{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T06:21:19Z","timestamp":1768285279619,"version":"3.49.0"},"reference-count":33,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T00:00:00Z","timestamp":1740096000000},"content-version":"am","delay-in-days":357,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100010186","name":"Brooke Army Medical Center","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010186","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009898","name":"Defense Health Agency","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009898","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Burns"],"published-print":{"date-parts":[[2024,3]]},"DOI":"10.1016\/j.burns.2023.11.007","type":"journal-article","created":{"date-parts":[[2023,11,23]],"date-time":"2023-11-23T17:20:53Z","timestamp":1700760053000},"page":"375-380","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Epidemiology and clinical significance of persistent bacteremia in severely burned patients"],"prefix":"10.1016","volume":"50","author":[{"given":"Joseph E.","family":"Marcus","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa C.","family":"Townsend","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie A.","family":"Rizzo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. Aden","family":"James","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana E.","family":"Markelz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dana M.","family":"Blyth","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.burns.2023.11.007_bib1","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1001\/archsurg.1986.01400090057009","article-title":"Association of burn mortality and bacteremia. a 25-year review","volume":"121","author":"Mason","year":"1986","journal-title":"Arch Surg"},{"issue":"2","key":"10.1016\/j.burns.2023.11.007_bib2","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1007\/s15010-015-0847-x","article-title":"Predicting mortality in burn patients with bacteraemia","volume":"44","author":"Ceniceros","year":"2016","journal-title":"Infection"},{"key":"10.1016\/j.burns.2023.11.007_bib3","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1186\/s12879-016-1622-z","article-title":"Sending repeat cultures: is there a role in the management of bacteremic episodes? (SCRIBE study)","volume":"16","author":"Wiggers","year":"2016","journal-title":"BMC Infect Dis"},{"issue":"5","key":"10.1016\/j.burns.2023.11.007_bib4","doi-asserted-by":"crossref","DOI":"10.1093\/ofid\/ofac173","article-title":"Follow-up blood culture practices for gram-negative bloodstream infections in immunocompromised hosts at a large academic medical center","volume":"9","author":"Buzzalino","year":"2022","journal-title":"Open Forum Infect Dis"},{"issue":"1","key":"10.1016\/j.burns.2023.11.007_bib5","doi-asserted-by":"crossref","DOI":"10.1186\/s12879-023-08021-5","article-title":"Clearance of blood stream infections in patients receiving extracorporeal membrane oxygenation: a retrospective single-center cohort study","volume":"23","author":"Frankford","year":"2023","journal-title":"BMC Infect Dis"},{"issue":"12","key":"10.1016\/j.burns.2023.11.007_bib6","doi-asserted-by":"crossref","DOI":"10.1093\/ofid\/ofac568","article-title":"Association of repeated blood cultures with mortality in adult patients with gram-negative bacilli bacteremia: a systematic review and meta-analysis","volume":"9","author":"Shinohara","year":"2022","journal-title":"Open Forum Infect Dis"},{"issue":"9","key":"10.1016\/j.burns.2023.11.007_bib7","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2022.32576","article-title":"Association of follow-up blood cultures with mortality in patients with gram-negative bloodstream infections: a systematic review and meta-analysis","volume":"5","author":"Thaden","year":"2022","journal-title":"JAMA Netw Open"},{"issue":"9","key":"10.1016\/j.burns.2023.11.007_bib8","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1016\/j.cmi.2023.02.024","article-title":"Impact on clinical outcome of follow-up blood cultures and risk factors for persistent bacteraemia in patients with gram-negative bloodstream infections: a systematic review with meta-analysis","volume":"29","author":"Gatti","year":"2023","journal-title":"Clin Microbiol Infect"},{"key":"10.1016\/j.burns.2023.11.007_bib9","article-title":"Persistent