{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T02:00:28Z","timestamp":1793066428468,"version":"4.5.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.fr","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Burns"],"published-print":{"date-parts":[[2019,2]]},"DOI":"10.1016\/j.burns.2018.08.011","type":"journal-article","created":{"date-parts":[[2018,10,16]],"date-time":"2018-10-16T18:56:27Z","timestamp":1539716187000},"page":"69-75","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":93,"title":["Comparison of efficacy and safety of intralesional triamcinolone and combination of triamcinolone with 5-fluorouracil in the treatment of keloids and hypertrophic scars: Randomised control trial"],"prefix":"10.1016","volume":"45","author":[{"given":"Farrukh Aslam","family":"Khalid","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Younas","family":"Mehrose","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Saleem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Amin","family":"Yousaf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdul Malik","family":"Mujahid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saif Ur","family":"Rehman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sania","family":"Ahmad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moazzam Nazeer","family":"Tarar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.burns.2018.08.011_bib0005","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1111\/j.1365-2230.2007.02631.x","article-title":"Intralesional triamcinolone alone or in combination with 5-fluorouracil for the treatment of keloid and hypertrophic scars","volume":"34","author":"Darougheh","year":"2009","journal-title":"Clin Exp Dermatol"},{"key":"10.1016\/j.burns.2018.08.011_bib0010","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1111\/j.1396-0296.2004.04022.x","article-title":"Medical and surgical therapies for keloids","volume":"17","author":"Kelly","year":"2004","journal-title":"Dermatol Ther"},{"key":"10.1016\/j.burns.2018.08.011_bib0015","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.clindermatol.2006.09.009","article-title":"Abnormal wound healing: keloids","volume":"25","author":"Robles","year":"2007","journal-title":"Clin Dermatol"},{"key":"10.1016\/j.burns.2018.08.011_bib0020","first-page":"97","article-title":"Keloids: clinical features and management. Part I","volume":"16","author":"Kakar","year":"2006","journal-title":"J Pak Assoc Dermatol"},{"key":"10.1016\/j.burns.2018.08.011_bib0025","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.asj.2008.11.006","article-title":"Efficacy of intralesional 5-fluorouracil and triamcinolone in the treatment of keloids","volume":"29","author":"Davison","year":"2009","journal-title":"Aesthetic Surg J"},{"key":"10.1016\/j.burns.2018.08.011_bib0030","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1080\/02844310500430003","article-title":"Long term outcome of intralesional injection of triamcinolone acetonide for the treatment of keloid scars in Asian patients","volume":"40","author":"Muneuchi","year":"2006","journal-title":"Scand J Plast Reconstr Surg Hand Surg"},{"key":"10.1016\/j.burns.2018.08.011_bib0035","first-page":"197","article-title":"Metal splints for ear keloids recurrence; experience in 10 cases","volume":"32","author":"Ahmed","year":"2007","journal-title":"Rawal Med J"},{"key":"10.1016\/j.burns.2018.08.011_bib0040","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1001\/archderm.138.9.1149","article-title":"Treatment response of keloidal and hypertrophic sternotomy scars: comparison among intralesional corticosteroid, 5-fluorouracil, and 585-nm flashlamp-pumped pulsed-dye laser treatments","volume":"138","author":"Manuskiatti","year":"2002","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.burns.2018.08.011_bib0045","first-page":"987","article-title":"The use of pulsed dye laser for the prevention and treatment of hypertrophic scars in Chinese persons","volume":"30","author":"Chan","year":"2004","journal-title":"Dermatol Surg"},{"issue":"6","key":"10.1016\/j.burns.2018.08.011_bib0050","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1097\/01.sap.0000164538.72375.93","article-title":"Keloid or hypertrophic scar: the controversy: review of the literature","volume":"54","author":"Atiyeh","year":"2005","journal-title":"Ann Plast Surg"},{"key":"10.1016\/j.burns.2018.08.011_bib0055","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1016\/S0002-9440(10)64803-1","article-title":"Keloid-derived fibroblasts are refractory to Fas-mediated apoptosis and neutralization of autocrine transforming growth factor-beta1 can abrogate this resistance","volume":"157","author":"Chodon","year":"2000","journal-title":"Am J