{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T18:52:22Z","timestamp":1784141542752,"version":"3.55.0"},"reference-count":35,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,10,1]],"date-time":"2023-10-01T00:00:00Z","timestamp":1696118400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,5,5]],"date-time":"2023-05-05T00:00:00Z","timestamp":1683244800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFD1800100"],"award-info":[{"award-number":["2022YFD1800100"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biosafety and Health"],"published-print":{"date-parts":[[2023,10]]},"DOI":"10.1016\/j.bsheal.2023.05.005","type":"journal-article","created":{"date-parts":[[2023,5,9]],"date-time":"2023-05-09T16:34:10Z","timestamp":1683650050000},"page":"308-319","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Incorporation of Escherichia coli heat-labile enterotoxin B subunit into rabies virus particles enhances its immunogenicity in mice and dogs"],"prefix":"10.1016","volume":"5","author":[{"given":"Zhiyuan","family":"Gong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hailun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meichen","family":"Qian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujie","family":"Bai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongli","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingxuan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengyao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuicui","family":"Jiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haili","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6961-1991","authenticated-orcid":false,"given":"Hualei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bsheal.2023.05.005_b0005","series-title":"Macsween\u2019s pathology of the liver","first-page":"416","article-title":"7 - Non-hepatotropic viral, bacterial, and parasitic infections of the liver","author":"Zaki","year":"2018"},{"key":"10.1016\/j.bsheal.2023.05.005_b0010","series-title":"Rabies","first-page":"7","article-title":"Chapter 2 - Clinical signs and symptoms of rabies","author":"Wilson","year":"2020"},{"key":"10.1016\/j.bsheal.2023.05.005_b0015","first-page":"1","article-title":"WHO expert consultation on rabies: Second report","volume":"982","author":"World Health Organization","year":"2013","journal-title":"World Health Organ. Tech. Rep. Ser."},{"key":"10.1016\/j.bsheal.2023.05.005_b0020","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1080\/22221751.2021.1923341","article-title":"A novel oral rabies vaccine enhances the immunogenicity through increasing dendritic cells activation and germinal center formation by expressing U-OMP19 in a mouse model","volume":"10","author":"Zhao","year":"2021","journal-title":"Emerg. Microbes Infect."},{"issue":"12","key":"10.1016\/j.bsheal.2023.05.005_b0025","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.3390\/vaccines9121436","article-title":"Impact of molecular modifications on the immunogenicity and efficacy of recombinant raccoon poxvirus-vectored rabies vaccine candidates in mice","volume":"9","author":"Malav\u00e9","year":"2021","journal-title":"Vaccines"},{"key":"10.1016\/j.bsheal.2023.05.005_b0030","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1016\/S0264-410X(02)00778-8","article-title":"A dog rabies vaccination campaign in rural Africa: impact on the incidence of dog rabies and human dog-bite injuries","volume":"21","author":"Cleaveland","year":"2003","journal-title":"Vaccine"},{"key":"10.1016\/j.bsheal.2023.05.005_b0035","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/0264-410X(95)00197-9","article-title":"Immunization coverage required to prevent outbreaks of dog rabies","volume":"14","author":"Coleman","year":"1996","journal-title":"Vaccine"},{"key":"10.1016\/j.bsheal.2023.05.005_b0040","first-page":"039","article-title":"Human rabies: prospects for elimination","volume":"16","author":"Changalucha","year":"2021","journal-title":"CAB Rev."},{"key":"10.1016\/j.bsheal.2023.05.005_b0045","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.antiviral.2017.01.022","article-title":"The ectodomain of rabies virus glycoprotein determines dendritic cell activation","volume":"141","author":"Huang","year":"2017","journal-title":"Antiviral Res."},{"key":"10.1016\/j.bsheal.2023.05.005_b0050","doi-asserted-by":"crossref","first-page":"6405","DOI":"10.1016\/j.vaccine.2008.08.069","article-title":"Immune modulating effect by a phosphoprotein-deleted rabies virus vaccine vector expressing two copies of the rabies virus glycoprotein gene","volume":"26","author":"Cenna","year":"2008","journal-title":"Vaccine"},{"key":"10.1016\/j.bsheal.2023.05.005_b0055","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1099\/0022-1317-40-3-595","article-title":"Immunoglobulin (IgG) and (IgM) antibody responses to rabies vaccine","volume":"40","author":"Turner","year":"1978","journal-title":"J. Gen. Virol."