{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T08:33:00Z","timestamp":1773909180230,"version":"3.50.1"},"reference-count":38,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100019673","name":"Bilimsel Ara\u015ft\u0131rma Projeleri Birimi, \u0130stanbul Teknik \u00dcniversitesi","doi-asserted-by":"publisher","award":["15H0230001"],"award-info":[{"award-number":["15H0230001"]}],"id":[{"id":"10.13039\/501100019673","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007613","name":"Ankara University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007613","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Burns"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.burns.2025.107811","type":"journal-article","created":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T07:51:32Z","timestamp":1764661892000},"page":"107811","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Microneedling accelerates burn wound healing and promotes collagen remodeling: Insights from a rodent model"],"prefix":"10.1016","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3563-3639","authenticated-orcid":false,"given":"Servet El\u00e7in","family":"Alpat","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8516-3658","authenticated-orcid":false,"given":"Burak","family":"Kaya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0901-8875","authenticated-orcid":false,"given":"Hilal G\u00f6kt\u00fcrk","family":"Nakka\u015f","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9924-7051","authenticated-orcid":false,"given":"P\u0131nar","family":"Bayram","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0616-1935","authenticated-orcid":false,"given":"\u015eule","family":"K\u0131z\u0131l","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0469-7998","authenticated-orcid":false,"given":"Belgin","family":"Can","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3158-2894","authenticated-orcid":false,"given":"Serdar Mehmet","family":"G\u00fcltan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.burns.2025.107811_bib1","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1093\/jbcr\/irae053","article-title":"The burden of burns: an analysis of public health measures","volume":"45","author":"Ivanko","year":"2024","journal-title":"J Burn care Res Publ Am Burn Assoc"},{"key":"10.1016\/j.burns.2025.107811_bib2","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.1136\/bmj.328.7453.1427","article-title":"ABC of burns: pathophysiology and types of burns","volume":"328","author":"Hettiaratchy","year":"2004","journal-title":"Bmj"},{"key":"10.1016\/j.burns.2025.107811_bib3","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1002\/bjs.18004016413","article-title":"The diagnosis of the depth of burning","volume":"40","author":"Jackson","year":"1953","journal-title":"Br J Surg"},{"key":"10.1016\/j.burns.2025.107811_bib4","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1111\/j.1600-0625.2010.01105.x","article-title":"The biology of burn injury","volume":"19","author":"Evers","year":"2010","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.burns.2025.107811_bib5","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1097\/CCM.0b013e318275cee7","article-title":"Secondary burn progression decreased by erythropoietin","volume":"41","author":"Tobalem","year":"2013","journal-title":"Crit Care Med"},{"key":"10.1016\/j.burns.2025.107811_bib6","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1097\/PRS.0b013e31827c6d6f","article-title":"The effect of subcutaneous mesenchymal stem cell injection on statis zone and apoptosis in an experimental burn model","volume":"131","author":"Oksuz","year":"2013","journal-title":"Plast Reconstr Surg"},{"key":"10.1016\/j.burns.2025.107811_bib7","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1002\/j.2040-4603.2018.tb00010.x","article-title":"Pathophysiologic mechanisms and current treatments for cutaneous sequelae of burn wounds","volume":"8","author":"Hall","year":"2017","journal-title":"Compr Physiol"},{"key":"10.1016\/j.burns.2025.107811_bib8","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1016\/j.burns.2017.02.006","article-title":"Percutaneous collagen induction as an additive treatment for scar formation following thermal injuries: Preliminary experience in 47 children","volume":"43","author":"Kubiak","year":"2017","journal-title":"Burns"},{"key":"10.1016\/j.burns.2025.107811_bib9","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.jss.2020.11.068","article-title":"Modeling Burn Progression Using Comb Burns: The Impact of Thermal Contact Duration on Model Outcomes","volume":"260","author":"Smith","year":"2021","journal-title":"J Surg