{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:30:06Z","timestamp":1791822606914,"version":"4.3.4"},"reference-count":46,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2014,12,1]],"date-time":"2014-12-01T00:00:00Z","timestamp":1417392000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["burnsjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Burns"],"published-print":{"date-parts":[[2014,12]]},"DOI":"10.1016\/j.burns.2014.04.004","type":"journal-article","created":{"date-parts":[[2014,6,5]],"date-time":"2014-06-05T21:16:00Z","timestamp":1402002960000},"page":"1661-1667","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":33,"title":["Immunohistochemical analysis of neuropeptides (protein gene product 9.5, substance P and calcitonin gene-related peptide) in hypertrophic burn scar with pain and itching"],"prefix":"10.1016","volume":"40","author":[{"given":"In Suk","family":"Kwak","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Hee","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Chul","family":"Jang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoon Kyung","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.burns.2014.04.004_bib0005","first-page":"44","article-title":"Abnormal scar formation in wound healing","volume":"96","author":"Beldon","year":"2000","journal-title":"Nurs Times"},{"key":"10.1016\/j.burns.2014.04.004_bib0010","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/0305-4179(96)00038-1","article-title":"Mechanical properties of normal skin and hypertrophic scars","volume":"22","author":"Clark","year":"1996","journal-title":"Burns"},{"key":"10.1016\/j.burns.2014.04.004_bib0015","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1097\/00005373-198310000-00009","article-title":"Hypertrophic burn scars: analysis of variables","volume":"23","author":"Deitch","year":"1983","journal-title":"J Trauma"},{"issue":"2","key":"10.1016\/j.burns.2014.04.004_bib0020","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1002\/(SICI)1097-4652(199805)175:2<149::AID-JCP4>3.0.CO;2-O","article-title":"Vitronectin decreases microvascular endothelial cell apoptosis","volume":"175","author":"Isik","year":"1998","journal-title":"J Cell Physiol"},{"issue":"13","key":"10.1016\/j.burns.2014.04.004_bib0025","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1016\/S0024-3205(99)00374-4","article-title":"Calcitonin gene-related peptide and other neuropeptides in the plasma of patients with soft tissue injury","volume":"65","author":"Onuoha","year":"1999","journal-title":"Life Sci"},{"issue":"4","key":"10.1016\/j.burns.2014.04.004_bib0030","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1177\/00220345950740040601","article-title":"The effects of neuropeptides (calcitonin gene-related peptide and substance P) on cultured human pulp cells","volume":"74","author":"Trantor","year":"1995","journal-title":"J Dent Res"},{"issue":"5","key":"10.1016\/j.burns.2014.04.004_bib0035","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1007\/BF00180235","article-title":"Substance P- and calcitonin gene-related peptide-immunofluorescent nerves in the repair of experimental bone defects","volume":"18","author":"Aoki","year":"1994","journal-title":"Int Orthop"},{"key":"10.1016\/j.burns.2014.04.004_bib0040","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1111\/j.1476-5381.1992.tb12758.x","article-title":"The actions of capsaicin applied topically to the skin of the rat on C-fibre afferents, antidromic vasodilatation and substance P levels","volume":"107","author":"Lynn","year":"1992","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.burns.2014.04.004_bib0045","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1111\/j.1460-9568.1991.tb00089.x","article-title":"C-fibre function during the 6 weeks following brief application of capsaicin to a cutaneous nerve in the rat","volume":"3","author":"Pini","year":"1991","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.burns.2014.04.004_bib0050","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1126\/science.242075","article-title":"Substance P localization in the central nervous system and in some primary sensory neurons","volume":"190","author":"Hokfelt","year":"1975","journal-title":"Science"},{"key":"10.1016\/j.burns.2014.04.004_bib0055","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1016\/0306-4522(81)90032-4","article-title":"Biochemical and anatomical observations on the degeneration of peptide-containing primary afferent neurons after neonatal capsaicin","volume":"6","author":"Nagy","year":"1981","journal-title":"Neuroscience"},{"issue":"Pt 1","key":"10.1016\/j.burns.2014.04.004_bib0060","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1111\/j.1469-7793.1997.00177.x","article-title":"Relationship of substance P to afferent characteristics of dorsal root ganglion neurones in guinea-pig","volume":"505","author":"Lawson","year":"1997","journal-title":"J Physiol"},{"key":"10.1016\/j.burns.2014.04.004_bib0065","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1097\/00006534-197402000-00004","article-title":"Hypertrophic scars and keloids. A collective review","volume":"53","author":"Ketchum","year":"1974","journal-title":"Plast Reconstr Surg"},{"key":"10.1016\/j.burns.2014.04.004_bib0070","doi-asserted-by":"crossref","first-page":"3299","DOI":"10.1073\/pnas.87.9.3299","article-title":"Calcitonin gene-related peptide stimulates proliferation of human endothelial