{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T22:50:00Z","timestamp":1790635800834,"version":"4.1.0"},"reference-count":48,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,4,19]],"date-time":"2021-04-19T00:00:00Z","timestamp":1618790400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Burns"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1016\/j.burns.2021.04.005","type":"journal-article","created":{"date-parts":[[2021,4,16]],"date-time":"2021-04-16T23:09:01Z","timestamp":1618614541000},"page":"1225-1240","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":34,"title":["A systematic review and meta-analysis of randomized trials evaluating the efficacy of autologous skin cell suspensions for re-epithelialization of acute partial thickness burn injuries and split-thickness skin graft donor sites"],"prefix":"10.1016","volume":"47","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8839-4494","authenticated-orcid":false,"given":"Anjana","family":"Bairagi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bronwyn","family":"Griffin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tara","family":"Banani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven M.","family":"McPhail","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roy","family":"Kimble","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zephanie","family":"Tyack","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.burns.2021.04.005_bib0005","series-title":"Fact sheet Burns","author":"World Health Organization","year":"2018"},{"issue":"5","key":"10.1016\/j.burns.2021.04.005_bib0010","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1590\/abd1806-4841.20164741","article-title":"Wound healing - A literature review","volume":"91","author":"Gonzalez","year":"2016","journal-title":"An Bras Dermatol"},{"issue":"1","key":"10.1016\/j.burns.2021.04.005_bib0015","first-page":"3","article-title":"A prospective study of time to healing and hypertrophic scarring in paediatric burns: every day counts","volume":"5","author":"Chipp","year":"2017","journal-title":"Burns Trauma"},{"key":"10.1016\/j.burns.2021.04.005_bib0020","doi-asserted-by":"crossref","first-page":"799","DOI":"10.2147\/CCID.S218134","article-title":"Skin Care Management For Medical And Aesthetic Procedures To Prevent Scarring","volume":"12","author":"Jourdan","year":"2019","journal-title":"Clin Cosmet Investig Dermatol"},{"issue":"3","key":"10.1016\/j.burns.2021.04.005_bib0025","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1097\/01.ASW.0000527287.28216.65","article-title":"Long-term Scar Quality after Treatment of Standardized Partial-Thickness Skin Graft Donor Sites","volume":"31","author":"Schulz","year":"2018","journal-title":"Adv Skin Wound Care"},{"issue":"3","key":"10.1016\/j.burns.2021.04.005_bib0030","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/S0092-8674(75)80001-8","article-title":"Serial cultivation of strains of human epidermal keratinocytes: the formation of keratinizing colonies from single cells","volume":"6","author":"Rheinwald","year":"1975","journal-title":"Cell"},{"key":"10.1016\/j.burns.2021.04.005_bib0035","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/srt.12317","article-title":"Models of wound healing: an emphasis on clinical studies","author":"Wilhelm","year":"2017","journal-title":"Skin Res Technol"},{"key":"10.1016\/j.burns.2021.04.005_bib0040","article-title":"Efficacy of autologous skin cell suspensions for re-epithelialisation of acute partial thickness burn injuries andsplit-thickness autograft donor sites: a systematic review and meta-analysis","author":"Bairagi","year":"2019","journal-title":"PROSPERO Int Prospective Register Syst Rev"},{"issue":"1","key":"10.1016\/j.burns.2021.04.005_bib0045","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1186\/s13643-017-0644-y","article-title":"Optimal database combinations for literature searches in systematic reviews: a prospective exploratory study","volume":"6","author":"Bramer","year":"2017","journal-title":"Syst Rev."