{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T22:18:07Z","timestamp":1775686687090,"version":"3.50.1"},"reference-count":33,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Burns"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.burns.2026.107967","type":"journal-article","created":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T07:45:07Z","timestamp":1773215107000},"page":"107967","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Management of burn patients is linked to the development of anti-HLA antibodies in patients receiving cryopreserved skin allografts: A retrospective cohort"],"prefix":"10.1016","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1469-4210","authenticated-orcid":false,"given":"Vicente","family":"Mirabet","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3926-7920","authenticated-orcid":false,"given":"Francisco","family":"Boix","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1251-866X","authenticated-orcid":false,"given":"Nieves","family":"Vanaclocha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabel","family":"Segura-Grau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6364-8838","authenticated-orcid":false,"given":"Luis","family":"Larrea","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Dolores","family":"P\u00e9rez del Caz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.burns.2026.107967_bib1","doi-asserted-by":"crossref","first-page":"757","DOI":"10.2217\/imt.11.2","article-title":"Immune recognition and rejection of allogeneic skin grafts","volume":"3","author":"Benichou","year":"2011","journal-title":"Immunotherapy"},{"key":"10.1016\/j.burns.2026.107967_bib2","series-title":"Autoimmunity: from bench to bedside","article-title":"Major histocompatibility complex: antigen processing and presentation","author":"Cruz-Tapias","year":"2013"},{"issue":"2","key":"10.1016\/j.burns.2026.107967_bib3","doi-asserted-by":"crossref","first-page":"716","DOI":"10.3390\/ijms23020716","article-title":"innate immune system response to burn damage-focus on cytokine alteration","volume":"23","author":"Sierawska","year":"2022","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.burns.2026.107967_bib4","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.586195","article-title":"Severe altered immune status after burn injury is associated with bacterial infection and septic shock","volume":"12","author":"Moins-Teisserenc","year":"2021","journal-title":"Front Immunol"},{"issue":"3","key":"10.1016\/j.burns.2026.107967_bib5","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/0011-2240(88)90025-9","article-title":"Development of a passive device for freezing large amounts of transplantable skin at one time in a -70 \u00b0 C mechanical refrigerator","volume":"25","author":"May","year":"1988","journal-title":"Cryobiology"},{"issue":"1","key":"10.1016\/j.burns.2026.107967_bib6","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1016\/0305-4179(94)90080-9","article-title":"Euro Skin Bank: large scale skin-banking in Europe based on glycerol-preservation of donor skin","volume":"20","author":"de Backere","year":"1994","journal-title":"Burns"},{"key":"10.1016\/j.burns.2026.107967_bib7","unstructured":"European Directorate for the Quality of Medicines & Health Care (EDQM). Guide to the quality and safety of tissues and cells for human application. European Council. Strasbourg, France. 2022."},{"issue":"5","key":"10.1016\/j.burns.2026.107967_bib8","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1111\/tri.12540","article-title":"Anti-HLA sensitisation in extensively burned patients: extent, associated factors, and reduction in potential access to vascularized composite allotransplantation","volume":"28","author":"Duhamel","year":"2015","journal-title":"Transpl Int"},{"issue":"4","key":"10.1016\/j.burns.2026.107967_bib9","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.clindermatol.2004.07.022","article-title":"Immunology of skin transplantation","volume":"23","author":"Richters","year":"2005","journal-title":"Clin Dermatol"},{"issue":"5","key":"10.1016\/j.burns.2026.107967_bib10","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/j.burns.2011.01.007","article-title":"Preservation methods of allografts and their (lack of) influence on clinical results in partial thickness