},{"key":"10.1016\/j.bsheal.2023.05.005_b0060","doi-asserted-by":"crossref","first-page":"3896","DOI":"10.1016\/j.vaccine.2010.03.039","article-title":"The immune response to rabies virus infection and vaccination","volume":"28","author":"Johnson","year":"2010","journal-title":"Vaccine"},{"key":"10.1016\/j.bsheal.2023.05.005_b0065","doi-asserted-by":"crossref","first-page":"38504","DOI":"10.18632\/oncotarget.5904","article-title":"Recombinant rabies virus expressing dog GM-CSF is an efficacious oral rabies vaccine for dogs","volume":"6","author":"Zhou","year":"2015","journal-title":"Oncotarget"},{"key":"10.1016\/j.bsheal.2023.05.005_b0070","doi-asserted-by":"crossref","first-page":"83539","DOI":"10.18632\/oncotarget.18368","article-title":"An optimized HMGB1 expressed by recombinant rabies virus enhances immunogenicity through activation of dendritic cells in mice","volume":"8","author":"Wang","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.bsheal.2023.05.005_b0075","doi-asserted-by":"crossref","first-page":"831","DOI":"10.18632\/oncotarget.23160","article-title":"Recombinant rabies virus with the glycoprotein fused with a DC-binding peptide is an efficacious rabies vaccine","volume":"9","author":"Zhang","year":"2018","journal-title":"Oncotarget"},{"issue":"11","key":"10.1016\/j.bsheal.2023.05.005_b0080","doi-asserted-by":"crossref","first-page":"e0007800","DOI":"10.1371\/journal.pntd.0007800","article-title":"Incorporating B cell activating factor (BAFF) into the membrane of rabies virus (RABV) particles improves the speed and magnitude of vaccine-induced antibody responses","volume":"13","author":"Plummer","year":"2019","journal-title":"PLoS Negl. Trop. Dis."},{"issue":"7","key":"10.1016\/j.bsheal.2023.05.005_b0085","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.3390\/v13071302","article-title":"Oral immunization with Lactobacillus casei expressing the porcine circovirus type 2 cap and LTB induces mucosal and systemic antibody responses in mice","volume":"13","author":"Li","year":"2021","journal-title":"Viruses"},{"issue":"5","key":"10.1016\/j.bsheal.2023.05.005_b0090","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/j.vaccine.2021.12.053","article-title":"Protection against avian coronavirus conferred by oral vaccination with live bacteria secreting LTB-fused viral proteins","volume":"40","author":"Lublin","year":"2022","journal-title":"Vaccine"},{"issue":"1","key":"10.1016\/j.bsheal.2023.05.005_b0095","first-page":"39","article-title":"Vaccine potential of LenA and LcpA proteins of Leptospira interrogans in combination with Escherichia coli heat-labile enterotoxin, B subunit (LTB)","volume":"11","author":"Ghazali-Bina","year":"2019","journal-title":"Iran. J. Microbiol."},{"key":"10.1016\/j.bsheal.2023.05.005_b0100","doi-asserted-by":"crossref","first-page":"169","DOI":"10.3389\/fmicb.2015.00169","article-title":"Incorporation of membrane-anchored flagellin or Escherichia coli heat-labile enterotoxin B subunit enhances the immunogenicity of rabies virus-like particles in mice and dogs","volume":"6","author":"Qi","year":"2015","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.bsheal.2023.05.005_b0105","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1046\/j.1365-2567.1998.00535.x","article-title":"Role of GM1 binding in the mucosal immunogenicity and adjuvant activity of the Escherichia coli heat-labile enterotoxin and its B subunit","volume":"94","author":"de Haan","year":"1998","journal-title":"Immunology"},{"issue":"2","key":"10.1016\/j.bsheal.2023.05.005_b0110","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/s11262-014-1160-y","article-title":"Using rabies virus vaccine strain SRV9 as viral vector to express exogenous gene","volume":"50","author":"Wang","year":"2015","journal-title":"Virus genes"},{"issue":"6","key":"10.1016\/j.bsheal.2023.05.005_b0115","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0009484","article-title":"An inactivated recombinant rabies virus displaying the Zika virus prM-E induces protective immunity against both pathogens","volume":"15","author":"Jin","year":"2021","journal-title":"PLoS Negl. Trop. Dis."