{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T17:51:42Z","timestamp":1793123502986,"version":"4.5.0"},"reference-count":60,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,12,19]],"date-time":"2023-12-19T00:00:00Z","timestamp":1702944000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004731","name":"Natural Science Foundation of Zhejiang Province","doi-asserted-by":"publisher","award":["LY22H280007"],"award-info":[{"award-number":["LY22H280007"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017594","name":"Medical Science and Technology Project of Zhejiang Province","doi-asserted-by":"publisher","award":["2024KY1194"],"award-info":[{"award-number":["2024KY1194"]}],"id":[{"id":"10.13039\/501100017594","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82174005"],"award-info":[{"award-number":["82174005"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["brainstimjrnl.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Stimulation"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1016\/j.brs.2023.12.008","type":"journal-article","created":{"date-parts":[[2023,12,23]],"date-time":"2023-12-23T12:02:06Z","timestamp":1703332926000},"page":"49-64","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"title":["Locus coeruleus tyrosine hydroxylase positive neurons mediated the peripheral and central therapeutic effects of transcutaneous auricular vagus nerve stimulation (taVNS) in MRL\/lpr mice"],"prefix":"10.1016","volume":"17","author":[{"given":"Hongjie","family":"Lv","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiu","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengxian","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yijun","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haimei","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keer","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anran","family":"Xi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengping","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0033-525X","authenticated-orcid":false,"given":"Zhenghao","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"Suppl 6","key":"10.1016\/j.brs.2023.12.008_bib1","doi-asserted-by":"crossref","first-page":"vi21","DOI":"10.1093\/rheumatology\/keab498","article-title":"New developments in systemic lupus erythematosus","volume":"60","author":"Tsang","year":"2021","journal-title":"Rheumatology (Oxford)"},{"issue":"2","key":"10.1016\/j.brs.2023.12.008_bib2","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1177\/0961203320979045","article-title":"Brain network reorganisation and spatial lesion distribution in systemic lupus erythematosus","volume":"30","author":"Vald\u00e9s Hern\u00e1ndez","year":"2021","journal-title":"Lupus"},{"issue":"3","key":"10.1016\/j.brs.2023.12.008_bib3","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1136\/ard-2022-223035","article-title":"Global epidemiology of systemic lupus erythematosus: a comprehensive systematic analysis and modelling study","volume":"82","author":"Tian","year":"2022","journal-title":"Ann Rheum Dis"},{"issue":"5","key":"10.1016\/j.brs.2023.12.008_bib4","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1097\/BOR.0000000000000527","article-title":"Glucocorticoids and antimalarials in systemic lupus erythematosus: an update and future directions","volume":"30","author":"Ugarte","year":"2018","journal-title":"Curr Opin Rheumatol"},{"issue":"1","key":"10.1016\/j.brs.2023.12.008_bib5","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s42234-021-00069-5","article-title":"Overview of therapeutic applications of non-invasive vagus nerve stimulation: a motivation for novel treatments for systemic lupus erythematosus","volume":"7","author":"Ramkissoon","year":"2021","journal-title":"Bioelectron Med"},{"issue":"1","key":"10.1016\/j.brs.2023.12.008_bib6","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/s12974-020-01732-5","article-title":"Neural networks and the anti-inflammatory effect of transcutaneous auricular vagus nerve stimulation in depression","volume":"17","author":"Liu","year":"2020","journal-title":"J Neuroinflammation"},{"issue":"1","key":"10.1016\/j.brs.2023.12.008_bib7","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1080\/03009742.2020.1764617","article-title":"Short-term transcutaneous non-invasive vagus nerve stimulation may reduce disease activity and pro-inflammatory cytokines in rheumatoid arthritis: results of a pilot study","volume":"50","author":"Drewes","year":"2021","journal-title":"Scand J Rheumatol"},{"issue":"20","key":"10.1016\/j.brs.2023.12.008_bib8","doi-asserted-by":"crossref","DOI":"10.3390\/s22207884","article-title":"Modulating