{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T12:22:10Z","timestamp":1788524530753,"version":"build-2803163510"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bulletin du Cancer"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.bulcan.2026.07.002","type":"journal-article","created":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T12:10:31Z","timestamp":1788523831000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["French treatment recommendations for malignant non-seminomatous germ cell tumours in children and adolescents"],"prefix":"10.1016","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1991-3585","authenticated-orcid":false,"given":"H\u00e9l\u00e8ne","family":"Sudour-Bonnange","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cile","family":"V\u00e9rit\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederic","family":"Hameury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Rod","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brice","family":"Fresneau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Orbach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Estelle","family":"Thebaud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ang\u00e9lique","family":"Rome","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Weinhart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederique","family":"Dijoud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9cile","family":"Faure-Conter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.bulcan.2026.07.002_bib0155","first-page":"145","article-title":"Germ cell tumours","volume":"5","author":"Talerman","year":"1985","journal-title":"Ann Pathol"},{"issue":"2","key":"10.1016\/j.bulcan.2026.07.002_bib0160","first-page":"195","article-title":"Could aberrant migration explain metachronous germ cell tumors?","volume":"39","author":"Kubicek","year":"2021","journal-title":"Cancer Invest"},{"key":"10.1016\/j.bulcan.2026.07.002_bib0165","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1089\/jayao.2024.0136","article-title":"Trends in the incidence of cancer among adolescents and young adults between 2000 and 2020: a study based on French population-based registry data","volume":"14","author":"Desandes","year":"2025","journal-title":"J Adolesc Young Adult Oncol"},{"key":"10.1016\/j.bulcan.2026.07.002_bib0170","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1053\/j.sempedsurg.2011.10.005","article-title":"Pediatric germ cell tumors","volume":"21","author":"Rescorla","year":"2012","journal-title":"Semin Pediatr Surg"},{"key":"10.1016\/j.bulcan.2026.07.002_bib0175","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/S0959-8049(99)00317-2","article-title":"Non-seminomatous ovarian germ cell tumours in children","volume":"36","author":"Baranzelli","year":"2000","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.bulcan.2026.07.002_bib0180","doi-asserted-by":"crossref","first-page":"1212","DOI":"10.1200\/JCO.1999.17.4.1212","article-title":"Prognostic factors in children with localized malignant nonseminomatous germ cell tumors","volume":"17","author":"Baranzelli","year":"1999","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.bulcan.2026.07.002_bib0185","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.ejca.2018.02.029","article-title":"Is alpha-fetoprotein decline a prognostic factor of childhood non-seminomatous germ cell tumours? Results of the French TGM95 study","volume":"95","author":"Fresneau","year":"2018","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.bulcan.2026.07.002_bib0190","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1097\/01.mph.0000141348.62532.73","article-title":"Platinum compound-related ototoxicity in children: long-term follow-up reveals continuous worsening of hearing loss","volume":"26","author":"Bertolini","year":"2004","journal-title":"J Pediatr Hematol Oncol"},{"key":"10.1016\/j.bulcan.2026.07.002_bib0195","doi-asserted-by":"crossref","first-page":"e30117","DOI":"10.1002\/pbc.30117","article-title":"Extracranial germ cell tumours in children and adolescents: results from the French TGM13 protocol","volume":"70","author":"Faure-Conter","year":"2023","journal-title":"Pediatr Blood Cancer"},{"key":"10.1016\/j.bulcan.2026.07.002_bib0200","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1200\/JCO.2014.58.3369","article-title":"Revised risk classification for pediatric extracranial germ cell tumors based on 25 years of clinical trial data from the United Kingdom and United States","volume":"33","author":"Frazier","year":"2015","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.bulcan.2026.07.002_bib0205","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1200\/JCO.1997.15.2.594","article-title":"International Germ Cell Consensus Classification: a prognostic factor-based staging system for metastatic germ cell cancers","volume":"15","year":"1997","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.bulcan.2026.07.002_bib0210","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ijgo.2013.10.001","article-title":"Staging classification for cancer of the ovary, fallopian tube, and peritoneum","volume":"124","author":"Prat","year":"2014","journal-title":"Int J Gynecol Obstet"},{"key":"10.1016\/j.bulcan.2026.07.002_bib0215","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s11604-015-0513-3","article-title":"Revised FIGO staging system for cancer of the ovary, fallopian tube, and peritoneum: important implications for radiologists","volume":"34","author":"Saida","year":"2016","journal-title":"Jpn J Radiol"},{"key":"10.1016\/j.bulcan.2026.07.002_bib0220","doi-asserted-by":"crossref","first-page":"e22","DOI":"10.1097\/PAS.0000000000000844","article-title":"Reporting and staging of testicular germ cell tumors: The International Society of Urological Pathology (ISUP) Testicular Cancer Consultation Conference","volume":"41","author":"Verrill","year":"2017","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.bulcan.2026.07.002_bib0225","first-page":"93","article-title":"The Eighth Edition AJCC Cancer Staging Manual: continuing to build a bridge from a population-based to a more \u201cpersonalized\u201d approach to cancer