{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T16:28:53Z","timestamp":1773937733210,"version":"3.50.1"},"reference-count":49,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bulletin du Cancer"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1016\/j.bulcan.2017.06.018","type":"journal-article","created":{"date-parts":[[2017,10,23]],"date-time":"2017-10-23T16:06:14Z","timestamp":1508774774000},"page":"1013-1021","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["Syndrome de Lynch et cancer de l\u2019endom\u00e8tre"],"prefix":"10.1016","volume":"104","author":[{"given":"Anne-Sophie","family":"Bats","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5330-4479","authenticated-orcid":false,"given":"L\u00e9a","family":"Rossi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie-Aude","family":"Le Frere-Belda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9line","family":"Narjoz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline","family":"Cournou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie","family":"Gosset","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charlotte","family":"Ngo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8239-3420","authenticated-orcid":false,"given":"Myriam","family":"Delomenie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claude","family":"Nos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00e9l\u00e8ne","family":"Blons","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Laurent-Puig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabrice","family":"Lecuru","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.bulcan.2017.06.018_bib0005","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1016\/j.ejca.2012.12.027","article-title":"Cancer incidence and mortality patterns in Europe: estimates for 40 countries in 2012","volume":"49","author":"Ferlay","year":"2013","journal-title":"Eur J Cancer Oxf Engl"},{"key":"10.1016\/j.bulcan.2017.06.018_bib0010","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/B978-0-12-394280-7.00004-X","article-title":"Lynch or not Lynch? Is that always a question?","volume":"113","author":"Colas","year":"2012","journal-title":"Adv Cancer Res"},{"issue":"11","key":"10.1016\/j.bulcan.2017.06.018_bib0015","doi-asserted-by":"crossref","first-page":"e79737","DOI":"10.1371\/journal.pone.0079737","article-title":"Prevalence of Lynch syndrome among patients with newly diagnosed endometrial cancers","volume":"8","author":"Egoavil","year":"2013","journal-title":"PloS One"},{"key":"10.1016\/j.bulcan.2017.06.018_bib0020","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1006\/gyno.2000.6065","article-title":"Cancer risk in young women at risk of hereditary nonpolyposis colorectal cancer: implications for gynecologic surveillance","volume":"80","author":"Brown","year":"2001","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.bulcan.2017.06.018_bib0025","doi-asserted-by":"crossref","DOI":"10.1155\/2010\/984013","article-title":"Genetics of endometrial cancers","author":"Okuda","year":"2010","journal-title":"Obst Gynecol Int"},{"key":"10.1016\/j.bulcan.2017.06.018_bib0030","first-page":"81S","article-title":"Clinical diagnosis and management of hereditary colorectal cancer syndromes","volume":"18","author":"Vasen","year":"2000","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.bulcan.2017.06.018_bib0035","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1136\/jmg.2004.024299","article-title":"Risk of colorectal and endometrial cancer for carriers of mutations of hMLH1 and hMSH2 gene: correction for ascertainement","volume":"42","author":"Quehenberger","year":"2005","journal-title":"J Med Genet"},{"issue":"22","key":"10.1016\/j.bulcan.2017.06.018_bib0040","doi-asserted-by":"crossref","first-page":"2304","DOI":"10.1001\/jama.2011.743","article-title":"Cancer risks associated with germline mutations in MLH1, MSH2, and MSH6 genes in Lynch syndrome","volume":"305","author":"Bonadona","year":"2011","journal-title":"JAMA J Am Med Assoc"},{"key":"10.1016\/j.bulcan.2017.06.018_bib0045","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1053\/j.gastro.2009.07.039","article-title":"Calculation of risk of colorectal and endometrial cancer among patients with Lynch syndrome","volume":"137","author":"Stoffel","year":"2009","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bulcan.2017.06.018_bib0050","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1097\/00000478-200412000-00021","article-title":"Possible precursor of HNPCC-related endometro\u00efd carcinoma of the uterus","volume":"28","author":"Zamecnik","year":"2004","journal-title":"Am J Surg Pathol"},{"issue":"3","key":"10.1016\/j.bulcan.2017.06.018_bib0055","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1097\/01.AOG.0000154885.44002.ae","article-title":"Gynecologic