heart rate variability through deep breathing exercises and transcutaneous auricular vagus nerve stimulation: a study in healthy participants and in patients with rheumatoid arthritis or systemic lupus erythematosus","volume":"22","author":"Jensen","year":"2022","journal-title":"Sensors (Basel)"},{"issue":"2","key":"10.1016\/j.brs.2023.12.008_bib9","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1136\/annrheumdis-2020-217872","article-title":"Transcutaneous auricular vagus nerve stimulation reduces pain and fatigue in patients with systemic lupus erythematosus: a randomised, double-blind, sham-controlled pilot trial","volume":"80","author":"Aranow","year":"2021","journal-title":"Ann Rheum Dis"},{"issue":"6","key":"10.1016\/j.brs.2023.12.008_bib10","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/0952-7915(94)90013-2","article-title":"Apoptosis, Fas and systemic autoimmunity: the MRL-lpr\/lpr model","volume":"6","author":"Singer","year":"1994","journal-title":"Curr Opin Immunol"},{"key":"10.1016\/j.brs.2023.12.008_bib11","doi-asserted-by":"crossref","DOI":"10.1155\/2011\/207504","article-title":"The MRL\/lpr mouse strain as a model for neuropsychiatric systemic lupus erythematosus","volume":"2011","author":"Gulinello","year":"2011","journal-title":"J Biomed Biotechnol"},{"issue":"2","key":"10.1016\/j.brs.2023.12.008_bib12","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/j.brs.2019.12.024","article-title":"Auricular transcutaneous vagus nerve stimulation improves memory persistence in na\u00efve mice and in an intellectual disability mouse model","volume":"13","author":"V\u00e1zquez-Oliver","year":"2020","journal-title":"Brain Stimul"},{"key":"10.1016\/j.brs.2023.12.008_bib13","article-title":"Laboratory administration of transcutaneous auricular vagus nerve stimulation (taVNS): technique, targeting, and considerations","volume":"143","author":"Badran","year":"2019","journal-title":"J Vis Exp"},{"key":"10.1016\/j.brs.2023.12.008_bib14","doi-asserted-by":"crossref","first-page":"854","DOI":"10.3389\/fnins.2019.00854","article-title":"Current directions in the auricular vagus nerve stimulation I - a physiological perspective","volume":"13","author":"Kaniusas","year":"2019","journal-title":"Front Neurosci"},{"issue":"5","key":"10.1016\/j.brs.2023.12.008_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuron.2018.07.037","article-title":"The locus coeruleus is a complex and differentiated neuromodulatory system","volume":"99","author":"Totah","year":"2018","journal-title":"Neuron"},{"issue":"5","key":"10.1016\/j.brs.2023.12.008_bib16","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1017\/S1461145712000971","article-title":"Role of GIRK channels on the noradrenergic transmission in vivo: an electrophysiological and neurochemical study on GIRK2 mutant mice","volume":"16","author":"Torrecilla","year":"2013","journal-title":"Int J Neuropsychopharmacol"},{"issue":"2","key":"10.1016\/j.brs.2023.12.008_bib17","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1111\/cei.12164","article-title":"Targeted silencing of DNA-specific B cells combined with partial plasma cell depletion displays additive effects on delaying disease onset in lupus-prone mice","volume":"174","author":"Nikolova-Ganeva","year":"2013","journal-title":"Clin Exp Immunol"},{"issue":"1","key":"10.1016\/j.brs.2023.12.008_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuron.2019.01.037","article-title":"A visual circuit related to habenula underlies the antidepressive effects of light therapy","volume":"102","author":"Huang","year":"2019","journal-title":"Neuron"},{"issue":"7","key":"10.1016\/j.brs.2023.12.008_bib19","doi-asserted-by":"crossref","first-page":"3109","DOI":"10.7150\/thno.53474","article-title":"Nasal administration of mitochondria reverses chemotherapy-induced cognitive deficits","volume":"11","author":"Alexander","year":"2021","journal-title":"Theranostics"},{"issue":"25","key":"10.1016\/j.brs.2023.12.008_bib20","doi-asserted-by":"crossref","first-page":"11794","DOI":"10.7150\/thno.44152","article-title":"Ultrasound with microbubbles improves memory, ameliorates pathology and modulates hippocampal proteomic changes in a triple transgenic mouse model of Alzheimer's disease","volume":"10","author":"Shen","year":"2020","journal-title":"Theranostics"},{"issue":"9","key":"10.1016\/j.brs.2023.12.008_bib21","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0185129","article-title":"Re-evaluation of the interrelationships among the behavioral tests in rats exposed to chronic unpredictable mild stress","volume":"12","author":"Hu","year":"2017","journal-title":"PLoS