burns","volume":"37","author":"Hermans","year":"2011","journal-title":"Burns"},{"issue":"4","key":"10.1016\/j.burns.2026.107967_bib11","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1016\/j.kint.2021.11.029","article-title":"Allorecognition and the spectrum of kidney transplant rejection","volume":"101","author":"Callemeyn","year":"2022","journal-title":"Kidney Int"},{"issue":"7","key":"10.1016\/j.burns.2026.107967_bib12","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1182\/blood.V85.7.1736.bloodjournal8571736","article-title":"Occurrence of allogeneic HLA and non-HLA antibodies after transfusion of prestorage filtered platelets and red blood cells: a prospective study","volume":"85","author":"Novotny","year":"1995","journal-title":"Blood"},{"issue":"8","key":"10.1016\/j.burns.2026.107967_bib13","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1111\/trf.14800","article-title":"Transfusion of leukoreduced blood products and risk of antibody-mediated rejection of renal allografts","volume":"58","author":"Bynum","year":"2018","journal-title":"Transfusion"},{"key":"10.1016\/j.burns.2026.107967_bib14","doi-asserted-by":"crossref","first-page":"30","DOI":"10.3389\/fimmu.2016.00030","article-title":"Alloantibody generation and effector function following sensitisation to human leukocyte antigen","volume":"7","author":"Hickey","year":"2016","journal-title":"Front Immunol"},{"issue":"4","key":"10.1016\/j.burns.2026.107967_bib15","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1016\/j.transproceed.2015.03.014","article-title":"Effect of different sensitisation events on HLA alloimmunisation in kidney transplantation candidates","volume":"47","author":"Lopes","year":"2015","journal-title":"Transpl Proc"},{"issue":"3","key":"10.1016\/j.burns.2026.107967_bib16","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1097\/BCR.0000000000000458","article-title":"Immunological effect of skin allograft in burn treatment: impact on future vascularized composite allotransplantation","volume":"38","author":"Garza","year":"2017","journal-title":"J Burn Care Res"},{"issue":"5","key":"10.1016\/j.burns.2026.107967_bib17","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1016\/j.burns.2018.01.010","article-title":"Screening of HLA sensitisation during acute burn care","volume":"44","author":"Klein","year":"2018","journal-title":"Burns"},{"issue":"3","key":"10.1016\/j.burns.2026.107967_bib18","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1111\/tri.12912","article-title":"Evaluation of human leukocyte antigen sensitisation in burn patients after treatment with skin allografts and transfusion of blood products","volume":"30","author":"Lindford","year":"2017","journal-title":"Transpl Int"},{"issue":"6","key":"10.1016\/j.burns.2026.107967_bib19","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1093\/jbcr\/iraa070","article-title":"Anti-human leukocyte antigen immune sensitisation effects of cryopreserved allograft and blood transfusion","volume":"41","author":"Tassin","year":"2020","journal-title":"J Burn Care Res"},{"issue":"8","key":"10.1016\/j.burns.2026.107967_bib20","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1016\/j.bjps.2015.04.018","article-title":"Allosensitisation following skin allografts in acute burn management: are burns patients suitable face transplant candidates?","volume":"68","author":"Win","year":"2015","journal-title":"J Plast Reconstr Aesthet Surg"},{"issue":"1","key":"10.1016\/j.burns.2026.107967_bib21","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.burns.2013.05.006","article-title":"Clinical application and viability of cryopreserved cadaveric skin allografts in severe burn: a retrospective analysis","volume":"40","author":"Cleland","year":"2014","journal-title":"Burns"},{"issue":"4","key":"10.1016\/j.burns.2026.107967_bib22","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/j.burns.2022.05.025","article-title":"Human skin processing affects clinical outcome in allograft recipients","volume":"49","author":"Antonioli","year":"2023","journal-title":"Burns"},{"issue":"2","key":"10.1016\/j.burns.2026.107967_bib23","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/s10561-011-9254-4","article-title":"Comparing the use of glycerol preserved and cryopreserved allogenic skin for the treatment of severe burns: differences in clinical outcomes and in vitro tissue viability","volume":"13","author":"Kua","year":"2012","journal-title":"Cell Tissue Bank"},{"issue":"3","key":"10.1016\/j.burns.2026.107967_bib24","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1016\/j.transproceed.2006.02.053","article-title":"Bloodstream