Pathol"},{"key":"10.1016\/j.burns.2018.08.011_bib0060","first-page":"105","article-title":"Morphological and immunochemical differences between keloid and hypertrophic scar","volume":"145","author":"Ehrlich","year":"1994","journal-title":"Am J Pathol"},{"key":"10.1016\/j.burns.2018.08.011_bib0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.burns.2018.02.017","article-title":"The efficacy of excision followed by intralesional 5-fluorouracil and triamcinolone acetonide versus excision followed by radiotherapy in the treatment of ear keloids: a randomized control trial","author":"Khalid","year":"2018","journal-title":"Burns"},{"issue":"2","key":"10.1016\/j.burns.2018.08.011_bib0070","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1097\/PRS.0b013e3181c82dd5","article-title":"The most current algorithms for the treatment and prevention of hypertrophic scars and keloids","volume":"125","author":"Ogawa","year":"2010","journal-title":"Plast Reconstr Surg"},{"key":"10.1016\/j.burns.2018.08.011_bib0075","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1177\/1534734608320786","article-title":"The use of corticosteroids to treat keloids: a review","volume":"7","author":"Roques","year":"2008","journal-title":"Int J Low Extrem Wounds"},{"key":"10.1016\/j.burns.2018.08.011_bib0080","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.jaad.2004.09.018","article-title":"Intralesional 5-fluorouracil in the treatment of keloids: an open clinical and histopathologic study","volume":"52","author":"Kontochristopoulos","year":"2005","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.burns.2018.08.011_bib0085","first-page":"907","article-title":"New combination of triamcinolone, 5-fluorouracil, and pulsed-dye laser for treatment of keloid and hypertrophic scars","volume":"32","author":"Asilian","year":"2006","journal-title":"Dermatol Surg"},{"key":"10.1016\/j.burns.2018.08.011_bib0090","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1111\/j.1365-2133.2005.06698.x","article-title":"Keloid-derived fibroblasts show increased secretion of factors involved in collagen turnover and depend on matrix metalloproteinase for migration","volume":"153","author":"Fujiwara","year":"2005","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.burns.2018.08.011_bib0095","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1097\/PRS.0b013e3181904d1b","article-title":"5-fluorouracil treatment of problematic scars","volume":"123","author":"Haurani","year":"2009","journal-title":"Plast Reconstr Surg"},{"key":"10.1016\/j.burns.2018.08.011_bib0100","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.bjps.2007.05.007","article-title":"Levels of evidence for the treatment of keloid disease","volume":"61","author":"Durani","year":"2008","journal-title":"J Plast Reconstr Aesthet Surg"},{"issue":"Suppl. Understanding","key":"10.1016\/j.burns.2018.08.011_bib0105","doi-asserted-by":"crossref","first-page":"S63","DOI":"10.1067\/mjd.2002.120788","article-title":"Keloidal scars: a review with a critical look at therapeutic options","volume":"46","author":"Shaffer","year":"2002","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.burns.2018.08.011_bib0110","unstructured":"Graphpad Software to randomly assign subjects to treatment groups http:\/\/www.graphpad.com\/quickcalcs\/randomize1.cfm."},{"key":"10.1016\/j.burns.2018.08.011_bib0115","doi-asserted-by":"crossref","DOI":"10.3332\/ecancer.2016.690","article-title":"Postoperative radiotherapy in the management of keloids","volume":"10","author":"Carvajal","year":"2016","journal-title":"Ecancermedicalscience"},{"key":"10.1016\/j.burns.2018.08.011_bib0120","first-page":"54","article-title":"Intralesional 5-fluorouracil as a treatment modality of keloids","volume":"30","author":"Nanda","year":"2004","journal-title":"Dermatol Surg"},{"issue":"3","key":"10.1016\/j.burns.2018.08.011_bib0125","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1097\/00006534-196609000-00005","article-title":"The treatment of hypertrophic scar, keloid and scar contracture by triamcinolone acetonide","volume":"38","author":"Ketchum","year":"1966","journal-title":"Plast Reconstr Surg"},{"key":"10.1016\/j.burns.2018.08.011_bib0130","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/S0190-9622(88)70209-1","article-title":"Perilesional linear atrophy and hypopigmentation after intralesional corticosteroid therapy","volume":"19","author":"Friedman","year":"1988","journal-title":"J Am Acad Dermatol"},{"issue":"5","key":"10.1016\/j.burns.2018.08.011_bib0135","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1097\/00006534-200110000-00018","article-title":"The effects of a single dose of 5-fluorouracil on keloid scars: a clinical trial of timed wound irrigation after extralesional excision","volume":"108","author":"Uppal","year":"2001","journal-title":"Plast