One"},{"issue":"22","key":"10.1016\/j.brs.2023.12.008_bib22","doi-asserted-by":"crossref","first-page":"5224","DOI":"10.1111\/bph.15261","article-title":"Arctigenin protects against depression by inhibiting microglial activation and neuroinflammation via HMGB1\/TLR4\/NF-\u03baB and TNF-\u03b1\/TNFR1\/NF-\u03baB pathways","volume":"177","author":"Xu","year":"2020","journal-title":"Br J Pharmacol"},{"issue":"11","key":"10.1016\/j.brs.2023.12.008_bib23","doi-asserted-by":"crossref","first-page":"3591","DOI":"10.1002\/art.22172","article-title":"Ik cytokine ameliorates the progression of lupus nephritis in MRL\/lpr mice","volume":"54","author":"Muraoka","year":"2006","journal-title":"Arthritis Rheum"},{"issue":"1","key":"10.1016\/j.brs.2023.12.008_bib24","doi-asserted-by":"crossref","first-page":"4379","DOI":"10.1038\/s41467-021-24609-4","article-title":"Genetic and chemical inhibition of IRF5 suppresses pre-existing mouse lupus-like disease","volume":"12","author":"Ban","year":"2021","journal-title":"Nat Commun"},{"issue":"2","key":"10.1016\/j.brs.2023.12.008_bib25","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.acthis.2015.12.011","article-title":"Antioxidant diet and sex interact to regulate NOS isoform expression and glomerular mesangium proliferation in Zucker diabetic rat kidney","volume":"118","author":"Slyvka","year":"2016","journal-title":"Acta Histochem"},{"key":"10.1016\/j.brs.2023.12.008_bib26","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.neuropharm.2015.09.003","article-title":"Depressive-like behavior observed with a minimal loss of locus coeruleus (LC) neurons following administration of 6-hydroxydopamine is associated with electrophysiological changes and reversed with precursors of norepinephrine","volume":"101","author":"Szot","year":"2016","journal-title":"Neuropharmacology"},{"issue":"4","key":"10.1016\/j.brs.2023.12.008_bib27","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1111\/joa.13122","article-title":"The anatomical basis for transcutaneous auricular vagus nerve stimulation","volume":"236","author":"Butt","year":"2020","journal-title":"J Anat"},{"issue":"21","key":"10.1016\/j.brs.2023.12.008_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.cub.2015.09.039","article-title":"Organization of the locus coeruleus-norepinephrine system","volume":"25","author":"Schwarz","year":"2015","journal-title":"Curr Biol"},{"issue":"11","key":"10.1016\/j.brs.2023.12.008_bib29","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19113588","article-title":"From systemic inflammation to neuroinflammation: the case of neurolupus","volume":"19","author":"Bendorius","year":"2018","journal-title":"Int J Mol Sci"},{"issue":"9","key":"10.1016\/j.brs.2023.12.008_bib30","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1038\/nm.4397","article-title":"Microglia emerge as central players in brain disease","volume":"23","author":"Salter","year":"2017","journal-title":"Nat Med"},{"issue":"1","key":"10.1016\/j.brs.2023.12.008_bib31","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1038\/s41392-021-00867-y","article-title":"Neuronal NR4A1 deficiency drives complement-coordinated synaptic stripping by microglia in a mouse model of lupus","volume":"7","author":"Han","year":"2022","journal-title":"Signal Transduct Targeted Ther"},{"issue":"6","key":"10.1016\/j.brs.2023.12.008_bib32","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1093\/stcltm\/szac021","article-title":"Intrathecal injection of mesenchymal stromal cell cultured on 3D fiber ameliorates multiple organ damage in murine lupus","volume":"11","author":"Saito","year":"2022","journal-title":"Stem Cells Transl Med"},{"key":"10.1016\/j.brs.2023.12.008_bib33","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/414102","article-title":"Diffuse calcifications of the spleen in a woman with systemic lupus erythematosus","volume":"2015","author":"Vaiopoulos","year":"2015","journal-title":"Case Rep Med"},{"issue":"11","key":"10.1016\/j.brs.2023.12.008_bib34","doi-asserted-by":"crossref","first-page":"819","DOI":"10.14740\/jocmr2717w","article-title":"Generalized lymphadenopathy as presenting feature of systemic lupus erythematosus: case report and review of the literature","volume":"8","author":"Afzal","year":"2016","journal-title":"J Clin Med Res"},{"key":"10.1016\/j.brs.2023.12.008_bib35","doi-asserted-by":"crossref","first-page":"3020","DOI":"10.3389\/fimmu.2019.03020","article-title":"Predominant role of immunoglobulin G in the pathogenesis of splenomegaly in murine lupus","volume":"10","author":"Zhang","year":"2019","journal-title":"Front