{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,21]],"date-time":"2026-06-21T04:25:37Z","timestamp":1782015937438,"version":"3.54.5"},"reference-count":23,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,11]],"date-time":"2025-07-11T00:00:00Z","timestamp":1752192000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Burns"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.burns.2025.107617","type":"journal-article","created":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T13:50:48Z","timestamp":1752587448000},"page":"107617","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["IBSP mediates fibroblast malignant behaviors in hypertrophic scars via interacting with SKP1"],"prefix":"10.1016","volume":"51","author":[{"given":"Ya","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunlin","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teng","family":"Quan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.burns.2025.107617_bib1","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1007\/s00403-022-02516-y","article-title":"SNHG1 functions as a ceRNA in hypertrophic scar fibroblast proliferation and apoptosis through miR-320b\/CTNNB1 axis","volume":"315","author":"Li","year":"2023","journal-title":"Arch Dermatol Res"},{"key":"10.1016\/j.burns.2025.107617_bib2","article-title":"ALA-PDT promotes the death and contractile capacity of hypertrophic scar fibroblasts through inhibiting the TGF-beta1\/Smad2\/3\/4 signaling pathway","volume":"45","author":"Qu","year":"2023","journal-title":"Photodiagnosis Photodyn Ther"},{"key":"10.1016\/j.burns.2025.107617_bib3","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1007\/s00109-023-02364-x","article-title":"Insufficient SIRT1 in macrophages promotes oxidative stress and inflammation during scarring","volume":"101","author":"He","year":"2023","journal-title":"J Mol Med (Berl)"},{"key":"10.1016\/j.burns.2025.107617_bib4","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1188256","article-title":"Pan-cancer analysis shows that IBSP is a potential prognostic and immunotherapeutic biomarker for multiple cancer types including osteosarcoma","volume":"14","author":"Pan","year":"2023","journal-title":"Front Immunol"},{"key":"10.1016\/j.burns.2025.107617_bib5","unstructured":"Ma Y., Chen B., Zhang B., Zhang C., Zhu Q., Wang X., et al. High expression of integrin-binding sialoprotein (IBSP) is associated with poor prognosis of osteosarcoma. LID - 10.18632\/aging.205235 [doi]."},{"key":"10.1016\/j.burns.2025.107617_bib6","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1177\/00220345221126716","article-title":"Bone sialoprotein is critical for alveolar bone healing in mice","volume":"102","author":"Chavez","year":"2023","journal-title":"J Dent Res"},{"key":"10.1016\/j.burns.2025.107617_bib7","doi-asserted-by":"crossref","first-page":"2787","DOI":"10.4103\/0366-6999.167359","article-title":"Process of hypertrophic scar formation: expression of eukaryotic initiation factor 6","volume":"128","author":"Yang","year":"2015","journal-title":"Chin Med J (Engl)"},{"key":"10.1016\/j.burns.2025.107617_bib8","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1016\/j.burns.2014.11.017","article-title":"A histological study on the effect of pressure therapy on the activities of myofibroblasts and keratinocytes in hypertrophic scar tissues after burn","volume":"41","author":"Li-Tsang","year":"2015","journal-title":"Burns"},{"key":"10.1016\/j.burns.2025.107617_bib9","first-page":"274","article-title":"A novel lncRNA FPASL regulates fibroblast proliferation via the PI3K\/AKT and MAPK signaling pathways in hypertrophic scar","volume":"55","author":"Ma","year":"2022","journal-title":"Acta Biochim Biophys Sin (Shanghai)"},{"key":"10.1016\/j.burns.2025.107617_bib10","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1186\/s12943-017-0700-1","article-title":"FOXP3 promotes tumor growth and metastasis by activating Wnt\/beta-catenin signaling pathway and EMT in non-small cell lung cancer","volume":"16","author":"Yang","year":"2017","journal-title":"Mol Cancer"},{"key":"10.1016\/j.burns.2025.107617_bib11","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1097\/DAD.0000000000001661","article-title":"Wnt signaling pathway proteins in scar, hypertrophic scar, and keloid: evidence for a continuum?","volume":"42","author":"Chaudet","year":"2020","journal-title":"Am J Derm"},{"key":"10.1016\/j.burns.2025.107617_bib12","doi-asserted-by":"crossref","DOI":"10.1002\/iid3.693","article-title":"BMS-202, a PD-1\/PD-L1 inhibitor, decelerates the pro-fibrotic effects of fibroblasts