{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T11:58:03Z","timestamp":1777895883989,"version":"3.51.4"},"reference-count":67,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,4]],"date-time":"2025-02-04T00:00:00Z","timestamp":1738627200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01EY036089"],"award-info":[{"award-number":["R01EY036089"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008497","name":"Boston Scientific Corporation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008497","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013521","name":"Cosmetic Surgery Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013521","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["RF1AG060754"],"award-info":[{"award-number":["RF1AG060754"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["brainstimjrnl.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Stimulation"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.brs.2025.02.002","type":"journal-article","created":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T03:16:53Z","timestamp":1738898213000},"page":"185-194","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Basal forebrain activation improves working memory in senescent monkeys"],"prefix":"10.1016","volume":"18","author":[{"given":"Kendyl R.","family":"Pennington","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8825-2920","authenticated-orcid":false,"given":"Luca","family":"Debs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6969-2139","authenticated-orcid":false,"given":"Sophia","family":"Chung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janki","family":"Bava","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0712-7330","authenticated-orcid":false,"given":"Cl\u00e9ment M.","family":"Garin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0830-5445","authenticated-orcid":false,"given":"Fernando L.","family":"Vale","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah K.","family":"Bick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dario J.","family":"Englot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2071-4767","authenticated-orcid":false,"suffix":"Jr.","given":"Alvin V.","family":"Terry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7441-022X","authenticated-orcid":false,"given":"Christos","family":"Constantinidis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6469-1865","authenticated-orcid":false,"given":"David T.","family":"Blake","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.brs.2025.02.002_bib1","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/0306-4522(84)90163-5","article-title":"Atlas of cholinergic neurons in the forebrain and upper brainstem of the macaque based on monoclonal choline acetyltransferase immunohistochemistry and acetylcholinesterase histochemistry","volume":"12","author":"Mesulam","year":"1984","journal-title":"Neuroscience"},{"key":"10.1016\/j.brs.2025.02.002_bib2","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1097\/00002093-199505000-00007","article-title":"Cholinergic neural regulation of regional cerebral blood flow","volume":"9","author":"Sato","year":"1995","journal-title":"Alzheimer Assoc Disord"},{"key":"10.1016\/j.brs.2025.02.002_bib3","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.neures.2008.11.004","article-title":"Basal forebrain stimulation induces NGF secretion in ipsilateral parietal cortex via nicotinic receptor activation in adult, but not aged rats","volume":"63","author":"Hotta","year":"2009","journal-title":"Neurosci Res"},{"key":"10.1016\/j.brs.2025.02.002_bib4","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1126\/science.6338589","article-title":"Alzheimer's disease: a disorder of cortical cholinergic innervation","volume":"219","author":"Coyle","year":"1983","journal-title":"Science"},{"key":"10.1016\/j.brs.2025.02.002_bib5","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/S0165-0173(96)00009-4","article-title":"Cognitive functions of cortical acetylcholine: toward a unifying hypothesis","volume":"23","author":"Sarter","year":"1997","journal-title":"Brain Res Rev"},{"key":"10.1016\/j.brs.2025.02.002_bib6","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1124\/jpet.102.041616","article-title":"The cholinergic hypothesis of age and Alzheimer's disease-related cognitive deficits: recent challenges and their implications for novel drug development","volume":"306","author":"Terry","year":"2003","journal-title":"J Pharmacol Exp Therapeut"},{"key":"10.1016\/j.brs.2025.02.002_bib7","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1007\/s00415-014-7439-z","article-title":"Atrophy of the cholinergic basal forebrain in dementia with Lewy bodies and Alzheimer's disease dementia","volume":"261","author":"Grothe","year":"2014","journal-title":"J Neurol"},{"key":"10.1016\/j.brs.2025.02.002_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2023.106243","article-title":"No