systemic inflammation in patients with severe burn injury is accompanied by influx of immature neutrophils and shifts in T cell subsets and cytokine profiles","volume":"11","author":"Mulder","year":"2020","journal-title":"Front Immunol"},{"issue":"3","key":"10.1016\/j.burns.2023.11.007_bib10","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1097\/BCR.0b013e3182331e87","article-title":"Correlation of American Burn Association sepsis criteria with the presence of bacteremia in burned patients admitted to the intensive care unit","volume":"33","author":"Hogan","year":"2012","journal-title":"J Burn Care Res"},{"issue":"9","key":"10.1016\/j.burns.2023.11.007_bib11","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1016\/j.amjmed.2010.03.021","article-title":"The clinical and prognostic importance of positive blood cultures in adults","volume":"123","author":"Pien","year":"2010","journal-title":"Am J Med"},{"issue":"2","key":"10.1016\/j.burns.2023.11.007_bib12","first-page":"89","article-title":"A comparison of injury scoring systems in predicting burn mortality","volume":"31","author":"Halgas","year":"2018","journal-title":"Ann Burns Fire Disasters"},{"issue":"3","key":"10.1016\/j.burns.2023.11.007_bib13","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1097\/TA.0000000000000124","article-title":"External validation of the revised Baux score for the prediction of mortality in patients with acute burn injury","volume":"76","author":"Dokter","year":"2014","journal-title":"J Trauma Acute Care Surg"},{"issue":"2","key":"10.1016\/j.burns.2023.11.007_bib14","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.burns.2019.08.008","article-title":"Characteristics and outcomes of patients with inhalation injury treated at a military burn center during U.S. combat operations","volume":"46","author":"Suresh","year":"2020","journal-title":"Burns"},{"issue":"9","key":"10.1016\/j.burns.2023.11.007_bib15","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0185195","article-title":"Does inhalation injury predict mortality in burns patients or require redefinition?","volume":"12","author":"Kim","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.burns.2023.11.007_bib16","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/1757-7241-21-31","article-title":"Inhalation injury: epidemiology, pathology, treatment strategies","volume":"21","author":"Dries","year":"2013","journal-title":"Scand J Trauma Resusc Emerg Med"},{"issue":"1","key":"10.1016\/j.burns.2023.11.007_bib17","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.burns.2018.08.026","article-title":"Comparison of military and civilian burn patients admitted to a single center during 12 years of war","volume":"45","author":"Rizzo","year":"2019","journal-title":"Burns"},{"issue":"9","key":"10.1016\/j.burns.2023.11.007_bib18","doi-asserted-by":"crossref","DOI":"10.1128\/aac.00688-22","article-title":"Multidrug-Resistant Gram-Negative Bacteria in Burn Patients","volume":"66","author":"Ruegsegger","year":"2022","journal-title":"Antimicrob Agents Chemother"},{"issue":"4","key":"10.1016\/j.burns.2023.11.007_bib19","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0095042","article-title":"Gram negative wound infection in hospitalised adult burn patients--systematic review and metanalysis","volume":"9","author":"Azzopardi","year":"2014","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.burns.2023.11.007_bib20","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.burns.2009.10.012","article-title":"Incidence and bacteriology of burn infections at a military burn center","volume":"36","author":"Keen","year":"2010","journal-title":"Burns"},{"key":"10.1016\/j.burns.2023.11.007_bib21","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.ijid.2018.11.371","article-title":"Incidence, risk factors and outcome of multi-drug resistant Acinetobacter baumannii nosocomial infections during an outbreak in a burn unit","volume":"79","author":"Munier","year":"2019","journal-title":"Int J Infect Dis"},{"issue":"2","key":"10.1016\/j.burns.2023.11.007_bib22","article-title":"Outbreak of Acinetobacter baumannii associated with extrinsic contamination of ultrasound gel in a tertiary centre burn unit","volume":"1","author":"Yagnik","year":"2019","journal-title":"Infect Prev