{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,21]],"date-time":"2026-06-21T04:25:36Z","timestamp":1782015936453,"version":"3.54.5"},"reference-count":33,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.es","clinicalkey.com.au","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Burns"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.burns.2024.107353","type":"journal-article","created":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T16:31:49Z","timestamp":1734021109000},"page":"107353","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["LINC00525 promotes cell proliferation and collagen expression through feedforward regulation of TGF-\u03b2 signaling in hypertrophic scar fibroblasts"],"prefix":"10.1016","volume":"51","author":[{"given":"Ling","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3212-9816","authenticated-orcid":false,"given":"Yiliang","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingyun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zezhang","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5419-2656","authenticated-orcid":false,"given":"Jun","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.burns.2024.107353_bib1","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1038\/s41572-023-00474-x","article-title":"Scars","volume":"9","author":"Jeschke","year":"2023","journal-title":"Nat Rev Dis Prim"},{"key":"10.1016\/j.burns.2024.107353_bib2","doi-asserted-by":"crossref","DOI":"10.3390\/cells12050678","article-title":"An Updated review of hypertrophic scarring","volume":"12","author":"Mony","year":"2023","journal-title":"Cells"},{"key":"10.1016\/j.burns.2024.107353_bib3","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/s40257-022-00744-6","article-title":"Hypertrophic scars and keloids: advances in treatment and review of established therapies","volume":"24","author":"Frech","year":"2023","journal-title":"Am J Clin Dermatol"},{"key":"10.1016\/j.burns.2024.107353_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110287","article-title":"Current potential therapeutic strategies targeting the TGF-beta\/Smad signaling pathway to attenuate keloid and hypertrophic scar formation.","volume":"129","author":"Zhang","year":"2020","journal-title":"Biomed Pharm"},{"key":"10.1016\/j.burns.2024.107353_bib5","first-page":"597","article-title":"New research advances in hypertrophic scar formation, prevention and treatment","volume":"57","author":"Chen","year":"2023","journal-title":"Zhonghua Yu Fang Yi Xue Za Zhi"},{"key":"10.1016\/j.burns.2024.107353_bib6","article-title":"Fibroblast and myofibroblast activation in normal tissue repair and fibrosis","author":"Younesi","year":"2024","journal-title":"Nat Rev Mol Cell Biol"},{"key":"10.1016\/j.burns.2024.107353_bib7","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1038\/s41580-022-00566-8","article-title":"Long non-coding RNAs: definitions, functions, challenges and recommendations","volume":"24","author":"Mattick","year":"2023","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"8","key":"10.1016\/j.burns.2024.107353_bib8","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1002\/jcb.25873","article-title":"Non-Coding RNAs: the new insight on hypertrophic scar","volume":"118","author":"Chen","year":"2017","journal-title":"J Cell Biochem"},{"key":"10.1016\/j.burns.2024.107353_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijbiomac.2023.128334","article-title":"Non-coding RNAs in hypertrophic scars and keloids: current research and clinical relevance: a review","volume":"256","author":"Su","year":"2024","journal-title":"Int J Biol Macromol"},{"key":"10.1016\/j.burns.2024.107353_bib10","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1159\/000369727","article-title":"Distinct expression profiles of lncRNAs between regressive and mature scars","volume":"35","author":"Li","year":"2015","journal-title":"Cell Physiol Biochem"},{"key":"10.1016\/j.burns.2024.107353_bib11","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1159\/000452548","article-title":"The long non-coding RNA LncRNA8975-1 is upregulated in hypertrophic scar fibroblasts and controls collagen expression","volume":"40","author":"Li","year":"2016","journal-title":"Cell Physiol Biochem"},{"key":"10.1016\/j.burns.2024.107353_bib12","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1007\/s11010-020-03966-6","article-title":"LINC00173 promotes the apoptosis of hypertrophic scar fibroblasts through increasing beta-catenin expression","volume":"476","author":"Li","year":"2021","journal-title":"Mol Cell Biochem"},{"key":"10.1016\/j.burns.2024.107353_bib13","article-title":"Comprehensive analysis of CDK1-associated ceRNA network revealing the key pathways LINC00460\/LINC00525-Hsa-Mir-338-FAM111\/ZWINT as prognostic biomarkers in lung adenocarcinoma combined with experiments","volume":"11","author":"Li","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.burns.2024.107353_bib14","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1002\/cac2.12181","article-title":"LncRNA LINC00525 suppresses p21 expression via mRNA decay and triplex-mediated changes in chromatin structure in lung adenocarcinoma","volume":"41","author":"Fang","year":"2021","journal-title":"Cancer Commun"},{"key":"10.1016\/j.burns.2024.107353_bib15","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.bbrc.2020.12.042","article-title":"Long non-coding RNA LINC00525 interacts with miR-31-5p and miR-125a-5p to act as an oncogenic molecule in spinal chordoma","volume":"536","author":"Gong","year":"2021","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.burns.2024.107353_bib16","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1007\/s00432-024-05830-2","article-title":"LINC00525 enhances ZNF460-regulated CD24 expression through the sponge miR-125a-5p to promote malignant progression of breast cancer","volume":"150","author":"Wang","year":"2024","journal-title":"J Cancer Res Clin Oncol"},{"key":"10.1016\/j.burns.2024.107353_bib17","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.2174\/1389201020666190725112304","article-title":"Overexpression