laughing white matter: reduced integrity of the cortical cholinergic pathways in Parkinson's disease-related cognitive impairment","volume":"185","author":"Crockett","year":"2023","journal-title":"Neurobiol Dis"},{"key":"10.1016\/j.brs.2025.02.002_bib9","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1002\/cne.903180308","article-title":"Differential cholinergic innervation within functional subdivisions of the human cerebral cortex: a choline acetyltransferase study","volume":"318","author":"Mesulam","year":"1992","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.brs.2025.02.002_bib10","doi-asserted-by":"crossref","first-page":"6735","DOI":"10.1073\/pnas.0510645103","article-title":"Activity-dependent release of precursor nerve growth factor, conversion to mature nerve growth factor, and its degradation by a protease cascade","volume":"103","author":"Bruno","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.brs.2025.02.002_bib11","doi-asserted-by":"crossref","DOI":"10.1093\/cercor\/bhad066","article-title":"Chronic basal forebrain activation improves spatial memory, boosts neurotrophin receptor expression, and lowers BACE1 and A\u03b242 levels in the cerebral cortex in mice","author":"Kumro","year":"2023","journal-title":"Cerebr Cortex"},{"key":"10.1016\/j.brs.2025.02.002_bib12","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1126\/science.1102541","article-title":"Aging in rhesus monkeys: relevance to human health interventions","volume":"305","author":"Roth","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.brs.2025.02.002_bib13","doi-asserted-by":"crossref","first-page":"2733","DOI":"10.1016\/j.bbadis.2017.07.008","article-title":"Non-human primates as a model for aging","volume":"1864","author":"Colman","year":"2018","journal-title":"Biochim Biophys Acta BBA - Mol Basis Dis"},{"key":"10.1016\/j.brs.2025.02.002_bib14","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.2174\/138161212799315885","article-title":"Nonhuman primate models of alzheimer-like cerebral proteopathy","volume":"18","author":"Heuer","year":"2012","journal-title":"Curr Pharm Des"},{"key":"10.1016\/j.brs.2025.02.002_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.xpro.2022.101136","article-title":"Protocol for behavioral and neural recording during stimulation of the macaque monkey nucleus basalis","volume":"3","author":"Qi","year":"2022","journal-title":"STAR Protoc"},{"key":"10.1016\/j.brs.2025.02.002_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuroimage.2021.117997","article-title":"A comprehensive macaque fMRI pipeline and hierarchical atlas","volume":"235","author":"Jung","year":"2021","journal-title":"NeuroImage"},{"key":"10.1016\/j.brs.2025.02.002_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuroimage.2021.117996","article-title":"The subcortical atlas of the rhesus macaque (SARM) for neuroimaging","volume":"235","author":"Hartig","year":"2021","journal-title":"NeuroImage"},{"key":"10.1016\/j.brs.2025.02.002_bib18","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1006\/cbmr.1996.0014","article-title":"AFNI: software for analysis and visualization of functional magnetic resonance neuroimages","volume":"29","author":"Cox","year":"1996","journal-title":"Comput Biomed Res"},{"key":"10.1016\/j.brs.2025.02.002_bib19","series-title":"Intraoperative imaging and image-guided therapy","first-page":"277","article-title":"3D slicer: a platform for subject-specific image analysis, visualization, and clinical support","author":"Kikinis","year":"2014"},{"key":"10.1016\/j.brs.2025.02.002_bib20","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1121\/1.1912375","article-title":"Transformed up\u2010down methods in psychoacoustics","volume":"49","author":"Levitt","year":"2005","journal-title":"J Acoust Soc Am"},{"key":"10.1016\/j.brs.2025.02.002_bib21","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.neuropharm.2012.10.019","article-title":"Positive allosteric modulator of alpha 7 nicotinic-acetylcholine receptors, PNU-120596 augments the effects of donepezil on learning and memory in aged rodents and non-human primates","volume":"67","author":"Callahan","year":"2013","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.brs.2025.02.002_bib22","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1152\/jn.1968.31.5.659","article-title":"Excitation of pyramidal tract cells by intracortical microstimulation: effective extent of stimulating current","volume":"31","author":"Stoney","year":"1968","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.brs.2025.02.002_bib23","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s40035-022-00327-9","article-title":"Deep brain stimulation of the nucleus basalis of Meynert modulates hippocampal\u2013frontoparietal networks in patients with advanced Alzheimer's disease","volume":"11","author":"Jiang","year":"2022","journal-title":"Transl