cancer as a \u201csentinel cancer\u201d for women with hereditary nonpolyposis colorectal cancer syndrome","volume":"105","author":"Lu","year":"2005","journal-title":"Obstet Gynecol"},{"issue":"5","key":"10.1016\/j.bulcan.2017.06.018_bib0060","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1097\/IGC.0000000000000985","article-title":"Clinicopathologic characteristics of endometrial cancer in Lynch syndrome: a French Multicenter Study","volume":"27","author":"Rossi","year":"2017","journal-title":"Int J Gynecol Cancer"},{"issue":"1","key":"10.1016\/j.bulcan.2017.06.018_bib0065","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1002\/cncr.21560","article-title":"Pathologic features of endometrial carcinoma associated with HNPCC: a comparison with sporadic endometrial carcinoma","volume":"106","author":"Broaddus","year":"2006","journal-title":"Cancer"},{"issue":"4B","key":"10.1016\/j.bulcan.2017.06.018_bib0070","first-page":"1675","article-title":"The epidemiology of endometrial cancer in hereditary nonpolyposis colorectal cancer","volume":"14","author":"Vasen","year":"1994","journal-title":"Anticancer Res"},{"issue":"33","key":"10.1016\/j.bulcan.2017.06.018_bib0075","doi-asserted-by":"crossref","first-page":"5158","DOI":"10.1200\/JCO.2007.10.8597","article-title":"Prospective determination of prevalence of Lynch syndrome in young women with endometrial cancer","volume":"25","author":"Lu","year":"2007","journal-title":"J Clin Oncol"},{"issue":"11","key":"10.1016\/j.bulcan.2017.06.018_bib0080","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1097\/PAS.0000000000000321","article-title":"Lynch syndrome screening should be considered for all patients with newly diagnosed endometrial cancer","volume":"38","author":"Mills","year":"2014","journal-title":"Am J Surg Pathol"},{"issue":"36","key":"10.1016\/j.bulcan.2017.06.018_bib0085","doi-asserted-by":"crossref","first-page":"5965","DOI":"10.1200\/JCO.2008.18.6296","article-title":"Carcinoma of the lower uterine segment: a newly described association with Lynch syndrome","volume":"26","author":"Westin","year":"2008","journal-title":"J Clin Oncol"},{"issue":"3","key":"10.1016\/j.bulcan.2017.06.018_bib0090","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1002\/cncr.26323","article-title":"Comparison of clinical schemas and morphologic features in predicting Lynch syndrome in mutation-positive patients with endometrial cancer encountered in the context of familial gastrointestinal cancer registries","volume":"118","author":"Ryan","year":"2012","journal-title":"Cancer"},{"issue":"6","key":"10.1016\/j.bulcan.2017.06.018_bib0095","doi-asserted-by":"crossref","first-page":"1692","DOI":"10.1158\/1078-0432.CCR-07-1849","article-title":"Molecular, pathologic, and clinical features of early-onset endometrial cancer: identifying presumptive Lynch syndrome patients","volume":"14","author":"Walsh","year":"2008","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.bulcan.2017.06.018_bib0100","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.ygyno.2009.11.021","article-title":"Lynch syndrome among gynecologic oncology patients meeting Bethesda guidelines for screening","volume":"116","author":"Walsh","year":"2010","journal-title":"Gynecol Oncol"},{"issue":"36","key":"10.1016\/j.bulcan.2017.06.018_bib0105","doi-asserted-by":"crossref","first-page":"9344","DOI":"10.1200\/JCO.2005.03.5915","article-title":"Women with synchronous primary cancers of the endometrium and ovary: do they have Lynch syndrome?","volume":"23","author":"Soliman","year":"2005","journal-title":"J Clin Oncol"},{"issue":"3","key":"10.1016\/j.bulcan.2017.06.018_bib0110","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1097\/IGC.0000000000000377","article-title":"Clinicopathologic analysis with immunohistochemistry for DNA mismatch repair protein expression in synchronous primary endometrial and ovarian cancers","volume":"25","author":"Kobayashi","year":"2015","journal-title":"Int J Gynecol Cancer"},{"key":"10.1016\/j.bulcan.2017.06.018_bib0115","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1097\/PAS.0b013e318197a046","article-title":"Selection of endometrial carcinomas for DNA mismatch repair protein immunohistochemistry using patient age and tumor morphology enhances detection of mismatch repair abnormalities","volume":"33","author":"Garg","year":"2009","journal-title":"Am J Surg Pathol"},{"issue":"7","key":"10.1016\/j.bulcan.2017.06.018_bib0120","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1158\/1055-9965.EPI-13-0105","article-title":"Hormonal and reproductive risk factors for sporadic microsatellite stable and unstable endometrial tumors","volume":"22","author":"Amankwah","year":"2013","journal-title":"Cancer Epidemiol Biomark