{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T04:30:58Z","timestamp":1775277058048,"version":"3.50.1"},"reference-count":40,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,4]],"date-time":"2026-01-04T00:00:00Z","timestamp":1767484800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2025YFC2311704"],"award-info":[{"award-number":["2025YFC2311704"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82241078"],"award-info":[{"award-number":["82241078"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82341052"],"award-info":[{"award-number":["82341052"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82372224"],"award-info":[{"award-number":["82372224"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biosafety and Health"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.bsheal.2026.01.001","type":"journal-article","created":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T00:25:51Z","timestamp":1767659151000},"page":"31-41","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["SEC11A identified as a critical host factor for HMPV through virus-induced alternative splicing"],"prefix":"10.1016","volume":"8","author":[{"given":"Yiman","family":"Huang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiayin","family":"Guo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shiyuan","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aijun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lihong","family":"Yao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ke","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8780-6191","authenticated-orcid":false,"given":"Lishu","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.bsheal.2026.01.001_b0005","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1038\/89098","article-title":"A newly discovered human pneumovirus isolated from young children with respiratory tract disease","volume":"7","author":"van den Hoogen","year":"2001","journal-title":"Nat. Med."},{"issue":"4","key":"10.1016\/j.bsheal.2026.01.001_b0010","doi-asserted-by":"crossref","first-page":"658","DOI":"10.3201\/eid1004.030393","article-title":"Antigenic and genetic variability of human metapneumoviruses","volume":"10","author":"van den Hoogen","year":"2004","journal-title":"Emerg. Infect. Dis."},{"issue":"1","key":"10.1016\/j.bsheal.2026.01.001_b0015","doi-asserted-by":"crossref","first-page":"147","DOI":"10.3201\/eid1201.050772","article-title":"Novel human metapneumovirus sublineage","volume":"12","author":"Huck","year":"2006","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.bsheal.2026.01.001_b0020","doi-asserted-by":"crossref","first-page":"105848","DOI":"10.1016\/j.jcv.2025.105848","article-title":"Phylodynamics of human metapneumovirus and evidence for a duplication-deletion model in G gene variant evolution","volume":"180","author":"Goya","year":"2025","journal-title":"J. Clin. Virol."},{"issue":"2","key":"10.1016\/j.bsheal.2026.01.001_b0025","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1007\/s11033-022-08092-8","article-title":"The emergence of human metapneumovirus G gene duplication in hospitalized patients with respiratory tract infection, India, 2016-2018","volume":"50","author":"Parida","year":"2023","journal-title":"Mol. Biol. Rep."},{"issue":"1","key":"10.1016\/j.bsheal.2026.01.001_b0030","doi-asserted-by":"crossref","first-page":"e33","DOI":"10.1016\/S2214-109X(20)30393-4","article-title":"Global burden of acute lower respiratory infection associated with human metapneumovirus in children under 5 years in 2018: a systematic review and modelling study","volume":"9","author":"Wang","year":"2021","journal-title":"Lancet Glob. Health"},{"key":"10.1016\/j.bsheal.2026.01.001_b0035","doi-asserted-by":"crossref","first-page":"105386","DOI":"10.1016\/j.meegid.2022.105386","article-title":"Human metapneumovirus in hospitalized children with acute respiratory tract infections in Beijing, China","volume":"106","author":"Cong","year":"2022","journal-title":"Infect. Genet. Evol."},{"key":"10.1016\/j.bsheal.2026.01.001_b0040","doi-asserted-by":"crossref","first-page":"101563","DOI":"10.1016\/j.nmni.2025.101563","article-title":"The surge of human metapneumovirus (hMPV) cases in China and global implications","volume":"63","author":"Al-Tawfiq","year":"2025","journal-title":"New Microbes New Infect."},{"issue":"1","key":"10.1016\/j.bsheal.2026.01.001_b0045","first-page":"1","article-title":"Ongoing hMPV outbreaks in China and other Asian countries","volume":"33","author":"Sah","year":"2025","journal-title":"Infez. Med."},{"issue":"2","key":"10.1016\/j.bsheal.2026.01.001_b0050","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1002\/jmv.26401","article-title":"Report of death in children with SARS-CoV-2 and human metapneumovirus (hMPV) coinfection: Is hMPV the trigger?","volume":"93","author":"Hashemi","year":"2021","journal-title":"J. Med. Virol."},{"key":"10.1016\/j.bsheal.2026.01.001_b0055","first-page":"13","article-title":"Severe respiratory failure due to co-infection with human metapneumovirus and Streptococcus pneumoniae","volume":"12","author":"Seki","year":"2014","journal-title":"Respir. Med. Case. Rep."