cells","volume":"87","author":"Haegerstrand","year":"1990","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.burns.2014.04.004_bib0075","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/S0306-3623(97)00078-5","article-title":"Neurogenic vasodilatation and plasma leakage in the skin","volume":"30","author":"Holzer","year":"1998","journal-title":"Gen Pharmacol"},{"key":"10.1016\/j.burns.2014.04.004_bib0080","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1159\/000210778","article-title":"Neurogenic inflammation","volume":"1","author":"Lynn","year":"1988","journal-title":"Skin Pharmacol"},{"key":"10.1016\/j.burns.2014.04.004_bib0085","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0162-3109(97)00055-6","article-title":"Sensory peptides: their role in inflammation and wound healing","volume":"37","author":"Susan","year":"1997","journal-title":"Immunopharmacology"},{"key":"10.1016\/j.burns.2014.04.004_bib0090","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1006\/jsre.2002.6525","article-title":"Diminished neuropeptide levels contribute to the impaired cutaneous healing response associated with diabetes mellitus","volume":"108","author":"Gibran","year":"2002","journal-title":"J Surg Res"},{"key":"10.1016\/j.burns.2014.04.004_bib0095","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1046\/j.1524-475X.2002.10504.x","article-title":"Neutral endopeptidase inhibition in diabetic wound repair","volume":"10","author":"Spenny","year":"2002","journal-title":"Wound Repair Regen"},{"key":"10.1016\/j.burns.2014.04.004_bib0100","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1038\/sj.bjp.0705004","article-title":"Nitric oxide enhances substance P-induced itch-associated responses in mice","volume":"138","author":"Andoh","year":"2003","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.burns.2014.04.004_bib0105","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1111\/1523-1747.ep12515092","article-title":"Flare and itch induced by substance P in human skin","volume":"71","author":"Hagermark","year":"1978","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.burns.2014.04.004_bib0115","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1111\/1523-1747.ep12263603","article-title":"The regeneration of substance P-containing nerve fibers in the process of burn wound healing in the guinea pig skin","volume":"83","author":"Kishimoto","year":"1984","journal-title":"J Invest Dermatol"},{"issue":"5","key":"10.1016\/j.burns.2014.04.004_bib0120","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1097\/00004630-199609000-00004","article-title":"Substance P has a role in neurogenic mediation of human burn wound healing","volume":"17","author":"Dunnick","year":"1996","journal-title":"J Burn Care Rehabil"},{"key":"10.1016\/j.burns.2014.04.004_bib0125","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1016\/0016-5085(86)90380-X","article-title":"Immunocytochemical identification of islet cells and nerve fibers containing calcitonin gene-related peptide-like immunoreactivity in the rat pancreas","volume":"90","author":"Sternini","year":"1986","journal-title":"Gastroenterology"},{"key":"10.1016\/j.burns.2014.04.004_bib0130","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1038\/298240a0","article-title":"Alternative RNA processing in calcitonin gene expression generates mRNAs encoding different polypeptide products","volume":"298","author":"Amara","year":"1982","journal-title":"Nature"},{"issue":"9","key":"10.1016\/j.burns.2014.04.004_bib0135","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1016\/j.bjps.2005.11.038","article-title":"The reinnervation pattern of wounds and scars may explain their sensory symptoms","volume":"59","author":"Henderson","year":"2006","journal-title":"J Plast Reconstr Aesthet Surg"},{"issue":"2","key":"10.1016\/j.burns.2014.04.004_bib0140","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1111\/j.1468-3083.2007.02399.x","article-title":"The role of selected neuropeptides in pathogenesis of atopic dermatitis","volume":"22","author":"Salomon","year":"2008","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"10.1016\/j.burns.2014.04.004_bib0145","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/0006-8993(83)90241-X","article-title":"PGP 9.5 \u2013 a new marker for vertebrate neurons and neuroendocrine cells","volume":"278","author":"Thompson","year":"1983","journal-title":"Brain Res"},{"issue":"5","key":"10.1016\/j.burns.2014.04.004_bib0150","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1046\/j.1365-2133.2003.05308.x","article-title":"Increased innervation of the vulval vestibule in patients with vulvodynia","volume":"148","author":"Tympanidis","year":"2003","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.burns.2014.04.004_bib0155","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/0306-4522(88)90064-4","article-title":"Local effector functions of capsaicin-sensitive sensory nerve endings: involvement of tachykinins, calcitonin gene-related peptide and other neuropeptides","volume":"24","author":"Holzer","year":"1988","journal-title":"Neuroscience"},{"key":"10.1016\/j.burns.2014.04.004_bib0160","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/BF00500282","article-title":"Substance P as neurogenic mediator of antidromic vasodilation and neurogenic plasma extravasation","volume":"310","author":"Lembeck","year":"1979","journal-title":"Naunyn Schmiedebergs Arch