{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T10:08:39Z","timestamp":1792750119001,"version":"4.5.0"},"reference-count":26,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007914","name":"UT Southwestern","doi-asserted-by":"publisher","award":["R01GM115366"],"award-info":[{"award-number":["R01GM115366"]}],"id":[{"id":"10.13039\/100007914","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007914","name":"UT Southwestern","doi-asserted-by":"publisher","award":["R01GM127791"],"award-info":[{"award-number":["R01GM127791"]}],"id":[{"id":"10.13039\/100007914","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Burns"],"published-print":{"date-parts":[[2022,2]]},"DOI":"10.1016\/j.burns.2021.04.007","type":"journal-article","created":{"date-parts":[[2021,4,18]],"date-time":"2021-04-18T18:25:27Z","timestamp":1618770327000},"page":"168-175","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"title":["The cGAS-STING pathway connects mitochondrial damage to inflammation in burn-induced acute lung injury in rat"],"prefix":"10.1016","volume":"48","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7941-8482","authenticated-orcid":false,"given":"Paul B.","family":"Comish","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming-Mei","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan","family":"Huebinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deborah","family":"Carlson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Kang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daolin","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.burns.2021.04.007_bib0005","series-title":"Hospitalizations related to burn injury: 40,000, including 30,000 at hospital burn centers. National inpatient sample (HCUP-NIS: 2010 Data)","year":"2020"},{"key":"10.1016\/j.burns.2021.04.007_bib0010","series-title":"Selected statistics: 2005\u20132014 burn admission to burn centers","year":"2015"},{"key":"10.1016\/j.burns.2021.04.007_bib0015","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1111\/j.1600-065X.2012.01146.x","article-title":"PAMPs and DAMPs: signal 0s that spur autophagy and immunity","volume":"249","author":"Tang","year":"2012","journal-title":"Immunol Rev"},{"key":"10.1016\/j.burns.2021.04.007_bib0020","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1038\/s41576-019-0151-1","article-title":"DNA sensing by the cGAS-STING pathway in health and disease","volume":"20","author":"Motwani","year":"2019","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.burns.2021.04.007_bib0025","doi-asserted-by":"crossref","DOI":"10.1111\/cpr.12579","article-title":"Induction of neutrophil extracellular traps during tissue injury: involvement of STING and Toll-like receptor 9 pathways","volume":"52","author":"Liu","year":"2019","journal-title":"Cell Prolif"},{"key":"10.1016\/j.burns.2021.04.007_bib0030","doi-asserted-by":"crossref","first-page":"H744","DOI":"10.1152\/ajpheart.00367.2004","article-title":"Role of cytosolic vs. mitochondrial Ca2+ accumulation in burn injury-related myocardial inflammation and function","volume":"288","author":"Maass","year":"2005","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.burns.2021.04.007_bib0035","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1038\/nri.2016.49","article-title":"Neutrophil migration in infection and wound repair: going forward in reverse","volume":"16","author":"de Oliveira","year":"2016","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.burns.2021.04.007_bib0040","doi-asserted-by":"crossref","first-page":"88","DOI":"10.2119\/molmed.2010.00080","article-title":"Interleukin-18 delays neutrophil apoptosis following alcohol intoxication and burn injury","volume":"17","author":"Akhtar","year":"2011","journal-title":"Mol Med"},{"key":"10.1016\/j.burns.2021.04.007_bib0045","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1097\/SHK.0000000000000075","article-title":"Burn plus lipopolysaccharide augments endoplasmic reticulum stress and NLRP3 inflammasome activation and reduces PGC-1alpha in liver","volume":"41","author":"Diao","year":"2014","journal-title":"Shock"},{"key":"10.1016\/j.burns.2021.04.007_bib0050","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1097\/BCR.0000000000000501","article-title":"Mitochondrial DNA-induced inflammatory responses and lung injury in thermal injury rat model: protective effect of epigallocatechin gallate","volume":"38","author":"Liu","year":"2017","journal-title":"J Burn Care Res"},{"key":"10.1016\/j.burns.2021.04.007_bib0055","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1093\/jbcr\/irz029","article-title":"Mitochondrial DNA-induced inflammatory responses and lung injury in thermal injury murine model: protective effect of cyclosporine-A","volume":"40","author":"Liu","year":"2019","journal-title":"J Burn Care Res"},{"key":"10.1016\/j.burns.2021.04.007_bib0060","doi-asserted-by":"crossref","first-page":"H882","DOI":"10.1152\/ajpheart.00475.2013","article-title":"Estrogen-provided cardiac protection following burn trauma is mediated through a reduction in mitochondria-derived DAMPs","volume":"306","author":"Yao","year":"2014","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"10.1016\/j.burns.2021.04.007_bib0065","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0143730","article-title":"Time-dependent and organ-specific