Neurodegener"},{"key":"10.1016\/j.brs.2025.02.002_bib24","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s13550-021-00771-0","article-title":"The pons as reference region for intensity normalization in semi-quantitative analysis of brain 18FDG PET: application to metabolic changes related to ageing in conventional and digital control databases","volume":"11","author":"Verger","year":"2021","journal-title":"EJNMMI Res"},{"key":"10.1016\/j.brs.2025.02.002_bib25","doi-asserted-by":"crossref","first-page":"7900","DOI":"10.1073\/pnas.1602413113","article-title":"Cluster failure: why fMRI inferences for spatial extent have inflated false-positive rates","volume":"113","author":"Eklund","year":"2016","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.brs.2025.02.002_bib26","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1016\/j.neuroimage.2011.09.016","volume":"62","author":"Saad","year":"2012","journal-title":"SUMA. NeuroImage"},{"key":"10.1016\/j.brs.2025.02.002_bib27","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1007\/s12031-002-0030-6","article-title":"A computer-assisted cognitive test battery for aged monkeys","volume":"19","author":"Buccafusco","year":"2002","journal-title":"J Mol Neurosci"},{"key":"10.1016\/j.brs.2025.02.002_bib28","doi-asserted-by":"crossref","first-page":"2640","DOI":"10.1016\/j.cub.2017.07.021","article-title":"Intermittent stimulation of the nucleus basalis of meynert improves working memory in adult monkeys","volume":"27","author":"Liu","year":"2017","journal-title":"Curr Biol"},{"key":"10.1016\/j.brs.2025.02.002_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.109469","article-title":"Nucleus basalis stimulation enhances working memory by stabilizing stimulus representations in primate prefrontal cortical activity","volume":"36","author":"Qi","year":"2021","journal-title":"Cell Rep"},{"key":"10.1016\/j.brs.2025.02.002_bib30","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1007\/s00259-008-1039-z","article-title":"FDG-PET changes in brain glucose metabolism from normal cognition to pathologically verified Alzheimer's disease","volume":"36","author":"Mosconi","year":"2009","journal-title":"Eur J Nucl Med Mol Imag"},{"key":"10.1016\/j.brs.2025.02.002_bib31","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/S1474-4422(20)30314-8","article-title":"Amyloid-PET and 18F-FDG-PET in the diagnostic investigation of Alzheimer's disease and other dementias","volume":"19","author":"Ch\u00e9telat","year":"2020","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.brs.2025.02.002_bib32","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s13550-021-00771-0","article-title":"The pons as reference region for intensity normalization in semi-quantitative analysis of brain 18FDG PET: application to metabolic changes related to ageing in conventional and digital control databases","volume":"11","author":"Verger","year":"2021","journal-title":"EJNMMI Res"},{"key":"10.1016\/j.brs.2025.02.002_bib33","doi-asserted-by":"crossref","first-page":"331","DOI":"10.14336\/AD.2015.0825","article-title":"The involvement of BDNF, NGF and GDNF in aging and Alzheimer's disease","volume":"6","author":"Budni","year":"2015","journal-title":"Aging Dis"},{"key":"10.1016\/j.brs.2025.02.002_bib34","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1007\/BF00335324","article-title":"The evaluation of cerebrospinal fluid flow and absorption: clinical and experimental studies","volume":"6","author":"Strecker","year":"1973","journal-title":"Neuroradiology"},{"key":"10.1016\/j.brs.2025.02.002_bib35","doi-asserted-by":"crossref","first-page":"6023","DOI":"10.1038\/s41380-020-0797-2","article-title":"The human brain NGF metabolic pathway is impaired in the pre-clinical and clinical continuum of Alzheimers disease","volume":"26","author":"Pentz","year":"2021","journal-title":"Mol Psychiatr"},{"key":"10.1016\/j.brs.2025.02.002_bib36","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1038\/s41587-019-0244-6","article-title":"Emerging technologies for improved deep brain stimulation","volume":"37","author":"Cagnan","year":"2019","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.brs.2025.02.002_bib37","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.neuron.2005.02.014","article-title":"Deep brain stimulation for treatment-resistant depression","volume":"45","author":"Mayberg","year":"2005","journal-title":"Neuron"},{"key":"10.1016\/j.brs.2025.02.002_bib38","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1159\/000521372","article-title":"Where are we with deep brain stimulation? A review of scientific publications and ongoing research","volume":"100","author":"Harmsen","year":"2022","journal-title":"Stereotact Funct Neurosurg"},{"key":"10.1016\/j.brs.2025.02.002_bib39","doi-asserted-by":"crossref","first-page":"2676","DOI":"10.1016\/j.neubiorev.2013.09.003","article-title":"The nucleus basalis of Meynert: a new target for deep brain stimulation in