{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T21:13:54Z","timestamp":1788556434840,"version":"build-2803163510"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Bulletin du Cancer"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.bulcan.2026.07.013","type":"journal-article","created":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T11:19:17Z","timestamp":1788434357000},"update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["A comprehensive review on the molecular basis and therapeutic potential of UBE2M in cancer"],"prefix":"10.1016","author":[{"given":"Bin","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.bulcan.2026.07.013_bib0145","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1038\/s41392-024-01800-9","article-title":"Protein neddylation and its role in health and diseases","volume":"9","author":"Zhang","year":"2024","journal-title":"Signal Transduct Target Ther"},{"issue":"7","key":"10.1016\/j.bulcan.2026.07.013_bib0150","doi-asserted-by":"crossref","first-page":"738","DOI":"10.3390\/biom14070738","article-title":"The double-edged effects of MLN4924: rethinking anti-cancer drugs targeting the neddylation pathway","volume":"14","author":"Tang","year":"2024","journal-title":"Biomolecules"},{"issue":"6","key":"10.1016\/j.bulcan.2026.07.013_bib0155","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1038\/s41375-023-01889-x","article-title":"Pharmacologic targeting of Nedd8-activating enzyme reinvigorates T-cell responses in lymphoid neoplasia","volume":"37","author":"Wang","year":"2023","journal-title":"Leukemia"},{"issue":"1","key":"10.1016\/j.bulcan.2026.07.013_bib0160","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s12964-022-00834-2","article-title":"Combination of artesunate and WNT974 induces KRAS protein degradation by upregulating E3 ligase ANACP2 and \u03b2-TrCP in the ubiquitin-proteasome pathway","volume":"20","author":"Gong","year":"2022","journal-title":"Cell Commun Signal"},{"issue":"Pt 3","key":"10.1016\/j.bulcan.2026.07.013_bib0165","doi-asserted-by":"crossref","first-page":"126801","DOI":"10.1016\/j.ijbiomac.2023.126801","article-title":"Neddylation-dependent LSD1 destabilization inhibits the stemness and chemoresistance of gastric cancer","volume":"254","author":"Guo","year":"2024","journal-title":"Int J Biol Macromol"},{"issue":"8","key":"10.1016\/j.bulcan.2026.07.013_bib0170","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1038\/s41419-024-06979-x","article-title":"UBE2M forms a positive feedback loop with estrogen receptor to drive breast cancer progression and drug resistance","volume":"15","author":"Lin","year":"2024","journal-title":"Cell Death Dis"},{"issue":"1","key":"10.1016\/j.bulcan.2026.07.013_bib0175","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/s12967-025-07531-x","article-title":"UBE2M inhibits neoplastic cell proliferation via MKK7-JNK-EGR1 axis in melanoma","volume":"24","author":"Xu","year":"2025","journal-title":"J Transl Med"},{"issue":"19","key":"10.1016\/j.bulcan.2026.07.013_bib0180","doi-asserted-by":"crossref","first-page":"4901","DOI":"10.3390\/cancers13194901","article-title":"UBE2M drives hepatocellular cancer progression as a p53 negative regulator by binding to MDM2 and Ribosomal Protein L11","volume":"13","author":"Kim","year":"2021","journal-title":"Cancers (Basel)"},{"issue":"6","key":"10.1016\/j.bulcan.2026.07.013_bib0185","first-page":"2670","article-title":"Knockdown of Nedd8-conjugating enzyme UBE2M suppresses the proliferation and induces the apoptosis of intrahepatic cholangiocarcinoma cells","volume":"42","author":"Zhao","year":"2019","journal-title":"Oncol Rep"},{"issue":"9","key":"10.1016\/j.bulcan.2026.07.013_bib0190","doi-asserted-by":"crossref","first-page":"5614","DOI":"10.21037\/tcr-20-2641","article-title":"Overexpression