of miR-340-5p inhibits skin fibroblast proliferation by targeting Kruppel-like Factor 2","volume":"20","author":"Chen","year":"2019","journal-title":"Curr Pharm Biotechnol"},{"key":"10.1016\/j.burns.2024.107353_bib18","doi-asserted-by":"crossref","first-page":"3770","DOI":"10.1172\/JCI94753","article-title":"Fibroblast-specific TGF-beta-Smad2\/3 signaling underlies cardiac fibrosis","volume":"127","author":"Khalil","year":"2017","journal-title":"J Clin Invest"},{"key":"10.1016\/j.burns.2024.107353_bib19","doi-asserted-by":"crossref","first-page":"206","DOI":"10.3389\/fphar.2017.00206","article-title":"Honokiol alleviates hypertrophic scar by targeting transforming growth factor-beta\/Smad2\/3 signaling pathway","volume":"8","author":"Zhao","year":"2017","journal-title":"Front Pharm"},{"key":"10.1016\/j.burns.2024.107353_bib20","first-page":"183","article-title":"The myofibroblast: a key cell for wound healing and fibrocontractive diseases","volume":"54","author":"Gabbiani","year":"1981","journal-title":"Prog Clin Biol Res"},{"key":"10.1016\/j.burns.2024.107353_bib21","doi-asserted-by":"crossref","DOI":"10.3390\/biom11081095","article-title":"Myofibroblasts: function, formation, and scope of molecular therapies for skin fibrosis","volume":"11","author":"Tai","year":"2021","journal-title":"Biomolecules"},{"key":"10.1016\/j.burns.2024.107353_bib22","doi-asserted-by":"crossref","first-page":"347","DOI":"10.15283\/ijsc19041","article-title":"Long Non-Coding RNA LINC00525 promotes the stemness and chemoresistance of colorectal cancer by targeting miR-507\/ELK3 Axis","volume":"12","author":"Wang","year":"2019","journal-title":"Int J Stem Cells"},{"key":"10.1016\/j.burns.2024.107353_bib23","doi-asserted-by":"crossref","first-page":"1846","DOI":"10.2174\/1389557523666230328125031","article-title":"The role of MiR-29 in the mechanism of fibrosis","volume":"23","author":"Wang","year":"2023","journal-title":"Mini Rev Med Chem"},{"key":"10.1016\/j.burns.2024.107353_bib24","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1080\/08916934.2019.1621856","article-title":"MicroRNA-21 and microRNA-29a modulate the expression of collagen in dermal fibroblasts of patients with systemic sclerosis","volume":"52","author":"Jafarinejad-Farsangi","year":"2019","journal-title":"Autoimmunity"},{"key":"10.1016\/j.burns.2024.107353_bib25","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1038\/mt.2016.127","article-title":"MiR-29a assists in preventing the activation of human stellate cells and promotes recovery from liver fibrosis in mice","volume":"24","author":"Matsumoto","year":"2016","journal-title":"Mol Ther"},{"key":"10.1016\/j.burns.2024.107353_bib26","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1111\/ced.12734","article-title":"A novel regulatory function for miR-29a in keloid fibrogenesis","volume":"41","author":"Zhang","year":"2016","journal-title":"Clin Exp Dermatol"},{"key":"10.1016\/j.burns.2024.107353_bib27","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1681\/ASN.2011010055","article-title":"Suppression of microRNA-29 expression by TGF-beta1 promotes collagen expression and renal fibrosis","volume":"23","author":"Wang","year":"2012","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.burns.2024.107353_bib28","article-title":"Lnc PVT1 facilitates TGF-beta1-induced human cardiac fibroblast activation in vitro and ISO-induced myocardial fibrosis in vivo through regulating MYC","author":"Wang","year":"2024","journal-title":"Mol Cell Biochem"},{"key":"10.1016\/j.burns.2024.107353_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2024.111373","article-title":"LncRNA H19 accelerates renal fibrosis by negatively regulating the let-7b-5p\/TGF-betaR1\/COL1A1 axis.","volume":"123","author":"Li","year":"2024","journal-title":"Cell Signal"},{"key":"10.1016\/j.burns.2024.107353_bib30","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1186\/s12967-024-05554-4","article-title":"A systematic review of non-coding RNA therapeutics in early clinical trials: a new perspective against cancer","volume":"22","author":"Grillone","year":"2024","journal-title":"J Transl Med"},{"key":"10.1016\/j.burns.2024.107353_bib31","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1038\/s41573-021-00219-z","article-title":"Noncoding RNA therapeutics - challenges and potential solutions","volume":"20","author":"Winkle","year":"2021","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.burns.2024.107353_bib32","doi-asserted-by":"crossref","first-page":"4007","DOI":"10.1016\/j.cell.2023.07.036","article-title":"TGF-beta signaling in health and disease.","volume":"186","author":"Massague","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.burns.2024.107353_bib33","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1038\/s41392-024-01764-w","article-title":"TGF-beta signaling in health, disease, and therapeutics","volume":"9","author":"Deng","year":"2024","journal-title":"Signal Transduct Target Ther"}],"container-title":["Burns"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0305417924003930?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0305417924003930?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T07:43:46Z","timestamp":1739259826000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0305417924003930"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":33,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["S0305417924003930"],"URL":"https:\/\/doi.org\/10.1016\/j.burns.2024.107353","relation":{},"ISSN":["0305-4179"],"issn-type":[{"value":"0305-4179","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"LINC00525 promotes cell proliferation and collagen expression through feedforward regulation of TGF-\u03b2 signaling in hypertrophic scar fibroblasts","name":"articletitle","label":"Article Title"},{"value":"Burns","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.burns.2024.107353","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Ltd and ISBI. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"107353"}}