dementia?","volume":"37","author":"Gratwicke","year":"2013","journal-title":"Neurosci Biobehav Rev"},{"key":"10.1016\/j.brs.2025.02.002_bib40","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1038\/mp.2014.32","article-title":"Deep brain stimulation of the nucleus basalis of Meynert in Alzheimer's dementia","volume":"20","author":"Kuhn","year":"2015","journal-title":"Mol Psychiatr"},{"key":"10.1016\/j.brs.2025.02.002_bib41","article-title":"Single-trajectory multiple-target deep brain stimulation for parkinsonian mobility and cognition","author":"Sasikumar","year":"2021","journal-title":"Mov Disord"},{"key":"10.1016\/j.brs.2025.02.002_bib42","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s42466-020-00086-w","article-title":"Combined subthalamic and nucleus basalis of Meynert deep brain stimulation for Parkinson's disease with dementia (DEMPARK-DBS): protocol of a randomized, sham-controlled trial","volume":"2","author":"Daniels","year":"2020","journal-title":"Neurol Res Pract"},{"key":"10.1016\/j.brs.2025.02.002_bib43","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1097\/00004691-200401000-00006","article-title":"How does deep brain stimulation work? Present understanding and future questions","volume":"21","author":"McIntyre","year":"2004","journal-title":"J Clin Neurophysiol"},{"key":"10.1016\/j.brs.2025.02.002_bib44","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1038\/266736a0","article-title":"Specific long-lasting potentiation of synaptic transmission in hippocampal slices","volume":"266","author":"Andersen","year":"1977","journal-title":"Nature"},{"key":"10.1016\/j.brs.2025.02.002_bib45","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/0006-8993(92)91715-Q","article-title":"Theta burst stimulation is optimal for induction of LTP at both apical and basal dendritic synapses on hippocampal CA1 neurons","volume":"591","author":"Capocchi","year":"1992","journal-title":"Brain Res"},{"key":"10.1016\/j.brs.2025.02.002_bib46","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1176\/appi.ajp.2019.19070720","article-title":"Stanford accelerated intelligent neuromodulation therapy for treatment-resistant depression","volume":"177","author":"Cole","year":"2020","journal-title":"Am J Psychiatr"},{"key":"10.1016\/j.brs.2025.02.002_bib47","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/0304-3940(89)90371-6","article-title":"Stimulation of the nucleus basalis of Meynert increases acetylcholine release in the cerebral cortex in rats","volume":"98","author":"Kurosawa","year":"1989","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.brs.2025.02.002_bib48","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1109\/10.32099","article-title":"Analysis of models for extracellular fiber stimulation","volume":"36","author":"Rattay","year":"1989","journal-title":"IEEE Trans Biomed Eng"},{"key":"10.1016\/j.brs.2025.02.002_bib49","doi-asserted-by":"crossref","first-page":"1457","DOI":"10.1152\/jn.00989.2003","article-title":"Cellular effects of deep brain stimulation : model-based analysis of activation and inhibition","volume":"91","author":"McIntyre","year":"2004","journal-title":"J Neurophysiol"},{"key":"10.1016\/j.brs.2025.02.002_bib50","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.brs.2021.11.015","article-title":"Stoney vs. Histed: quantifying the spatial effects of intracortical microstimulation","volume":"15","author":"Kumaravelu","year":"2022","journal-title":"Brain Stimul"},{"key":"10.1016\/j.brs.2025.02.002_bib51","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.neuron.2009.07.016","article-title":"Direct activation of sparse, distributed populations of cortical neurons by electrical microstimulation","volume":"63","author":"Histed","year":"2009","journal-title":"Neuron"},{"key":"10.1016\/j.brs.2025.02.002_bib52","doi-asserted-by":"crossref","first-page":"707","DOI":"10.2165\/00002512-200825080-00007","article-title":"Defining treatment response to donepezil in alzheimer's disease","volume":"25","author":"Burns","year":"2008","journal-title":"Drugs Aging"},{"key":"10.1016\/j.brs.2025.02.002_bib53","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1093\/cercor\/bhp232","article-title":"Reduction of basal forebrain cholinergic system parallels cognitive impairment in patients at high risk of developing alzheimer's disease","volume":"20","author":"Grothe","year":"2010","journal-title":"Cerebr Cortex"},{"key":"10.1016\/j.brs.2025.02.002_bib54","doi-asserted-by":"crossref","first-page":"4124","DOI":"10.1002\/cne.23415","article-title":"Cholinergic circuitry of the human nucleus basalis and its fate in Alzheimer's disease","volume":"521","author":"Mesulam","year":"2013","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.brs.2025.02.002_bib55","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/S0165-0173(97)00017-9","article-title":"Animal models of cerebral \u03b2-amyloid