},{"key":"10.1016\/j.burns.2021.04.005_bib0050","doi-asserted-by":"crossref","first-page":"g1687","DOI":"10.1136\/bmj.g1687","article-title":"Better reporting of interventions: template for intervention description and replication (TIDieR) checklist and guide","volume":"348","author":"Hoffmann","year":"2014","journal-title":"BMJ"},{"key":"10.1016\/j.burns.2021.04.005_bib0055","doi-asserted-by":"crossref","first-page":"d5928","DOI":"10.1136\/bmj.d5928","article-title":"The Cochrane Collaboration\u2019s tool for assessing risk of bias in randomised trials","volume":"343","author":"Higgins","year":"2011","journal-title":"BMJ"},{"key":"10.1016\/j.burns.2021.04.005_bib0060","series-title":"Cochrane handbook for systematic reviews of interventions","author":"Higgins","year":"2011"},{"issue":"4","key":"10.1016\/j.burns.2021.04.005_bib0065","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.jclinepi.2010.09.011","article-title":"GRADE guidelines: a new series of articles in the Journal of Clinical Epidemiology","volume":"64","author":"Guyatt","year":"2011","journal-title":"J Clin Epidemiol"},{"issue":"2","key":"10.1016\/j.burns.2021.04.005_bib0070","doi-asserted-by":"crossref","first-page":"107","DOI":"10.3102\/10769986006002107","article-title":"Distribution Theory for Glass\u2019s Estimator of Effect Size and Related Estimators","volume":"6","author":"Hedges","year":"1981","journal-title":"J Educ Stat"},{"issue":"3","key":"10.1016\/j.burns.2021.04.005_bib0075","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0197-2456(86)90046-2","article-title":"Meta-analysis in clinical trials","volume":"7","author":"DerSimonian","year":"1986","journal-title":"Control Clin Trials"},{"issue":"3","key":"10.1016\/j.burns.2021.04.005_bib0080","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1097\/BCR.0000000000000259","article-title":"Trace Element Supplementation Following Severe Burn Injury: A Systematic Review and Meta-Analysis","volume":"37","author":"Kurmis","year":"2016","journal-title":"J Burn Care Res"},{"issue":"3","key":"10.1016\/j.burns.2021.04.005_bib0085","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1111\/iwj.12313","article-title":"Growth factor therapy in patients with partial-thickness burns: a systematic review and meta-analysis","volume":"13","author":"Zhang","year":"2016","journal-title":"Int Wound J"},{"issue":"2","key":"10.1016\/j.burns.2021.04.005_bib0090","doi-asserted-by":"crossref","first-page":"215","DOI":"10.3102\/1076998609346961","article-title":"How Many Studies Do You Need?","volume":"35","author":"Valentine","year":"2010","journal-title":"J Educ Behav Stat"},{"issue":"8","key":"10.1016\/j.burns.2021.04.005_bib0095","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1016\/j.burns.2007.04.011","article-title":"A randomized trial comparing ReCell system of epidermal cells delivery versus classic skin grafts for the treatment of deep partial thickness burns","volume":"33","author":"Gravante","year":"2007","journal-title":"Burns"},{"issue":"5","key":"10.1016\/j.burns.2021.04.005_bib0100","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1093\/jbcr\/iry029","article-title":"A Comparative Study of the ReCell(R) Device and Autologous Spit-Thickness Meshed Skin Graft in the Treatment of Acute Burn Injuries","volume":"39","author":"Holmes","year":"2018","journal-title":"J Burn Care Res"},{"issue":"1","key":"10.1016\/j.burns.2021.04.005_bib0105","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1755-1536-6-8","article-title":"Autologous keratinocyte suspension in platelet concentrate accelerates and enhances wound healing - a prospective randomized clinical trial on skin graft donor sites: platelet concentrate and keratinocytes on donor sites","volume":"6","author":"Guerid","year":"2013","journal-title":"Fibrogenesis Tissue Repair"},{"issue":"7","key":"10.1016\/j.burns.2021.04.005_bib0110","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1002\/bjs.10508","article-title":"Randomized clinical trial of autologous skin cell suspension for accelerating re-epithelialization of split-thickness donor sites","volume":"104","author":"Hu","year":"2017","journal-title":"Br J Surg"},{"issue":"6","key":"10.1016\/j.burns.2021.04.005_bib0115","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1016\/j.burns.2011.12.020","article-title":"A prospective randomised clinical pilot study to compare the effectiveness of Biobrane(R) synthetic wound dressing, with or without autologous cell suspension, to the local standard treatment regimen in paediatric scald injuries","volume":"38","author":"Wood","year":"2012","journal-title":"Burns"},{"key":"10.1016\/j.burns.2021.04.005_bib0120","author":"ACTRN12618000245291","year":"2018"},{"key":"10.1016\/j.burns.2021.04.005_bib0125","series-title":"The effect of CUTICERIN\u00ae with or without a Regenerative Epithelial Suspension (RES\u2122), on pigmentation of donor sites in children: The pilot randomised DRESSIng