{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T20:20:54Z","timestamp":1784751654613,"version":"3.55.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T00:00:00Z","timestamp":1775606400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004267","name":"Royal Adelaide Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004267","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Burns"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.burns.2026.108013","type":"journal-article","created":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T01:01:05Z","timestamp":1775782865000},"page":"108013","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Differentiating scar behaviour: Transepidermal water loss in delayed healing and skin graft scars"],"prefix":"10.1016","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8466-4821","authenticated-orcid":false,"given":"Tanja","family":"Klotz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2213-9460","authenticated-orcid":false,"given":"Brad","family":"Schmitt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guy","family":"Maddern","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus","family":"Wagstaff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.burns.2026.108013_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.5114\/pdia.2015.48037","article-title":"Structural and biophysical characteristics of human skin in maintaining proper epidermal barrier function","volume":"1","author":"Boer","year":"2016","journal-title":"Adv Dermatol Allergol"},{"key":"10.1016\/j.burns.2026.108013_bib2","doi-asserted-by":"crossref","unstructured":"Merk H.F. Barrier Skin. 2018. In: Environment and Skin [Internet]. Switzerland: Springer.","DOI":"10.1007\/978-3-319-43102-4_1"},{"issue":"5","key":"10.1016\/j.burns.2026.108013_bib3","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1111\/bjd.17025","article-title":"Transepidermal water loss in healthy adults: a systematic review and meta-analysis update","volume":"179","author":"Akdeniz","year":"2018","journal-title":"Br J Dermatol"},{"issue":"3","key":"10.1016\/j.burns.2026.108013_bib4","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1111\/srt.12599","article-title":"The revised EEMCO guidance for the in vivo measurement of water in the skin","volume":"24","author":"Berardesca","year":"2018","journal-title":"Ski Res Technol"},{"issue":"3","key":"10.1016\/j.burns.2026.108013_bib5","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1111\/srt.12037","article-title":"International guidelines for the in vivo assessment of skin properties in non-clinical settings: part 2. transepidermal water loss and skin hydration","volume":"19","author":"du Plessis","year":"2013","journal-title":"Ski Res Technol"},{"key":"10.1016\/j.burns.2026.108013_bib6","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s41038-016-0036-x","article-title":"A systematic review of objective burn scar measurements","volume":"4","author":"Lee","year":"2016","journal-title":"Burns Trauma"},{"issue":"7","key":"10.1016\/j.burns.2026.108013_bib7","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1111\/j.1600-0625.2006.00437.x","article-title":"Transepidermal water loss reflects permeability barrier status: validation in human and rodent in vivo and ex vivo models","volume":"15","author":"Fluhr","year":"2006","journal-title":"Exp Dermatol"},{"issue":"4","key":"10.1016\/j.burns.2026.108013_bib8","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1111\/j.1467-2494.2005.00270.x","article-title":"Comparative assessment of the performance of two generations of Tewameter: TM210 and TM300","volume":"24","author":"Rosado","year":"2005","journal-title":"Int J Cosmet Sci"},{"issue":"1","key":"10.1016\/j.burns.2026.108013_bib9","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1111\/j.1600-0846.2005.00101.x","article-title":"Validation of the VapoMeter, a closed unventilated chamber system to assess transepidermal water loss vs. the open chamber Tewameter","volume":"11","author":"De Paepe","year":"2005","journal-title":"Ski Res Technol"},{"issue":"3","key":"10.1016\/j.burns.2026.108013_bib10","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.burns.2012.07.026","article-title":"Measurement of elasticity and transepidermal water loss rate of burn scars with the Dermalab(R)","volume":"39","author":"Anthonissen","year":"2013","journal-title":"Burns"},{"issue":"12","key":"10.1016\/j.burns.2026.108013_bib11","doi-asserted-by":"crossref","first-page":"1453","DOI":"10.1001\/archderm.1996.03890360039008","article-title":"Functional analysis of the stratum corneum in scars. Sequential studies after injury and comparison among keloids, hypertrophic scars and atrophic scars","volume":"123","author":"Suetake","year":"1996","journal-title":"Arch Dermatol"},{"issue":"2","key":"10.1016\/j.burns.2026.108013_bib12","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s10353-012-0074-y","article-title":"On the surgical treatment of hypertrophic scars: a comprehensive guideline for surgical treatemnt of hypertrophic scars","volume":"44","author":"Stekelenburg","year":"2012","journal-title":"Eur Surg"},{"issue":"1","key":"10.1016\/j.burns.2026.108013_bib13","first-page":"s16","article-title":"The role of the epidermis and the mechanism of action of occlusive dressings in scarring","volume":"19","author":"Mustoe","year":"2011","journal-title":"Wound Repair Regen"},{"issue":"7","key":"10.1016\/j.burns.2026.108013_bib14","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1016\/j.burns.2013.03.025","article-title":"Scar management by means of occlusion and hydration: a comparative study of silicones versus a hydrating gel-cream","volume":"39","author":"Hoeksema","year":"2013","journal-title":"Burns"},{"issue":"8","key":"10.1016\/j.burns.2026.108013_bib15","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1016\/j.burns.2014.02.005","article-title":"The effect of burn rehabilitation massage therapy on hypertrophic scar after burn: a randomized controlled