Immunol"},{"key":"10.1016\/j.brs.2023.12.008_bib36","article-title":"Deletion of Mir223 exacerbates lupus nephritis by targeting S1pr1 in fas(lpr\/lpr) mice","volume":"11","author":"Hiramatsu-Asano","year":"2020","journal-title":"Front Immunol"},{"issue":"2","key":"10.1016\/j.brs.2023.12.008_bib37","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1097\/BOR.0000000000000778","article-title":"Double-negative T cells in autoimmune diseases","volume":"33","author":"Li","year":"2021","journal-title":"Curr Opin Rheumatol"},{"key":"10.1016\/j.brs.2023.12.008_bib38","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.696074","article-title":"Lactobacillus acidophilus supplementation exerts a synergistic effect on tacrolimus efficacy by modulating Th17\/treg balance in lupus-prone mice via the SIGNR3 pathway","volume":"12","author":"Kim","year":"2021","journal-title":"Front Immunol"},{"issue":"1\u20132","key":"10.1016\/j.brs.2023.12.008_bib39","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.cellimm.2013.06.011","article-title":"Helper T cells down-regulate CD4 expression upon chronic stimulation giving rise to double-negative T cells","volume":"284","author":"Grishkan","year":"2013","journal-title":"Cell Immunol"},{"issue":"3","key":"10.1016\/j.brs.2023.12.008_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbspin.2021.105149","article-title":"Vagus nerve stimulation in musculoskeletal diseases","volume":"88","author":"Courties","year":"2021","journal-title":"Joint Bone Spine"},{"issue":"6","key":"10.1016\/j.brs.2023.12.008_bib41","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.brs.2014.07.031","article-title":"Non-invasive vagus nerve stimulation in healthy humans reduces sympathetic nerve activity","volume":"7","author":"Clancy","year":"2014","journal-title":"Brain Stimul"},{"issue":"20","key":"10.1016\/j.brs.2023.12.008_bib42","doi-asserted-by":"crossref","first-page":"5781","DOI":"10.1113\/JP271539","article-title":"Anti-inflammatory properties of the vagus nerve: potential therapeutic implications of vagus nerve stimulation","volume":"594","author":"Bonaz","year":"2016","journal-title":"J Physiol"},{"key":"10.1016\/j.brs.2023.12.008_bib43","doi-asserted-by":"crossref","DOI":"10.1002\/cam4.6466","article-title":"Putative role of non-invasive vagus nerve stimulation in cancer pathology and immunotherapy: can this be a hidden treasure, especially for the elderly?","author":"Abdullahi","year":"2023","journal-title":"Cancer Med"},{"key":"10.1016\/j.brs.2023.12.008_bib44","doi-asserted-by":"crossref","first-page":"680","DOI":"10.3389\/fnins.2020.00680","article-title":"Transcutaneous auricular vagus nerve stimulation at 20 Hz improves depression-like behaviors and down-regulates the hyperactivity of HPA Axis in chronic unpredictable mild stress model rats","volume":"14","author":"Li","year":"2020","journal-title":"Front Neurosci"},{"key":"10.1016\/j.brs.2023.12.008_bib45","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1016\/j.ijbiomac.2018.12.146","article-title":"TNF-\u03b1 regulates microglial activation via the NF-\u03baB signaling pathway in systemic lupus erythematosus with depression","volume":"125","author":"Kong","year":"2019","journal-title":"Int J Biol Macromol"},{"key":"10.1016\/j.brs.2023.12.008_bib46","doi-asserted-by":"crossref","first-page":"2189","DOI":"10.3389\/fimmu.2018.02189","article-title":"Neuropsychiatric systemic lupus erythematosus is dependent on sphingosine-1-phosphate signaling","volume":"9","author":"Mike","year":"2018","journal-title":"Front Immunol"},{"issue":"7","key":"10.1016\/j.brs.2023.12.008_bib47","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/0166-2236(90)90112-N","article-title":"Compensations after lesions of central dopaminergic neurons: some clinical and basic implications","volume":"13","author":"Zigmond","year":"1990","journal-title":"Trends Neurosci"},{"issue":"1","key":"10.1016\/j.brs.2023.12.008_bib48","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/0006-8993(87)90651-2","article-title":"Effect of spinal norepinephrine depletion on descending inhibition of the tail flick reflex from the locus coeruleus and lateral reticular nucleus in the rat","volume":"400","author":"Janss","year":"1987","journal-title":"Brain Res"},{"issue":"4","key":"10.1016\/j.brs.2023.12.008_bib49","doi-asserted-by":"crossref","first-page":"3049","DOI":"10.1007\/s12035-017-0529-z","article-title":"Prolonged dysfunction of astrocytes and activation of microglia accelerate degeneration of dopaminergic neurons in the rat substantia nigra and block compensation of early motor dysfunction induced by 6-OHDA","volume":"55","author":"Kuter","year":"2018","journal-title":"Mol