staging","volume":"67","author":"Amin","year":"2017","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.bulcan.2026.07.002_bib0230","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1016\/j.purol.2022.09.009","article-title":"French AFU Cancer Committee Guidelines\u00a0\u2013\u00a0Update 2022\u20132024: testicular germ cell cancer","volume":"32","author":"Murez","year":"2022","journal-title":"Prog Urol"},{"key":"10.1016\/j.bulcan.2026.07.002_bib0235","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1684\/bdc.2013.1729","article-title":"Les tumeurs germinales de l\u2019enfant","volume":"100","author":"Faure-Conter","year":"2013","journal-title":"Bull Cancer (Paris)"},{"issue":"6","key":"10.1016\/j.bulcan.2026.07.002_bib0240","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.bulcan.2015.04.012","article-title":"Specificities of sex-cord stromal tumors in children and adolescents","volume":"102","author":"Thebaud","year":"2015","journal-title":"Bull Cancer"},{"issue":"5","key":"10.1016\/j.bulcan.2026.07.002_bib0245","doi-asserted-by":"crossref","first-page":"151343","DOI":"10.1016\/j.sempedsurg.2023.151343","article-title":"Critical elements of pediatric testicular germ cell tumors surgery","volume":"32","author":"Saltzman","year":"2023","journal-title":"Semin Pediatr Surg"},{"issue":"7","key":"10.1016\/j.bulcan.2026.07.002_bib0250","doi-asserted-by":"crossref","first-page":"e360","DOI":"10.1016\/S1470-2045(20)30091-7","article-title":"ESGO\u2013SIOPE guidelines for the management of adolescents and young adults with non-epithelial ovarian cancers","volume":"21","author":"Sessa","year":"2020","journal-title":"The Lancet Oncology"},{"issue":"9","key":"10.1016\/j.bulcan.2026.07.002_bib0255","doi-asserted-by":"crossref","first-page":"e26494","DOI":"10.1002\/pbc.26494","article-title":"Primary mediastinal and retroperitoneal malignant germ cell tumors in children and adolescents: results of the TGM95 trial, a study of the French Society of Pediatric Oncology (Soci\u00e9t\u00e9 fran\u00e7aise des cancers de l\u2019enfant)","volume":"64","author":"Sudour-Bonnange","year":"2017","journal-title":"Pediatr Blood Cancer"},{"key":"10.1016\/j.bulcan.2026.07.002_bib0260","first-page":"398549","article-title":"Long-term outcomes of sacrococcygeal germ cell tumors in infancy and childhood","volume":"2015","author":"Niramis","year":"2015","journal-title":"Surg Res Pract"},{"issue":"1","key":"10.1016\/j.bulcan.2026.07.002_bib0265","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1007\/s00383-023-05454-6","article-title":"It is all about form and function: a new approach to giant neonatal sacrococcygeal teratomas","volume":"39","author":"Bougie","year":"2023","journal-title":"Pediatr Surg Int"},{"key":"10.1016\/j.bulcan.2026.07.002_bib0270","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1200\/JCO.23.01099","article-title":"Adolescent and young adult germ cell tumors: epidemiology, genomics, treatment, and survivorship","volume":"42","author":"Travis","year":"2024","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.bulcan.2026.07.002_bib0275","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1016\/j.bulcan.2016.10.005","article-title":"Tumeur germinale extracr\u00e2nienne de l\u2019adolescent et de l\u2019adulte jeune, de l\u2019int\u00e9r\u00eat d\u2019un regard crois\u00e9 entre oncologues d\u2019adultes et oncop\u00e9diatres","volume":"103","author":"Chevreau","year":"2016","journal-title":"Bull Cancer (Paris)"},{"key":"10.1016\/j.bulcan.2026.07.002_bib0280","doi-asserted-by":"crossref","first-page":"3270","DOI":"10.1200\/JCO.23.01960","article-title":"Personalized chemotherapy on the basis of tumor marker decline in poor-prognosis germ-cell tumors: updated analysis of the GETUG-13 phase III trial","volume":"42","author":"Fizazi","year":"2024","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.bulcan.2026.07.002_bib0285","unstructured":"clinciatrial.gov. Validation of a treatment algorithm for poor-risk NSGCTnon seminomatous germ-cell tumors (VAPOR) n.d. https:\/\/www.clinicaltrials.gov\/study\/NCT05705687."},{"key":"10.1016\/j.bulcan.2026.07.002_bib0290","unstructured":"A randomised phase III trial comparing conventional-dose chemotherapy using paclitaxel, ifosfamide, and cisplatin (TIP) with high dose chemotherapy using mobilizing paclitaxel followed by high dose carboplatin and etoposide (TI-CE) as first salvage treatment in relapsed or refractory germ cell tumours. EUCT\/ID-RCB: 2014-003930-17. ClinicaltrialsregisterEu n.d. https:\/\/www.clinicaltrialsregister.eu\/ctr-search\/search?query=2014-003930-17."},{"key":"10.1016\/j.bulcan.2026.07.002_bib0295","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.annpat.2014.01.007","article-title":"Observatoire des tumeurs malignes rares gyn\u00e9cologiques","volume":"34","author":"Devouassoux-Shisheboran","year":"2014","journal-title":"Ann Pathol"},{"key":"10.1016\/j.bulcan.2026.07.002_bib0300","doi-asserted-by":"crossref","first-page":"e360","DOI":"10.1016\/S1470-2045(20)30091-7","article-title":"ESGO\u2013SIOPE guidelines for the management of adolescents and young adults with non-epithelial ovarian cancers","volume":"21","author":"Sessa","year":"2020","journal-title":"Lancet Oncol"}],"container-title":["Bulletin du Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0007455126003930?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0007455126003930?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T12:10:35Z","timestamp":1788523835000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0007455126003930"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":30,"alternative-id":["S0007455126003930"],"URL":"https:\/\/doi.org\/10.1016\/j.bulcan.2026.07.002","relation":{},"ISSN":["0007-4551"],"issn-type":[{"value":"0007-4551","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"French treatment recommendations for malignant non-seminomatous germ cell tumours in children and adolescents","name":"articletitle","label":"Article Title"},{"value":"Bulletin du Cancer","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bulcan.2026.07.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Soci\u00e9t\u00e9 Fran\u00e7aise du Cancer. Published by Elsevier Masson SAS. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}