{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T05:11:45Z","timestamp":1778908305900,"version":"3.51.4"},"reference-count":22,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,3,20]],"date-time":"2024-03-20T00:00:00Z","timestamp":1710892800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2023A1515140117"],"award-info":[{"award-number":["2023A1515140117"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2022B1515120043"],"award-info":[{"award-number":["2022B1515120043"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["YKY-KF202208"],"award-info":[{"award-number":["YKY-KF202208"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012151","name":"Sanming Project of Medicine in Shenzen Municipality","doi-asserted-by":"publisher","award":["SZSM202211023"],"award-info":[{"award-number":["SZSM202211023"]}],"id":[{"id":"10.13039\/501100012151","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFE0118700"],"award-info":[{"award-number":["2023YFE0118700"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2021YFC2301604"],"award-info":[{"award-number":["2021YFC2301604"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["21623406"],"award-info":[{"award-number":["21623406"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["92169102"],"award-info":[{"award-number":["92169102"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81902097"],"award-info":[{"award-number":["81902097"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["92374203"],"award-info":[{"award-number":["92374203"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2023M741379"],"award-info":[{"award-number":["2023M741379"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2023TQ0136"],"award-info":[{"award-number":["2023TQ0136"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biosafety and Health"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1016\/j.bsheal.2024.03.005","type":"journal-article","created":{"date-parts":[[2024,3,25]],"date-time":"2024-03-25T13:50:35Z","timestamp":1711374635000},"page":"143-152","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["A novel method for identifying SARS-CoV-2 infection mutants via an epitope-specific CD8+ T cell test"],"prefix":"10.1016","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1796-6111","authenticated-orcid":false,"given":"Congling","family":"Qiu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Peng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chanchan","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pengfei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lipeng","family":"Mao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaolu","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziquan","family":"Lv","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qiuying","family":"Lv","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaomin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaxin","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanhao","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qinghua","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guobing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xuan","family":"Zou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaofeng","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bsheal.2024.03.005_b0005","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1016\/S0140-6736(20)32007-9","article-title":"Lessons learnt from easing COVID-19 restrictions: an analysis of countries and regions in Asia Pacific and Europe","volume":"396","author":"Han","year":"2020","journal-title":"Lancet"},{"key":"10.1016\/j.bsheal.2024.03.005_b0010","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.jiph.2020.12.022","article-title":"Swift contact tracing can prevent transmission-case report of an early COVID-19 positive case","volume":"14","author":"Goel","year":"2021","journal-title":"J. Infect. Public Health"},{"key":"10.1016\/j.bsheal.2024.03.005_b0015","doi-asserted-by":"crossref","first-page":"2001410","DOI":"10.2807\/1560-7917.ES.2020.25.32.2001410","article-title":"Geographical and temporal distribution of SARS-CoV-2 clades in the WHO European Region, January to June 2020","volume":"25","author":"Alm","year":"2020","journal-title":"Euro. Surveill."},{"key":"10.1016\/j.bsheal.2024.03.005_b0020","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.jhin.2021.02.022","article-title":"Investigation of intra-hospital SARS-CoV-2 transmission using nanopore whole-genome sequencing","volume":"111","author":"L\u00f8vestad","year":"2021","journal-title":"J. Hosp. Infect."},{"key":"10.1016\/j.bsheal.2024.03.005_b0025","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1111\/all.14622","article-title":"Antibody dynamics to SARS-CoV-2 in asymptomatic COVID-19 infections","volume":"76","author":"Lei","year":"2021","journal-title":"Allergy"},{"key":"10.1016\/j.bsheal.2024.03.005_b0030","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/s41586-021-04389-z","article-title":"Considerable escape of SARS-CoV-2 omicron to antibody neutralization","volume":"602","author":"Planas","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.bsheal.2024.03.005_b0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111650","article-title":"Molecular analysis of a public cross-neutralizing antibody response to SARS-CoV-2","volume":"41","author":"Yuan","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.bsheal.2024.03.005_b0040","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1002\/JLB.4MA0621-020R","article-title":"Identification of HLA-A2 restricted CD8(+) T cell epitopes in SARS-CoV-2 structural proteins","volume":"110","author":"Deng","year":"2021","journal-title":"J. Leukoc Biol."