},{"issue":"6","key":"10.1016\/j.bsheal.2026.01.001_b0060","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1016\/j.virs.2022.08.007","article-title":"Clinical characteristics and molecular epidemiology of human metapneumovirus in children with acute lower respiratory tract infections in China, 2017 to 2019: A multicentre prospective observational study","volume":"37","author":"Zhao","year":"2022","journal-title":"Virol. Sin."},{"key":"10.1016\/j.bsheal.2026.01.001_b0065","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1146\/annurev-biochem-060614-034316","article-title":"Mechanisms and regulation of alternative pre-mRNA splicing","volume":"84","author":"Lee","year":"2015","journal-title":"Annu. Rev. Biochem."},{"issue":"3","key":"10.1016\/j.bsheal.2026.01.001_b0070","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1016\/j.tim.2018.11.004","article-title":"Advances in analyzing virus-induced alterations of host cell splicing","volume":"27","author":"Ashraf","year":"2019","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.bsheal.2026.01.001_b0075","doi-asserted-by":"crossref","first-page":"28075","DOI":"10.1038\/srep28075","article-title":"Cellular responses to HSV-1 infection are linked to specific types of alterations in the host transcriptome","volume":"6","author":"Hu","year":"2016","journal-title":"Sci. Rep."},{"issue":"8","key":"10.1016\/j.bsheal.2026.01.001_b0080","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1005841","article-title":"The dengue virus NS5 protein intrudes in the cellular spliceosome and modulates splicing","volume":"12","author":"De Maio","year":"2016","journal-title":"PLoS Pathog."},{"issue":"17","key":"10.1016\/j.bsheal.2026.01.001_b0085","doi-asserted-by":"crossref","first-page":"e00518","DOI":"10.1128\/JVI.00518-18","article-title":"Strand-specific, dual RNA sequencing of bronchial epithelial cells infected with influenza A\/H3N2 viruses reveals splicing of gene segment 6 and novel host-virus interactions","volume":"92","author":"Fabozzi","year":"2018","journal-title":"J. Virol."},{"issue":"3","key":"10.1016\/j.bsheal.2026.01.001_b0090","first-page":"304","article-title":"The influenza virus NS1 protein binds to a specific region in human U6 snRNA and inhibits U6-U2 and U6-U4 snRNA interactions during splicing","volume":"1","author":"Qiu","year":"1995","journal-title":"RNA"},{"key":"10.1016\/j.bsheal.2026.01.001_b0095","doi-asserted-by":"crossref","first-page":"1484245","DOI":"10.3389\/fcimb.2024.1484245","article-title":"Fumarprotocetraric acid and geraniin were identified as novel inhibitors of human respiratory syncytial virus infection in vitro","volume":"14","author":"Wang","year":"2024","journal-title":"Front. Cell. Infect. Microbiol."},{"issue":"3","key":"10.1016\/j.bsheal.2026.01.001_b0100","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1128\/JCM.42.3.981-986.2004","article-title":"Real-time reverse transcriptase PCR assay for detection of human metapneumoviruses from all known genetic lineages","volume":"42","author":"Maertzdorf","year":"2004","journal-title":"J. Clin. Microbiol."},{"issue":"3","key":"10.1016\/j.bsheal.2026.01.001_b0105","doi-asserted-by":"crossref","first-page":"285","DOI":"10.4149\/av_2011_03_285","article-title":"Development of real-time RT-PCR for human metapneumovirus","volume":"55","author":"Xue","year":"2011","journal-title":"Acta Virol."},{"issue":"5","key":"10.1016\/j.bsheal.2026.01.001_b0110","doi-asserted-by":"crossref","first-page":"e1543","DOI":"10.1002\/wrna.1543","article-title":"Viral modulation of cellular RNA alternative splicing: a new key player in virus-host interactions?","volume":"10","author":"Boudreault","year":"2019","journal-title":"Wiley Interdiscip. Rev. RNA"},{"issue":"2","key":"10.1016\/j.bsheal.2026.01.001_b0115","doi-asserted-by":"crossref","first-page":"218","DOI":"10.3390\/v13020218","article-title":"Alternative mRNA processing of innate response pathways in respiratory syncytial virus (RSV) infection","volume":"13","author":"Xu","year":"2021","journal-title":"Viruses"},{"issue":"1","key":"10.1016\/j.bsheal.2026.01.001_b0120","doi-asserted-by":"crossref","first-page":"2407","DOI":"10.1038\/s41467-018-04779-4","article-title":"Co-regulatory activity of hnRNP K and NS1-BP in influenza and human mRNA splicing","volume":"9","author":"Thompson","year":"2018","journal-title":"Nat. Commun."},{"issue":"9","key":"10.1016\/j.bsheal.2026.01.001_b0125","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0161914","article-title":"Global profiling of the cellular alternative RNA splicing landscape during virus-host interactions","volume":"11","author":"Boudreault","year":"2016","journal-title":"PLoS One"},{"issue":"7","key":"10.1016\/j.bsheal.2026.01.001_b0130","doi-asserted-by":"crossref","first-page":"e02488","DOI":"10.1128\/JVI.02488-16","article-title":"A cytoplasmic RNA virus alters the function of the cell splicing protein SRSF2","volume":"91","author":"Rivera-Serrano","year":"2017","journal-title":"J. Virol."