{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T03:01:13Z","timestamp":1787972473973,"version":"build-2784847793"},"reference-count":43,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2011,6,1]],"date-time":"2011-06-01T00:00:00Z","timestamp":1306886400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Burns"],"published-print":{"date-parts":[[2011,6]]},"DOI":"10.1016\/j.burns.2010.12.011","type":"journal-article","created":{"date-parts":[[2011,2,19]],"date-time":"2011-02-19T04:53:07Z","timestamp":1298091187000},"page":"638-645","source":"Crossref","is-referenced-by-count":13,"title":["Mechanistic aspects of inducible nitric oxide synthase-induced lung injury in burn trauma"],"prefix":"10.1016","volume":"37","author":[{"given":"Perenlei","family":"Enkhbaatar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianpu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fiona","family":"Saunders","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthias","family":"Lange","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsumori","family":"Hamahata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Rehberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John F.","family":"Parkinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lillian D.","family":"Traber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David N.","family":"Herndon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel L.","family":"Traber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.burns.2010.12.011_bib0005","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1056\/NEJM200005043421806","article-title":"The acute respiratory distress syndrome","volume":"342","author":"Ware","year":"2000","journal-title":"N Engl J Med"},{"key":"10.1016\/j.burns.2010.12.011_bib0010","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1042\/CS20040135","article-title":"Pathophysiology of acute lung injury in combined burn and smoke inhalation injury","volume":"107","author":"Enkhbaatar","year":"2004","journal-title":"Clin Sci (Lond)"},{"key":"10.1016\/j.burns.2010.12.011_bib0015","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1164\/rccm.200209-1031PP","article-title":"The inducible nitric oxide synthase inhibitor BBS-2 prevents acute lung injury in sheep after burn and smoke inhalation injury","volume":"167","author":"Enkhbaatar","year":"2003","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.burns.2010.12.011_bib0020","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1097\/01.shk.0000129201.38588.85","article-title":"Aerosolized tissue plasminogen activator improves pulmonary function in sheep with burn and smoke inhalation","volume":"22","author":"Enkhbaatar","year":"2004","journal-title":"Shock"},{"key":"10.1016\/j.burns.2010.12.011_bib0025","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1097\/01.shk.0000208805.23182.a7","article-title":"Aerosolized alpha-tocopherol ameliorates acute lung injury following combined burn and smoke inhalation injury in sheep","volume":"25","author":"Morita","year":"2006","journal-title":"Shock"},{"key":"10.1016\/j.burns.2010.12.011_bib0030","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1074\/jbc.M105691200","article-title":"Mechanistic studies with potent and selective inducible nitric-oxide synthase dimerization inhibitors","volume":"277","author":"Blasko","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1016\/j.burns.2010.12.011_bib0035","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1073\/pnas.97.4.1506","article-title":"Allosteric inhibitors of inducible nitric oxide synthase dimerization discovered via combinatorial chemistry","volume":"97","author":"McMillan","year":"2000","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.burns.2010.12.011_bib0040","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1097\/SHK.0b013e318193e2ba","article-title":"Role of neuronal nitric oxide synthase in ovine sepsis model","volume":"32","author":"Enkhbaatar","year":"2009","journal-title":"Shock"},{"key":"10.1016\/j.burns.2010.12.011_bib0045","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1097\/01.shk.0000209525.50990.28","article-title":"The inhibition of inducible nitric oxide synthase in ovine sepsis model","volume":"25","author":"Enkhbaatar","year":"2006","journal-title":"Shock"},{"key":"10.1016\/j.burns.2010.12.011_bib0050","doi-asserted-by":"crossref","first-page":"L440","DOI":"10.1152\/ajplung.00202.2001","article-title":"Increased expansion of the lung stimulates calmodulin 2 expression in fetal sheep","volume":"282","author":"Gillett","year":"2002","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.burns.2010.12.011_bib0055","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1164\/rccm.200407-953OC","article-title":"The critical role of hematopoietic cells in lipopolysaccharide-induced airway inflammation","volume":"171","author":"Hollingsworth","year":"2005","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.burns.2010.12.011_bib0060","doi-asserted-by":"crossref","first-page":"L240","DOI":"10.1152\/ajplung.00319.2002","article-title":"Effect of poly(ADP ribose) synthetase inhibition on burn and smoke inhalation injury in