Prev"},{"issue":"2","key":"10.1016\/j.bulcan.2017.06.018_bib0125","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1002\/ijc.25050","article-title":"Reproductive risk factors and endometrial cancer: the European Prospective Investigation into Cancer and Nutrition","volume":"127","author":"Dossus","year":"2010","journal-title":"Int J Cancer J Int Cancer"},{"issue":"9","key":"10.1016\/j.bulcan.2017.06.018_bib0130","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1038\/sj.bjc.6603731","article-title":"Reproductive risk factors for endometrial cancer among Polish women","volume":"96","author":"Brinton","year":"2007","journal-title":"Br J Cancer"},{"issue":"6","key":"10.1016\/j.bulcan.2017.06.018_bib0135","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1002\/(SICI)1097-0215(19980610)76:6<784::AID-IJC2>3.0.CO;2-U","article-title":"Role of reproductive factors on the risk of endometrial cancer","volume":"76","author":"Parazzini","year":"1998","journal-title":"Int J Cancer J Int Cancer"},{"issue":"1","key":"10.1016\/j.bulcan.2017.06.018_bib0140","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s10654-015-0030-9","article-title":"An epidemiological model for prediction of endometrial cancer risk in Europe","volume":"31","author":"H\u00fcsing","year":"2016","journal-title":"Eur J Epidemiol"},{"issue":"9484","key":"10.1016\/j.bulcan.2017.06.018_bib0145","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/S0140-6736(05)67063-8","article-title":"Endometrial cancer","volume":"366","author":"Amant","year":"2005","journal-title":"Lancet Lond Engl"},{"issue":"2","key":"10.1016\/j.bulcan.2017.06.018_bib0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajog.2007.08.075","article-title":"Trends in demographic and clinical characteristics in women diagnosed with corpus cancer and their potential impact on the increasing number of deaths","volume":"198","author":"Ueda","year":"2008","journal-title":"Am J Obstet Gynecol"},{"issue":"20","key":"10.1016\/j.bulcan.2017.06.018_bib0155","doi-asserted-by":"crossref","first-page":"2607","DOI":"10.1200\/JCO.2012.48.2596","article-title":"Type I and II endometrial cancers: have they different risk factors?","volume":"31","author":"Setiawan","year":"2013","journal-title":"J Clin Oncol"},{"issue":"1","key":"10.1016\/j.bulcan.2017.06.018_bib0160","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.ygyno.2011.11.008","article-title":"Revision of FIGO surgical staging in 2009 for endometrial cancer validates to improve risk stratification","volume":"125","author":"Werner","year":"2012","journal-title":"Gynecol Oncol"},{"issue":"1","key":"10.1016\/j.bulcan.2017.06.018_bib0165","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1097\/00004347-199701000-00007","article-title":"Tumors of the uterine isthmus: clinicopathologic features and immunohistochemical characterization of p53 expression and hormone receptors","volume":"16","author":"Jacques","year":"1997","journal-title":"Int J Gynecol Pathol"},{"issue":"2","key":"10.1016\/j.bulcan.2017.06.018_bib0170","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1006\/gyno.2001.6400","article-title":"Simultaneously detected endometrial and ovarian carcinomas--a prospective clinicopathologic study of 74 cases: a gynecologic oncology group study","volume":"83","author":"Zaino","year":"2001","journal-title":"Gynecol Oncol"},{"issue":"3","key":"10.1016\/j.bulcan.2017.06.018_bib0175","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/0090-8258(89)90523-4","article-title":"Synchronous primary neoplasms of the female reproductive tract","volume":"33","author":"Eisner","year":"1989","journal-title":"Gynecol Oncol"},{"issue":"3","key":"10.1016\/j.bulcan.2017.06.018_bib0180","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1002\/1096-9896(2000)9999:9999<::AID-PATH701>3.0.CO;2-2","article-title":"Prediction of a mismatch repair gene defect by microsatellite instability and immunohistochemical analysis in endometrial tumours from HNPCC patients","volume":"192","author":"de Leeuw","year":"2000","journal-title":"J Pathol"},{"issue":"2","key":"10.1016\/j.bulcan.2017.06.018_bib0185","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1158\/1940-6207.CAPR-16-0219","article-title":"Clinical challenges associated with universal screening for lynch syndrome-associated endometrial cancer","volume":"10","author":"Bruegl","year":"2017","journal-title":"Cancer Prev Res (Phila)"},{"key":"10.1016\/j.bulcan.2017.06.018_bib0190","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1111\/j.1525-1438.2006.00219.x","article-title":"Successful pregnancy after hysteroscopic removal of grade I endometrial carcinoma in a young woman with Lynch syndrome","volume":"16","author":"Sparac","year":"2006","journal-title":"Int J Gynecol Cancer"},{"key":"10.1016\/j.bulcan.2017.06.018_bib0195","series-title":"Chirurgie