},{"key":"10.1016\/j.bsheal.2026.01.001_b0135","first-page":"63","article-title":"Can the HIV-1 splicing machinery be targeted for drug discovery?","volume":"9","author":"Dlamini","year":"2017","journal-title":"HIV AIDS (Auckl)"},{"issue":"1","key":"10.1016\/j.bsheal.2026.01.001_b0140","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1038\/s41392-025-02377-7","article-title":"Epidemiological and phylogenetic characteristics of human metapneumovirus in Beijing, China, 2014-2024","volume":"10","author":"Li","year":"2025","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.bsheal.2026.01.001_b0145","doi-asserted-by":"crossref","first-page":"S37","DOI":"10.1093\/infdis\/jiaf084","article-title":"Clinical features and gene expression patterns in adults hospitalized with respiratory syncytial virus and human metapneumovirus infection","volume":"232","author":"Samoriski","year":"2025","journal-title":"J. Infect. Dis."},{"issue":"1","key":"10.1016\/j.bsheal.2026.01.001_b0150","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.virol.2007.12.024","article-title":"Identification of human metapneumovirus-induced gene networks in airway epithelial cells by microarray analysis","volume":"374","author":"Bao","year":"2008","journal-title":"Virology"},{"issue":"19","key":"10.1016\/j.bsheal.2026.01.001_b0155","doi-asserted-by":"crossref","first-page":"3934","DOI":"10.1016\/j.molcel.2021.07.031","article-title":"Structure of the human signal peptidase complex reveals the determinants for signal peptide cleavage","volume":"81","author":"Liaci","year":"2021","journal-title":"Mol. Cell"},{"issue":"30","key":"10.1016\/j.bsheal.2026.01.001_b0160","doi-asserted-by":"crossref","first-page":"3918","DOI":"10.1038\/onc.2013.364","article-title":"Signal peptidase complex 18, encoded by SEC11A, contributes to progression via TGF-\u03b1 secretion in gastric cancer","volume":"33","author":"Oue","year":"2014","journal-title":"Oncogene"},{"issue":"3","key":"10.1016\/j.bsheal.2026.01.001_b0165","doi-asserted-by":"crossref","first-page":"297","DOI":"10.3390\/jcm8030297","article-title":"Comparative gene expression profiles in parathyroid adenoma and normal parathyroid tissue","volume":"8","author":"Chai","year":"2019","journal-title":"J. Clin. Med."},{"issue":"1","key":"10.1016\/j.bsheal.2026.01.001_b0170","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1111\/cas.13121","article-title":"Clinicopathological significance of SPC18 in colorectal cancer: SPC18 participates in tumor progression","volume":"108","author":"Hattori","year":"2017","journal-title":"Cancer Sci."},{"issue":"4","key":"10.1016\/j.bsheal.2026.01.001_b0175","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1159\/000506956","article-title":"SPC18 expression is an independent prognostic indicator of patients with esophageal squamous cell carcinoma","volume":"87","author":"Yamamoto","year":"2020","journal-title":"Pathobiology"},{"issue":"7610","key":"10.1016\/j.bsheal.2026.01.001_b0180","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1038\/nature18625","article-title":"A CRISPR screen defines a signal peptide processing pathway required by flaviviruses","volume":"535","author":"Zhang","year":"2016","journal-title":"Nature"},{"issue":"22","key":"10.1016\/j.bsheal.2026.01.001_b0185","doi-asserted-by":"crossref","first-page":"12323","DOI":"10.1128\/JVI.01506-07","article-title":"Localization and membrane topology of coronavirus nonstructural protein 4: Involvement of the early secretory pathway in replication","volume":"81","author":"Oostra","year":"2007","journal-title":"J. Virol."},{"issue":"47","key":"10.1016\/j.bsheal.2026.01.001_b0190","doi-asserted-by":"crossref","first-page":"28131","DOI":"10.1074\/jbc.M115.692350","article-title":"Competitive inhibition of the endoplasmic reticulum signal peptidase by non-cleavable mutant preprotein cargos","volume":"290","author":"Cui","year":"2015","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.bsheal.2026.01.001_b0195","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.celrep.2017.03.071","article-title":"The natural product cavinafungin selectively interferes with Zika and dengue virus replication by inhibition of the host signal peptidase","volume":"19","author":"Estoppey","year":"2017","journal-title":"Cell Rep."},{"issue":"3","key":"10.1016\/j.bsheal.2026.01.001_b0200","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1021\/np500854j","article-title":"Cyclic colisporifungin and linear cavinafungins, antifungal lipopeptides isolated from Colispora cavincola","volume":"78","author":"Ort\u00edz-L\u00f3pez","year":"2015","journal-title":"J. Nat. Prod."}],"container-title":["Biosafety and Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590053626000017?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590053626000017?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T20:48:01Z","timestamp":1771534081000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2590053626000017"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":40,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["S2590053626000017"],"URL":"https:\/\/doi.org\/10.1016\/j.bsheal.2026.01.001","relation":{},"ISSN":["2590-0536"],"issn-type":[{"value":"2590-0536","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"SEC11A identified as a critical host factor for HMPV through virus-induced alternative splicing","name":"articletitle","label":"Article Title"},{"value":"Biosafety and Health","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bsheal.2026.01.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Chinese Medical Association Publishing House Co. Ltd. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}