Pr"},{"issue":"4","key":"10.1016\/j.burns.2023.11.007_bib23","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.jamcollsurg.2006.06.013","article-title":"Impact of Acinetobacter infection on the mortality of burn patients","volume":"203","author":"Albrecht","year":"2006","journal-title":"J Am Coll Surg"},{"key":"10.1016\/j.burns.2023.11.007_bib24","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s41038-016-0038-8","article-title":"Burns infection profile of Singapore: prevalence of multidrug-resistant Acinetobacter baumannii and the role of blood cultures","volume":"4","author":"Song","year":"2016","journal-title":"Burns Trauma"},{"key":"10.1016\/j.burns.2023.11.007_bib25","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2022.877995","article-title":"Klebsiella pneumoniae Biofilms and Their Role in Disease Pathogenesis","volume":"12","author":"Guerra","year":"2022","journal-title":"Front Cell Infect Microbiol"},{"key":"10.1016\/j.burns.2023.11.007_bib26","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1186\/1471-2334-13-365","article-title":"Can a routine follow-up blood culture be justified in Klebsiella pneumoniae bacteremia? A retrospective case-control study","volume":"13","author":"Kang","year":"2013","journal-title":"BMC Infect Dis"},{"issue":"8","key":"10.1016\/j.burns.2023.11.007_bib27","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0255636","article-title":"Resistance patterns and clinical outcomes of Klebsiella pneumoniae and invasive Klebsiella variicola in trauma patients","volume":"16","author":"Kiley","year":"2021","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.burns.2023.11.007_bib28","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.amjms.2015.12.018","article-title":"Klebsiella pneumoniae liver abscess: an emerging disease","volume":"351","author":"Fazili","year":"2016","journal-title":"Am J Med Sci"},{"issue":"9","key":"10.1016\/j.burns.2023.11.007_bib29","doi-asserted-by":"crossref","first-page":"2016","DOI":"10.1016\/j.clinthera.2016.08.001","article-title":"Intravenous antibiotic and antifungal agent pharmacokinetic-pharmacodynamic dosing in adults with severe burn injury","volume":"38","author":"Cota","year":"2016","journal-title":"Clin Ther"},{"issue":"8","key":"10.1016\/j.burns.2023.11.007_bib30","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1086\/677165","article-title":"Reduction in central line-associated bloodstream infections in patients with burns","volume":"35","author":"van Duin","year":"2014","journal-title":"Infect Control Hosp Epidemiol"},{"issue":"1","key":"10.1016\/j.burns.2023.11.007_bib31","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s00011-020-01426-x","article-title":"Burn injury induces elevated inflammatory traffic: the role of NF-\u03baB","volume":"70","author":"George","year":"2021","journal-title":"Inflamm Res"},{"issue":"7","key":"10.1016\/j.burns.2023.11.007_bib32","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1016\/j.cmi.2020.01.025","article-title":"Positive follow-up blood cultures identify high mortality risk among patients with Gram-negative bacteraemia","volume":"26","author":"Maskarinec","year":"2020","journal-title":"Clin Microbiol Infect"},{"issue":"2","key":"10.1016\/j.burns.2023.11.007_bib33","article-title":"Impact of persistent multidrug-resistant gram-negative bacteremia on clinical outcome and mortality","volume":"12","author":"Kitaya","year":"2023","journal-title":"Antibiot (Basel)"}],"container-title":["Burns"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0305417923002498?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0305417923002498?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,5]],"date-time":"2025-10-05T08:20:02Z","timestamp":1759652402000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0305417923002498"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":33,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["S0305417923002498"],"URL":"https:\/\/doi.org\/10.1016\/j.burns.2023.11.007","relation":{},"ISSN":["0305-4179"],"issn-type":[{"value":"0305-4179","type":"print"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Epidemiology and clinical significance of persistent bacteremia in severely burned patients","name":"articletitle","label":"Article Title"},{"value":"Burns","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.burns.2023.11.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}