prophylactique des cancers avec pr\u00e9disposition g\u00e9n\u00e9tique. Syndrome HNPCC\/Lynch","year":"2009"},{"issue":"1","key":"10.1016\/j.bulcan.2017.06.018_bib0200","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1093\/annonc\/mdv484","article-title":"ESMO-ESGO-ESTRO Endometrial Consensus Conference Working Group. ESMO-ESGO-ESTRO consensus conference on endometrial cancer: diagnosis, treatment and follow-up","volume":"27","author":"Colombo","year":"2016","journal-title":"Ann Oncol"},{"issue":"2","key":"10.1016\/j.bulcan.2017.06.018_bib0205","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1002\/ijc.10667","article-title":"Survival analysis of endometrial carcinoma associated with hereditary nonpolyposis colorectal cancer","volume":"102","author":"Boks","year":"2002","journal-title":"Int J Cancer J Int Cancer"},{"key":"10.1016\/j.bulcan.2017.06.018_bib0210","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/S0090-8258(03)00371-8","article-title":"Gynecologic screening in hereditary non polyposis colorectal cancer","volume":"91","author":"Rijcken","year":"2003","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.bulcan.2017.06.018_bib0215","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1111\/IGC.0b013e3181d7283a","article-title":"Contribution of ultrasonography to endometrial cancer screening in patients with hereditary nonpolyposis colorectal cancer\/Lynch syndrome","volume":"20","author":"L\u00e9curu","year":"2010","journal-title":"Int J Gynecol Cancer"},{"key":"10.1016\/j.bulcan.2017.06.018_bib0220","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1002\/ijc.22446","article-title":"Surveillance for endometrial cancer in hereditary nonpolyposis colorectal cancer syndrome","volume":"120","author":"Renkonen-Sinisalo","year":"2006","journal-title":"Int J Cancer"},{"issue":"4","key":"10.1016\/j.bulcan.2017.06.018_bib0225","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1111\/IGC.0b013e3181d7283a","article-title":"Contribution of ultrasonography to endometrial cancer screening in patients with hereditary nonpolyposis colorectal cancer\/Lynch syndrome","volume":"20","author":"L\u00e9curu","year":"2010","journal-title":"Int J Gynecol Cancer"},{"issue":"6","key":"10.1016\/j.bulcan.2017.06.018_bib0230","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1007\/s00404-012-2492-2","article-title":"Annual outpatient hysteroscopy and endometrial sampling (OHES) in HNPCC\/Lynch syndrome (LS)","volume":"286","author":"Manchanda","year":"2012","journal-title":"Arch Gynecol Obstet"},{"issue":"3","key":"10.1016\/j.bulcan.2017.06.018_bib0235","doi-asserted-by":"crossref","first-page":"526","DOI":"10.1016\/j.ygyno.2014.03.012","article-title":"The results of gynecologic surveillance in families with hereditary nonpolyposis colorectal cancer","volume":"133","author":"Ketabi","year":"2014","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.bulcan.2017.06.018_bib0240","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1056\/NEJMoa052627","article-title":"Prophylactic surgery to reduce the risk of gynaecologic cancers in the Lynch syndrome","volume":"354","author":"Schmeler","year":"2006","journal-title":"N Engl J Med"},{"issue":"8","key":"10.1016\/j.bulcan.2017.06.018_bib0245","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1158\/1940-6207.CAPR-13-0020","article-title":"Prospective multicenter randomized intermediate biomarker study of oral contraceptive versus depo-provera for prevention of endometrial cancer in women with Lynch syndrome","volume":"6","author":"Lu","year":"2013","journal-title":"Cancer Prev Res (Phila)"}],"container-title":["Bulletin du Cancer"],"original-title":[],"language":"fr","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0007455117302370?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0007455117302370?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,6,27]],"date-time":"2024-06-27T23:12:42Z","timestamp":1719529962000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0007455117302370"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12]]},"references-count":49,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2017,12]]}},"alternative-id":["S0007455117302370"],"URL":"https:\/\/doi.org\/10.1016\/j.bulcan.2017.06.018","relation":{},"ISSN":["0007-4551"],"issn-type":[{"value":"0007-4551","type":"print"}],"subject":[],"published":{"date-parts":[[2017,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Syndrome de Lynch et cancer de l\u2019endom\u00e8tre","name":"articletitle","label":"Article Title"},{"value":"Bulletin du Cancer","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bulcan.2017.06.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Soci\u00e9t\u00e9 Fran\u00e7aise du Cancer. Published by Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}]}}