{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T00:53:00Z","timestamp":1793321580751,"version":"4.5.0"},"reference-count":61,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,8]],"date-time":"2025-10-08T00:00:00Z","timestamp":1759881600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG038961"],"award-info":[{"award-number":["R01AG038961"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000070","name":"National Institute of Biomedical Imaging and Bioengineering","doi-asserted-by":"publisher","award":["R01EB009041"],"award-info":[{"award-number":["R01EB009041"]}],"id":[{"id":"10.13039\/100000070","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016744","name":"Naval Information Warfare Center Pacific","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016744","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004917","name":"Cancer Prevention and Research Institute of Texas","doi-asserted-by":"publisher","award":["RP220518"],"award-info":[{"award-number":["RP220518"]}],"id":[{"id":"10.13039\/100004917","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000185","name":"Defense Advanced Research Projects Agency","doi-asserted-by":"publisher","award":["N66001-19-C-4020"],"award-info":[{"award-number":["N66001-19-C-4020"]}],"id":[{"id":"10.13039\/100000185","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["brainstimjrnl.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain Stimulation"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.brs.2025.10.006","type":"journal-article","created":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T07:58:51Z","timestamp":1759996731000},"page":"1939-1951","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["A multifunctional theranostic ultrasound platform for remote magnetogenetics and expanded blood-brain barrier opening"],"prefix":"10.1016","volume":"18","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6979-9389","authenticated-orcid":false,"given":"Alec J.","family":"Batts","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1273-2311","authenticated-orcid":false,"given":"Fotios N.","family":"Tsitsos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7308-3068","authenticated-orcid":false,"given":"Jeannette","family":"Ingabire","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1910-9025","authenticated-orcid":false,"given":"Guillaume","family":"Duret","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-4923-7940","authenticated-orcid":false,"given":"Samantha L.","family":"Gorman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-1978-5864","authenticated-orcid":false,"given":"Deny","family":"Tsakri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca L.","family":"Noel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nancy","family":"Kwon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9283-4835","authenticated-orcid":false,"given":"Quoc-Khanh","family":"Pham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linlin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5501-554X","authenticated-orcid":false,"given":"Gang","family":"Bao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob T.","family":"Robinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9636-7936","authenticated-orcid":false,"given":"Elisa E.","family":"Konofagou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.brs.2025.10.006_bib1","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.jconrel.2021.07.042","article-title":"Cavitation-modulated inflammatory response following focused ultrasound blood-brain barrier opening","volume":"337","author":"Ji","year":"2021","journal-title":"J Contr Release"},{"key":"10.1016\/j.brs.2025.10.006_bib2","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1109\/TUFFC.2013.6644731","article-title":"Dependence of the reversibility of focused-ultrasound-induced blood\u2013brain barrier opening on pressure and pulse length in vivo","volume":"60","author":"Samiotaki","year":"2013","journal-title":"IEEE Trans Ultrason Ferroelectrics Freq Control"},{"key":"10.1016\/j.brs.2025.10.006_bib3","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.7150\/thno.76199","article-title":"Using a novel rapid alternating steering angles pulse sequence to evaluate the impact of theranostic ultrasound-mediated ultra-short pulse length on blood-brain barrier opening volume and closure, cavitation mapping, drug delivery feasibility, and safety","volume":"13","author":"Batts","year":"2023","journal-title":"Theranostics"},{"key":"10.1016\/j.brs.2025.10.006_bib4","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1109\/TBME.2021.3120919","article-title":"Transcranial theranostic ultrasound for