{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T12:33:09Z","timestamp":1768825989572,"version":"3.49.0"},"reference-count":23,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2016,10,6]],"date-time":"2016-10-06T00:00:00Z","timestamp":1475712000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biotechnology Reports"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1016\/j.btre.2016.10.003","type":"journal-article","created":{"date-parts":[[2016,10,10]],"date-time":"2016-10-10T11:52:35Z","timestamp":1476100355000},"page":"26-32","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["An easy method for preparation of Cre-loxP regulated fluorescent adenoviral expression vectors and its application for direct reprogramming into hepatocytes"],"prefix":"10.1016","volume":"12","author":[{"given":"Chitose","family":"Kurihara","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4446-5734","authenticated-orcid":false,"given":"Koji","family":"Nakade","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianzhi","family":"Pan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bohdan","family":"Wasylyk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuichi","family":"Obata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.btre.2016.10.003_bib0005","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1097\/00004397-200201000-00008","article-title":"A twenty-one year surveillance of adenoviral conjunctivitis in Sapporo, Japan","volume":"42","author":"Aoki","year":"2002","journal-title":"Int. Ophthalmol. Clin."},{"issue":"10","key":"10.1016\/j.btre.2016.10.003_bib0010","doi-asserted-by":"crossref","first-page":"2290","DOI":"10.3390\/v2102290","article-title":"Tropism-modification strategies for targeted gene delivery using adenoviral vectors","volume":"2","author":"Coughlan","year":"2010","journal-title":"Viruses"},{"issue":"7-8","key":"10.1016\/j.btre.2016.10.003_bib0015","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/j.addr.2009.03.013","article-title":"Targeting cancer by transcriptional control in cancer gene therapy and viral oncolysis","volume":"61","author":"Dorer","year":"2009","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.btre.2016.10.003_bib0020","first-page":"29","article-title":"Adenovirus-mediated gene delivery to skeletal muscle","volume":"246","author":"Douglas","year":"2004","journal-title":"Methods: Mol. Biol."},{"issue":"8","key":"10.1016\/j.btre.2016.10.003_bib0025","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1111\/j.1348-0421.2006.tb03829.x","article-title":"Possible mechanism of adenovirus generation from a cloned viral genome tagged with nucleotides at its ends","volume":"50","author":"Fukuda","year":"2006","journal-title":"Microbiol. Immunol."},{"issue":"12","key":"10.1016\/j.btre.2016.10.003_bib0030","doi-asserted-by":"crossref","first-page":"2511","DOI":"10.1007\/s00705-006-0816-x","article-title":"Molecular epidemiology of subgenus F adenoviruses associated with pediatric gastroenteritis during eight years in Hiroshima Prefecture as a limited area","volume":"151","author":"Fukuda","year":"2006","journal-title":"Arch. Virol"},{"issue":"6","key":"10.1016\/j.btre.2016.10.003_bib0035","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1002\/ijc.28132","article-title":"Cyclophosphamide enhances antitumor efficacy of oncolytic adenovirus expressing uracil phosphoribosyltransferase (UPRT) in immunocompetent Syrian hamsters","volume":"133","author":"Hasegawa","year":"2013","journal-title":"Int. J. Cancer"},{"issue":"11","key":"10.1016\/j.btre.2016.10.003_bib0040","doi-asserted-by":"crossref","first-page":"5978","DOI":"10.1128\/JVI.02650-06","article-title":"New adenovirus species found in a patient presenting with gastroenteritis","volume":"81","author":"Jones","year":"2007","journal-title":"J. Virol."},{"issue":"10","key":"10.1016\/j.btre.2016.10.003_bib0045","doi-asserted-by":"crossref","first-page":"4594","DOI":"10.1128\/JCM.41.10.4594-4599.2003","article-title":"Genome type analysis of adenovirus types 3 and 7 isolated during successive outbreaks of lower respiratory tract infections in children","volume":"41","author":"Kim","year":"2003","journal-title":"J. Clin. Microbiol."},{"issue":"1","key":"10.1016\/j.btre.2016.10.003_bib0050","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.ymthe.2005.03.006","article-title":"Combined genetic and chemical capsid modifications enable flexible and efficient de- and retargeting of adenovirus vectors","volume":"12","author":"Kreppel","year":"2005","journal-title":"Mol. Ther."},{"issue":"1","key":"10.1016\/j.btre.2016.10.003_bib0055","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1038\/sj.mt.6300321","article-title":"Modification of adenovirus gene transfer vectors with synthetic polymers: a scientific review and technical guide","volume":"16","author":"Kreppel","year":"2008","journal-title":"Mol. Ther."