},{"key":"10.1016\/j.bsheal.2024.03.005_b0045","doi-asserted-by":"crossref","first-page":"2016","DOI":"10.3390\/v14092016","article-title":"Effectiveness of booster doses of the SARS-CoV-2 inactivated vaccine KCONVAC against the mutant strains","volume":"14","author":"Xiao","year":"2022","journal-title":"Viruses"},{"key":"10.1016\/j.bsheal.2024.03.005_b0050","doi-asserted-by":"crossref","first-page":"3310","DOI":"10.1093\/bioinformatics\/btu548","article-title":"OptiType: precision HLA typing from next-generation sequencing data","volume":"30","author":"Szolek","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.bsheal.2024.03.005_b0055","article-title":"Optimization of antigen-specific CD8(+) T cell activation conditions for infectious diseases including COVID-19","volume":"2","author":"Xiao","year":"2021","journal-title":"StarProtoc"},{"key":"10.1016\/j.bsheal.2024.03.005_b0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2022.103934","article-title":"SARS-CoV-2 variant B.1.1.7 caused HLA-A2(+) CD8(+) T cell epitope mutations for impaired cellular immune response","volume":"25","author":"Xiao","year":"2022","journal-title":"iScience"},{"key":"10.1016\/j.bsheal.2024.03.005_b0065","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1186\/s12864-022-08936-4","article-title":"Cov2clusters: genomic clustering of SARS-CoV-2 sequences","volume":"23","author":"Sobkowiak","year":"2022","journal-title":"BMC Genomics"},{"key":"10.1016\/j.bsheal.2024.03.005_b0070","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.7326\/L21-0491","article-title":"The proportion of SARS-CoV-2 infections that are asymptomatic","volume":"174","author":"Oran","year":"2021","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.bsheal.2024.03.005_b0075","doi-asserted-by":"crossref","first-page":"e02438","DOI":"10.1128\/JCM.02438-20","article-title":"A new SARS-CoV-2 dual-purpose serology test: highly accurate infection tracing and neutralizing antibody response detection","volume":"59","author":"Taylor","year":"2021","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.bsheal.2024.03.005_b0080","doi-asserted-by":"crossref","first-page":"2161","DOI":"10.1056\/NEJMc2104192","article-title":"Cross-reactive neutralizing antibody responses elicited by SARS-CoV-2 501Y.V2 (B.1.351)","volume":"384","author":"Moyo-Gwete","year":"2021","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bsheal.2024.03.005_b0085","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.cell.2021.01.007","article-title":"Adaptive immunity to SARS-CoV-2 and COVID-19","volume":"184","author":"Sette","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.bsheal.2024.03.005_b0090","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1111\/pai.13263","article-title":"Two X-linked agammaglobulinemia patients develop pneumonia as COVID-19 manifestation but recover","volume":"31","author":"Soresina","year":"2020","journal-title":"Pediatr. Allergy Immunol."},{"key":"10.1016\/j.bsheal.2024.03.005_b0095","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1038\/s41591-020-01143-2","article-title":"Characterization of pre-existing and induced SARS-CoV-2-specific CD8(+) T cells","volume":"27","author":"Schulien","year":"2021","journal-title":"Nat. Med."},{"key":"10.1016\/j.bsheal.2024.03.005_b0100","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1038\/s41590-020-00808-x","article-title":"SARS-CoV-2-derived peptides define heterologous and COVID-19-induced T cell recognition","volume":"22","author":"Nelde","year":"2021","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.bsheal.2024.03.005_b0105","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.cell.2020.08.017","article-title":"Robust T cell immunity in convalescent individuals with asymptomatic or mild COVID-19","volume":"183","author":"Sekine","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.bsheal.2024.03.005_b0110","doi-asserted-by":"crossref","first-page":"D784","DOI":"10.1093\/nar\/gku1166","article-title":"Allele frequency net 2015 update: new features for HLA epitopes, KIR and disease and HLA adverse drug reaction associations","volume":"43","author":"Gonz\u00e1lez-Galarza","year":"2015","journal-title":"Nucl. Acids Res."}],"container-title":["Biosafety and Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590053624000326?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590053624000326?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T04:46:37Z","timestamp":1778906797000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2590053624000326"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":22,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["S2590053624000326"],"URL":"https:\/\/doi.org\/10.1016\/j.bsheal.2024.03.005","relation":{},"ISSN":["2590-0536"],"issn-type":[{"value":"2590-0536","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A novel method for identifying SARS-CoV-2 infection mutants via an epitope-specific CD8+ T cell test","name":"articletitle","label":"Article Title"},{"value":"Biosafety and Health","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bsheal.2024.03.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Chinese Medical Association Publishing House. Published by Elsevier BV.","name":"copyright","label":"Copyright"}]}}