pre-planning and blood-brain barrier opening: a feasibility study using an imaging phased array in vitro and in vivo","volume":"69","author":"Batts","year":"2022","journal-title":"IEEE Trans Biomed Eng"},{"key":"10.1016\/j.brs.2025.10.006_bib5","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1109\/TBME.2009.2034533","article-title":"Microbubble-size dependence of focused ultrasound-induced blood-brain barrier opening in mice in vivo","volume":"57","author":"Choi","year":"2010","journal-title":"IEEE Trans Biomed Eng"},{"key":"10.1016\/j.brs.2025.10.006_bib6","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1148\/radiol.2202001804","article-title":"Noninvasive MR imaging\u2013guided focal opening of the blood-brain barrier in rabbits","volume":"220","author":"Hynynen","year":"2001","journal-title":"Radiology"},{"key":"10.1016\/j.brs.2025.10.006_bib7","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2023.1229683","article-title":"Getting ahead of Alzheimer's disease: early intervention with focused ultrasound","volume":"17","author":"Noel","year":"2023","journal-title":"Front Neurosci"},{"key":"10.1016\/j.brs.2025.10.006_bib8","doi-asserted-by":"crossref","first-page":"5396","DOI":"10.7150\/thno.28717","article-title":"Unilateral focused ultrasound-induced blood-brain barrier opening reduces phosphorylated tau from the rTg4510 mouse model","volume":"9","author":"Karakatsani","year":"2019","journal-title":"Theranostics"},{"key":"10.1016\/j.brs.2025.10.006_bib9","first-page":"1","article-title":"Characterization of the responses of brain macrophages to focused ultrasound-mediated blood\u2013brain barrier opening","author":"Kline-Schoder","year":"2023","journal-title":"Nat Biomed Eng"},{"key":"10.1016\/j.brs.2025.10.006_bib10","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aaa2512","article-title":"Scanning ultrasound removes amyloid-\u03b2 and restores memory in an Alzheimer's disease mouse model","volume":"7","author":"Leinenga","year":"2015","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.brs.2025.10.006_bib11","doi-asserted-by":"crossref","first-page":"4102","DOI":"10.7150\/thno.79898","article-title":"Focused ultrasound mitigates pathology and improves spatial memory in Alzheimer's mice and patients","volume":"13","author":"Karakatsani","year":"2023","journal-title":"Theranostics"},{"key":"10.1016\/j.brs.2025.10.006_bib12","doi-asserted-by":"crossref","first-page":"4519","DOI":"10.7150\/thno.94206","article-title":"Transcranial blood-brain barrier opening in Alzheimer's disease patients using a portable focused ultrasound system with real-time 2-D cavitation mapping","volume":"14","author":"Bae","year":"2024","journal-title":"Theranostics"},{"key":"10.1016\/j.brs.2025.10.006_bib13","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1056\/NEJMoa2308719","article-title":"Ultrasound blood\u2013brain barrier opening and aducanumab in alzheimer's disease","volume":"390","author":"Rezai Ali","year":"2024","journal-title":"N Engl J Med"},{"key":"10.1016\/j.brs.2025.10.006_bib14","doi-asserted-by":"crossref","first-page":"9180","DOI":"10.1073\/pnas.2002571117","article-title":"Noninvasive hippocampal blood\u2212brain barrier opening in Alzheimer's disease with focused ultrasound","volume":"117","author":"Rezai","year":"2020","journal-title":"Proc Natl Acad Sci"},{"key":"10.1016\/j.brs.2025.10.006_bib15","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1038\/s41598-018-36340-0","article-title":"Blood-brain barrier opening in primary brain tumors with non-invasive MR-Guided focused ultrasound: a clinical safety and feasibility study","volume":"9","author":"Mainprize","year":"2019","journal-title":"Sci Rep"},{"key":"10.1016\/j.brs.2025.10.006_bib16","doi-asserted-by":"crossref","first-page":"6521","DOI":"10.1038\/s41598-021-85180-y","article-title":"Focused ultrasound mediated blood\u2013brain barrier opening is safe and feasible in a murine pontine glioma model","volume":"11","author":"Englander","year":"2021","journal-title":"Sci Rep"},{"key":"10.1016\/j.brs.2025.10.006_bib17","article-title":"MRI-guided focused ultrasound blood\u2013brain barrier opening increases drug delivery and efficacy in a diffuse midline glioma mouse model","volume":"5","author":"Martinez","year":"2023","journal-title":"Neuro-Oncol Adv"},{"key":"10.1016\/j.brs.2025.10.006_bib18","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/s11060-021-03887-4","article-title":"Profiling of the immune landscape in murine glioblastoma following blood brain\/tumor barrier disruption with MR image-guided focused ultrasound","volume":"156","author":"Sheybani","year":"2022","journal-title":"J Neuro