Reconstr Surg"},{"key":"10.1016\/j.burns.2018.08.011_bib0140","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1046\/j.1524-4725.1999.08165.x","article-title":"Treatment of inflamed hypertrophic scars using intralesional 5-FU","volume":"25","author":"Fitzpatrick","year":"1999","journal-title":"Dermatol Surg"},{"key":"10.1016\/j.burns.2018.08.011_bib0145","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1159\/000051830","article-title":"Efficacy and safety of intralesional 5-fluorouracil in the treatment of keloids","volume":"204","author":"Gupta","year":"2002","journal-title":"Dermatology"},{"key":"10.1016\/j.burns.2018.08.011_bib0150","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1111\/j.1440-0960.2004.00072.x","article-title":"Intralesional 5-fluorouracil in the treatment of keloid scars","volume":"45","author":"Apikian","year":"2004","journal-title":"Australas J Dermatol"},{"issue":"3.1","key":"10.1016\/j.burns.2018.08.011_bib0155","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.jaad.2004.09.018","article-title":"Intralesional 5-fluorouracil in the treatment of keloids: an open clinical and histopathologic study","volume":"52","author":"Kontochristopoulos","year":"2005","journal-title":"J Am Acad Dermatol"},{"issue":"1","key":"10.1016\/j.burns.2018.08.011_bib0160","doi-asserted-by":"crossref","first-page":"53","DOI":"10.5021\/ad.2015.27.1.53","article-title":"Postoperative electron beam radiotherapy for keloids: treatment outcome and factors associated with occurrence and recurrence","volume":"27","author":"Lee","year":"2015","journal-title":"Ann Dermatol"},{"key":"10.1016\/j.burns.2018.08.011_bib0165","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1097\/00000372-200410000-00006","article-title":"Histopathological differential diagnosis of keloid and hypertrophic scar","volume":"26","author":"Lee","year":"2004","journal-title":"Am J Dermatopathol"},{"key":"10.1016\/j.burns.2018.08.011_bib0170","doi-asserted-by":"crossref","DOI":"10.1186\/1471-5945-9-8","article-title":"Description of familial keloids in five pedigrees: evidence for autosomal dominant inheritance and phenotypic heterogeneity","volume":"9","author":"Clark","year":"2009","journal-title":"BMC Dermatol"},{"key":"10.1016\/j.burns.2018.08.011_bib0175","first-page":"547","article-title":"Postoperative electron-beam irradiation therapy for keloids and hypertrophic scars: retrospective study of 147 cases followed for more than 18 months","volume":"111","author":"Ogawa","year":"2003","journal-title":"Plast Reconstr Surg"},{"key":"10.1016\/j.burns.2018.08.011_bib0180","first-page":"907","article-title":"New combination of triamci-nolone, 5-fluorouracil, and pulsed-dye laser for treatment of keloid and hypertrophic scars","volume":"32","author":"Asilian","year":"2006","journal-title":"Dermatol Surg"},{"key":"10.1016\/j.burns.2018.08.011_bib0185","first-page":"1003","article-title":"Intralesional triamcinolone alone and in combination with 5-fluorouracil for the treatment of keloid and hypertrophic scars","volume":"64","author":"Khan","year":"2014","journal-title":"J Pak Med Assoc"},{"issue":"June (3)","key":"10.1016\/j.burns.2018.08.011_bib0190","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1111\/iwj.12629","article-title":"Efficacy and safety of triamcinolone acetonide alone and in combination with 5-fluorouracil for treating hypertrophic scars and keloids: a systematic review and meta-analysis","volume":"14","author":"Ren","year":"2017","journal-title":"Int Wound J."}],"container-title":["Burns"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0305417918306983?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0305417918306983?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,8]],"date-time":"2019-01-08T20:28:19Z","timestamp":1546979299000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0305417918306983"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,2]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2019,2]]}},"alternative-id":["S0305417918306983"],"URL":"https:\/\/doi.org\/10.1016\/j.burns.2018.08.011","relation":{},"ISSN":["0305-4179"],"issn-type":[{"value":"0305-4179","type":"print"}],"subject":[],"published":{"date-parts":[[2019,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comparison of efficacy and safety of intralesional triamcinolone and combination of triamcinolone with 5-fluorouracil in the treatment of keloids and hypertrophic scars: Randomised control trial","name":"articletitle","label":"Article Title"},{"value":"Burns","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.burns.2018.08.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd and ISBI. All rights reserved.","name":"copyright","label":"Copyright"}]}}