},{"issue":"10","key":"10.1016\/j.btre.2016.10.003_bib0060","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1086\/598521","article-title":"A community-based outbreak of severe respiratory illness caused by human adenovirus serotype 14","volume":"199","author":"Lewis","year":"2009","journal-title":"J. Infect. Dis."},{"issue":"3","key":"10.1016\/j.btre.2016.10.003_bib0065","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1002\/(SICI)1096-9071(199607)49:3<170::AID-JMV3>3.0.CO;2-1","article-title":"Molecular epidemiology of adenovirus types 3 and 7 isolated from children with pneumonia in Beijing","volume":"49","author":"Li","year":"1996","journal-title":"J. Med. Virol."},{"issue":"4","key":"10.1016\/j.btre.2016.10.003_bib0070","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1038\/sj.gt.3302875","article-title":"Decreased immune reactivity towards a knobless, affibody-targeted adenovirus type 5 vector","volume":"14","author":"Myhre","year":"2007","journal-title":"Gene Ther."},{"issue":"2","key":"10.1016\/j.btre.2016.10.003_bib0075","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0378-1119(91)90434-D","article-title":"Efficient selection for high-expression transfectants with a novel eukaryotic vector","volume":"108","author":"Niwa","year":"1991","journal-title":"Gene"},{"issue":"6","key":"10.1016\/j.btre.2016.10.003_bib0080","doi-asserted-by":"crossref","first-page":"e67091","DOI":"10.1371\/journal.pone.0067091","article-title":"Development of adenoviral delivery systems to target hepatic stellate cells in vivo","volume":"8","author":"Reetz","year":"2013","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.btre.2016.10.003_bib0085","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1038\/gt.2010.165","article-title":"Evaluation of systemic targeting of RET oncogene-based MTC with tumor-selective peptide-tagged Ad vectors in clinical mouse models","volume":"18","author":"Schmidt","year":"2011","journal-title":"Gene Ther."},{"issue":"11","key":"10.1016\/j.btre.2016.10.003_bib0090","doi-asserted-by":"crossref","first-page":"2910","DOI":"10.1634\/stemcells.2007-0238","article-title":"Selective targeting of adenoviral vectors to neural precursor cells in the hippocampus of adult mice: new prospects for in situ gene therapy","volume":"25","author":"Schmidt","year":"2007","journal-title":"Stem Cells"},{"issue":"7356","key":"10.1016\/j.btre.2016.10.003_bib0095","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1038\/nature10263","article-title":"Direct conversion of mouse fibroblasts to hepatocyte-like cells by defined factors","volume":"475","author":"Sekiya","year":"2011","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.btre.2016.10.003_bib0100","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/j.stem.2016.01.010","article-title":"Direct reprogramming of hepatic myofibroblasts into hepatocytes in vivo attenuates liver fibrosis","volume":"18","author":"Song","year":"2016","journal-title":"Cell Stem Cell"},{"issue":"10","key":"10.1016\/j.btre.2016.10.003_bib0105","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1086\/598520","article-title":"Outbreak of severe respiratory disease associated with emergent human adenovirus serotype 14 at a US air force training facility in 2007","volume":"199","author":"Tate","year":"2009","journal-title":"J. Infect. Dis."},{"issue":"6","key":"10.1016\/j.btre.2016.10.003_bib0110","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1002\/rmv.1852","article-title":"Role of adenoviruses in obesity","volume":"25","author":"Voss","year":"2015","journal-title":"Rev. Med. Virol."},{"issue":"8","key":"10.1016\/j.btre.2016.10.003_bib0115","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1038\/nrg2141","article-title":"Engineering targeted viral vectors for gene therapy","volume":"8","author":"Waehler","year":"2007","journal-title":"Nat. Rev. Genet."}],"container-title":["Biotechnology Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2215017X16300455?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2215017X16300455?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T06:00:26Z","timestamp":1762408826000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2215017X16300455"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":23,"alternative-id":["S2215017X16300455"],"URL":"https:\/\/doi.org\/10.1016\/j.btre.2016.10.003","relation":{},"ISSN":["2215-017X"],"issn-type":[{"value":"2215-017X","type":"print"}],"subject":[],"published":{"date-parts":[[2016,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"An easy method for preparation of Cre-loxP regulated fluorescent adenoviral expression vectors and its application for direct reprogramming into hepatocytes","name":"articletitle","label":"Article Title"},{"value":"Biotechnology Reports","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.btre.2016.10.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}