Oncol"},{"key":"10.1016\/j.brs.2025.10.006_bib19","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.jconrel.2021.01.023","article-title":"ImmunoPET-informed sequence for focused ultrasound-targeted mCD47 blockade controls glioma","volume":"331","author":"Sheybani","year":"2021","journal-title":"J Contr Release"},{"key":"10.1016\/j.brs.2025.10.006_bib20","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adf4888","article-title":"BBB opening with focused ultrasound in nonhuman primates and Parkinson's disease patients: targeted AAV vector delivery and PET imaging","volume":"9","author":"Blesa","year":"2023","journal-title":"Sci Adv"},{"key":"10.1016\/j.brs.2025.10.006_bib21","doi-asserted-by":"crossref","first-page":"3533","DOI":"10.1021\/acs.nanolett.7b00616","article-title":"Novel focused ultrasound gene therapy approach noninvasively restores dopaminergic neuron function in a rat parkinson's disease model","volume":"17","author":"Mead","year":"2017","journal-title":"Nano Lett"},{"key":"10.1016\/j.brs.2025.10.006_bib22","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.jconrel.2015.08.059","article-title":"Drug and gene delivery across the blood-brain barrier with focused ultrasound","volume":"219","author":"Timbie","year":"2015","journal-title":"J Control Release Off J Control Release Soc"},{"key":"10.1016\/j.brs.2025.10.006_bib23","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0052925","article-title":"Targeted delivery of GDNF through the blood-brain barrier by MRI-guided focused ultrasound","volume":"7","author":"Wang","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.brs.2025.10.006_bib24","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1038\/jcbfm.2014.236","article-title":"Enhanced delivery and bioactivity of the neurturin neurotrophic factor through focused ultrasound-mediated blood--brain barrier opening in vivo","volume":"35","author":"Samiotaki","year":"2015","journal-title":"J Cereb Blood Flow Metab Off J Int Soc Cereb Blood Flow Metab"},{"key":"10.1016\/j.brs.2025.10.006_bib25","doi-asserted-by":"crossref","first-page":"6532","DOI":"10.1038\/s41598-021-85535-5","article-title":"Transcranial focused ultrasound phase correction using the hybrid angular spectrum method","volume":"11","author":"Leung","year":"2021","journal-title":"Sci Rep"},{"key":"10.1016\/j.brs.2025.10.006_bib26","series-title":"2020 IEEE International Ultrasonics Symposium (IUS)","first-page":"1","article-title":"Targeting accuracy of transcranial power cavitation imaging for blood-brain barrier opening using a theranostic phased array","author":"Batts","year":"2020"},{"key":"10.1016\/j.brs.2025.10.006_bib27","series-title":"2021 IEEE International Ultrasonics Symposium (IUS)","first-page":"1","article-title":"The effect of pulse length on theranostic ultrasound-mediated blood-brain barrier opening volume, closing timeline, and cavitation mapping in vivo","author":"Batts","year":"2021"},{"key":"10.1016\/j.brs.2025.10.006_bib28","series-title":"2019 IEEE International Ultrasonics Symposium (IUS)","first-page":"2","article-title":"Transcranial blood-brain barrier opening and power cavitation imaging using a diagnostic imaging array","author":"Ji","year":"2019"},{"key":"10.1016\/j.brs.2025.10.006_bib29","series-title":"Optimization of focused ultrasound mediated blood-brain barrier opening","author":"Ji","year":"2021"},{"key":"10.1016\/j.brs.2025.10.006_bib30","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a034322","article-title":"Electromagnetic regulation of cell activity","volume":"9","author":"Stanley","year":"2019","journal-title":"Cold Spring Harb Perspect Med"},{"key":"10.1016\/j.brs.2025.10.006_bib31","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1038\/s41563-022-01281-7","article-title":"Subsecond multichannel magnetic control of select neural circuits in freely moving flies","volume":"21","author":"Sebesta","year":"2022","journal-title":"Nat Mater"},{"key":"10.1016\/j.brs.2025.10.006_bib32","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1126\/science.1261821","article-title":"Wireless magnetothermal deep brain stimulation","volume":"347","author":"Chen","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.brs.2025.10.006_bib33","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1038\/nnano.2010.125","article-title":"Remote control of ion channels and neurons through magnetic-field heating of nanoparticles","volume":"5","author":"Huang","year":"2010","journal-title":"Nat Nanotechnol"},{"key":"10.1016\/j.brs.2025.10.006_bib34","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/nn.4416","article-title":"TRPA1 mediates sensation of the rate of temperature change in Drosophila