changes in mitochondrial function, mitochondrial DNA integrity, oxidative stress and mononuclear cell infiltration in a mouse model of burn injury","volume":"10","author":"Szczesny","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.burns.2021.04.007_bib0070","doi-asserted-by":"crossref","first-page":"2705","DOI":"10.1016\/j.bbadis.2017.07.006","article-title":"Hepatic mitochondrial bioenergetics in aged C57BL\/6 mice exhibit delayed recovery from severe burn injury","volume":"1863","author":"Auger","year":"2017","journal-title":"Biochim Biophys Acta Mol Basis Dis"},{"key":"10.1016\/j.burns.2021.04.007_bib0075","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1126\/science.1232458","article-title":"Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway","volume":"339","author":"Sun","year":"2013","journal-title":"Science"},{"key":"10.1016\/j.burns.2021.04.007_bib0080","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0050238","article-title":"Burn injury triggered dysfunction in dendritic cell response to TLR9 activation and resulted in skewed T cell functions","volume":"7","author":"Shen","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.burns.2021.04.007_bib0085","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aan5689","article-title":"ALK is a therapeutic target for lethal sepsis","volume":"9","author":"Zeng","year":"2017","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.burns.2021.04.007_bib0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.chom.2020.02.004","article-title":"TMEM173 drives lethal coagulation in sepsis","volume":"27","author":"Zhang","year":"2020","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.burns.2021.04.007_bib0095","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.burns.2016.10.001","article-title":"Damage-associated molecular patterns (DAMPs) released after burn are associated with inflammation and monocyte activation","volume":"43","author":"Rani","year":"2017","journal-title":"Burns"},{"key":"10.1016\/j.burns.2021.04.007_bib0100","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1097\/SHK.0b013e318173f329","article-title":"Alterations in the cardiac inflammatory response to burn trauma in mice lacking a functional Toll-like receptor 4 gene","volume":"30","author":"Bruns","year":"2008","journal-title":"Shock"},{"key":"10.1016\/j.burns.2021.04.007_bib0105","doi-asserted-by":"crossref","first-page":"E751","DOI":"10.1152\/ajpendo.00180.2019","article-title":"NLRP3 inflammasome mediates white adipose tissue browning after burn","volume":"317","author":"Vinaik","year":"2019","journal-title":"Am J Physiol Endocrinol Metab"},{"key":"10.1016\/j.burns.2021.04.007_bib0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.cmet.2019.08.003","article-title":"Mitochondrial damage and activation of the STING pathway lead to renal inflammation and fibrosis","volume":"30","author":"Chung","year":"2019","journal-title":"Cell Metab"},{"issue":"5","key":"10.1016\/j.burns.2021.04.007_bib0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.molcel.2018.07.034","article-title":"Non-canonical activation of the DNA sensing adaptor STING by ATM and IFI16 mediates NF-kappaB signaling after nuclear DNA damage","volume":"71","author":"Dunphy","year":"2018","journal-title":"Mol Cell"},{"key":"10.1016\/j.burns.2021.04.007_bib0120","doi-asserted-by":"crossref","first-page":"0","DOI":"10.1152\/ajpcell.00187.2003","article-title":"Suppression of mitochondria-dependent neutrophil apoptosis with thermal injury","volume":"286","author":"Hu","year":"2004","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.burns.2021.04.007_bib0125","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/nrmicro2070","article-title":"Pyroptosis: host cell death and inflammation","volume":"7","author":"Bergsbaken","year":"2009","journal-title":"Nat Rev Microbiol"},{"issue":"3","key":"10.1016\/j.burns.2021.04.007_bib0130","doi-asserted-by":"crossref","first-page":"851","DOI":"10.3390\/ijms21030851","article-title":"Neutrophil Adaptations Upon Recruitment to the Lung: New Concepts and Implications for Homeostasia and Disease","volume":"21","author":"Giacalone","year":"2020","journal-title":"International Journal of Molecular Sciences"}],"container-title":["Burns"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0305417921000887?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0305417921000887?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T08:16:47Z","timestamp":1759652207000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0305417921000887"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2]]},"references-count":26,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,2]]}},"alternative-id":["S0305417921000887"],"URL":"https:\/\/doi.org\/10.1016\/j.burns.2021.04.007","relation":{},"ISSN":["0305-4179"],"issn-type":[{"value":"0305-4179","type":"print"}],"subject":[],"published":{"date-parts":[[2022,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The cGAS-STING pathway connects mitochondrial damage to inflammation in burn-induced acute lung injury in rat","name":"articletitle","label":"Article Title"},{"value":"Burns","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.burns.2021.04.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd and ISBI. All rights reserved.","name":"copyright","label":"Copyright"}]}}