sheep","volume":"285","author":"Shimoda","year":"2003","journal-title":"Am. J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.burns.2010.12.011_bib0065","doi-asserted-by":"crossref","first-page":"221","DOI":"10.2119\/2006-00055.Toth-Zsamboki","article-title":"Activation of poly(ADP-ribose) polymerase by myocardial ischemia and coronary reperfusion in human circulating leukocytes","volume":"12","author":"T\u00f3th-Zs\u00e1mboki","year":"2006","journal-title":"Mol Med"},{"key":"10.1016\/j.burns.2010.12.011_bib0070","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1016\/j.jvs.2005.11.021","article-title":"Activation of the peroxynitrite-poly (adenosine diphosphate-ribose) polymerase pathway during neointima proliferation: a new target to prevent restenosis after endarterectomy","volume":"43","author":"Beller","year":"2006","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.burns.2010.12.011_bib0075","series-title":"Molecular cloning. A laboratory manual","author":"Sambrook","year":"1989"},{"key":"10.1016\/j.burns.2010.12.011_bib0080","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1053\/j.gastro.2005.07.058","article-title":"Negative transcriptional regulation of human colonic smooth muscle cav1.2 channels by p50 and p65 subunits of nuclear factor-kappab","volume":"129","author":"Shi","year":"2005","journal-title":"Gastroenterology"},{"key":"10.1016\/j.burns.2010.12.011_bib0085","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0005-2728(99)00019-5","article-title":"Relationships between nitric oxide, nitroxyl ion, nitrosonium cation and peroxynitrite","volume":"1411","author":"Hughes","year":"1999","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.burns.2010.12.011_bib0090","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1038\/nrd2222","article-title":"Peroxynitrite: biochemistry, pathophysiology and development of therapeutics","volume":"6","author":"Szabo","year":"2007","journal-title":"Nat Rev Drug Disc"},{"key":"10.1016\/j.burns.2010.12.011_bib0095","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1126\/science.8080500","article-title":"Nitric oxide activation of poly(ADP-ribose) synthetase in neurotoxicity","volume":"263","author":"Zhang","year":"1994","journal-title":"Science"},{"key":"10.1016\/j.burns.2010.12.011_bib0100","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1172\/JCI119585","article-title":"Endothelial dysfunction in a rat model of endotoxic shock. Importance of the activation of poly (ADP-ribose) synthetase by peroxynitrite","volume":"100","author":"Szab\u00f3","year":"1997","journal-title":"J Clin Invest"},{"key":"10.1016\/j.burns.2010.12.011_bib0105","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1164\/ajrccm.156.3.9701033","article-title":"Nitric oxide synthase inhibition restores hypoxic pulmonary vasoconstriction in sepsis","volume":"156","author":"Fischer","year":"1997","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.burns.2010.12.011_bib0110","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1164\/ajrccm.153.1.8542138","article-title":"Effect of sodium nitroprusside and diethylcarbamazine on hypoxic pulmonary vasoconstriction and regional distribution of pulmonary blood flow in experimental pneumonia","volume":"153","author":"Light","year":"1996","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.burns.2010.12.011_bib0115","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1097\/CCM.0b013e318193226a","article-title":"Inhibition of neuronal nitric oxide synthase in ovine model of acute lung injury","volume":"37","author":"Enkhbaatar","year":"2009","journal-title":"Crit Care Med"},{"key":"10.1016\/j.burns.2010.12.011_bib0120","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1097\/CCM.0b013e3181926104","article-title":"Combined neuronal and inducible nitric oxide synthase inhibition in ovine acute lung injury","volume":"37","author":"Lange","year":"2009","journal-title":"Crit Care Med"},{"key":"10.1016\/j.burns.2010.12.011_bib0125","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1097\/01.shk.0000108397.56565.4a","article-title":"Inhibition of poly (ADP-ribose) polymerase attenuates acute lung injury in an ovine model of sepsis","volume":"21","author":"Murakami","year":"2004","journal-title":"Shock"},{"key":"10.1016\/j.burns.2010.12.011_bib0130","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1097\/01.shk.0000140304.71215.f7","article-title":"Inducible nitric oxide synthase inhibitor reverses exacerbating effects of hypertonic saline on lung injury in shock","volume":"22","author":"Chen","year":"2004","journal-title":"Shock"},{"key":"10.1016\/j.burns.2010.12.011_bib0135","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1016\/j.bbrc.2008.10.066","article-title":"Lung-protective effects of the metalloporphyrinic peroxynitrite decomposition catalyst WW-85 in interleukin-2 induced toxicity","volume":"377","author":"Maybauer","year":"2008","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.burns.2010.12.011_bib0140","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1007\/s00018-002-8527-2","article-title":"The functional role of poly(ADP-ribose)polymerase 1 as novel coactivator of NF-kappaB in inflammatory