larvae","volume":"20","author":"Luo","year":"2017","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.brs.2025.10.006_bib35","doi-asserted-by":"crossref","first-page":"3674","DOI":"10.1038\/ncomms4674","article-title":"Imaging neural spiking in brain tissue using FRET-opsin protein voltage sensors","volume":"5","author":"Gong","year":"2014","journal-title":"Nat Commun"},{"key":"10.1016\/j.brs.2025.10.006_bib36","doi-asserted-by":"crossref","first-page":"9977","DOI":"10.1523\/JNEUROSCI.1095-16.2016","article-title":"Genetically encoded voltage indicators: opportunities and challenges","volume":"36","author":"Yang","year":"2016","journal-title":"J Neurosci"},{"key":"10.1016\/j.brs.2025.10.006_bib37","doi-asserted-by":"crossref","DOI":"10.1126\/science.abm8797","article-title":"Dual-polarity voltage imaging of the concurrent dynamics of multiple neuron types","volume":"378","author":"Kannan","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.brs.2025.10.006_bib38","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2022.1051559","article-title":"Kinetics and durability of transgene expression after intrastriatal injection of AAV9 vectors","volume":"13","author":"Hollidge","year":"2022","journal-title":"Front Neurol"},{"key":"10.1016\/j.brs.2025.10.006_bib39","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2021.747726","article-title":"A multifaceted approach to optimizing AAV delivery to the brain for the treatment of neurodegenerative diseases","volume":"15","author":"Fischell","year":"2021","journal-title":"Front Neurosci"},{"key":"10.1016\/j.brs.2025.10.006_bib40","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.jcis.2008.09.066","article-title":"Microbubble size isolation by differential centrifugation","volume":"329","author":"Feshitan","year":"2009","journal-title":"J Colloid Interface Sci"},{"key":"10.1016\/j.brs.2025.10.006_bib41","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.ultrasmedbio.2013.09.015","article-title":"Microbubble type and distribution dependence of focused ultrasound-induced blood\u2013brain barrier opening","volume":"40","author":"Wang","year":"2014","journal-title":"Ultrasound Med Biol"},{"key":"10.1016\/j.brs.2025.10.006_bib42","doi-asserted-by":"crossref","DOI":"10.1063\/5.0198346","article-title":"Sensitive, accurate, and high spatiotemporal resolution photonic thermometry","volume":"124","author":"Hassan","year":"2024","journal-title":"Appl Phys Lett"},{"key":"10.1016\/j.brs.2025.10.006_bib43","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.jconrel.2022.09.048","article-title":"Efficacy of gene delivery to the brain using AAV and ultrasound depends on serotypes and brain areas","volume":"351","author":"Kofoed","year":"2022","journal-title":"J Control Release Off J Control Release Soc"},{"key":"10.1016\/j.brs.2025.10.006_bib44","doi-asserted-by":"crossref","DOI":"10.1088\/1361-6560\/aab05c","article-title":"Power cavitation-guided blood-brain barrier opening with focused ultrasound and microbubbles","volume":"63","author":"Burgess","year":"2018","journal-title":"Phys Med Biol"},{"key":"10.1016\/j.brs.2025.10.006_bib45","doi-asserted-by":"crossref","first-page":"2056","DOI":"10.1007\/s12640-021-00432-z","article-title":"Effects of local administration of iron oxide nanoparticles in the prefrontal cortex, striatum, and Hippocampus of rats","volume":"39","author":"Irrsack","year":"2021","journal-title":"Neurotox Res"},{"key":"10.1016\/j.brs.2025.10.006_bib46","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1142\/S2339547814500198","article-title":"Accounting for biological aggregation in heating and imaging of magnetic nanoparticles","volume":"2","author":"Etheridge","year":"2014","journal-title":"Technology"},{"key":"10.1016\/j.brs.2025.10.006_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2021.135956","article-title":"Comparative study of neuron-specific promoters in mouse brain transduced by intravenously administered AAV-PHP.eB","volume":"756","author":"Radhiyanti","year":"2021","journal-title":"Neurosci Lett"},{"key":"10.1016\/j.brs.2025.10.006_bib48","doi-asserted-by":"crossref","first-page":"2019","DOI":"10.1002\/cne.23819","article-title":"Evaluation of the expression pattern of rAAV2\/1, 2\/5, 2\/7, 2\/8, and 2\/9 serotypes with different promoters in the mouse visual cortex","volume":"523","author":"Scheyltjens","year":"2015","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.brs.2025.10.006_bib49","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.neuron.2009.11.031","article-title":"Are the dorsal and ventral hippocampus functionally distinct