angiopathy","volume":"25","author":"Walker","year":"1997","journal-title":"Brain Res Rev"},{"key":"10.1016\/j.brs.2025.02.002_bib56","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/0197-4580(91)90048-O","article-title":"Aged monkeys exhibit behavioral deficits indicative of widespread cerebral dysfunction","volume":"12","author":"Bachevalier","year":"1991","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.brs.2025.02.002_bib57","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s13195-018-0362-2","article-title":"Addition of the A\u03b242\/40 ratio to the cerebrospinal fluid biomarker profile increases the predictive value for underlying Alzheimer's disease dementia in mild cognitive impairment","volume":"10","author":"Baldeiras","year":"2018","journal-title":"Alzheimers Res Ther"},{"key":"10.1016\/j.brs.2025.02.002_bib58","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/j.neuropharm.2018.04.026","article-title":"Intermittent stimulation in the nucleus basalis of meynert improves sustained attention in rhesus monkeys","volume":"137","author":"Liu","year":"2018","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.brs.2025.02.002_bib59","doi-asserted-by":"crossref","first-page":"2096","DOI":"10.1016\/j.neurobiolaging.2014.03.006","article-title":"18F-fluorodeoxyglucose positron emission tomography, aging, and apolipoprotein E genotype in cognitively normal persons","volume":"35","author":"Knopman","year":"2014","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.brs.2025.02.002_bib60","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.neuroimage.2016.02.042","article-title":"Different partial volume correction methods lead to different conclusions: an 18F-FDG-PET study of aging","volume":"132","author":"Greve","year":"2016","journal-title":"NeuroImage"},{"key":"10.1016\/j.brs.2025.02.002_bib61","doi-asserted-by":"crossref","first-page":"e185","DOI":"10.1097\/RLU.0000000000002948","article-title":"Longitudinal 18F-FDG images in patients with alzheimer disease over more than 9 Years from a preclinical stage","volume":"45","author":"Ishibashi","year":"2020","journal-title":"Clin Nucl Med"},{"key":"10.1016\/j.brs.2025.02.002_bib62","doi-asserted-by":"crossref","DOI":"10.1016\/S0166-4328(00)00254-0","article-title":"Multiple output pathways of the basal forebrain: organization, chemical heterogeneity, and roles in vigilance","author":"Semba","year":"2000","journal-title":"Behav Brain Res"},{"key":"10.1016\/j.brs.2025.02.002_bib63","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1126\/science.1100135","article-title":"Cleavage of proBDNF by tPA\/plasmin is essential for long-term hippocampal plasticity","volume":"306","author":"Pang","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.brs.2025.02.002_bib64","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1038\/nrn1787","article-title":"Critical period plasticity in local cortical circuits","volume":"6","author":"Hensch","year":"2005","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.brs.2025.02.002_bib65","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/S0959-4388(02)00326-4","article-title":"Retrograde neurotrophin signaling: trk-ing along the axon","volume":"12","author":"Ginty","year":"2002","journal-title":"Curr Opin Neurobiol"},{"key":"10.1016\/j.brs.2025.02.002_bib66","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1093\/schbul\/sbaa139","article-title":"BDNF and JNK signaling modulate cortical interneuron and perineuronal net development: implications for schizophrenia-linked 16p11.2 duplication syndrome","volume":"47","author":"Willis","year":"2021","journal-title":"Schizophr Bull"},{"issue":"6","key":"10.1016\/j.brs.2025.02.002_bib67","first-page":"1643","article-title":"Rethinking NBM DBS: intermittent stimulation improves sustained attention in Parkinson\u2019s disease","volume":"16","author":"Sasikumar","year":"2023","journal-title":"Brain Stimul. Basic Transl. Clin. Res. Neuromodulation 0"}],"container-title":["Brain Stimulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1935861X25000336?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1935861X25000336?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T08:09:18Z","timestamp":1777622958000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1935861X25000336"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":67,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["S1935861X25000336"],"URL":"https:\/\/doi.org\/10.1016\/j.brs.2025.02.002","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2024.03.01.582925","asserted-by":"object"}]},"ISSN":["1935-861X"],"issn-type":[{"value":"1935-861X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Basal forebrain activation improves working memory in senescent monkeys","name":"articletitle","label":"Article Title"},{"value":"Brain Stimulation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brs.2025.02.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}