{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T14:17:56Z","timestamp":1787062676196,"version":"build-2736575974"},"reference-count":28,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Burns"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1016\/j.burns.2020.06.003","type":"journal-article","created":{"date-parts":[[2020,6,21]],"date-time":"2020-06-21T10:23:05Z","timestamp":1592734985000},"page":"1839-1847","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["Lactate and lactate clearance in critically burned patients: usefulness and limitations as a resuscitation guide and as a prognostic factor"],"prefix":"10.1016","volume":"46","author":[{"given":"Eva","family":"Herrero De Lucas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Sanchez-Sanchez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Cachafeiro Fuci\u00f1os","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander","family":"Agrifoglio Rotaeche","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Ram\u00f3n","family":"Mart\u00ednez Mendez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Flores Cabeza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Millan Esta\u00f1","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abelardo","family":"Garc\u00eda-de-Lorenzo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.burns.2020.06.003_bib0005","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1097\/BCR.0b013e31815f5a62","article-title":"The Parkland formula under fire: is the criticism justified?","volume":"29","author":"Blumetti","year":"2008","journal-title":"J Burn Care Res"},{"key":"10.1016\/j.burns.2020.06.003_bib0010","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1097\/00004630-200207000-00006","article-title":"How well does the parkland formula estimate actual fluid resuscitation volumes?","volume":"23","author":"Cartotto","year":"2002","journal-title":"J Burn Care Rehabil"},{"key":"10.1016\/j.burns.2020.06.003_bib0015","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1097\/00003246-199103000-00007","article-title":"Adequate resuscitation of burn patients may not be measured by urine output and vital signs","volume":"19","author":"Dries","year":"1991","journal-title":"Crit Care Med"},{"key":"10.1016\/j.burns.2020.06.003_bib0020","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1097\/01.CCM.0000249851.94101.4F","article-title":"Cardiac filling pressures are not appropriate to predict hemodynamic response to volume challenge","volume":"35","author":"Osman","year":"2007","journal-title":"Crit Care Med"},{"key":"10.1016\/j.burns.2020.06.003_bib0025","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1097\/00004630-200201000-00005","article-title":"Transcardiopulmonary vs pulmonary arterial thermodilution methods for hemodynamic monitoring of burned patients","volume":"23","author":"K\u00fcntscher","year":"2002","journal-title":"J Burn Care Rehabil"},{"key":"10.1016\/j.burns.2020.06.003_bib0030","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.medin.2013.10.006","article-title":"Monitorizaci\u00f3n hemodin\u00e1mica en el paciente cr\u00edtico. recomendaciones del grupo de trabajo de cuidados intensivos cardiol\u00f3gicos y rcp de la sociedad espa\u00f1ola de medicina intensiva, cr\u00edtica y unidades coronarias","volume":"38","author":"Ochagav\u00eda","year":"2014","journal-title":"Med Intensiva"},{"key":"10.1016\/j.burns.2020.06.003_bib0035","doi-asserted-by":"crossref","first-page":"2494","DOI":"10.1097\/01.CCM.0000185642.33586.9D","article-title":"Monitoring global volume-related hemodynamic or regional variables after initial resuscitation: what is a better predictor of outcome in critically ill septic patients?","volume":"33","author":"Poeze","year":"2005","journal-title":"Crit Care Med"},{"key":"10.1016\/j.burns.2020.06.003_bib0040","doi-asserted-by":"crossref","first-page":"2309","DOI":"10.1056\/NEJMra1309483","article-title":"Lactic acidosis","volume":"371","author":"Kraut","year":"2014","journal-title":"N Engl J Med"},{"key":"10.1016\/j.burns.2020.06.003_bib0045","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1097\/00003246-198306000-00012","article-title":"Serial lactate determinations during circulatory shock","volume":"11","author":"Vincent","year":"1983","journal-title":"Crit Care Med"},{"key":"10.1016\/j.burns.2020.06.003_bib0050","first-page":"212","article-title":"Delayed lactate clearance in patients surviving circulatory shock","volume":"11","author":"Falk","year":"1985","journal-title":"Acute Care"},{"key":"10.1016\/j.burns.2020.06.003_bib0055","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1097\/01.CCM.0000132904.35713.A7","article-title":"Early lactate clearance is associated with improved outcome in severe sepsis and septic shock","volume":"32","author":"Nguyen","year":"2004","journal-title":"Crit Care Med"},{"key":"10.1016\/j.burns.2020.06.003_bib0060","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/1757-7241-19-74","article-title":"Blood lactate as a predictor for in-hospital mortality in patients admitted acutely to hospital: a systematic review","volume":"19","author":"Kruse","year":"2011","journal-title":"Scand J Trauma Resusc Emerg Med"},{"key":"10.1016\/j.burns.2020.06.003_bib0065","doi-asserted-by":"crossref","first-page":"R25","DOI":"10.1186\/cc8888","article-title":"Relative hyperlactatemia and hospital mortality in critically ill patients: a retrospective multi-centre study","volume":"14","author":"Nichol","year":"2010","journal-title":"Crit Care"},{"key":"10.1016\/j.burns.2020.06.003_bib0070","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1016\/j.burns.2005.06.019","article-title":"Lactate: early predictor of morbidity and mortality in patients with severe burns","volume":"31","author":"Kamolz","year":"2005","journal-title":"Burns"},{"key":"10.1016\/j.burns.2020.06.003_bib0075","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/S0305-4179(01)00098-5","article-title":"Serum lactate, not base deficit, rapidly predicts survival after major burns","volume":"28","author":"Jeng","year":"2002","journal-title":"Burns"},{"key":"10.1016\/j.burns.2020.06.003_bib0080","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1001\/jama.2010.158","article-title":"Lactate clearance vs central venous oxygen saturation as goals of early sepsis therapy: a randomized clinical trial","volume":"303","author":"Jones","year":"2010","journal-title":"JAMA"},{"key":"10.1016\/j.burns.2020.06.003_bib0085","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1007\/BF02067117","article-title":"The metabolic effects of thermal injury","volume":"16","author":"Tredget","year":"1992","journal-title":"World J Surg"},{"key":"10.1016\/j.burns.2020.06.003_bib0090","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/S0140-6736(05)71045-X","article-title":"Relation between muscle Na+K+ ATPase activity and raised lactate concentrations in septic shock: a prospective study","volume":"365","author":"Levy","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.burns.2020.06.003_bib0095","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1002\/ams2.207","article-title":"Lactate, a useful marker for disease mortality and severity but an unreliable marker of tissue hypoxia\/hypoperfusion in critically ill patients","volume":"3","author":"Kushimoto","year":"2016","journal-title":"Acute Med Surg"},{"key":"10.1016\/j.burns.2020.06.003_bib0100","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1016\/0026-0495(79)90007-6","article-title":"Glucose metabolism in severely burned patients","volume":"28","author":"Wolfe","year":"1979","journal-title":"Metabolism"},{"key":"10.1016\/j.burns.2020.06.003_bib0105","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1097\/00000658-199106000-00006","article-title":"Propanolol diminishes extremity blood flow in burned patients","volume":"213","author":"Gore","year":"1991","journal-title":"Ann Surg"},{"key":"10.1016\/j.burns.2020.06.003_bib0110","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1097\/00005768-200004000-00011","article-title":"Intra and extra-cellular lactate shuttles","volume":"32","author":"Brooks","year":"2000","journal-title":"Med Sci Sports Exerc"},{"key":"10.1016\/j.burns.2020.06.003_bib0115","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1177\/0310057X1204000307","article-title":"Lactate\/pyruvate ratio as a marker of tissue hypoxia in circulatory and septic shock","volume":"40","author":"Rimachi","year":"2012","journal-title":"Anaesth Intensive Care"},{"key":"10.1016\/j.burns.2020.06.003_bib0120","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1097\/00024382-200014010-00002","article-title":"Time-pattern of lactate and lactate to pyruvate ratio in the first 24 hours of intensive care emergency admissions","volume":"14","author":"Suistomaa","year":"2000","journal-title":"Shock"},{"key":"10.1016\/j.burns.2020.06.003_bib0125","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.medin.2011.08.002","article-title":"La microdi\u00e1lisis cerebral en el \u00e1mbito cl\u00ednico actual","volume":"36","author":"Revuelto-Rey","year":"2012","journal-title":"Med Intensiva"},{"key":"10.1016\/j.burns.2020.06.003_bib0130","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1097\/BCR.0b013e3182642b32","article-title":"Volume overload of fluid resuscitation in acutely burned patients using transpulmonary thermodilution technique","volume":"34","author":"Aboelatta","year":"2013","journal-title":"J Burn Care Res"},{"issue":"4","key":"10.1016\/j.burns.2020.06.003_bib0135","doi-asserted-by":"crossref","first-page":"R176","DOI":"10.1186\/cc12855","article-title":"A protocol for resuscitation of severe burn patients guided by transpulmonary thermodilution and lactate levels: a 3-year prospective cohort study","volume":"17","author":"S\u00e1nchez","year":"2013","journal-title":"Crit Care"},{"key":"10.1016\/j.burns.2020.06.003_bib0140","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1097\/ALN.0000000000002314","article-title":"Early hemodynamic management of critically ill burn patients","volume":"129","author":"Soussi","year":"2018","journal-title":"Anesthesiology"}],"container-title":["Burns"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0305417920304204?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0305417920304204?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T08:15:28Z","timestamp":1759652128000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0305417920304204"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":28,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2020,12]]}},"alternative-id":["S0305417920304204"],"URL":"https:\/\/doi.org\/10.1016\/j.burns.2020.06.003","relation":{},"ISSN":["0305-4179"],"issn-type":[{"value":"0305-4179","type":"print"}],"subject":[],"published":{"date-parts":[[2020,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lactate and lactate clearance in critically burned patients: usefulness and limitations as a resuscitation guide and as a prognostic factor","name":"articletitle","label":"Article Title"},{"value":"Burns","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.burns.2020.06.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd and ISBI. All rights reserved.","name":"copyright","label":"Copyright"}]}}