},{"key":"10.1016\/j.bsheal.2023.05.005_b0120","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0022-1759(98)00204-X","article-title":"An advanced culture method for generating large quantities of highly pure dendritic cells from mouse bone marrow","volume":"223","author":"Lutz","year":"1999","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.bsheal.2023.05.005_b0125","doi-asserted-by":"crossref","first-page":"1195","DOI":"10.1172\/JCI31205","article-title":"DC-based cancer vaccines","volume":"117","author":"Gilboa","year":"2007","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bsheal.2023.05.005_b0130","doi-asserted-by":"crossref","first-page":"2534","DOI":"10.1016\/S0264-410X(00)00553-3","article-title":"Mucosal vaccines: non toxic derivatives of LT and CT as mucosal adjuvants","volume":"19","author":"Pizza","year":"2001","journal-title":"Vaccine"},{"issue":"2","key":"10.1016\/j.bsheal.2023.05.005_b0135","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.rvsc.2011.09.015","article-title":"Oral immunisation of mice with a recombinant rabies virus vaccine incorporating the heat-labile enterotoxin B subunit of Escherichia coli in an attenuated Salmonella strain","volume":"93","author":"Wang","year":"2012","journal-title":"Res. Vet. Sci."},{"key":"10.1016\/j.bsheal.2023.05.005_b0140","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1080\/14760584.2016.1182868","article-title":"Recent advances in nontoxic Escherichia coli heat-labile toxin and its derivative adjuvants","volume":"15","author":"Ma","year":"2016","journal-title":"Expert. Rev. Vaccines"},{"issue":"2","key":"10.1016\/j.bsheal.2023.05.005_b0145","doi-asserted-by":"crossref","first-page":"2836","DOI":"10.1096\/fj.201800289RRR","article-title":"Targeting peptide-enhanced antibody and CD11c(+) dendritic cells to inclusion bodies expressing protective antigen against ETEC in mice","volume":"33","author":"Jiang","year":"2019","journal-title":"FASEB J."},{"key":"10.1016\/j.bsheal.2023.05.005_b0150","doi-asserted-by":"crossref","first-page":"636","DOI":"10.1016\/j.vaccine.2005.08.052","article-title":"Heat labile enterotoxin of E. coli: a potential adjuvant for transcutaneous cancer immunotherapy","volume":"24","author":"Pitcovski","year":"2006","journal-title":"Vaccine"},{"key":"10.1016\/j.bsheal.2023.05.005_b0155","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1089\/vim.2017.0049","article-title":"Adjuvants for animal vaccines","volume":"31","author":"Burakova","year":"2018","journal-title":"Viral Immunol."},{"key":"10.1016\/j.bsheal.2023.05.005_b0160","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.it.2017.10.002","article-title":"Improving vaccine and immunotherapy design using biomaterials","volume":"39","author":"Bookstaver","year":"2018","journal-title":"Trends Immunol."},{"key":"10.1016\/j.bsheal.2023.05.005_b0165","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/j.biopha.2018.06.026","article-title":"Efficacy and safety of immunological adjuvants. Where is the cut-off?","volume":"105","author":"Batista-Duharte","year":"2018","journal-title":"Biomed. Pharmacother."},{"issue":"3","key":"10.1016\/j.bsheal.2023.05.005_b0170","doi-asserted-by":"crossref","first-page":"266","DOI":"10.3390\/vaccines9030266","article-title":"Escherichia coli heat-labile enterotoxin B subunit combined with Ginsenoside Rg1 as an intranasal adjuvant triggers type I interferon signaling pathway and enhances adaptive immune responses to an inactivated PRRSV vaccine in ICR mice","volume":"9","author":"Su","year":"2021","journal-title":"Vaccines"},{"key":"10.1016\/j.bsheal.2023.05.005_b0175","doi-asserted-by":"crossref","first-page":"103353","DOI":"10.1016\/j.ebiom.2021.103353","article-title":"Novel Japanese encephalitis virus NS1-based vaccine: truncated NS1 fused with E. coli heat labile enterotoxin B subunit","volume":"67","author":"Wan","year":"2021","journal-title":"EBioMedicine"}],"container-title":["Biosafety and Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590053623000551?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590053623000551?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T01:01:23Z","timestamp":1762909283000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2590053623000551"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10]]},"references-count":35,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["S2590053623000551"],"URL":"https:\/\/doi.org\/10.1016\/j.bsheal.2023.05.005","relation":{},"ISSN":["2590-0536"],"issn-type":[{"value":"2590-0536","type":"print"}],"subject":[],"published":{"date-parts":[[2023,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Incorporation of Escherichia coli heat-labile enterotoxin B subunit into rabies virus particles enhances its immunogenicity in mice and dogs","name":"articletitle","label":"Article Title"},{"value":"Biosafety and Health","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bsheal.2023.05.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Chinese Medical Association Publishing House. Published by Elsevier BV.","name":"copyright","label":"Copyright"}]}}