structures?","volume":"65","author":"Fanselow","year":"2010","journal-title":"Neuron"},{"key":"10.1016\/j.brs.2025.10.006_bib50","doi-asserted-by":"crossref","first-page":"9697","DOI":"10.1073\/pnas.92.21.9697","article-title":"Spatial learning with a minislab in the dorsal hippocampus","volume":"92","author":"Moser","year":"1995","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.brs.2025.10.006_bib51","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1111\/j.0953-816X.2004.03170.x","article-title":"Dissociation of function between the dorsal and the ventral hippocampus in spatial learning abilities of the rat: a within-subject, within-task comparison of reference and working spatial memory","volume":"19","author":"Pothuizen","year":"2004","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.brs.2025.10.006_bib52","series-title":"Gene therapy for neurological disorders: methods and protocols","first-page":"485","article-title":"AAV2-Neurturin for parkinson's disease: what lessons have we learned?","author":"Kordower","year":"2016"},{"key":"10.1016\/j.brs.2025.10.006_bib53","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1002\/mds.23442","article-title":"Bioactivity of AAV2-neurturin gene therapy (CERE-120): differences between Parkinson's disease and nonhuman primate brains","volume":"26","author":"Bartus","year":"2011","journal-title":"Mov Disord Off J Mov Disord Soc"},{"key":"10.1016\/j.brs.2025.10.006_bib54","article-title":"Characterization of microbubble cavitation in theranostic ultrasound-mediated blood-brain barrier opening for gene delivery","volume":"113986","author":"Tsitsos","year":"2025","journal-title":"Journal of Controlled Release"},{"key":"10.1016\/j.brs.2025.10.006_bib55","doi-asserted-by":"crossref","first-page":"3445","DOI":"10.2147\/IJN.S30320","article-title":"Superparamagnetic iron oxide nanoparticles: magnetic nanoplatforms as drug carriers","volume":"7","author":"Wahajuddin & Arora","year":"2012","journal-title":"Int J Nanomed"},{"key":"10.1016\/j.brs.2025.10.006_bib56","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1007\/s11596-018-1989-8","article-title":"Biodistribution and toxicity assessment of superparamagnetic iron oxide nanoparticles in vitro and in vivo","volume":"38","author":"Yu","year":"2018","journal-title":"Curr Med Sci"},{"key":"10.1016\/j.brs.2025.10.006_bib57","doi-asserted-by":"crossref","first-page":"205","DOI":"10.3390\/ijms19010205","article-title":"Biodistribution and clearance of stable superparamagnetic maghemite iron oxide nanoparticles in mice following intraperitoneal administration","volume":"19","author":"Pham","year":"2018","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.brs.2025.10.006_bib58","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1056\/NEJMoa2307798","article-title":"Death after high-dose rAAV9 gene therapy in a patient with Duchenne's muscular dystrophy","volume":"389","author":"Lek","year":"2023","journal-title":"N Engl J Med"},{"key":"10.1016\/j.brs.2025.10.006_bib59","article-title":"High-dose AAV gene therapy deaths","volume":"38","year":"2020","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.brs.2025.10.006_bib60","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1089\/hum.2022.29216.bfs","article-title":"Novartis confirms deaths of two patients treated with gene therapy zolgensma","volume":"33","author":"Philippidis","year":"2022","journal-title":"Hum Gene Ther"},{"key":"10.1016\/j.brs.2025.10.006_bib61","doi-asserted-by":"crossref","first-page":"2018","DOI":"10.1016\/j.ymthe.2019.07.017","article-title":"AAV-PHP.B administration results in a differential pattern of CNS biodistribution in non-human Primates compared with mice","volume":"27","author":"Liguore","year":"2019","journal-title":"Mol Ther"}],"container-title":["Brain Stimulation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1935861X25003523?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1935861X25003523?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T07:48:53Z","timestamp":1780991333000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1935861X25003523"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":61,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["S1935861X25003523"],"URL":"https:\/\/doi.org\/10.1016\/j.brs.2025.10.006","relation":{},"ISSN":["1935-861X"],"issn-type":[{"value":"1935-861X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A multifunctional theranostic ultrasound platform for remote magnetogenetics and expanded blood-brain barrier opening","name":"articletitle","label":"Article Title"},{"value":"Brain Stimulation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.brs.2025.10.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}