trial","volume":"40","author":"Cho","year":"2014","journal-title":"Burns"},{"issue":"1","key":"10.1016\/j.burns.2026.108013_bib16","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1046\/j.1524-4725.2000.99143.x","article-title":"A pilot study of noninvasive methods to assess healed acute and chronic wounds","volume":"26","author":"Ho","year":"2000","journal-title":"Dermatol Surg"},{"issue":"3","key":"10.1016\/j.burns.2026.108013_bib17","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1097\/BCR.0b013e3181710881","article-title":"Quantitative measurement of hypertrophic scar: interrater reliability and concurrent validity","volume":"29","author":"Nedelec","year":"2008","journal-title":"J Burn Care Res"},{"key":"10.1016\/j.burns.2026.108013_bib18","series-title":"Burn trauma rehabilitation: allied health practice guidelines","year":"2014"},{"issue":"2","key":"10.1016\/j.burns.2026.108013_bib19","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1097\/01.prs.0000172982.43599.d6","article-title":"Reliable and feasible evaluation of linear scars by the patient and observer scar assessment scale","volume":"116","author":"van de Kar","year":"2005","journal-title":"Plast Reconstr Surg"},{"key":"10.1016\/j.burns.2026.108013_bib20","unstructured":"Klotz T., Schmitt B., Wagstaff M., Maddern G., Caplash Y. Burn scar activity defined \u2013 the relationships between subjective and objective measures and scar activity (Unpublished). 2025."},{"key":"10.1016\/j.burns.2026.108013_bib21","unstructured":"Cortex Technology SkinLab Z5010114. Dermalab(R) Combo: Instruction Manual Hadsund, Denmark2019."},{"issue":"1","key":"10.1016\/j.burns.2026.108013_bib22","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1159\/000504063","article-title":"the EG. EEMCO Guidance for the in vivo assessment of biomechanical properties of the human skin and its annexes: revisiting instrumentation and test modes","volume":"33","author":"Rodrigues","year":"2020","journal-title":"Ski Pharm Physiol"},{"issue":"5","key":"10.1016\/j.burns.2026.108013_bib23","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1213\/ANE.0000000000002864","article-title":"Correlation coefficients: appropriate use and interpretation","volume":"126","author":"Schober","year":"2018","journal-title":"Anesth & Analg"},{"key":"10.1016\/j.burns.2026.108013_bib24","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1111\/j.1600-0536.1990.tb01553.x","article-title":"Guidelines for transepidermal water loss (TEWL) measurement","volume":"22","author":"Pinnagoda","year":"1990","journal-title":"Cont Derm"},{"issue":"3","key":"10.1016\/j.burns.2026.108013_bib25","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.burns.2012.07.026","article-title":"Measurement of elasticity and transepidermal water loss rate of burn scars with the Dermalab((R))","volume":"39","author":"Anthonissen","year":"2013","journal-title":"Burns"},{"issue":"1","key":"10.1016\/j.burns.2026.108013_bib26","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1159\/000330486","article-title":"Comparison of transepidermal water loss and laser scanning microscopy measurements to assess their value in the characterization of cutaneous barrier defects","volume":"25","author":"Czaika","year":"2012","journal-title":"Ski Pharm Physiol"},{"issue":"11","key":"10.1016\/j.burns.2026.108013_bib27","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1177\/21621918251382448","article-title":"High transepidermal water loss at the closed wound site marks compromised functional wound closure and associates with wound recurrence in diabetic foot ulcers: a prognostic factor study","volume":"14","author":"Schmidt","year":"2025","journal-title":"Adv Wound Care (N Rochelle)"},{"issue":"11","key":"10.1016\/j.burns.2026.108013_bib28","doi-asserted-by":"crossref","first-page":"1871","DOI":"10.1007\/s00018-011-0663-0","article-title":"Matrix control of scarring","volume":"68","author":"Yates","year":"2011","journal-title":"Cell Mol Life Sci"},{"issue":"1","key":"10.1016\/j.burns.2026.108013_bib29","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1159\/000339613","article-title":"Wound repair and regeneration","volume":"49","author":"Reinke","year":"2012","journal-title":"Eur Surg Res"},{"issue":"2","key":"10.1016\/j.burns.2026.108013_bib30","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s10353-012-0074-y","article-title":"On the surgical treatment of hypertrophic scars: a comprehensive guideline for the surgical treatment of hypertrophic scars","volume":"44","author":"Stekelenburg","year":"2012","journal-title":"Eur Surg"},{"issue":"8","key":"10.1016\/j.burns.2026.108013_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.burns.2025.107629","article-title":"Commonly recommended moisturising products: effect on transepidermal water loss and hydration in a scar model","volume":"51","author":"Klotz","year":"2025","journal-title":"Burns"},{"key":"10.1016\/j.burns.2026.108013_bib32","doi-asserted-by":"crossref","unstructured":"Klotz T., Edwards S., Maddern G., Wagstaff M. Choosing the Right TEWL Device: A Comparison of Reliability of the VapoMeter\u00ae and DermaLab\u00ae Across Measurement Ranges (Unpublished). 2026.","DOI":"10.1111\/srt.70358"}],"container-title":["Burns"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0305417926001658?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0305417926001658?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T19:43:56Z","timestamp":1784749436000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0305417926001658"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":32,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["S0305417926001658"],"URL":"https:\/\/doi.org\/10.1016\/j.burns.2026.108013","relation":{},"ISSN":["0305-4179"],"issn-type":[{"value":"0305-4179","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Differentiating scar behaviour: Transepidermal water loss in delayed healing and skin graft scars","name":"articletitle","label":"Article Title"},{"value":"Burns","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.burns.2026.108013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"108013"}}