of UBE2M through Wnt\/\u03b2-Catenin signaling is associated with poor prognosis and chemotherapy resistance in colorectal cancer","volume":"9","author":"Xu","year":"2020","journal-title":"Transl Cancer Res"},{"key":"10.1016\/j.bulcan.2026.07.013_bib0195","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.ebiom.2019.06.005","article-title":"Validation of NEDD8-conjugating enzyme UBC12 as a new therapeutic target in lung cancer","volume":"45","author":"Li","year":"2019","journal-title":"EBioMedicine"},{"issue":"2","key":"10.1016\/j.bulcan.2026.07.013_bib0200","doi-asserted-by":"crossref","first-page":"112614","DOI":"10.1016\/j.yexcr.2021.112614","article-title":"NPRL2 reduces the niraparib sensitivity of castration-resistant prostate cancer via interacting with UBE2M and enhancing neddylation","volume":"403","author":"Zhao","year":"2021","journal-title":"Exp Cell Res"},{"issue":"8","key":"10.1016\/j.bulcan.2026.07.013_bib0205","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20220994","article-title":"Inhibition of NEDD8 NEDDylation induced apoptosis in acute myeloid leukemia cells via p53 signaling pathway","volume":"42","author":"Chen","year":"2022","journal-title":"Biosci Rep"},{"issue":"7","key":"10.1016\/j.bulcan.2026.07.013_bib0210","doi-asserted-by":"crossref","first-page":"3363","DOI":"10.1002\/cam4.1578","article-title":"Overactivated neddylation pathway in human hepatocellular carcinoma","volume":"7","author":"Yu","year":"2018","journal-title":"Cancer Med"},{"issue":"10","key":"10.1016\/j.bulcan.2026.07.013_bib0215","doi-asserted-by":"crossref","first-page":"100551","DOI":"10.1016\/j.jhepr.2022.100551","article-title":"Dual role of neddylation in transcription of hepatitis B virus RNAs from cccDNA and production of viral surface antigen","volume":"4","author":"Qu","year":"2022","journal-title":"JHEP Rep"},{"issue":"29","key":"10.1016\/j.bulcan.2026.07.013_bib0220","doi-asserted-by":"crossref","first-page":"45263","DOI":"10.18632\/oncotarget.9481","article-title":"MLN4924 suppresses neddylation and induces cell cycle arrest, senescence, and apoptosis in human osteosarcoma","volume":"7","author":"Zhang","year":"2016","journal-title":"Oncotarget"},{"issue":"6","key":"10.1016\/j.bulcan.2026.07.013_bib0225","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1007\/s00280-018-3582-z","article-title":"A first-in-class inhibitor, MLN4924 (pevonedistat), induces cell-cycle arrest, senescence, and apoptosis in human renal cell carcinoma by suppressing UBE2M-dependent neddylation modification","volume":"81","author":"Xu","year":"2018","journal-title":"Cancer Chemother Pharmacol"},{"issue":"3","key":"10.1016\/j.bulcan.2026.07.013_bib0230","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1016\/j.bbrc.2018.12.048","article-title":"Disruption of protein neddylation with MLN4924 attenuates paclitaxel-induced apoptosis and microtubule polymerization in ovarian cancer cells","volume":"508","author":"Hong","year":"2019","journal-title":"Biochem Biophys Res Commun"},{"issue":"2","key":"10.1016\/j.bulcan.2026.07.013_bib0235","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1038\/s12276-026-01636-z","article-title":"UBE2M as a bridge spanning neddylation and cell cycle regulation in colorectal adenocarcinoma","volume":"58","author":"Wang","year":"2026","journal-title":"Exp Mol Med"},{"key":"10.1016\/j.bulcan.2026.07.013_bib0240","doi-asserted-by":"crossref","first-page":"146646","DOI":"10.1016\/j.brainres.2020.146646","article-title":"Proteome and miRNome profiling of microvesicles derived from medulloblastoma cell lines with stem-like properties reveals biomarkers of poor prognosis","volume":"1730","author":"Kaid","year":"2020","journal-title":"Brain