Neurobiol"},{"issue":"3","key":"10.1016\/j.brs.2023.12.008_bib50","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1055\/s-0042-1757217","article-title":"Prognostic role of catecholamine in moderate-to-severe traumatic brain injury: a prospective observational cohort study","volume":"17","author":"Singh","year":"2022","journal-title":"Asian J Neurosurg"},{"issue":"3","key":"10.1016\/j.brs.2023.12.008_bib51","doi-asserted-by":"crossref","DOI":"10.1152\/ajpheart.00590.2021","article-title":"Sympathetic neural responses to sleep disorders and insufficiencies","volume":"322","author":"Greenlund","year":"2022","journal-title":"Am J Physiol Heart Circ Physiol"},{"issue":"4","key":"10.1016\/j.brs.2023.12.008_bib52","doi-asserted-by":"crossref","DOI":"10.3390\/ijms19041188","article-title":"Sympathetic nerve hyperactivity in the spleen: causal for nonpathogenic-driven chronic immune-mediated inflammatory diseases (IMIDs)?","volume":"19","author":"Bellinger","year":"2018","journal-title":"Int J Mol Sci"},{"issue":"1","key":"10.1016\/j.brs.2023.12.008_bib53","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1186\/s13075-016-1087-x","article-title":"Impact of heart rate variability, a marker for cardiac health, on lupus disease activity","volume":"18","author":"Thanou","year":"2016","journal-title":"Arthritis Res Ther"},{"issue":"5","key":"10.1016\/j.brs.2023.12.008_bib54","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23052449","article-title":"The interplay between autonomic nervous system and inflammation across systemic autoimmune diseases","volume":"23","author":"Bellocchi","year":"2022","journal-title":"Int J Mol Sci"},{"issue":"1","key":"10.1016\/j.brs.2023.12.008_bib55","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/0889-1591(89)90007-X","article-title":"Sympathetic neural modulation of the immune system. I. Depression of T cell immunity in vivo and vitro following chemical sympathectomy","volume":"3","author":"Madden","year":"1989","journal-title":"Brain Behav Immun"},{"issue":"7","key":"10.1016\/j.brs.2023.12.008_bib56","doi-asserted-by":"crossref","first-page":"R711","DOI":"10.1152\/ajpregu.00602.2012","article-title":"Hypertension in an experimental model of systemic lupus erythematosus occurs independently of the renal nerves","volume":"305","author":"Mathis","year":"2013","journal-title":"Am J Physiol Regul Integr Comp Physiol"},{"key":"10.1016\/j.brs.2023.12.008_bib57","article-title":"Sympathetic denervation ameliorates renal fibrosis via inhibition of cellular senescence","volume":"12","author":"Li","year":"2021","journal-title":"Front Immunol"},{"issue":"7908","key":"10.1016\/j.brs.2023.12.008_bib58","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1038\/s41586-022-04673-6","article-title":"Neuroimmune cardiovascular interfaces control atherosclerosis","volume":"605","author":"Mohanta","year":"2022","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.brs.2023.12.008_bib59","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24065378","article-title":"Chronic pain-associated cardiovascular disease: the role of sympathetic nerve activity","volume":"24","author":"Reynolds","year":"2023","journal-title":"Int J Mol Sci"},{"issue":"1\u20132","key":"10.1016\/j.brs.2023.12.008_bib60","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/0006-8993(91)91384-D","article-title":"Chemical stimulation of the locus coeruleus: inhibitory effects on hemodynamics and renal sympathetic nerve activity","volume":"568","author":"Miyawaki","year":"1991","journal-title":"Brain Res"}],"container-title":["Brain Stimulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1935861X23019733?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1935861X23019733?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,30]],"date-time":"2025-10-30T14:24:16Z","timestamp":1761834256000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1935861X23019733"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":60,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["S1935861X23019733"],"URL":"https:\/\/doi.org\/10.1016\/j.brs.2023.12.008","relation":{},"ISSN":["1935-861X"],"issn-type":[{"value":"1935-861X","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Locus coeruleus tyrosine hydroxylase positive neurons mediated the peripheral and central therapeutic effects of transcutaneous auricular vagus nerve stimulation (taVNS) in MRL\/lpr mice","name":"articletitle","label":"Article Title"},{"value":"Brain Stimulation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brs.2023.12.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}