disorders","volume":"59","author":"Hassa","year":"2002","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.burns.2010.12.011_bib0145","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/S0092-8674(03)00433-1","article-title":"PARP goes transcription","volume":"113","author":"Kraus","year":"2003","journal-title":"Cell"},{"key":"10.1016\/j.burns.2010.12.011_bib0150","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.1101\/gad.1228704","article-title":"Signaling to NF-kappaB","volume":"18","author":"Hayden","year":"2004","journal-title":"Genes Dev"},{"key":"10.1016\/j.burns.2010.12.011_bib0155","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/1749-7922-1-15","article-title":"Trauma: the role of the innate immune system","volume":"1","author":"Hietbrink","year":"2006","journal-title":"World J Emerg Surg"},{"key":"10.1016\/j.burns.2010.12.011_bib0160","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1016\/j.injury.2005.03.009","article-title":"Enhanced neutrophil migratory activity following major blunt trauma","volume":"36","author":"Bhatia","year":"2005","journal-title":"Injury"},{"key":"10.1016\/j.burns.2010.12.011_bib0165","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1006\/niox.2001.0378","article-title":"Role of mitogen activated protein kinases and tyrosine kinases on IL-1-induced NF-kB activation and iNOS expression in bovine articular chondrocytes","volume":"6","author":"Mendes","year":"2002","journal-title":"Nitric Oxide"},{"key":"10.1016\/j.burns.2010.12.011_bib0170","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1006\/bbrc.1993.1637","article-title":"Induction of nitric oxide synthase in human chondrocytes","volume":"193","author":"Palmer","year":"1993","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.burns.2010.12.011_bib0175","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1164\/ajrccm.163.3.9912052","article-title":"Role of nitric oxide in vascular permeability after combined burns and smoke inhalation injury","volume":"163","author":"Soejima","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.burns.2010.12.011_bib0180","doi-asserted-by":"crossref","first-page":"L427","DOI":"10.1152\/ajplung.00147.2009","article-title":"Molecular biological effects of selective neuronal nitric oxide synthase inhibition in ovine lung injury","volume":"298","author":"Saunders","year":"2010","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.burns.2010.12.011_bib0185","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.pupt.2005.12.006","article-title":"The role of the bronchial circulation in the acute lung injury resulting from burn and smoke inhalation","volume":"20","author":"Traber","year":"2007","journal-title":"Pulm Pharmacol Ther"},{"key":"10.1016\/j.burns.2010.12.011_bib0190","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1097\/00004630-200101000-00012","article-title":"The expression of cyclooxygenase and the production of prostaglandin E2 in neutrophils after burn injury and infection","volume":"22","author":"He","year":"2001","journal-title":"J. Burn Care Rehabil"},{"key":"10.1016\/j.burns.2010.12.011_bib0195","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1097\/00000658-199109000-00008","article-title":"The role of prostaglandin E2 in immune suppression following injury","volume":"214","author":"Grbic","year":"1991","journal-title":"Ann Surg"},{"key":"10.1016\/j.burns.2010.12.011_bib0200","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1097\/00005373-199808000-00003","article-title":"Cyclooxygenase-2 inhibitor NS-398 improves survival and restores leukocyte counts in burn infection","volume":"45","author":"Shoup","year":"1998","journal-title":"J Trauma"},{"key":"10.1016\/j.burns.2010.12.011_bib0205","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/S0076-6879(96)69005-3","article-title":"Interactions of nitric oxide with cyclooxygenase: in vitro, ex vivo, and in vivo studies","volume":"269","author":"Salvemini","year":"1996","journal-title":"Methods Enzymol"},{"key":"10.1016\/j.burns.2010.12.011_bib0210","first-page":"H1854","article-title":"Cyclooxygenase inhibition decreases nitric oxide synthase activity in human platelets","volume":"273","author":"Chen","year":"1997","journal-title":"Am J Physiol"},{"key":"10.1016\/j.burns.2010.12.011_bib0215","doi-asserted-by":"crossref","first-page":"7240","DOI":"10.1073\/pnas.90.15.7240","article-title":"Nitric oxide activates cyclooxygenase enzymes","volume":"90","author":"Salvemini","year":"1993","journal-title":"Proc Natl Acad Sci USA"}],"container-title":["Burns"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0305417910003311?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0305417910003311?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,4]],"date-time":"2018-12-04T13:20:06Z","timestamp":1543929606000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0305417910003311"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,6]]},"references-count":43,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2011,6]]}},"alternative-id":["S0305417910003311"],"URL":"https:\/\/doi.org\/10.1016\/j.burns.2010.12.011","relation":{},"ISSN":["0305-4179"],"issn-type":[{"value":"0305-4179","type":"print"}],"subject":[],"published":{"date-parts":[[2011,6]]}}}