Trial","author":"ACTRN12620000227998","year":"2020"},{"key":"10.1016\/j.burns.2021.04.005_bib0130","series-title":"RES\u00ae Prepared With RECELL\u00ae Compared to Standard of Care Dressings of Partial-thickness Burns in Ages 1-16 Years","author":"NCT03626701","year":"2018"},{"key":"10.1016\/j.burns.2021.04.005_bib0135","series-title":"RES Prepared With RECELL\u00ae Compared to Conventional Care for Healing of Donor Sites in Ages 1-16 Years","author":"NCT03624192","year":"2018"},{"issue":"1","key":"10.1016\/j.burns.2021.04.005_bib0140","first-page":"33","article-title":"Comparative effectiveness of Biobrane(R), RECELL(R) Autologous skin Cell suspension and Silver dressings in partial thickness paediatric burns: BRACS randomised trial protocol","volume":"7","author":"Bairagi","year":"2019","journal-title":"Burns Trauma"},{"issue":"12","key":"10.1016\/j.burns.2021.04.005_bib0145","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1111\/j.1553-2712.2001.tb01132.x","article-title":"Reliability of the visual analog scale for measurement of acute pain","volume":"8","author":"Bijur","year":"2001","journal-title":"Acad Emerg Med"},{"issue":"3","key":"10.1016\/j.burns.2021.04.005_bib0150","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1046\/j.1460-9592.2000.00530.x","article-title":"Analysis of behavioural and physiological parameters for the assessment of postoperative analgesic demand in newborns, infants and young children: a comprehensive report on seven consecutive studies","volume":"10","author":"Buttner","year":"2000","journal-title":"Paediatr Anaesth"},{"issue":"10","key":"10.1016\/j.burns.2021.04.005_bib0155","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1097\/00000446-200210000-00024","article-title":"Pain Control: Pain Assessment in Infants and Young Children: The FLACC Scale","volume":"102","author":"Merkel","year":"2002","journal-title":"Am J Nurs"},{"issue":"4","key":"10.1016\/j.burns.2021.04.005_bib0160","doi-asserted-by":"crossref","first-page":"e971","DOI":"10.1542\/peds.2013-1509","article-title":"Validation of self-report pain scales in children","volume":"132","author":"Tsze","year":"2013","journal-title":"Pediatrics"},{"issue":"5","key":"10.1016\/j.burns.2021.04.005_bib0165","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1097\/00004630-199509000-00013","article-title":"The Vancouver Scar Scale: an administration tool and its interrater reliability","volume":"16","author":"Baryza","year":"1995","journal-title":"J Burn Care Rehabil"},{"issue":"1","key":"10.1016\/j.burns.2021.04.005_bib0170","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s11136-011-9924-5","article-title":"Rasch analysis of the Patient and Observer Scar Assessment Scale (POSAS) in burn scars","volume":"21","author":"van der Wal","year":"2012","journal-title":"Qual Life Res"},{"issue":"1","key":"10.1016\/j.burns.2021.04.005_bib0175","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1111\/j.1524-4725.1988.tb03343.x","article-title":"Keratinocyte grafting: a new means of transplantation for full-thickness wounds","volume":"14","author":"Hunyadi","year":"1988","journal-title":"J Dermatol Surg Oncol"},{"issue":"6","key":"10.1016\/j.burns.2021.04.005_bib0180","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1097\/00004630-200021060-00007","article-title":"Sprayed keratinocyte suspensions accelerate epidermal coverage in a porcine microwound model","volume":"21","author":"Navarro","year":"2000","journal-title":"J Burn Care Rehabil"},{"issue":"1","key":"10.1016\/j.burns.2021.04.005_bib0185","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.burns.2011.03.001","article-title":"Characterisation of the cell suspension harvested from the dermal epidermal junction using a ReCell(R) kit","volume":"38","author":"Wood","year":"2012","journal-title":"Burns"},{"issue":"8","key":"10.1016\/j.burns.2021.04.005_bib0190","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1016\/j.burns.2016.06.013","article-title":"Calculations for reproducible autologous skin cell-spray grafting","volume":"42","author":"Esteban-Vives","year":"2016","journal-title":"Burns"},{"issue":"4","key":"10.1016\/j.burns.2021.04.005_bib0195","doi-asserted-by":"crossref","first-page":"e19","DOI":"10.1016\/j.burns.2011.01.022","article-title":"Autologous skin cell spray-transplantation for a deep dermal burn patient in an ambulant treatment room setting","volume":"37","author":"Gerlach","year":"2011","journal-title":"Burns"},{"issue":"2","key":"10.1016\/j.burns.2021.04.005_bib0200","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.burns.2018.05.014","article-title":"Comparative