cells phenotypically identical to human mesenchymal bone marrow stem cells circulate in large amounts under the influence of acute large skin damage: new evidence for their use in regenerative medicine","volume":"38","author":"Mansilla","year":"2006","journal-title":"Transpl Proc"},{"issue":"6","key":"10.1016\/j.burns.2026.107967_bib25","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1111\/wrr.13226","article-title":"National burn care, education & research group, The Netherlands. Outcomes of dermal substitutes in burns and burn scar reconstruction: A systematic review and meta-analysis","volume":"32","author":"van den Bosch","year":"2024","journal-title":"Wound Repair Regen"},{"issue":"3","key":"10.1016\/j.burns.2026.107967_bib26","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1097\/00004630-199705000-00009","article-title":"Immunogenicity of glycerol-preserved human cadaver skin in vitro","volume":"18","author":"Richters","year":"1997","journal-title":"J Burn Care Rehabil"},{"issue":"2","key":"10.1016\/j.burns.2026.107967_bib27","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1093\/jbcr\/irz145","article-title":"Clinical impact of cryopreservation on split thickness skin grafts in the porcine model","volume":"41","author":"Holzer","year":"2020","journal-title":"J Burn Care Res"},{"key":"10.1016\/j.burns.2026.107967_bib28","article-title":"Regulated cell death and DAMPs as biomarkers and therapeutic targets in normothermic perfusion of transplant organs. Part 1: their emergence from injuries to the donor organ","volume":"4","author":"Land","year":"2025","journal-title":"Front Transpl"},{"issue":"3","key":"10.1016\/j.burns.2026.107967_bib29","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/BF00456841","article-title":"HLA class I antigen (heavy and light chain) expression by Langerhans cells and keratinocytes of the normal human epidermis: ultrastructural quantitation using immunogold labelling procedure","volume":"280","author":"Gielen","year":"1988","journal-title":"Arch Dermatol Res"},{"issue":"4","key":"10.1016\/j.burns.2026.107967_bib30","first-page":"199","article-title":"Decrease of circulating dendritic cells in burn patients","volume":"20","author":"D'Arpa","year":"2007","journal-title":"Ann Burns Fire Disasters"},{"issue":"1 Pt 1","key":"10.1016\/j.burns.2026.107967_bib31","first-page":"255","article-title":"Preformed antibodies in sensitised recipients: effect of immunoglobulin titre, class, and specificity on liver and heart allografts","volume":"25","author":"Furuya","year":"1993","journal-title":"Transpl Proc"},{"issue":"4","key":"10.1016\/j.burns.2026.107967_bib32","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1111\/tan.12537","article-title":"Interindividual differences in HLA expression can impact the CDC crossmatch","volume":"85","author":"H\u00f6nger","year":"2015","journal-title":"Tissue Antigens"},{"issue":"5","key":"10.1016\/j.burns.2026.107967_bib33","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1038\/ki.2014.106","article-title":"Impact of donor mismatches at individual HLA-A, -B, -C, -DR, and -DQ loci on the development of HLA-specific antibodies in patients listed for repeat renal transplantation","volume":"86","author":"Kosmoliaptsis","year":"2014","journal-title":"Kidney Int"}],"container-title":["Burns"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0305417926001191?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0305417926001191?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T21:23:30Z","timestamp":1775683410000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0305417926001191"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":33,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["S0305417926001191"],"URL":"https:\/\/doi.org\/10.1016\/j.burns.2026.107967","relation":{},"ISSN":["0305-4179"],"issn-type":[{"value":"0305-4179","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Management of burn patients is linked to the development of anti-HLA antibodies in patients receiving cryopreserved skin allografts: A retrospective cohort","name":"articletitle","label":"Article Title"},{"value":"Burns","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.burns.2026.107967","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd and ISBI. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"107967"}}