Pharmacol"},{"key":"10.1016\/j.burns.2014.04.004_bib0165","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1001\/archsurg.133.10.1107","article-title":"Neuropeptides. Mediators of inflammation and tissue repair","volume":"133","author":"Schaffer","year":"1998","journal-title":"Arch Surg"},{"key":"10.1016\/j.burns.2014.04.004_bib0170","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/jidsymp.1997.2","article-title":"Organization of the peripheral nervous system: autonomic and sensory ganglia","volume":"2","author":"Sternini","year":"1997","journal-title":"J Investig Dermatol Symp Proc"},{"key":"10.1016\/j.burns.2014.04.004_bib0175","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1007\/BF00492495","article-title":"Cutaneous innervation in man visualized with protein gene product 9.5 (PGP 9.5) antibodies","volume":"92","author":"Dalsgaard","year":"1989","journal-title":"Histochemistry"},{"key":"10.1016\/j.burns.2014.04.004_bib0180","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1002\/aja.1001910404","article-title":"An immunohistochemical study of cutaneous innervation and the distribution of neuropeptides and protein gene product 9.5 in man and commonly employed laboratory animals","volume":"191","author":"Karanth","year":"1991","journal-title":"Am J Anat"},{"key":"10.1016\/j.burns.2014.04.004_bib0185","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/jidsymp.1997.6","article-title":"Interactions of the skin and nervous system","volume":"2","author":"Ansel","year":"1997","journal-title":"J Investig Dermatol Symp Proc"},{"key":"10.1016\/j.burns.2014.04.004_bib0190","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1006\/exer.1997.0345","article-title":"Synergistic effect of substance P with epidermal growth factor on epithelial migration in rabbit cornea","volume":"65","author":"Nakamura","year":"1997","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.burns.2014.04.004_bib0195","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/0014-2999(95)00818-7","article-title":"Induction of endothelial cell differentiation into capillary-like structures by substance P","volume":"298","author":"Wiedermann","year":"1996","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.burns.2014.04.004_bib0200","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1038\/315061a0","article-title":"Stimulation of connective tissue cell growth by substance P and substance K","volume":"315","author":"Nilsson","year":"1985","journal-title":"Nature"},{"key":"10.1016\/j.burns.2014.04.004_bib0205","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1159\/000028051","article-title":"Expression of substance P receptors in normal and psoriatic skin","volume":"67","author":"Staniek","year":"1999","journal-title":"Pathobiology"},{"key":"10.1016\/j.burns.2014.04.004_bib0210","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0305-4179(00)00102-9","article-title":"Silicones in the rehabilitation of burns: a review and overview","volume":"27","author":"Van den Kerckhove","year":"2001","journal-title":"Burns"},{"key":"10.1016\/j.burns.2014.04.004_bib0215","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1136\/bmj.328.7452.1329","article-title":"Scars and keloids","volume":"328","author":"Mustoe","year":"2004","journal-title":"BMJ"},{"key":"10.1016\/j.burns.2014.04.004_bib0220","first-page":"95","article-title":"Itching following burns: epidemiology and predictors","volume":"158","author":"Van Loey","year":"2008","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.burns.2014.04.004_bib0225","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1097\/BCR.0b013e3181b47cc2","article-title":"Burn therapists\u2019 opinion on the application and essential characteristics of a burn scar outcome measure","volume":"30","author":"Forbes-Duchart","year":"2009","journal-title":"J Burn Care Res"},{"key":"10.1016\/j.burns.2014.04.004_bib0230","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1111\/j.1529-8019.2008.00167.x","article-title":"Neuropathic and psychogenic itch","volume":"21","author":"Yosipovitch","year":"2008","journal-title":"Dermatol Ther"},{"key":"10.1016\/j.burns.2014.04.004_bib0235","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1111\/j.1365-2230.2009.03463.x","article-title":"Opioid-induced pruritus: an update","volume":"35","author":"Reich","year":"2010","journal-title":"Clin Exp Dermatol"}],"container-title":["Burns"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0305417914001272?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0305417914001272?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T10:29:48Z","timestamp":1716805788000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0305417914001272"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12]]},"references-count":46,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2014,12]]}},"alternative-id":["S0305417914001272"],"URL":"https:\/\/doi.org\/10.1016\/j.burns.2014.04.004","relation":{},"ISSN":["0305-4179"],"issn-type":[{"value":"0305-4179","type":"print"}],"subject":[],"published":{"date-parts":[[2014,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Immunohistochemical analysis of neuropeptides (protein gene product 9.5, substance P and calcitonin gene-related peptide) in hypertrophic burn scar with pain and itching","name":"articletitle","label":"Article Title"},{"value":"Burns","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.burns.2014.04.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ltd and ISBI. All rights reserved.","name":"copyright","label":"Copyright"}]}}