Res"},{"key":"10.1016\/j.burns.2025.107811_bib10","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1097\/00005373-199205000-00004","article-title":"Elucidating the vascular response to burns with a new rat model","volume":"32","author":"Regas","year":"1992","journal-title":"J Trauma"},{"key":"10.1016\/j.burns.2025.107811_bib11","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1007\/s13346-021-00909-6","article-title":"Enhancement strategies for transdermal drug delivery systems: current trends and applications","volume":"12","author":"Ramadon","year":"2022","journal-title":"Drug Deliv Transl Res"},{"key":"10.1016\/j.burns.2025.107811_bib12","doi-asserted-by":"crossref","DOI":"10.4103\/jdds.jdds_126_20","article-title":"Microneedling: a means of collagen induction therapy","volume":"25","author":"Nair","year":"2021","journal-title":"J Dermatol Dermatol Surg"},{"key":"10.1016\/j.burns.2025.107811_bib13","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202103317","article-title":"Polydopamine decorated microneedles with Fe-MSC-derived nanovesicles encapsulation for wound healing.","volume":"9","author":"Ma","year":"2022","journal-title":"Adv Sci"},{"key":"10.1016\/j.burns.2025.107811_bib14","doi-asserted-by":"crossref","first-page":"836","DOI":"10.1016\/j.burns.2009.11.014","article-title":"Percutaneous collagen induction therapy: an alternative treatment for burn scars","volume":"36","author":"Aust","year":"2010","journal-title":"Burns"},{"key":"10.1016\/j.burns.2025.107811_bib15","doi-asserted-by":"crossref","first-page":"2321","DOI":"10.1007\/s00266-023-03820-2","article-title":"Microneedling in the Treatment of Post-burn Hypertrophic Scars","volume":"48","author":"Mota","year":"2024","journal-title":"Aesthetic Plast Surg"},{"key":"10.1016\/j.burns.2025.107811_bib16","doi-asserted-by":"crossref","first-page":"193","DOI":"10.3390\/cosmetics11060193","article-title":"Current Understanding of Microneedling Procedures for Acne Skin: A Narrative Review","volume":"11","author":"M\u0103geru\u0219an","year":"2024","journal-title":"Cosmetics"},{"key":"10.1016\/j.burns.2025.107811_bib17","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1002\/ncp.10376","article-title":"The role of vitamin A in wound healing","volume":"34","author":"Polcz","year":"2019","journal-title":"Nutr Clin Pr"},{"key":"10.1016\/j.burns.2025.107811_bib18","doi-asserted-by":"crossref","first-page":"537","DOI":"10.3390\/ebj4040035","article-title":"Nutrition considerations for burn patients: optimizing recovery and healing","volume":"4","author":"Shields","year":"2023","journal-title":"Eur Burn J"},{"key":"10.1016\/j.burns.2025.107811_bib19","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1111\/j.1365-2133.2010.09936.x","article-title":"Topical retinoids in the management of photodamaged skin: from theory to evidence-based practical approach","volume":"163","author":"Darlenski","year":"2010","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.burns.2025.107811_bib20","doi-asserted-by":"crossref","DOI":"10.1097\/PRS.0000000000000043","article-title":"Reversal of skin aging with topical retinoids","volume":"133","author":"Hubbard","year":"2014","journal-title":"Plast Reconstr Surg"},{"key":"10.1016\/j.burns.2025.107811_bib21","first-page":"867","article-title":"Topical treatments for photoaged skin","volume":"22","author":"Sadick","year":"2023","journal-title":"J Drugs Dermatol"},{"key":"10.1016\/j.burns.2025.107811_bib22","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1186\/s13054-015-0961-2","article-title":"Burn wound healing and treatment: review and advancements","volume":"19","author":"Rowan","year":"2015","journal-title":"Crit Care"},{"key":"10.1016\/j.burns.2025.107811_bib23","doi-asserted-by":"crossref","first-page":"128","DOI":"10.3390\/medicina61010128","article-title":"Strategies for optimizing acute burn wound therapy: a comprehensive review","volume":"61","author":"Cretu","year":"2025","journal-title":"Medicina"},{"key":"10.1016\/j.burns.2025.107811_bib24","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.bjps.2010.03.038","article-title":"Percutaneous collagen induction-regeneration in place of cicatrisation?","volume":"64","author":"Aust","year":"2011","journal-title":"J Plast Reconstr Aesthet Surg"},{"key":"10.1016\/j.burns.2025.107811_bib25","doi-asserted-by":"crossref","DOI":"10.1097\/PRS.0b013e3181ea93da","article-title":"Percutaneous collagen induction therapy as a novel therapeutic option for Striae distensae","volume":"126","author":"Aust","year":"2010","journal-title":"Plast Reconstr Surg"},{"key":"10.1016\/j.burns.2025.107811_bib26","doi-asserted-by":"crossref","first-page":"1421","DOI":"10.1097\/01.prs.0000304612.72899.02","article-title":"Percutaneous collagen induction therapy: an alternative treatment for scars, wrinkles, and skin laxity","volume":"121","author":"Aust","year":"2008","journal-title":"Plast Reconstr Surg"},{"key":"10.1016\/j.burns.2025.107811_bib27","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1016\/j.burns.2013.12.008","article-title":"Microneedling: matching the results of medical needling and repetitive treatments to maximize potential for skin regeneration","volume":"40","author":"Zeitter","year":"2014","journal-title":"Burns"},{"key":"10.1016\/j.burns.2025.107811_bib28","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1016\/j.bjps.2014.01.019","article-title":"Improving fat graft survival through preconditioning of the recipient site with microneedling","volume":"67","author":"Sezgin","year":"2014","journal-title":"J Plast Reconstr Aesthet Surg"},{"key":"10.1016\/j.burns.2025.107811_bib29","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1016\/S0002-9440(10)61213-8","article-title":"Novel function for vascular endothelial growth factor receptor-1 on epidermal keratinocytes","volume":"167","author":"Wilgus","year":"2005","journal-title":"Am J Pathol"},{"key":"10.1016\/j.burns.2025.107811_bib30","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1208\/s12248-011-9288-3","article-title":"Characterization of microchannels created by metal microneedles: formation and closure","volume":"13","author":"Kalluri","year":"2011","journal-title":"Aaps J"},{"key":"10.1016\/j.burns.2025.107811_bib31","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1159\/000360527","article-title":"Topical retinoids in skin ageing: a focused update with reference to sun-induced epidermal vitamin a deficiency","volume":"228","author":"Sorg","year":"2014","journal-title":"Dermatology"},{"key":"10.1016\/j.burns.2025.107811_bib32","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.1097\/PRS.0b013e318188245e","article-title":"Percutaneous collagen induction: minimally invasive skin rejuvenation without risk of hyperpigmentation-fact or fiction?","volume":"122","author":"Aust","year":"2008","journal-title":"Plast Reconstr Surg"},{"key":"10.1016\/j.burns.2025.107811_bib33","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1189\/jlb.0910538","article-title":"The paradox of the neutrophil's role in tissue injury","volume":"89","author":"Segel","year":"2011","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.burns.2025.107811_bib34","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1159\/000339613","article-title":"Wound repair and regeneration","volume":"49","author":"Reinke","year":"2012","journal-title":"Eur Surg Res"},{"key":"10.1016\/j.burns.2025.107811_bib35","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.clindermatol.2007.09.006","article-title":"Combating photoaging with percutaneous collagen induction","volume":"26","author":"Fernandes","year":"2008","journal-title":"Clin Dermatol"},{"key":"10.1016\/j.burns.2025.107811_bib36","doi-asserted-by":"crossref","DOI":"10.1097\/PRS.0b013e3182131e0f","article-title":"A prospective controlled assessment of microneedling with the Dermaroller device","volume":"127","author":"Schwarz","year":"2011","journal-title":"Plast Reconstr Surg"},{"key":"10.1016\/j.burns.2025.107811_bib37","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1152\/physrev.00067.2017","article-title":"Wound healing: a cellular perspective","volume":"99","author":"Rodrigues","year":"2019","journal-title":"Physiol Rev"},{"key":"10.1016\/j.burns.2025.107811_bib38","doi-asserted-by":"crossref","first-page":"3241","DOI":"10.1007\/s00018-014-1612-5","article-title":"Animal models in burn research","volume":"71","author":"Abdullahi","year":"2014","journal-title":"Cell Mol Life Sci"}],"container-title":["Burns"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0305417925004401?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0305417925004401?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T04:21:42Z","timestamp":1773894102000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0305417925004401"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":38,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["S0305417925004401"],"URL":"https:\/\/doi.org\/10.1016\/j.burns.2025.107811","relation":{},"ISSN":["0305-4179"],"issn-type":[{"value":"0305-4179","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Microneedling accelerates burn wound healing and promotes collagen remodeling: Insights from a rodent model","name":"articletitle","label":"Article Title"},{"value":"Burns","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.burns.2025.107811","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd and ISBI. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"107811"}}