derived from scar tissues via ERK and TGFbeta1\/Smad signaling pathways","volume":"10","author":"Cai","year":"2022","journal-title":"Immun Inflamm Dis"},{"key":"10.1016\/j.burns.2025.107617_bib13","doi-asserted-by":"crossref","first-page":"2398","DOI":"10.3892\/or.2017.5454","article-title":"USP39 promotes colorectal cancer growth and metastasis through the Wnt\/beta-catenin pathway","volume":"37","author":"Yuan","year":"2017","journal-title":"Oncol Rep"},{"key":"10.1016\/j.burns.2025.107617_bib14","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.85494","article-title":"Transferred mitochondria accumulate reactive oxygen species, promoting proliferation","volume":"12","author":"Kidwell","year":"2023","journal-title":"Elife"},{"key":"10.1016\/j.burns.2025.107617_bib15","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/s41388-023-02907-z","article-title":"ROS production by mitochondria: function or dysfunction?","volume":"43","author":"Palma","year":"2024","journal-title":"Oncogene"},{"key":"10.1016\/j.burns.2025.107617_bib16","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/s11103-023-01389-7","article-title":"Genetic diversity, transcript heterogeneity and allele mining of TaSKP1-6B-4 gene variants across diverse genotypes under terminal heat stress and genome wide characterization of TaSKP1 gene family from bread wheat (Triticum aestivum L.)","volume":"113","author":"Jaiswal","year":"2023","journal-title":"Plant Mol Biol"},{"key":"10.1016\/j.burns.2025.107617_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2022.106059","article-title":"Brusatol has therapeutic efficacy in non-small cell lung cancer by targeting Skp1 to inhibit cancer growth and metastasis","volume":"176","author":"Xing","year":"2022","journal-title":"Pharm Res"},{"key":"10.1016\/j.burns.2025.107617_bib18","article-title":"Needle-free jet injector-assisted triamcinolone treatment of keloids and hypertrophic scars is effective and well tolerated in children","author":"Bekkers","year":"2023","journal-title":"Clin Drug Invest"},{"key":"10.1016\/j.burns.2025.107617_bib19","article-title":"Recent understandings of biology, prophylaxis and treatment strategies for hypertrophic scars and keloids","volume":"19","author":"Lee","year":"2018","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.burns.2025.107617_bib20","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1272\/jnms.JNMS.2021_88-106","article-title":"The latest strategy for keloid and hypertrophic scar prevention and treatment: the Nippon Medical School (NMS) Protocol","volume":"88","author":"Ogawa","year":"2021","journal-title":"J Nippon Med Sch"},{"key":"10.1016\/j.burns.2025.107617_bib21","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1097\/PRS.0000000000008488","article-title":"USP15 enhances the proliferation, migration, and collagen deposition of hypertrophic scar-derived fibroblasts by deubiquitinating TGF-betaR1 in vitro","volume":"148","author":"Tu","year":"2021","journal-title":"Plast Reconstr Surg"},{"key":"10.1016\/j.burns.2025.107617_bib22","doi-asserted-by":"crossref","DOI":"10.3892\/mmr.2021.11843","article-title":"Knockdown of FAM225B inhibits the progression of the hypertrophic scar following glaucoma surgery by inhibiting autophagy","volume":"23","author":"Ma","year":"2021","journal-title":"Mol Med Rep"},{"key":"10.1016\/j.burns.2025.107617_bib23","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.4251\/wjgo.v15.i9.1531","article-title":"RNA-binding protein CPSF6 regulates IBSP to affect pyroptosis in gastric cancer","volume":"15","author":"Wang","year":"2023","journal-title":"World J Gastrointest Oncol"}],"container-title":["Burns"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0305417925002463?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0305417925002463?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,8,6]],"date-time":"2025-08-06T14:06:08Z","timestamp":1754489168000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0305417925002463"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":23,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["S0305417925002463"],"URL":"https:\/\/doi.org\/10.1016\/j.burns.2025.107617","relation":{},"ISSN":["0305-4179"],"issn-type":[{"value":"0305-4179","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"IBSP mediates fibroblast malignant behaviors in hypertrophic scars via interacting with SKP1","name":"articletitle","label":"Article Title"},{"value":"Burns","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.burns.2025.107617","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"107617"}}