Res"},{"issue":"1","key":"10.1016\/j.bulcan.2026.07.013_bib0245","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1038\/s41467-017-01243-7","article-title":"A potent small-molecule inhibitor of the DCN1-UBC12 interaction that selectively blocks Cullin 3 neddylation","volume":"8","author":"Zhou","year":"2017","journal-title":"Nat Commun"},{"issue":"3","key":"10.1016\/j.bulcan.2026.07.013_bib0250","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1038\/s41401-022-00992-6","article-title":"Arctigenin impairs UBC12 enzyme activity and cullin neddylation to attenuate cancer cells","volume":"44","author":"Chen","year":"2023","journal-title":"Acta Pharmacol Sin"},{"key":"10.1016\/j.bulcan.2026.07.013_bib0255","doi-asserted-by":"crossref","first-page":"107142","DOI":"10.1016\/j.bioorg.2024.107142","article-title":"Proapoptotic effect of WS-299 induced by NOXA accumulation and NRF2-counterbalanced oxidative stress damage through targeting RBX1-UBE2M interaction in gastric cancers","volume":"144","author":"Ma","year":"2024","journal-title":"Bioorg Chem"},{"issue":"6","key":"10.1016\/j.bulcan.2026.07.013_bib0260","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1038\/s41375-023-01889-x","article-title":"Pharmacologic targeting of Nedd8-activating enzyme reinvigorates T-cell responses in lymphoid neoplasia","volume":"37","author":"Wang","year":"2023","journal-title":"Leukemia"},{"issue":"1","key":"10.1016\/j.bulcan.2026.07.013_bib0265","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1186\/s13046-022-02284-7","article-title":"SKP2 drives the sensitivity to neddylation inhibitors and cisplatin in malignant pleural mesothelioma","volume":"41","author":"Salaroglio","year":"2022","journal-title":"J Exp Clin Cancer Res"},{"issue":"8","key":"10.1016\/j.bulcan.2026.07.013_bib0270","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1016\/j.cmet.2023.05.011","article-title":"UBE2M-mediated neddylation of TRIM21 regulates obesity-induced inflammation and metabolic disorders","volume":"35","author":"Lu","year":"2023","journal-title":"Cell Metab"},{"issue":"1","key":"10.1016\/j.bulcan.2026.07.013_bib0275","doi-asserted-by":"crossref","first-page":"108085","DOI":"10.1016\/j.jbc.2024.108085","article-title":"Inhibition of the neddylation E2 enzyme UBE2M in macrophages protects against E.\u00a0coli-induced sepsis","volume":"301","author":"Wen","year":"2025","journal-title":"J Biol Chem"},{"issue":"6","key":"10.1016\/j.bulcan.2026.07.013_bib0280","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1016\/j.molcel.2018.06.002","article-title":"UBE2M is a stress-inducible dual E2 for neddylation and ubiquitylation that promotes targeted degradation of UBE2F","volume":"70","author":"Zhou","year":"2018","journal-title":"Mol Cell"}],"container-title":["Bulletin du Cancer"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0007455126003917?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0007455126003917?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T20:31:02Z","timestamp":1788553862000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0007455126003917"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":28,"alternative-id":["S0007455126003917"],"URL":"https:\/\/doi.org\/10.1016\/j.bulcan.2026.07.013","relation":{},"ISSN":["0007-4551"],"issn-type":[{"value":"0007-4551","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A comprehensive review on the molecular basis and therapeutic potential of UBE2M in cancer","name":"articletitle","label":"Article Title"},{"value":"Bulletin du Cancer","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bulcan.2026.07.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Soci\u00e9t\u00e9 Fran\u00e7aise du Cancer. Published by Elsevier Masson SAS. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}