study of Silver Sulfadiazine with other materials for healing and infection prevention in burns: A systematic review and meta-analysis","volume":"45","author":"Nimia","year":"2019","journal-title":"Burns"},{"issue":"1","key":"10.1016\/j.burns.2021.04.005_bib0205","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/1523-1747.ep12551488","article-title":"Regional differences of cell sizes in the human stratum corneum. II. Effects of sex and age","volume":"54","author":"Plewig","year":"1970","journal-title":"J Invest Dermatol"},{"issue":"2","key":"10.1016\/j.burns.2021.04.005_bib0210","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1111\/j.1525-1470.2009.00973.x","article-title":"Infant skin microstructure assessed in vivo differs from adult skin in organization and at the cellular level","volume":"27","author":"Stamatas","year":"2010","journal-title":"Pediatr Dermatol"},{"issue":"8","key":"10.1016\/j.burns.2021.04.005_bib0215","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1007\/s00403-017-1764-x","article-title":"Change in skin properties over the first 10 years of life: a cross-sectional study","volume":"309","author":"Kong","year":"2017","journal-title":"Arch Dermatol Res"},{"issue":"3","key":"10.1016\/j.burns.2021.04.005_bib0220","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1111\/pde.12798","article-title":"Water-Holding and Transport Properties of Skin Stratum Corneum of Infants and Toddlers Are Different from Those of Adults: Studies in Three Geographical Regions and Four Ethnic Groups","volume":"33","author":"Mack","year":"2016","journal-title":"Pediatr Dermatol"},{"issue":"4","key":"10.1016\/j.burns.2021.04.005_bib0225","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1111\/wrr.12196","article-title":"Nonsilver treatment vs. silver sulfadiazine in treatment of partial-thickness burn wounds in children: a systematic review and meta-analysis","volume":"22","author":"Rashaan","year":"2014","journal-title":"Wound Repair Regen"},{"issue":"6","key":"10.1016\/j.burns.2021.04.005_bib0230","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1097\/BCR.0b013e3181599bc9","article-title":"American Burn Association consensus conference to define sepsis and infection in burns","volume":"28","author":"Greenhalgh","year":"2007","journal-title":"J Burn Care Res"},{"issue":"7","key":"10.1016\/j.burns.2021.04.005_bib0235","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1016\/j.burns.2019.07.012","article-title":"The Brisbane Burn Scar Impact Profile (child and young person version) for measuring health-related quality of life in children with burn scars: A longitudinal cohort study of reliability, validity and responsiveness","volume":"45","author":"Simons","year":"2019","journal-title":"Burns"},{"issue":"8","key":"10.1016\/j.burns.2021.04.005_bib0240","doi-asserted-by":"crossref","first-page":"1792","DOI":"10.1016\/j.burns.2019.04.015","article-title":"The longitudinal validity, reproducibility and responsiveness of the Brisbane Burn Scar Impact Profile (caregiver report for young children version) for measuring health-related quality of life in children with burn scars","volume":"45","author":"Simons","year":"2019","journal-title":"Burns"}],"container-title":["Burns"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0305417921000863?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0305417921000863?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T08:16:02Z","timestamp":1759652162000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0305417921000863"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":48,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2021,9]]}},"alternative-id":["S0305417921000863"],"URL":"https:\/\/doi.org\/10.1016\/j.burns.2021.04.005","relation":{},"ISSN":["0305-4179"],"issn-type":[{"value":"0305-4179","type":"print"}],"subject":[],"published":{"date-parts":[[2021,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A systematic review and meta-analysis of randomized trials evaluating the efficacy of autologous skin cell suspensions for re-epithelialization of acute partial thickness burn injuries and split-thickness skin graft donor sites","name":"articletitle","label":"Article Title"},{"value":"Burns","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.burns.2021.04.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Crown Copyright \u00a9 2021 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}