive events?","volume":"47","author":"Ursu","year":"2009","journal-title":"Neuropsychologia"},{"issue":"5","key":"10.1016\/j.brs.2018.11.012_bib44","first-page":"740","article-title":"Metabolic imaging of anterior capsular stimulation in refractory obsessive-compulsive disorder: a key role for the subgenual anterior cingulate and ventral striatum","volume":"47","author":"Van Laere","year":"2006","journal-title":"J\u00a0Nucl Med"},{"issue":"5","key":"10.1016\/j.brs.2018.11.012_bib45","first-page":"1087","article-title":"Acute deep brain stimulation changes in regional cerebral blood flow in obsessive-compulsive disorder","volume":"125","author":"Dougherty","year":"2016","journal-title":"J\u00a0Neurosurg"},{"issue":"4","key":"10.1016\/j.brs.2018.11.012_bib46","first-page":"558","article-title":"A\u00a0functional neuroimaging investigation of deep brain stimulation in patients with obsessive-compulsive disorder","volume":"104","author":"Rauch","year":"2006","journal-title":"J\u00a0Neurosurg"},{"issue":"1","key":"10.1016\/j.brs.2018.11.012_bib47","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1227\/01.neu.0000279719.75403.f7","article-title":"Deep brain stimulation for treatment-refractory obsessive-compulsive disorder: the search for a valid target","volume":"61","author":"Lipsman","year":"2007","journal-title":"Neurosurgery"},{"issue":"2","key":"10.1016\/j.brs.2018.11.012_bib48","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.brs.2010.01.003","article-title":"Patient-specific models of deep brain stimulation: influence of field model complexity on neural activation predictions","volume":"3","author":"Chaturvedi","year":"2010","journal-title":"Brain Stimul"}],"container-title":["Brain Stimulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1935861X18304133?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1935861X18304133?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T14:10:35Z","timestamp":1761833435000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1935861X18304133"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,3]]},"references-count":48,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2019,3]]}},"alternative-id":["S1935861X18304133"],"URL":"https:\/\/doi.org\/10.1016\/j.brs.2018.11.012","relation":{},"ISSN":["1935-861X"],"issn-type":[{"value":"1935-861X","type":"print"}],"subject":[],"published":{"date-parts":[[2019,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inferior thalamic peduncle deep brain stimulation for treatment-refractory obsessive-compulsive disorder: A phase 1 pilot trial","name":"articletitle","label":"Article Title"},{"value":"Brain Stimulation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brs.2018.11.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}